We examined parental psychopathology and family environment in subthreshold and DSM-IV threshold conditions of social anxiety disorder (SAD) in a representative cohort sample of 1,395 adolescents. Offspring and parental psychopathology was assessed using the DIAX/ M-CIDI; recalled parental rearing and family functioning via questionnaire. Diagnostic interviews in parents were supplemented by family history reports from offspring. The cumulative lifetime incidence was 23.07% for symptomatic SAD, and 18.38 and 7.41% for subthreshold and threshold SAD, respectively. The specific parent-tooffspring association for SAD occurred for threshold SAD only. For subthreshold and threshold SAD similar associations were found with other parental anxiety disorders, depression and substance use disorders. Parental rearing behaviour, but not family functioning, was associated with offspring threshold SAD, and although less strong and less consistent, also with subthreshold SAD. Results suggest a continued graded relationship between familial risk factors and offspring SAD. Parental psychopathology and negative parental styles may be used defining high-risk groups to assign individuals with already subthreshold conditions of SAD to early intervention programs.

Generalized anxiety disorder (GAD) is associated with painful physical symptoms (PPS). These post hoc analyses of previous trial data assessed PPS and their response to duloxetine treatment in GAD patients. Studies 1 and 2 (n = 840) were 9- to 10-week efficacy trials; study 3 (n = 887) was a relapse prevention trial comprising a 26-week open-label treatment phase and a 26-week double-blind, placebo-controlled treatment continuation phase. Mean baseline visual analog scale scores (VAS, 0–100; n = 1727) ranged from 26 to 37 for overall pain, headache, back pain, shoulder pain, interference with daily activities, and time in pain while awake. In studies 1 and 2, improvement on all VAS scores was greater in duloxetine-treated than in placebo-treated patients (p ≤ 0.01). In study 3, pain symptoms worsened in responders switched to placebo compared with those maintained on duloxetine (p ≤ 0.02). In conclusion, duloxetine was efficacious in the short- and long-term treatment of PPS, which are common in GAD patients.

Background: Subtle and inconsistent differences in hypothalamic-pituitary-adrenal (HPA) axis activity have been reported for patients with panic disorder. While these patients show little or no alterations in basal ACTH and cortisol levels, it has been hypothesized that HPA hyperresponsivity was a trait in panic patients when exposed to novel and uncontrollable stimulation. Methods: Thirty-four patients (23 females, mean age 35 yrs) diagnosed with panic disorder were compared to 34 healthy controls matched for age, gender, smoking status, and use of oral contraceptives. Both groups were exposed twice to a potent laboratory stress protocol, the Trier Social Stress Test (TSST) on consecutive days. Free salivary cortisol levels and heart rate responses were repeatedly measured before and following the TSST. In addition, the cortisol awakening response (CAR) was assessed to further investigate HPA reactivity in PD patients. Results: While the TSST induced similar heart rate stress responses in both groups, cortisol responses were clearly absent in the panic patients with normal responses in the controls (F(1.96, 66) = 20.16; p < 0.001). No differences in basal cortisol levels were observed in the extended baseline period. The same cortisol stress non-response patterns were observed when patients with/without comorbid depression, or with/without psychotropic medication were compared. In contrast to their non-response to the psychosocial stressor, panic patients showed a significant CAR. Conclusion: These findings provide strong evidence to suggest that PD patients present with a striking lack of cortisol responsivity to acute uncontrollable psychosocial stress under laboratory conditions. This unresponsiveness of the HPA axis appears to be rather specific, since a normal CAR in the morning could be documented in these patients. Thus, the present results do not support the hypothesis that PD patients show a trait HPA hyperresponsiveness to novel and uncontrollable stimulation. In contrast, the data provide support for a hyporesponsive HPA axis under emotional stress in PD patients.

This study aims to gain an increased understanding of generalized anxiety disorder based on how the target group describe their experiences. The data was gathered through podcasts where people with GAD talked about their life situation, what strategies they use to manage general anxiety and what they think relieves general anxiety. The gathered data was then analyzed through a thematic analysis where four main themes were developed; a constant worry, managing stigma, controlling or avoiding and only relive, not cure. These themes were analyzed based on Goffman's theory of stigma and Gidden's theory of the risk society. The results show that people with GAD live with a constant anxiety that affects their entire life situation, such as their work, leisure, and social relationships. Their anxiety can be likened to an allergy to uncertainty as it´s triggered by something they cannot control. They feel stigmatized by others and feel that they often need to hide their stigma by living behind a facade. To deal with generalized anxiety, three different strategies are used, which are trying to control everything, avoiding anxiety by not exposing oneself to things that cause concern or by keeping oneself busy. However, these strategies can aggravate the condition but there are many things that can relieve general anxiety. The most prominent factors are medicine, therapy, emotional support and self-help such as exercise and meditation. But the results show that the symptoms persist despite great efforts and several treatments, which indicates that more research and more effective interventions are required. The study concludes that GAD is not only a problem that exists within the individual but also in interpersonal relationships and in the society. It also concludes that there must be a change in the structures of society regarding mental illness, and that interventions should not only be directed towards the individual but also towards the relatives. This because the results show that relatives are also affected and that their influence can both aggravate and improve the individual's condition. / Den här studien syftar till att få en ökad förståelse för generaliserat ångestsyndrom utifrån hur målgruppen själva beskriver sina upplevelser. Empirin samlades in genom poddar där personer med GAD berättade om sin livssituation, vilka strategier de använder för att hantera generell ångest och vad de anser lindrar generell ångest. Materialet analyserades genom en tematisk analys där fyra huvudteman togs fram; en konstant oro, hantera stigma, kontrollera eller undvika och endast lindra inte bota. Dessa teman analyserades utifrån Goffmans stigmateori och Giddens risksamhällesteori. Resultatet visar att personer med GAD lever med en konstant oro som påverkar hela deras livssituation, så som deras arbete, fritid och sociala relationer. Deras oro kan liknas med en allergi mot ovisshet då den triggas av sådant de inte kan kontrollera. De upplever sig stigmatiserade av andra och känner att de ofta behöver dölja sitt stigma genom att leva bakom en fasad. För att hantera generaliserad ångest används tre olika strategier vilka är att försöka kontrollera allt eller att undvika ångesten genom att inte utsätta sig för sådant som väcker oro eller att ständigt aktivera sig. Dessa strategier kan dock förvärra tillståndet, men det finns mycket som kan lindra generell ångest. De mest framträdande faktorerna är medicin, terapi, emotionellt stöd och självhjälp, som exempelvis meditation och träning. Resultatet visar dock att symtomen kvarstår trots stora ansträngningar och flertalet behandlingar vilket tyder på att mer forskning och effektivare interventioner krävs. Studien konkluderar att GAD inte enbart är ett problem som existerar inom individen utan även i mellanmänskliga relationer och i samhället som helhet. Därmed dras också slutsatsen att det måste ske en förändring i samhällsstrukturerna avseende psykisk ohälsa och att interventioner inte enbart bör riktas mot individen utan även anhöriga. Detta då resultatet visar att anhöriga också påverkas och att deras inflytande både kan förvärra och förbättra individens tillstånd.

博士(心理学) / Doctor of Philosophy in Psychology / 同志社大学 / Doshisha University

Background. To examine the role of parental psychopathology and family environment for the risk of social anxiety disorder (SAD) in offspring from childhood to early adulthood, covering an observational period of 10 years. Method. A community sample of 1,395 adolescents (aged 14 to 17 years at baseline) was prospectively followed-up over the core high risk period for SAD onset. DSM-IV offspring and parental psychopathology was assessed using the Munich-Composite International Diagnostic Interview; direct diagnostic interviews in parents were supplemented by family history reports from offspring. Parental rearing was assessed by the Questionnaire of Recalled Rearing Behavior in offspring, family functioning by the McMaster Family Assessment Device in parents. Results. Parental SAD was associated with the offspring’s risk to develop SAD (OR = 3.3, 95%CI: 1.4-8.0). Additionally, other parental anxiety disorders (OR = 2.9, 95%CI: 1.4-6.1), depression (OR = 2.6, 95%CI: 1.2-5.4) and alcohol use disorders (OR = 2.8, 95%CI: 1.3-6.1) were associated with offspring SAD. Offspring’s reports of parental overprotection, rejection and lack of emotional warmth, but not parental reports of family functioning were associated with offspring SAD. Analyses of interaction of parental psychopathology and parental rearing indicated combined effects on the risk for offspring SAD. Conclusions. These findings extend previous results in showing that both parental psychopathology and parental rearing are consistently associated with the risk for offspring SAD. As independent and interactive effects of parental psychopathology and parental rearing may have already manifested in early adolescence, these factors appear crucial and promising for targeted prevention programs.

Det finns en växande oro för den inverkan som sociala medier har på ungas psykiska hälsa. Sociala jämförelser och orealistiska skönhetsideal nämns ofta i relation till sådana samband. Flickor i tonåren rapporterar högre förekomst av psykiska besvär samt lägre självkänsla än pojkar. Syftet med föreliggande studie var att undersöka högstadieflickors användning av sociala medier (med fokus på Instagram och Snapchat) och huruvida denna är associerad med generaliserad ångest. Medieringsanalys användes för att testa om självkänsla kunde förklara det potentiella sambandet bland ett slumpmässigt urval unga flickor i Stockholms län (N = 1161; medelålder = 14 år). Urvalet baseras på sekundärdata från en studie av Nationellt centrum för suicidforskning och prevention (NASP). För att mäta ångest användes Generalized Anxiety Disorder 7-item scale (GAD-7). Självkänsla mättes med Rosenberg Self-Esteem Scale (RSES). Resultatet visade på små effekter men indikerar att det finns ett samband mellan flickornas ångest och tid på sociala medier, och att drygt hälften (51%) av sambandet kan förklaras genom att tid på sociala medier indirekt påverkade deras självkänsla negativt (β = 0,13; p &lt; 0,001). Vidare antydde resultatet att flickor, vars självkänsla påverkades av sociala medier, ökade sin ångest med 1,16 GAD-poäng för varje extra 2,54 timmar på sociala medier, i kontrast till en ökning av 0,56 GAD-poäng hos flickorna med mer stabil självkänsla. Genom att få en ökad förståelse för det eventuella sambandet mellan flickors upplevda ångest och användning av sociala medier kan preventiva åtgärder, som exempelvis stärker deras självkänsla, utvecklas som ett led i att minska potentiella skadeverkningar av sociala medier.

The short version of the Bielefeld Partnership Expectations Questionnaire (BPEQ-12) assesses the partner-related attachment dimensions fear of rejection, readiness for selfdisclosure, and conscious need for care. The presented study investigated the factor structure in two samples and evaluated the convergent validity of scales. The sample included N = 175 patients with panic disorder and/or agoraphobia and N = 143 healthy controls. Besides, the BPEQ, the Experiences in Close Relationships Questionnaire (ECR), and the Brief Symptom Inventory (BSI) were assessed as well, and the Adult Attachment Prototype Rating (AAPR) was conducted. A confirmatory factor analysis of the three factor model (using a WLSMV estimator) revealed an acceptable model fit for the entire sample, patients and controls in terms of low RMSEA and SRMR (< 0.08) and high CFI and TLI (> 0.95). We found metric, scalar, and strict measurement invariance for the presence of anxiety disorder (ΔCFI ≤ –0.01 and ΔRMSEA ≥ 0.01). However, only for fear of rejection and readiness for self-disclosure the reliability was acceptable (Cronbach’s a > 0.7), and convergent validity in terms of large correlations (r > 0.7) with the ECR scales was found in both samples. The scale conscious need for care had a questionable reliability (Cronbach’s a > 0.6) and correlated only slightly with ECR-R scales. We conclude that fear of rejection and readiness for self-disclosure of the BPEQ-12 are reliable and valid scales for measuring partner-related attachment in healthy and clinical samples.

Im Rahmen der vorliegenden Arbeit wurde eine Metaanalyse der Daten aller verfügbaren Studien (n = 109) zur medikamentösen Behandlung der drei für den Kliniker wesentlichen Angststörungen (PDA, GAD, SAD) durchgeführt. In die Metaanalyse wurden 187 Studienarme sowie die Daten von insgesamt 28785 Patienten eingeschlossen. Eine vergleichbare Metaanalyse, die alle drei Angststörungen zusammengefasst untersucht hat, wurde in dieser Form bisher nicht durchgeführt, wobei neben der zusammengefassten Analyse im Weiteren auch eine separate Betrachtung jeder einzelnen Angststörung erfolgte. Während im Rahmen aller bisher durchgeführten Metaanalysen zumeist lediglich Treated-vs.-Control-Effektstärken berechnet wurden, wurden in der vorliegenden Arbeit darüberhinaus auch Prae-Post-Effektstärken bestimmt. Dies ermöglicht einen besseren Vergleich der Wirksamkeit verschiedener Medikamente. Es ergab sich folgendes: Die in die Metaanalyse eingeschlossenen Studien zeigten trotz ähnlicher Ein- und Ausschlusskriterien sowie oftmaliger Verwendung gleicher Skalen eine hohe bis sehr hohe Heterogenität. Alle Medikamente bis auf Citalopram, Moclobemid und Opipramol zeigten einen signifikanten Unterschied zu Placebo. Die höchsten unadjustierten Treated-vs.-Control-Effektstärken konnten für Phenelzin (d = 0,98), Lorazepam und Clomipramin (d = 0,87) sowie Hydroxyzin (d = 0,79) berechnet werden. Die höchsten Prae-Post-Effektstärken wurden für Benzodiazepine (z. B. Delorazepam: d = 3,54; Bromazepam: d = 2,86; Lorazepam: d = 2,53), Quetiapin (d = 3,39), Escitalopram (d = 2,67) und Hyd-roxyzin (d = 2,56) berechnet, wobei in die Berechnung dieser Effektstärken zum Teil nur sehr wenige Primärstudien eingingen, so dass diese Ergebnisse als weniger reliabel zu werten sind. Bei Betrachtung der einzelnen Stoffgruppen erreichten die SNRIs mit d = 2,25 die höchste Prae-Post-Effektstärke, gefolgt von den Benzodiazepinen (d = 2,14) und den SSRIs (d = 2,09). Bei der Wahl eines Arzneimittels sollte auf ein angemessenes Verhältnis seines Nutzens zu seinen Risiken (Nebenwirkungen) geachtet werden. Viele der Medikamente, für die in der vorliegenden Arbeit relativ hohe Effektstärken berechnet werden konnten, weisen ein ungünstigeres Nebenwirkungsprofil als beispielsweise SNRIs und SSRIs auf. Vor allem wird aufgrund des bestehenden Abhängigkeitspotentials nicht empfohlen, Benzodiazepine routinemäßig zu verordnen. Ebenso führen trizyklische Antidepressiva häufiger zu Nebenwirkungen als SSRIs (Bandelow et al. 2008a). Weiterhin konnte in der vorliegenden Arbeit gezeigt werden, dass die Effektstärken der Pillenplacebos zwischen 1983 und 2013 stark anstiegen. Die Studien wurden mit Hilfe verschiedener Methoden zur Detektion eines Publication Bias analysiert. Hierbei ergaben sich zwar für mehrere Medikamente Hinweise auf das Vorliegen eines Publication Bias, dies hatte jedoch nicht zur Folge, dass die Annahme einer vormals berechneten signifikanten Überlegenheit des Medikamentes gegenüber Placebo wieder verworfen werden musste. Für 50,8% von insgesamt 187 Studienarmen wurden Allegiance-Effekte angenommen. Die durchschnittliche Effektstärke der Studien mit angenommenem Allegiance-Effekt unterschied sich jedoch nicht signifikant von der ohne solche Effekte. Klinisch tätige Ärzte können sich an den Ergebnissen der Metaanalyse orientieren, um – unter Berücksichtigung von potentiellen Nebenwirkungen und Kontraindikationen – für ihre Patienten das Präparat mit dem günstigsten Nutzen-Risiko-Verhältnis auszuwählen.

Le trouble d’anxiété de séparation (TAS) est le trouble anxieux le plus prévalent chez les enfants. Il apparaît tôt et entraîne plusieurs conséquences négatives. La thérapie cognitivo-comportementale (TCC) a été reconnue efficace pour traiter les troubles anxieux. Toutefois, peu d’études ont vérifié son efficacité pour le traitement spécifique du TAS et très peu en ont examiné l’effet auprès d’enfants de moins de 7 ans. Les quelques interventions étudiées visant les moins de 7 ans ont en commun d’inclure le parent dans le traitement ou de l’offrir directement à celui-ci. L’objectif principal de cette thèse est de vérifier l’efficacité d’un programme d’entraînement parental de type TCC, adapté pour les parents d’enfants de 4 à 7 ans souffrant de TAS. Cette étude vise également deux objectifs spécifiques : observer la fluctuation des symptômes de TAS de l’enfant pendant le traitement et examiner l’impact du programme sur les variables parentales. Un devis à cas unique à niveaux de base multiples a été utilisé. Six familles ont pris part à l’étude. Des entrevues semi-structurées, des questionnaires auto-administrés et des calepins d’auto-observations quotidiennes ont été utilisés auprès des parents pour mesurer les symptômes anxieux des enfants, leurs pratiques parentales, le stress parental et leurs symptômes anxieux et dépressifs. Des questionnaires sur les difficultés de l’enfant incluant l’anxiété ont aussi été envoyés à l’éducatrice ou à l’enseignante. Tous les questionnaires ont été administrés aux trois temps de mesure (prétraitement, post-traitement et relance 3 mois). Les calepins d’auto-observations ont été remplis quotidiennement durant le niveau de base, pour toute la durée de l’intervention et pendant une à deux semaines à la relance. Les résultats de l’étude indiquent que cinq enfants sur six ne répondent plus au diagnostic de TAS suite au traitement ainsi que trois mois plus tard. Les résultats des calepins d’auto-observations montrent une amélioration claire des manifestations principales de TAS pour la moitié des enfants et plus mitigée pour l’autre moitié, de même qu’une amélioration systématique de la fréquence hebdomadaire totale de manifestations de TAS suite à l’intervention pour quatre enfants. Les résultats aux questionnaires remplis par les parents montrent une amélioration des symptômes d’anxiété et de TAS chez quatre enfants au post-test et/ou à la relance, tandis que les questionnaires de l’éducatrice (ou enseignante) suggèrent que les symptômes anxieux des enfants se manifestaient peu dans leur milieu scolaire ou de garde. L’impact du programme sur le stress parental et les pratiques parentales est également mitigé. Ces résultats suggèrent que le Programme d’entraînement parental pour les enfants souffrant d’anxiété de séparation (PEP-AS) est efficace pour réduire les symptômes de TAS chez les enfants d’âge préscolaire ou en début de parcours scolaire et appuient la pertinence d’offrir le traitement aux parents et d’inclure un volet relationnel. D’autres études seront cependant nécessaires pour répliquer ces résultats auprès d’un plus vaste échantillon. Il serait également intéressant de vérifier les effets indépendants des différentes composantes du traitement et d’évaluer les effets du programme sur davantage de pratiques parentales associées spécifiquement à l’anxiété. / Separation anxiety disorder (SAD) is the most prevalent anxiety disorder among children. It appears early in development and has multiple negative consequences. Cognitive-behavioral therapy (CBT) has been shown to be an effective treatment for anxiety disorders. However, few studies have examined the efficacy of CBT to treat SAD in particular, and even fewer have examined the impact of this form of therapy on children younger than 7 years old. The main objective of the present doctoral thesis was to evaluate the efficacy of a CBT parent-training program, that was adapted specifically for parents of children aged 4 to 7 years old suffering from SAD. This study had two specific objectives: to observe any fluctuations in the child’s SAD symptoms during the treatment and to examine the impact of the program on parental variables. A single-case multiple baseline across-subjects design was used. Six families with a child aged 4-7 years old and with a diagnosis of SAD participated. Semi-structured interviews, self-reported questionnaires and daily diaries were used with the parents to assess the child’s anxiety symptoms, parental practices, parenting stress, and the parents anxious and/or depressive symptoms. Questionnaires on child problems were also sent to the children’ teacher or educator. All questionnaires were administered at three times of measurement (pre-treatment, post-treatment and 3 months follow-up). Daily diaries were also completed by the parents at baseline, throughout the treatment, and during one to two weeks at follow-up. Results revealed that five of the six children no longer met the criteria of a SAD diagnosis after treatment and three months later. Findings from the daily diaries showed a clear reduction of the principal SAD symptoms for half of the children but mixed results for the other half of the children and that four of six children presented a systematic favourable change of the total weekly frequency of SAD symptoms after the intervention. The results of parent questionnaires showed an improvement of SAD symptoms for four children at post-treatment and/or follow-up. The teacher/educator questionnaires indicated low impact of anxiety symptoms. The impact of the program on parenting stress and parental practices is mixed with some parents showing improvement and others less so. The results support the efficacy of the Programme d’entraînement parental pour les enfants souffrant d’anxiété de séparation (PEP-AS) to reduce SAD symptoms in preschool age children and support the relevance of directing the treatment towards parents and including a relational component in the intervention. However, more research is needed to replicate these findings with larger samples and randomized control trials. It would also be interesting to dismantle the program and to examine the various components of the treatment in different combinations, and to explore more specifically the program effects on parental variables.