As anormalidades hematológicas de origem paraneoplásica são identificadas em diversos tipos de neoplasias que acometem cães e gatos. Nas neoplasias mamárias em cadelas, já foram identificadas anormalidades relacionadas com a coagulação, onde verificou-se que a coagulação intravascular disseminada (CID) clínica e subclínica pode estar presente em 83% das cadelas com carcinoma mamário. Na medicina humana, é dada relevância à investigação de tais alterações uma vez que são fatores indicadores de prognóstico do câncer. Enquanto isso, na medicina veterinária, são escassos os estudos que relacionam as alterações hematológicas com o tipo tumoral, estadiamento e determinação de prognóstico. O objetivo do presente estudo foi realizar a avaliação hematológica, bioquímica e da hemostasia de cadelas acometidas por neoplasia mamária para identificar a alteração mais frequente, além de relacionar as anormalidades com o estadiamento tumoral. Para isso, foram utilizadas 25 cadelas atendidas pelo Grupo de Estudos em Oncologia em pequenos animais (ONCOVET) do Hospital de Clínicas Veterinárias da UFRGS (HCV-UFRGS) durante o período de 4 meses. Foi realizado coleta de sangue para hemograma, contagem de plaquetas, bioquímica sérica (albumina, ALT, cálcio, creatinina, FA, glicose, ureia) e teste de coagulação que constou de TP (tempo de protrombina), TTPa (tempo de tromboplastina parcial ativada), TT (tempo de trombina), fibrinogênio e mensuração do dímero-D. O estadiamento tumoral foi obtido através do exame físico e do resultado da biopsia das mamas. As anormalidades encontradas incluíram anemia, leucocitose neutrofílica, monocitose, eosinofilia, trombocitose, hipoalbuminemia, hipocalcemia, hipoglicemia e diminuição dos níveis de ureia sanguínea. Entretanto, essas alterações não foram relacionadas diretamente com a progressão tumoral, uma vez que não houve diferença entre os grupos avaliados. Apenas as variáveis RDW e ALT apresentaram relação significativa entre os grupos, contudo, sem relevância clínica. No teste de coagulação, houve diferença significativa entre os grupos apenas no TT e fibrinogênio, que foi relacionado com o estadiamento tumoral. / Hematological abnormalities of paraneoplastic origin are identified in several types of cancers that affect dogs and cats. In dogs with mammary neoplasms, abnormalities associated with coagulation have been identified, and verified that disseminated intravascular coagulation (DIC) clinical and subclinical may be present in 83% of dogs with mammary carcinoma. In human medicine, research in this field has been relevant since those factors are indicators of cancer prognosis. Meanwhile, in veterinary medicine, there are few studies that relate hematological changes with tumor type, staging and determination of prognosis. The aim of this study was to evaluate the hematological, biochemical and hemostathic abnormalities in bitches affected by mammary cancer to identify the most frequent alteration and associate with tumor staging. For this, 25 bitches attended by the Oncology Study Group in small animals (ONCOVET) of the Veterinary Hospital of UFRGS (HCV-UFRGS) for the period of 4 months were used. Blood collection for complete blood count, platelet count, serum biochemistry (albumin, ALT, calcium, creatinine, ALP, glucose, urea) and coagulation test that consisted of PT (prothrombin time), aPTT (activated partial thromboplastin time), TT (thrombin time), fibrinogen and D-dimer measurement were performed. Tumor staging was obtained by physical examination and the results of the biopsy of the breast. The abnormalities found included anemia, neutrophilic leukocytosis, monocytosis, eosinophilia, thrombocytosis, hypoalbuminemia, hypocalcemia, hypoglycemia and decreased levels of urea. However, these changes were not associated directly with tumor progression, since there was no difference among the groups. Only the RDW and ALT variables was associated significantly between the groups, however, with no clinical relevance. In the coagulation test, there was significant difference between the groups only in TT and fibrinogen, which was associated with tumor staging.

<p>In the last two decades, there has been significant improvements in pile design methods. These methods include variables that have been studied using laboratory and full-scale experiments. Refined understanding of the underlying mechanisms controlling pile response to loading enables introduction of variables in the design equations that reflect observations made in high-quality experimental data.</p><p>The mechanisms involved in the mobilization of the pile resistance (both base and shaft resistance) are studied in this thesis using a large-scale model pile testing facility consisting of a half-cylindrical calibration chamber with image analysis capabilities, instrumented model piles, and data and digital image acquisition systems. The thesis focuses on the effect of the pile surface roughness on the mobilization of tensile shaft resistance, the effect of the pile base geometry on the mobilization of base resistance, the analysis of possible mechanisms responsible for time-dependent increases in pile axial capacity, and particle crushing produced by pile installation. </p><p>A set of model pile tests were performed to study the effects of three different surface roughnesses on the shaft resistance of model piles jacked in the half-cylindrical calibration chamber. Digital images of the model piles and surrounding sand captured during tensile static loading were analyzed using the digital image correlation (DIC) technique. The base and shaft resistance measured for the instrumented model piles and the displacement and strain fields obtained with the DIC technique show that an increase in the roughness of the pile shaft results in an increase in the average unit shaft resistance and in the displacements and strains in the sand next to the shaft of the pile. Guidance is provided for consideration of pile shaft surface roughness in the calculation of the tensile limit unit shaft resistance of jacked piles in sand.</p><p>Base geometry effects were studied using jacked and pre-installed model piles with flat and conical bases tested in the DIC calibration chamber. The results show that the mobilized base resistance of a model pile with a conical tip was less than that of an equal pile with a flat base, all other things being equal, by a factor ranging from 0.64 to 0.84. The displacement and strain fields obtained with DIC also show that the slip pattern below the pile with a conical base differs from that of a pile with a flat base. </p><p>Finally, the degree of crushing of silica sand particles below the base of model piles jacked in sand samples is studied. The particle size distribution curves are obtained before and after pile installation. Relationships between the load mobilized at the base of the model piles and two well-known breakage parameters are proposed. This work also provides detailed measurements of the trajectories followed by crushed and uncrushed particles during pile installation, and characterizes the typical particle crushing modes produced by piles jacked in silica sand.</p><div><br></div>

This diploma thesis tries to find the most suitable optical system for measuring deformation displacements on the surfaces of bodies. The first chapter describes the systems and methods that will be used. The second chapter is devoted to the design of the experiment. It describes the preparation of the experiment from the point of view of software and hardware and what are the important preliminary preparations. The last chapter contains the results of experiments and evaluation of the systems.

This thesis deals with measurement of residual stress by hole drilling method. This method is based on drilling a hole and measurement of deformation in the area around this hole. Measured deformations are then converted to residual stresses by using calibration coefficients. The deformation around the drilled hole is measured by optical non contact method called digital image correlation (DIC). First part of the thesis is focused on current state of research. The thesis contains evaluation of residual stresses by using different methods and evaluation of used methods.

The thesis aimed to identify fracture strain for multiaxial loading for laminate material of Al and LDPE that is mostly used in the food packing technology specially in liquid packaging industry. These materials are thin and flexible which make it difficult to handle and test it. The investigation was through applying new Nakajima test setup on such a material by designing a custom setup and 3D printing the Nakajima setup prototype to be able to use it in this study. DIC technique was used to get the results from the Nakajima test and the software used to apply the DIC technique is GOM correlate. As a validation for measurement from such a technique, a tensile test has been done and measured strains were compared with those from the specimen from the Nakajima that has smallest width as it was close to a uniaxial loading. One more validation technique was by creating a FE-model using (Abaqus software) for the biaxial loading and comparing it to the biaxial loading results that obtained from the DIC analysis.

Different rock formations may appear within the same mass, or even within the same formation there may exist layers of different materials, creating interfaces between layers (an interface may be defined, in more general terms, as a frictional contact that separates two similar or dissimilar materials). Currently, there is no well-established experimental work that investigates the influence of frictional interfaces, interface orientation and flaw geometries on crack behavior (i.e. initiation, propagation and coalescence) in brittle specimens under compressive loading. A series of experiments on homogeneous gypsum specimens, used as a rock-model material, containing two pre-existing open flaws and a frictional interface has been performed under uniaxial compression. The experiments investigate how cracks interact with interfaces and how different variables (i.e. flaw geometry, interface inclination angle and interface roughness) affect crack behavior in homogeneous materials separated by an interface. The specimens are 203.2mm high, 101.6mm wide, and 25.4mm thick. The two flaws, with 0.1mm aperture and 12.7mm length (2a), are created through the thickness of the specimen. The spacing (S) between flaws, continuity (C), and inclination angle, measured from the horizontal, (β) define the geometry of the flaws. Three flaw geometries are tested: S=0, C= -2a= -12.7mm, β= 30° (i.e. a left-stepping geometry); S= 2a= 12.7 mm, C=a=6.35 mm, β= 30° (i.e. an overlapping geometry) and S= 3a= 19.05mm, C=0, β= 30° (i.e. a right-stepping geometry). Smooth and rough unbonded interfaces are created by casting the specimen in two parts. The first half of the specimen is cast against a PVC block with an inclined face (i.e. 90°, 80° or 70°) with respect to the vertical axis of the specimen. The second half is then cast against the first one. Sandpaper may be attached to the PVC block to provide different roughness to the interface; a debonding agent applied to the interface ensures a cohesionless contact. In the experiments, digital image correlation (DIC) is used to monitor crack propagation on the specimen surface. The experiments indicate that the interface itself is an important contributor to new cracks and its presence in the specimens reduce crack initiation stress. Furthermore, the increase in roughness and inclination of the interface (i.e. from horizontal to 70° from the vertical) causes crack initiation stress to decrease. It was also observed that the angle between the incident crack plane and the interface affects whether an incident crack will penetrate an interface or be arrested: Tensile cracks that meet the interface at 30° to 60° angle get arrested, while those at or above 70° cross the interface with an offset of 0 – 1.2 mm. While shear cracks that meet the interface at 20° to 63° angles get arrested at the interface, while those at or above 70° cross the interface with an offset in the range of 0 – 1.76 mm. Another relevant finding is the fact that changes in interface roughness or inclination angle did not affect the angles at which cracks initiate or reinitiate at the interface.<div>A numerical study was conducted using the Extended Finite Element Method (XFEM) capability in ABAQUS, to further investigate the fracture behavior observed in the experiments and, more specifically, the influence of the different types of interfaces. An extensive investigation of the stress fields around the tips of the flaws and of the new cracks, as well as along the interface in the specimens, was conducted to determine the relationship between stresses and crack initiation and propagation (i.e. type and direction of cracks). The stress-based approach yields predictions of tensile and shear cracks location and initiation direction that are in good agreement with experimental results. The numerical investigation indicated that rougher horizontal interfaces induced slightly higher tensile stresses around the interior and exterior flaw tips than smoother interfaces, which may explain why tensile cracks at these locations initiated earlier in specimens with a rough interface. Moreover, inclined interfaces induced higher tensile stresses around the interior and exterior flaw tips than horizontal interfaces, which may justify that, in the experiments, inclined interfaces promoted crack initiation earlier than horizontal interfaces.</div>

The present paper studied the influence of hydrogen on the mechanical properties and microstructure of the materials. This study is done by doing hydrogen charging of steel bar specimens. The two types of steel are used for study, structural steel S235 and stainless steel 316L. The tensile test has been performed to get the data of the charged and uncharged specimens. Different strain rates were used to study the effect of the material after charging. The charging time ranged from 24 hours to 144 hours. The specimens are cylindrical shape. Digital image analysis is performed for the uncharged specimens to correctly analyse the strain field and compare it with the results from tensile test. For DIC analysis a GOM correlate software was used to study the 2D strain analysis of the specimen. The results show that hydrogen influences the mechanical properties of the material and microstructure.

Experimental characterization of the mechanical properties in a thin injection moulded Low-Density Polyethylene (LDPE) plate is per- formed in this work. Anisotropy in LDPE at different material orientations is measured from the Digital Image Correlation (DIC) observation of the specimens during uniaxial tensile test. From the test response and observation from DIC, the studied material is found to be significantly anisotropic. Finite Element simulation (FE-simulation) of in-plane anisotropy of material is carried in AbaqusTM R2020 using available models like Hill48 and Barlat2004. When necessary the simulation plastic potentials for these models are optimized against experimental yield stress ratio (R) and anisotropic ratio (r). To express the nonlinear mechanical behavior, a suitable hardening extrapolation model, namely Swift/Hockett-Sherby is selected from several extrapolation models based on experimental data. To validate the experimental methods, simulation methods and material characterization process, finite element simulation results such as force displacement, strain distribution and different anisotropic related properties are compared with the experimental data. Finally, advantages and disadvantages of different simulation models are discussed.

Traditional all wooden construction joints are currently widely used when historically valuable buildings are being reconstructed. These construction joints are indispensable and irreplaceable in order to maintain cultural heritage for our future generations. They underline the importance of the wooden structures and buildings, which in many cases might have incalculable historical, artistic as well as financial value. However, increased interest brings many challenges and potential risks that need to be taken into account and eliminated by appropriate solution(s). Adequate employment of these wooden joints requires a research-based approaches, which allows proper implementation within existing constructions while maintaining its reliability and safety. Main aim of preset doctoral thesis was to contribute to the development of suitable methods for analyzing mechanical behavior of all wooden construction joints, especially dowel joints, which are mainly used for reconstruction of damaged wooden elements or their parts. For such purposes, various methods (models), based on combination of theoretical, experimental and numerical approaches, has been used. This work was divided to a) basic mechanical tests of solid wood and b) complex finite element analyses of all wooden joints and constructions. Mechanical behavior in tension, compression, bending and shear was tested on small clear specimens made of spruce (Picea abies L. Karst.), beech (Fagus sylvatica L.) and oak (Quercus robur L.). Analyzed species were chosen as a most important historical as well as present European building materials. Mechanical response was captured using cameras in stereovision 3D configuration in order to obtain full-field displacement and strain data sets. Based on obtained data, material characteristics were determined and verified in frame of assembled material models for finite element analyses (FEA). Verified elasto-plastic material models were used as main material inputs for complex FEA for evaluation of mechanical response of joints and constructions subjected to load. Furthermore, material characteristics were used in calculations of mechanical properties of dowel joints. Numerical analyses were done using ANSYS software with parametric design language (APDL). Experimental results of single-shear dowel joints are in agreement with theoretical approach according to European Yield Method (EYM) theory, which was used for determination of joints and fasteners yield strength. FEA proved that assembled elasto-plastic material models can predict the ultimate strength even in complex tasks, and therefore, can be used for more reliable designing of wooden constructions and joints in variety of configurations.

This work deals with strain analysis of tree during felling. The main goal is to describe the origin of the deformation field. Another aim is to explain the effect of individual cuts on the size of deformation forces. Two relatively new methods in the field of wood are used to investigate the experimentally, namely digital image correlation (DIC) and finite element method. The work deals with methodical foundations for tree research during its felling. The DIC method measured seven trees in the forest when felling. Using the results obtained by this experiment, the numerical model was validated. This comparison suggested higher rigidity of the body using the finite element method compared to the actual tree, but the reaction was similar. With respect to the higher stiffness, the model was used to describe the deformation field inside the tree and to describe the effect of each cut on this field. The thesis also draws attention to the methodological errors that can occur during felling and which have been described in the experiment. Another output is an indication of the direction in which further measurements should be made and the errors that occurred during this measurement to avoid repetition.