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Programs written in managed languages are compiled to a platform-independent intermediate representation, such as Java bytecode. The relative high level of Java bytecode has engendered a widespread practice of changing the bytecode directly, without modifying the maintained version of the source code. This practice, called bytecode engineering or enhancement, has become indispensable in transparently introducing various concerns, including persistence, distribution, and security. For example, transparent persistence architectures help avoid the entanglement of business and persistence logic in the source code by changing the bytecode directly to synchronize objects with stable storage. With functionality added directly at the bytecode level, the source code reflects only partial semantics of the program. Specifically, the programmer can neither ascertain the program's runtime behavior by browsing its source code, nor map the runtime behavior back to the original source code. This research presents an approach that improves the utility of source-level programming tools by providing enhancement specifications written in a domain-specific language. By interpreting the specifications, a source-level programming tool can gain an awareness of the bytecode enhancements and improve its precision and usability. We demonstrate the applicability of our approach by making a source code editor and a symbolic debugger enhancements-aware. / Master of Science

The rapid development of wireless applications has created a demand for low-cost, compact, low-power hardware solutions. This demand has driven efforts to realize fully integrated, "single-chip" systems. While substantial progress had been made in the integration of many RF and baseband processing elements through the development of new technologies and refinements of existing technologies, progress in the area of fully monolithic filters has been limited due to the losses (low Qs) associated with integrated passive elements in standard IC processes. The work in this thesis focuses on the development low-loss, Q-enhanced LC filters in GaAs E/D-SAGFET technology. This thesis presents a methodology for designing Q-enhanced LC resonators and low-loss, monolithic LC filters based on these resonators. The first phase of this work focused on the Q-enhancement of LC resonator structures using FET-based active negative resistance circuits. Three passive resonators were designed, fabricated, and measured to determine their loss and frequency response. Furthermore, six Q-enhanced resonators were designed, fabricated, and measured to compare the performance of various negative resistance circuit designs. In the second phase of this work, four of these Q-enhanced resonator designs were used to implement fully-integrated second-order Butterworth bandpass filters. Each filter was designed for a 60 MHz, -3 dB bandwidth centered at 1.88 GHz, corresponding to the North American PCS transmit band. The best filter design achieves 0 dB of passband insertion loss while consuming 16 mA of current from a 3 V source (48 mW). Passband gain (up to 15 dB) can be achieved with increased bias current before instability is encountered. The filter provides more than 30 dB of rejection at 1.7 and 2 GHz and more than 70 dB of rejection below 1.5 GHz. In the filter passband, the noise figure is 12 dB and the output 1 dB compression point is -18 dBm. These Q-enhanced LC filters have potential application as image-reject filters in GaAs integrated transceiver designs. / Master of Science

Yes / Herein the potential of a relatively new water soluble fiber, resistant maltodextrin (RMD) to encapsulate grapefruit polyphenol, naringin, using spray drying was evaluated. Full factorial Design Of Experiments (DOE) for spray drying with two levels of fiber–naringin ratio and spray dryer inlet temperature was executed. Resulting powders were characterized with respect to particle size and morphology, crystallinity, thermal properties, moisture sorption and naringin aqueous solubility increase. A 60–80% encapsulation was achieved. Thermal and moisture sorption behaviors of these dispersions were found to be dominated by RMD. By varying fiber–naringin ratio and spray drying temperatures, naringin was able to disperse in amorphous form in RMD matrix, which led to 20–55% increase in aqueous solubility. Solubility enhancement was found to correlate positively with increasing fiber: naringin ratio and spray drying temperature due to multiple factors discussed in this study. In conclusion, fiber–polyphenol bicomponent nutraceutical was successfully developed based on a well-established encapsulation technology i.e. spray-drying.

Yes / There is a need to understand the nature of aggregation of cyclodextrins (CDs) with guest molecules in increasingly complex formulation systems. To this end an innovative application of Taylor dispersion analysis (TDA) and comparison with dynamic light scattering (DLS) have been carried out to probe the nature of ICT01-2588 (ICT-2588), a novel tumor-targeted vascular disrupting agent, in solvents including a potential buffered formulation containing 10% hydroxypropyl-β-cyclodextrin. The two hydrodynamic sizing techniques give measurement responses are that fundamentally different for aggregated solutions containing the target molecule, and the benefits of using TDA in conjunction with DLS are that systems are characterised through measurement of both mass- and z-average hydrodynamic radii. Whereas DLS measurements primarily resolve the large aggregates of ICT01-2588 in its formulation medium, methodology for TDA is described to determine the size and notably to quantify the proportion of monomers in the presence of large aggregates, and at the same time measure the formulation viscosity. Interestingly TDA and DLS have also distinguished between aggregate profiles formed using HP-β-CD samples from different suppliers. The approach is expected to be widely applicable to this important class of drug formulations where drug solubility is enhanced by cyclodextrin and other excipients.

Turbulent mixing enhancement has received a great deal of attention in the fluid mechanics community in the last few decades. Generally speaking, mixing enhancement involves the increased dispersion of the fluid that makes up a flow. The current work focuses on mixing enhancement of an axisymmetric jet via high amplitude fluidic pulses applied at the nozzle exit with high aspect ratio actuator nozzles. The work consists of small scale clean jet experiments, small scale micro-turbine engine experiments, and full scale laboratory simulated core exhaust experiments using actuators designed to fit within the engine nacelle of a full scale aircraft. The small scale clean jet experiments show that mixing enhancement compared to the unforced case is likely due to a combination of mechanisms. The first mechanism is the growth of shear layer instabilities, similar to that which occurs with an acoustically excited jet except that, in this case, the forcing is highly nonlinear. The result of the instability is a frequency bucket with an optimal forcing frequency. The second mechanism is the generation of counter rotating vortex pairs similar to those generated by mechanical tabs. The penetration depth determines the extent to which this mechanism acts. The importance of this mechanism is therefore a function of the pulsing amplitude. The key mixing parameters were found to be the actuator to jet momentum ratio (amplitude) and the pulsing frequency, where the optimal frequency depends on the amplitude. The importance of phase, offset, duty cycle, and geometric configuration were also explored. The experiments on the jet engine and full scale simulated core nozzle demonstrated that pulse fluidic mixing enhancement was effective on realistic flows. The same parameters that were important for the cleaner small scale experiments were found to be important for the more realistic cases as well. This suggests that the same mixing mechanisms are at work. Additional work was done to optimize, in real time, mixing on the small jet engine using an evolution strategy.

Inom en snar framtid kan effektiva behandlingsmetoder mot antisocial personlighetsstörning komma att bli tillgängliga för användning. I denna uppsats driver jag en tes om hur vi på ett etiskt försvarbart sätt skulle kunna använda dessa metoder. Tesen begränsar sig till (1) tvångsbehandling (2) av våldsamma återfallsbrottslingar (3) som diagnostiserats med antisocial personlighetsstörning och psykopati, samt till (4) behandlingsmetoder som klassificeras som kapacitetsförbättringar riktade mot moralisk kompetens. Jag argumenterar för att vi har starka skäl att godta tesen, främst med hänseende på fördelarna det skulle innebära för patienten, potentiella brottsoffer, och samhället i stort. Jag diskuterar också de två allvarligaste invändningarna mot min tes – att behandlingen hotar patientens autonomi, respektive personliga identitet – men konstaterar slutligen att de inte tycks kunna falsifiera tesen.

As music production moves from the big professional studios into small bedroom studios, Headphones become more commonly used for monitoring. This brings a new set of problems based on the limitations of headphones compared to loudspeakers. This research explores how a bass enhancement algorithm impacts the results when mixing low frequency audio on headphones. This is done through a simple mixing experiment where subjects are tasked with balancing the amplitude of a low frequency element in a song, both with and without a bass enhancement algorithm enhancing the headphone monitoring. It is shown that while subjects do not perceive a difference in difficulty with this task, the results differ as subjects overall mix the bass frequencies lower in amplitude when aided by the bass enhancement algorithm. It is concluded that the bass enhancement algorithm is useful in this manner.

This thesis studies several methods for enhancing details in digital photographs. Methods' algorithms are described and implemented to existing system using C++ and OpenCV. Methods are then compared in terms of the time and memory complexity and their results are evaluated using users' questionnaire. Work overally gives overview of present photographic detail enhancement methods and discuses their future development.

Die Fallot-Tetralogie ist ein angeborener Herzfehler, der sich aus der Kombination von vier verschiedenen anatomischen Fehlbildungen zusammensetzt. In der Diagnostik kommen bevorzugt die Echokardiografie und die Magnetresonztomografie (MRT) zum Einsatz. Die MRT stellt dabei bei der Erfassung volumetrischer Parameter, insbesondere beim echokardiographisch nicht immer vollständig einsehbaren rechten Ventrikel, den Goldstandard dar. Zudem bietet die MRT die Möglichkeit der Gewebecharakterisierung, inklusive der Darstellung von myokardialer Fibrose. In dieser Studie wurden 67 Patienten nach korrigierter Fallot-Tetralogie mittels MRT untersucht. Dabei lag der Schwerpunkt auf der Visualisierung und Quantifizierung der myokardialen Fibrose mittels Delayed Enhancement-Technik in beiden Ventrikeln. Ziel war es, die Prädilektionsstellen von Delayed Enhancement nach Korrektur einer Fallot-Tetralogie zu beschreiben und seine Beziehung zum Auftreten von ventrikulären Arrhythmien und weiteren kardialen und anamnestischen Parametern zu ermitteln. Es stellte sich heraus, dass Delayed Enhancement bevorzugt im rechten Ventrikel zu finden ist. Es konnte kein Zusammenhang mit dem Auftreten ventrikulärer Arrhythmien, zum Patientenalter während der Korrektur-Operation sowie zu volumetrischen- und Ergometriedaten hergestellt werden. Das Auftreten ventrikulärer Arrhythmien war jedoch signifikant abhängig sowohl vom Patientenalter zum Zeitpunkt der Korrektur-Operation als auch vom Patientenalter zum Zeitpunkt der MRT-Untersuchung.