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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
311

The p53-p21-Cyclin E Pathway in Centrosome Amplification and Chromosome Instability

BENNETT, RICHARD A. January 2007 (has links)
No description available.
312

The transient response of a cam-and-follower system with uniformly varying frequency of excitation

Yu, Chen-Teh January 1982 (has links)
No description available.
313

Investigation of Capstan Friction and its Potential Use as a Mechanical Amplifier

Starkey, Michael M. 05 August 2010 (has links)
No description available.
314

Restriction landmark genomic scanning to identify novel methylated and amplified DNA sequences in human lung cancer

Dai, Zunyan January 2002 (has links)
No description available.
315

Development of high repetition rate no planar laser induced fluorescence imaging

Jiang, Naibo 12 September 2006 (has links)
No description available.
316

Analysis of cooperative, correlated motions in dynamic chiral secondary conformational states of macromolecular dendritic structures

Hofacker, Amanda Lynn 13 September 2006 (has links)
No description available.
317

Target region amplification polymorphism (TRAP) analysis of <i>Pelargonium</i>

Palumbo, Rose E. 07 January 2008 (has links)
No description available.
318

Seeds of (inter)action : Applying amplification and systems approaches to seed initiatives in Italy

Voigt, Franca Josefa January 2022 (has links)
Seeds are essential elements within agricultural production and food systems. However, seed systems face multiple issues, including processes of commercialisation, privatisation, and crop diversity loss, that require reconsidering current approaches to seeds and varieties. Seed initiatives hold a potential to contribute to alternative and desirable seed system configurations and outcomes. In this thesis, I analyse how existing seed initiatives increase their impact, drawing on the typology of amplification processes by Lam et al. (2020). Furthermore, due to the long-term occurrence of variety losses and the complexity of the processes involved, this thesis uses system dynamics concepts and diagramming tools to map the use of local varieties from the initiatives’ perceptions. Thereby, I attempt to operationalise amplification, depict local variety use, and combine the two approaches within the context of seed initiatives. I employ a case-study approach in Italy and conducted semi-structured interviews with members of six seed initiatives. Concrete actions for almost all the frameworks’ processes were found. Building stability, influencing values and mindsets, and strategically impacting higher institutional levels emerged as suitable ways to amplify and might indicate that initiatives prepare and potentially navigate change. Enhancing the initiatives’ impact range and speed benefitted from more nuance due to diverging notions on these processes. A qualitative systems diagram with social and ecological components maps causal structures that influence the use of local varieties, showing a potential for desirable dynamics. By indicating how amplifying actions relate to the system structure, I illustrate how the seed initiatives are influencing multiple system parts. Thus, the system maps revealed perceived system structure, which by itself might run the risk of portraying path dependency, while amplification relates to agency on how initiatives might influence the system.
319

Arctic low-level mixed-phase clouds and their complex interactions with aerosol and radiation: Remote sensing of the Arctic troposphere with the shipborne supersite OCEANET-Atmosphere

Griesche, Hannes Jascha 28 June 2022 (has links)
In the course of this thesis, Arctic low-level mixed-phase clouds and their interaction with aerosol and radiation have been investigated. To do so, measurements with the shipborne remote sensing supersite OCEANET-Atmosphere were conducted during the PS106 expedition in the Arctic summer 2017. OCEANET-Atmosphere comprises among other instruments a multiwavelength polarization lidar PollyXT and a microwave radiometer HATPRO. For PS106 the OCEANET-Atmosphere facility was complemented for the first time with a motion-stabilized vertically pointing Doppler cloud radar Mira-35. The cloud radar Doppler velocity was corrected for the ship’s vertical movement. The stabilization and the correction enabled, e.g., the derivation of eddy dissipation rates from the Doppler velocities. A data set of cloud microphysical and macrophysical properties was derived by applying the synergistic Cloudnet algorithm to the combined measurements of cloud radar, lidar, and microwave radiometer. Within this thesis, the set of the Cloudnet retrievals was improved to account for the complex structure of the Arctic cloud system. A new detection approach for the frequently observed low-level stratus clouds was developed based on the lidar signal-to-noise ratio. These clouds, which were below the lowest range gate of the cloud radar were observed during 50 % of the observational time. A new approach for the continuous determination of the ice crystal effective radius was introduced. This new retrieval made the data set suitable to perform high-resolved radiative transfer simulations. The retrieved data set was utilized to derive the first temperature relationship for heterogeneous ice formation in Arctic mixed-phase clouds. A strong dependence of the surface coupling state for high subzero ice-formation temperatures was found. For an ice-formation temperature above -15 °C, surface-coupled ice-containing clouds occur more frequently by a factor of 5 in numbers of observed clouds and by a factor of 2 in frequency of occurrence. Possible causes of the observed effect were discussed by sensitivity studies and a literature survey. Instrumental and methodological effects, and previously published similar observations of an increased ice occurrence at such high subzero temperatures have been ruled out as a possible explanation. The most likely cause of the observed effect was attributed to a larger reservoir of biogenic ice-nucleating particles in the surface-coupled marine boundary layer. This larger reservoir led to a higher freezing efficiency in these clouds which had at least their base in that layer. Finally, the importance of the detailed classification of the low-level clouds was highlighted by the evaluation of radiative transfer simulations. A difference in the cloud radiative effect of up to 100 W m-2 was calculated when these clouds were considered.:1 Introduction 2 Arctic — Amplified climate change 2.1 The Arctic climate system 2.2 Cloud radiation budget 2.3 Arctic mixed-phase clouds 2.4 Heterogeneous ice formation in Arctic mixed-phase clouds — constraints and previous findings 2.5 Motivating research questions 3 Data set — Applied instrumentation, processing, and retrievals 3.1 Introduction to ground-based active remote sensing of aerosol and clouds 3.1.1 Lidar principle 3.1.2 Radio Detection and Ranging — Radar 3.2 The Arctic expedition PS106 3.3 Instrumentation 3.3.1 The OCEANET-Atmosphere observatory 3.3.2 Other instruments used in this study 3.4 Data processing and synergistic retrievals 3.4.1 Correction of vertical-stare cloud radar observations for ship motion 3.4.2 Retrieval of eddy dissipation rate from Doppler radar spectra 3.4.3 Cloud macro- and microphysical properties from instrument-synergies 3.5 Summary of the data processing for PS106 4 Cloud and aerosol observations during PS106 4.1 Meteorological conditions during PS106 4.2 Case studies 4.3 Cloud and aerosol statistics during PS106 4.4 Discussion of the observational data sets 5 Contrasting surface-coupling effects on heterogeneous ice formation 5.1 Methodology 5.1.1 Ice-containing cloud analysis 5.1.2 Surface-coupling state 5.2 Results: influence of surface coupling on heterogeneous ice formation temperature 5.3 Discussion of the observed surface-coupling effects 5.3.1 Methodological and instrumental effects 5.3.2 Possible causes for increased ice occurrence in surface-coupled clouds 6 Application of the data set in collaborative studies and radiative transfer simulations within (AC)3 6.1 Radiative transfer simulations and cloud radiative effect 6.2 LLS treatment for improved radiative transfer simulations 6.3 Discussion 7 Summary and outlook Appendices A Determination of a volume depolarization threshold forlidar-based ice detection Bibliography / Im Rahmen dieser Arbeit wurden niedrige arktische Mischphasenwolken und ihre Wechselwirkung mit Aerosolen und Strahlung untersucht. Dazu wurden Messungen mit der schiffsgestützten Fernerkundungs-Supersite OCEANET-Atmosphere während der PS106-Expedition im arktischen Sommer 2017 durchgeführt. OCEANET-Atmosphere vereint, u.a., ein Multiwellenlängen-Polarisations-Lidar PollyXT und ein Mikrowellen-Radiometer HATPRO. Für PS106 wurde OCEANET-Atmosphere erstmalig um ein stabilisiertes, vertikal ausgerichtetes Doppler-Wolkenradar Mira-35 erweitert. Die Doppler-Geschwindigkeit wurde in Bezug auf die Vertikalbewegung des Schiffes korrigiert. Dank Stabilisierung und Korrektur war, z.B., die Ableitung von Wirbeldissipationsraten aus den Doppler-Geschwindigkeiten möglich. Unter Anwendung des synergetischen Cloudnet-Algorithmus wurde aus den kombinierten Wolkenradar, Lidar und Mikrowellenradiometer Messungen ein Datensatz der mikro- und makrophysikalischen Wolkeneigenschaften für PS106 erstellt. Im Rahmen dieser Arbeit wurde Cloudnet verbessert, um der komplexen Struktur der arktischen Wolken Rechnung zu tragen. Ein neuer Ansatz zur Erkennung der häufig beobachteten niedrigen Stratuswolken wurde entwickelt, basierend auf dem Lidar-Signal-zu-Rausch-Verhältnis. Diese Wolken, die unterhalb des untersten Höhenlevels des Wolkenradars auftraten, wurden während 50% der Beobachtungszeit identifiziert. Ein neuer Ansatz für die kontinuierliche Bestimmung des effektiven Radius der Eiskristalle wurde eingeführt. Dank dieser neuen Methode eignet sich der erstellte Datensatz für die Durchführung von Strahlungstransfersimulationen. Zum ersten Mal wurde eine Temperaturbeziehung für heterogene Eisbildung in arktischen Mischphasenwolken in Abhängigkeit ihres Oberflächen-Kopplungsstatus abgeleitet. Bei Temperaturen über -15°C war die relative Häufigkeit von Eis beinhaltenden Wolken doppelt so hoch und die Anzahl fünf Mal höher wenn sie mxit der Oberfläche gekoppelt waren, als bei entkoppelte Wolken. Mögliche Ursachen für den beobachteten Effekt wurden anhand von Sensitivitätsstudien und einer Literaturanalyse diskutiert. Instrumentelle und methodische Effekte sowie früher veröffentlichte ähnliche Beobachtungen konnten als mögliche Erklärung ausgeschlossen werden. Die wahrscheinlichste Ursache für den beobachteten Effekt wurde auf ein größeres Reservoir an biogenen Eiskristallisationskeimen in der oberflächengekoppelten marinen Grenzschicht zurückgeführt. Dieses größere Reservoir hat zu einer höheren Gefriereffizienz in Wolken geführt, die zumindest ihre Basis in dieser Schicht hatten. Die Bedeutung der detaillierten Klassifizierung von tiefliegenden Wolken auf Strahlungstransfersimulationen wurde hervorgehoben. Der simulierte Effekt der Wolken auf den Strahlungshaushalt unterschied sich bis zu 100 W m-2, unter Berücksichtigung dieser Wolken.:1 Introduction 2 Arctic — Amplified climate change 2.1 The Arctic climate system 2.2 Cloud radiation budget 2.3 Arctic mixed-phase clouds 2.4 Heterogeneous ice formation in Arctic mixed-phase clouds — constraints and previous findings 2.5 Motivating research questions 3 Data set — Applied instrumentation, processing, and retrievals 3.1 Introduction to ground-based active remote sensing of aerosol and clouds 3.1.1 Lidar principle 3.1.2 Radio Detection and Ranging — Radar 3.2 The Arctic expedition PS106 3.3 Instrumentation 3.3.1 The OCEANET-Atmosphere observatory 3.3.2 Other instruments used in this study 3.4 Data processing and synergistic retrievals 3.4.1 Correction of vertical-stare cloud radar observations for ship motion 3.4.2 Retrieval of eddy dissipation rate from Doppler radar spectra 3.4.3 Cloud macro- and microphysical properties from instrument-synergies 3.5 Summary of the data processing for PS106 4 Cloud and aerosol observations during PS106 4.1 Meteorological conditions during PS106 4.2 Case studies 4.3 Cloud and aerosol statistics during PS106 4.4 Discussion of the observational data sets 5 Contrasting surface-coupling effects on heterogeneous ice formation 5.1 Methodology 5.1.1 Ice-containing cloud analysis 5.1.2 Surface-coupling state 5.2 Results: influence of surface coupling on heterogeneous ice formation temperature 5.3 Discussion of the observed surface-coupling effects 5.3.1 Methodological and instrumental effects 5.3.2 Possible causes for increased ice occurrence in surface-coupled clouds 6 Application of the data set in collaborative studies and radiative transfer simulations within (AC)3 6.1 Radiative transfer simulations and cloud radiative effect 6.2 LLS treatment for improved radiative transfer simulations 6.3 Discussion 7 Summary and outlook Appendices A Determination of a volume depolarization threshold forlidar-based ice detection Bibliography
320

Development of nucleic acid therapeutics based on the control of their intracellular distribution / 細胞内動態制御を基盤とした核酸医薬品開発に関する研究

Umemura, Keisuke 23 March 2023 (has links)
京都大学 / 新制・課程博士 / 博士(薬学) / 甲第24563号 / 薬博第861号 / 新制||薬||243(附属図書館) / 京都大学大学院薬学研究科薬学専攻 / (主査)教授 髙倉 喜信, 教授 山下 富義, 教授 小野 正博 / 学位規則第4条第1項該当 / Doctor of Pharmaceutical Sciences / Kyoto University / DFAM

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