Tesis por compendio / [EN] The long-lasting trend in the field of computation of stress and resource distribution has found its way into computer networks via the concept of peer-to-peer (P2P) connectivity. P2P is a symmetrical model, where each network node is enabled a comparable range of capacities and resources. It stands in a stark contrast to the classical, strongly asymmetrical client-server approach. P2P, originally considered only a complimentary, server-side structure to the straightforward client-server model, has been shown to have the substantial potential on its own, with multiple, widely known benefits: good fault tolerance and recovery, satisfactory scalability and intrinsic load distribution. However, contrary to client-server, P2P networks require sophisticated solutions on all levels, ranging from network organization, to resource location and managing. In this thesis we address one of the key issues of P2P networks: performing efficient resource searches of semantic nature under realistic, dynamic conditions. There have been numerous solutions to this matter, with evolutionary, stigmergy-based, and simple computational foci, but few attempt to resolve the full range of challenges this problem entails. To name a few: real-life P2P networks are rarely static, nodes disconnect, reconnect and change their content. In addition, a trivial incorporation of semantic searches into well-known algorithms causes significant decrease in search efficiency. In our research we build a solution incrementally, starting with the classic Ant Colony System (ACS) within the Ant Colony Optimization metaheuristic (ACO). ACO is an algorithmic framework used for solving combinatorial optimization problems that fits contractually the problem very well, albeit not providing an immediate solution to any of the aforementioned problems. First, we propose an efficient ACS variant in structured (hypercube structured) P2P networks, by enabling a path-post processing algorithm, which called Tabu Route Optimization (TRO). Next, we proceed to resolve the issue of network dynamism with an ACO-compatible information diffusion approach. Consequently, we attempt to incorporate the semantic component of the searches. This initial approximation to the problem was achieved by allowing ACS to differentiate between search types with the pheromone-per-concept idea. We called the outcome of this merger Routing Concept ACS (RC-ACS). RC-ACS is a robust, static multipheromone implementation of ACS. However, we were able to conclude from it that the pheromone-per-concept approach offers only limited scalability and cannot be considered a global solution. Thus, further progress was made in this respect when we introduced to RC-ACS our novel idea: dynamic pheromone creation, which replaces the static one-to-one assignment. We called the resulting algorithm Angry Ant Framework (AAF). In AAF new pheromone levels are created as needed and during the search, rather than prior to it. The final step was to enable AAF, not only to create pheromone levels, but to reassign them to optimize the pheromone usage. The resulting algorithm is called EntropicAAF and it has been evaluated as one of the top-performing algorithms for P2P semantic searches under all conditions. / [ES] La popular tendencia de distribución de carga y recursos en el ámbito de la computación se ha transmitido a las redes computacionales a través del concepto de la conectividad peer-to-peer (P2P). P2P es un modelo simétrico, en el cual a cada nodo de la red se le otorga un rango comparable de capacidades y recursos. Se trata de un fuerte contraste con el clásico y fuertemente asimétrico enfoque cliente-servidor. P2P, originalmente considerado solo como una estructura del lado del servidor complementaria al sencillo modelo cliente-servidor, ha demostrado tener un potencial considerable por sí mismo, con múltiples beneficios ampliamente conocidos: buena tolerancia a fallos y recuperación, escalabilidad satisfactoria y distribución de carga intrínseca. Sin embargo, al contrario que el modelo cliente-servidor, las redes P2P requieren de soluciones sofisticadas a todos los niveles, desde la organización de la red hasta la gestión y localización de recursos. Esta tesis aborda uno de los problemas principales de las redes P2P: la búsqueda eficiente de recursos de naturaleza semántica bajo condiciones dinámicas y realistas. Ha habido numerosas soluciones a este problema basadas en enfoques evolucionarios, estigmérgicos y simples, pero pocas han tratado de resolver el abanico completo de desafíos. En primer lugar, las redes P2P reales son raramente estáticas: los nodos se desconectan, reconectan y cambian de contenido. Además, la incorporación trivial de búsquedas semánticas en algoritmos conocidos causa un decremento significativo de la eficiencia de la búsqueda. En esta investigación se ha construido una solución de manera incremental, comenzando por el clásico Ant Colony System (ACS) basado en la metaheurística de Ant Colony Optimization (ACO). ACO es un framework algorítmico usado para búsquedas en grafos que encaja perfectamente con las condiciones del problema, aunque no provee una solución inmediata a las cuestiones mencionadas anteriormente. En primer lugar, se propone una variante eficiente de ACS para redes P2P estructuradas (con estructura de hipercubo) permitiendo el postprocesamiento de las rutas, al que hemos denominado Tabu Route Optimization (TRO). A continuación, se ha tratado de resolver el problema del dinamismo de la red mediante la difusión de la información a través de una estrategia compatible con ACO. En consecuencia, se ha tratado de incorporar el componente semántico de las búsquedas. Esta aproximación inicial al problema ha sido lograda permitiendo al ACS diferenciar entre tipos de búsquedas através de la idea de pheromone-per-concept. El resultado de esta fusión se ha denominado Routing Concept ACS (RC-ACS). RC-ACS es una implementación multiferomona estática y robusta de ACS. Sin embargo, a partir de esta implementación se ha podido concluir que el enfoque pheromone-per-concept ofrece solo escalabilidad limitada y que no puede ser considerado una solución global. Por lo tanto, para lograr una mejora a este respecto, se ha introducido al RC-ACS una novedosa idea: la creación dinámica de feromonas, que reemplaza la asignación estática uno a uno. En el algoritmo resultante, al que hemos denominado Angry Ant Framework (AAF), los nuevos niveles de feromona se crean conforme se necesitan y durante la búsqueda, en lugar de crearse antes de la misma. La mejora final se ha obtenido al permitir al AAF no solo crear niveles de feromona, sino también reasignarlos para optimizar el uso de la misma. El algoritmo resultante se denomina EntropicAAF y ha sido evaluado como uno de los algoritmos más exitosos para las búsquedas semánticas P2P bajo todas las condiciones. / [CA] La popular tendència de distribuir càrrega i recursos en el camp de la computació s'ha estès cap a les xarxes d'ordinadors a través del concepte de connexions d'igual a igual (de l'anglès, peer to peer o P2P). P2P és un model simètric on cada node de la xarxa disposa del mateix nombre de capacitats i recursos. P2P, considerat originàriament només una estructura situada al servidor complementària al model client-servidor simple, ha provat tindre el suficient potencial per ella mateixa, amb múltiples beneficis ben coneguts: una bona tolerància a errades i recuperació, una satisfactòria escalabilitat i una intrínseca distribució de càrrega. No obstant, contràriament al client-servidor, les xarxes P2P requereixen solucions sofisticades a tots els nivells, que varien des de l'organització de la xarxa a la localització de recursos i la seua gestió. En aquesta tesi s'adreça un dels problemes clau de les xarxes P2P: ser capaç de realitzar eficientment cerques de recursos de naturalesa semàntica sota condicions realistes i dinàmiques. Existeixen nombroses solucions a aquest tema basades en la computació simple, evolutiva i també basades en l'estimèrgia (de l'anglès, stigmergy), però pocs esforços s'han realitzat per intentar resoldre l'ampli conjunt de reptes existent. En primer lloc, les xarxes P2P reals són rarament estàtiques: els nodes es connecten, desconnecten i canvien els seus continguts. A més a més, la incorporació trivial de cerques semàntiques als algorismes existents causa una disminució significant de l'eficiència de la cerca. En aquesta recerca s'ha construït una solució incremental, començant pel sistema clàssic de colònia de formigues (de l'anglés, Ant Colony System o ACS) dins de la metaheurística d'optimització de colònies de formigues (de l'anglès, Ant Colony Optimization o ACO). ACO és un entorn algorísmic utilitzat per cercar en grafs i que aborda el problema de forma satisfactòria, tot i que no proveeix d'una solució immediata a cap dels problemes anteriorment mencionats. Primer, s'ha proposat una variant eficient d'ACS en xarxes P2P estructurades (en forma d'hipercub) a través d'un algorisme de processament post-camí el qual s'ha anomenat en anglès Tabu Route Optimization (TRO). A continuació, s'ha procedit a resoldre el problema del dinamisme de les xarxes amb un enfocament de difusió d'informació compatible amb ACO. Com a conseqüència, s'ha intentat incorporar la component semàntica de les cerques. Aquest enfocament inicial al problema s'ha realitzat permetent a ACS diferenciar entre tipus de cerques amb la idea de ''feromona per concepte'', i s'ha anomenat a aquest producte Routing Concept ACS o RC-ACS. RC-ACS és una implementació multi-feromona robusta i estàtica d'ACS. No obstant, s'ha pogut concloure que l'enfocament de feromona per concepte ofereix només una escalabilitat limitada i no pot ser considerada una solució global. En aquest respecte s'ha realitzat progrés posteriorment introduint una nova idea a RC-ACS: la creació dinàmica de feromones, la qual reemplaça a l'assignació un a un de les mateixes. A l'algorisme resultant se l'ha anomenat en anglès Angry Ant Framework (AAF). En AAF es creen nous nivells de feromones a mesura que es necessiten durant la cerca, i no abans d'aquesta. El progrés final s'ha aconseguit quan s'ha permès a AAF, no sols crear nivells de feromones, sinó reassignar-los per optimitzar la utilització de feromones. L'algorisme resultant s'ha anomenat EntropicAAF i ha sigut avaluat com un dels algorismes per a cerques semàntiques P2P amb millors prestacions. / Krynicki, KK. (2016). Ant Colony Algorithms for the Resolution of Semantic Searches in P2P Networks [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/61293 / TESIS / Premios Extraordinarios de tesis doctorales / Compendio

Indiana University-Purdue University Indianapolis (IUPUI) / In the United States, 10% of pregnancies are complicated by diabetes mellitus (DM). Intrauterine DM exposure can have long-lasting implications for the fetus, including cardiovascular morbidity. Previously, we showed that fetal endothelial colony forming cells (ECFCs) from DM pregnancies have decreased vessel-forming ability and increased senescence. However, the molecular mechanisms responsible for this dysfunction remain largely unknown. The objective of this thesis was to understand how Mesenchyme Homeobox 2 (MEOX2) interacts with pathways that regulate cell cycle progression and migration, and how this interaction results in impaired vasculogenesis in DM exposed ECFCs. We tested the hypothesis that upregulated MEOX2 in DM-exposed ECFCs decreases network formation through impairments in senescence, cell cycle progression, migration, and adhesion. MEOX2 is a transcription factor which inhibits angiogenesis by upregulating cyclin dependent kinase inhibitors. Here, data show that nuclear MEOX2 is increased in DM-exposed ECFCs. Lentiviral-mediated overexpression of MEOX2 in control ECFCs increased network formation, altered cell cycle progression, increased senescence, and enhanced migration. In contrast, MEOX2-knockdown in DM-exposed ECFCs decreased network formation and migration, while cell cycle progression and senescence were unchanged. Adhesion and integrin expression defects were evaluated as mechanisms by which MEOX2 altered ECFC migration. While MEOX2-overexpression did not alter adhesion or cell surface integrin levels in control cells, MEOX2 overexpression in DM-exposed ECFCs resulted in an increase in α6 integrin surface expression. Similarly, MEOX2-knockdown in DM-exposed ECFCs did not alter adhesion, though did reduce α6 integrin surface expression and total cellular α6 mRNA and protein levels. Together, these data suggest that alterations in cell cycle progression and senescence are not responsible for the disrupted vasculogenesis of DM-exposed ECFCs. Importantly, these data suggest that altered migration may be a key mechanism involved and that altered cell surface levels of the α6 integrin may modify migratory capacity. Moreover, these data suggest that the α6 integrin may be a previously unrecognized transcriptional target of MEOX2. Ultimately, while initially believed to be maladaptive, these data suggest that increased nuclear MEOX2 in DM-exposed ECFCs may serve a protective role, enabling vessel formation despite exposure to a DM intrauterine environment.

Indiana University-Purdue University Indianapolis (IUPUI) / This thesis discusses about developing a routing protocol of mobile ad hoc networks in a bio inspired manner. Algorithms inspired by collective behaviour of social insect colonies, bird flocking, honey bee dancing, etc., promises to be capable of catering to the challenges faced by tiny wireless sensor networks. Challenges include but are not limited to low bandwidth, low memory, limited battery life, etc. This thesis proposes an energy efficient multi-path routing algorithm based on foraging nature of ant colonies and considers many other meta-heuristic factors to provide good robust paths from source node to destination node in a hope to overcome the challenges posed by resource constrained sensors. / 2020-12-31

[pt] À leitura do epistolário jesuíta, principalmente as Cartas (1549-1558) redigidas pelo padre Manuel da Nóbrega, evidenciam-se assuntos concernentes ao trato com o indígena que através da língua, liturgia e catequese possibilitam um aprofundamento fecundo quando as comparam com os temas do opúsculo Diálogo sobre a Conversão do Gentio. O Discurso versa com suportes bíblico, filosófico, teológico e literário, argumentos importantes ainda não resolvidos no convívio do colono e mesmo dos jesuítas com os silvícolas do Brasil. Nóbrega compôs a peça para dar voz ao homem americano, demonstrando sua humanidade pela alma que possuía; a cultura que vivenciava e pela aptidão natural e moral de receber a mensagem do evangelho e se converter como tantos outros povos tornaram-se cristãos. O texto é primoroso no debate dos dois oponentes Matheus Nogueira e Gonçalo Álvares, um e outro pretendendo demonstrar a possibilidade ou não da conversão do aborígine - que as tímidas Cartas não explicitavam a opinião de muitos como contrária, e o Diálogo revelou de forma tão contundente e grave o parecer melancólico e pessimista entre colonos e jesuítas da impossibilidade de conversão do gentio brasil. Entretanto, as entrelinhas querem provar o contrário: a crença do autor (Nóbrega) na aceitação do evangelho pelo índio e sua conversão. / [en] The Jesuit letters, particularly those written by the priest Manuel da Nóbrega and collected in Cartas (1549-1558), offer a glimpse of how Brazilian Indians were dealt with through language, liturgy and catechism. This material allows for deep understanding of such topics, specially when compared with those tackled in Diálogo sobre a Conversão do Gentio, which draws on philosophy, theology, literature and the Bible to address major unresolved arguments in the relationship of the settlers and the Jesuits with the Brazilian Indians. Nóbrega wrote it with the purpose of giving voice to the American man, arguing that the natives were human, since they possessed a soul which endowed them with the moral and natural ability to be open to the message of the Gospel and to convert to Christianity as many other peoples before them. In the text, the debate between the two opponents, Matheus Nogueira and Gonçalo Alvares, is superbly rendered, both trying to establish whether it was possible or impossible for the natives to convert. Whereas the Cartas fails to proclaim the opinion of many as opposing, the Diálogo reveals unequivocally the melancholic and pessimistic view of settlers and Jesuits, who believed that it was impossible to convert the Brazilian Indians. However, if we read between the lines we perceive the opposite: namely, that Nóbrega did believe that the natives would eventually accept the Gospel and become Christians.

Patterns of DNA synthesis and mitosis in the coenobial alga Pediastrum boryanum (Turp.) Meneghini were analyzed by cytophotometric measurements of individual, Feulgen‐stained nuclei from swarming zoospores aggregating into colonies, and cells in colonies varying in age from 12 to 96 h after their initial transfer to fresh culture medium. A haploid genome size of 0.2 pg DNA (corresponding to roughly 11 × 1012 daltons, or 1.64 × 105 kb) was estimated by comparative measurements of nuclei from zoospores or young colonies and chicken erythrocyte (RBC) nuclei which were included with each set of Pediastrum slides as an internal reference standard of 2.5 pg DNA/cell. Although nuclear morphology and extent of chromatin condensation vary with different stages of colony development, nuclear division in P. boryanum appears to follow each cycle of DNA replication with no accumulation of DNA beyond the 2C level. Cytoplasmic cleavage resulting in the formation of individual zoospores is delayed until completion of mitosis, as is the demise of the pyrenoid. After 96 h of culture, 40% of all colonies have cells that are 8‐ or 16‐nucleate and some colonies have 32 nuclei/cell. Release of zoospores within vesicles occurs at this time to complete a cycle of asexual reproduction.

Master thesis project presents a strategy for wide area of Bratislava river-front, the Pecniansky forest. Aim of proposal is to get that large and forgotten place, the part of Bratislava city centre, back into the life. By controlled changes achieve space that will be attractive to all animal and plant species. The space is transformed to system of functional, relax and pure natural sites. The new space can offer new possibilities for Bratislava inhabitants in their free time and will be educational in self-sufficiency, sustainability and ecology in general.

No description available.

Substantial comparative analyses of Puritanism and Mormonism are lacking in historical scholarship, despite noted similarities between the two religions. This study helps to fill that void by comparing the Puritan and Mormon proselytization efforts among the Indians that occurred at the respective sites of Massachusetts Bay Colony and the Southern Indian Mission. In my examination of the missionization attempts that took place at these two locations, I analyze a common motive and method of the two denominations for attempting to Christianize the Indians. The Puritan and Mormon missionaries proselytizing in Massachusetts Bay Colony and the Southern Indian Mission shared an identical motive for seeking to convert the Indians to Christianity. The missionaries' conviction that the regional natives were descendants of the House of Israel prompted them to proselytize among the Indians, as they understood that the conversion of the House of Israel constituted one of the important events to precede the prophesied return of Christ to the earth. The Puritans and Mormons engaged in and overseeing the missionary endeavors of the two locales under study likewise shared several parallel conversion methods. One such method consisted of utilizing one of the largest resources available to the two religions: their constituents. The Puritans and Mormons each implemented the association and example of their missionaries and congregational members as a primary method of conversion. Moreover, they applied that technique in a corresponding manner.

The first missionaries of the Church of Jesus Christ of Latter-day Saints went to Hawaii in 1850. As native converts joined the Church, many desired to gather in Utah with converts from other parts of the world, in order to perform Church ordinances in the temples located there. Until about 1870, Hawaiians were prohibited by their government from leaving the Islands permanently. As the laws were relaxed they came to Utah a few at a time with returning missionaries until by 1889 about seventy-five were living in Salt Lake City.Cultural and social problems arose causing the Church officials to decide to locate all the Polynesians in one place by themselves. Under the direction of the First Presidency of the Mormon Church a committee of three former Hawaiian missioanries and three natives selected the ranch of John Irch in Skull Valley, Tooele County, Utah as the site for a Polynesian colony. A Church-controlled corporation was established to purchase and hold the colony's properties. The Polynesians were hired to work on the ranch.A townsite was laid out, lots were sold and homes were bult for the colonists. The colony was named Iosepa, in honor of the sixth president of the Church, Joseph F. Smith, who had served as a missionary among the Hawaiians and was solicitous of their welfare.For the first decade, the company operated at a loss due to the financial difficulties of the 1890's. Gradually financial conditions improved, the company began to feed more livestock, a store was opened and then Iosepa began to realize a profit.At first Iosepa was isolated from other Utah communities. The only way in or out of the colony was by foot or horses. Its post office was in Grantsville, about thirty miles to the northeast. In 1906 the Western Pacific Railroad Company built a line through Utah passing through Timpie, fifteen miles north of Iosepa. A Stagecoach line was established between Timpie and the colony and mail services were extended to the settlement. About the same time, a long distance telephone line gave the colonists a means of rapid communciation with the outside world. By about 1910 the Hawaiians were enjoying as many of the amenities of modern life as any other Utah community its size.Ecclesiastically Iosepa held a unique position in the Church. As a mission branch, all its reports went directly to the First Preidency. Religious leadership was vested in a returned Hawaiian missionary. Hawaiian members usually served as officers in the auxillary organizations.Leprosy and various illnesses caused some concern in the colony, but by 1900 the lepers had died. As doctors became more attainable and as the Hawaiians became more acclimated, problems of sickness decereased.In 1915 the Church announced that a temple was to be built at Laie, Hawaii. Upon hearing this some of the Hawaiians announced that they were returning to the Islands. Soon the movement to return was under way and all were swept with it. By 1917 all had returned to the Islands but one family which remained in Salt Lake City. That fall the Deseret Livestock Company purchased the Iosepa property and Utah's Polynesian colony ceased to exist.Some have asserted that leprosy, other sickness, financial failure or failure of the Polynesians to become acclimated to the area caused the failure and closing of the colony. Each one of these problems was overcome years before the colony's end. The colony was a success. It had been established for a purpose; when its purpose was fulfilled it ceased to exist.

yes / This paper introduces a novel symbolic regression approach, namely biogeographical-based programming (BBP), for the prediction of elastic modulus of self-compacting concrete (SCC). The BBP model was constructed directly from a comprehensive dataset of experimental results of SCC available in the literature. For comparison purposes, another new symbolic regression model, namely artificial bee colony programming (ABCP), was also developed. Furthermore, several available formulas for predicting the elastic modulus of SCC were assessed using the collected database. The results show that the proposed BBP model provides slightly closer results to experiments than ABCP model and existing available formulas. A sensitivity analysis of BBP parameters also shows that the prediction by BBP model improves with the increase of habitat size, colony size and maximum tree depth. In addition, among all considered empirical and design code equations, Leemann and Hoffmann and ACI 318-08’s equations exhibit a reasonable performance but Persson and Felekoglu et al.’s equations are highly inaccurate for the prediction of SCC elastic modulus.