Orientador: Mauro Antonio de Arruda Nobilo / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-04T03:53:51Z (GMT). No. of bitstreams: 1 Damaceno_AlessandraReginaDerogis_M.pdf: 1414206 bytes, checksum: c7d213655bfe8d988e6311566b91787d (MD5) Previous issue date: 2005 / Resumo: Este estudo avaliou comparativamente duas técnicas indicadas para a obtenção de melhor assentamento de próteses implanto-suportadas através da análise fotoelástica. Para isso, foram obtidos dois grupos de infra-estruturas metálicas em titânio construídas sobre uma matriz metálica com forma e dimensões similares ao arco mandibular, sendo: Grupo 1- três infra-estruturas confeccionadas pela técnica da soldagem de borda a laser de cilindros pré-fabricados; Grupo 2- três infra-estruturas fundidas em monobloco e submetidas ao sistema de retificação de cilindros fundidos. Após avaliação em microscopia óptica, apenas a infra-estrutura mais bem adaptada de cada grupo foi submetida à análise fotoelástica variando-se três seqüências de aperto dos parafusos (1/2/3/4/5, 5/4/3/2/1 e 3/2/4/1/5). De maneira adicional, a infra-estrutura representante do grupo 2 foi submetida, após a primeira análise, à secção e soldagem vertical das partes, e reavaliada. Os resultados mostraram formação de maior quantidade de tensões nas seqüências de aperto 1/2/3/4/5 e 5/4/3/2/1, para ambos os grupos analisados. A estrutura submetida à soldagem de borda de cilindros pré-fabricados mostrou melhores resultados, apesar de a mesma apresentar maiores valores de desadaptação (165µm) quando comparada àquela que teve seus cilindros submetidos à retificação de borda antes (54µm) ou após a secção e soldagem vertical (117µm). A seqüência de aperto 3/2/4/1/5 mostrou melhores resultados. Portanto, o grupo dos cilindros submetidos à soldagem de borda induziu melhores resultados principalmente quando associada à seqüência de aperto 3/2/4/1/5 / Abstract: This study evaluated two techniques indicated to obtain implant-supported fixed prostheses with satisfactory passive fit by means of photoelastic analysis. Two titanium casts groups were fabricated in a metallic master cast: Group I ¿ three frameworks fabricated by laser welded cylinder technique and Group II ¿ three frameworks cast in one-piece and submitted to Rectification Cylinder System. After optical microscopy evaluation, only the better-fit framework of both groups was submitted to the photoelastic analysis, testing three screw tightening sequences (5/4/3/2/1; 1/2/3/4/5 and 3/2/4/1/5). Subsequent to the first analysis, the selective framework of Group II was sectioned and laser welded to be submitted to a new evaluation. Results showed superior stress magnitude in 1/2/3/4/5 and 5/4/3/2/1 sequences of both groups, while 3/2/4/1/5 screw tightening sequence presented better stress results of them. Laser welded cylinder framework illustrated better results, even though had showed superior values of misfit (165µm) compared to the rectified framework before (54µm) and after section and vertical laser welded (117µm). Laser welded cylinder group achieved better results mainly allied to 3/2/4/1/5 screw tightening sequence / Mestrado / Protese Dental / Mestre em Clínica Odontológica

Background: In the last two decades the discovery of the Toll-Like Receptor (TLR) family in humans revealed the importance of innate immunity in providing host defence against invading pathogens. Moreover, TLRs have a vital role in mediating the interactions between the reproductive and immune systems. Similar to TLRs, (NOD)-like receptors (NLRs); retinoic acid-inducible gene-1, RIG-1-like receptors (RLRs) are also important pattern recognition receptors in the female reproductive system. Successful implantation requires effective reciprocal interactions between receptive endometrium and competent embryo. The endometrial innate immunity during implantation has been intensively investigated. However, little is known about the expression of innate immunity during the early stages of human embryo development. Objective: To investigate the expression of innate immunity molecules during the early stages of human embryo development and to determine the functions of TLRs in blastocysts. Material and methods: The expression of TLRs, a panel of downstream signalling molecules, NLRs, RLRs, inflammatory cytokines, chemokines and the hyaluronic acid system were investigated in the following developmental stages: oocyte, 4- cell, blastomeres, 8- cell, blastocyst, inner cell mass and trophectoderm using Affymetrix Human Genome U133 Plus 2.0 arrays. Microarray data were validated by Q-PCR. TLR function in human blastocysts was investigated by treating day five blastocysts with TLR3 or TLR5 specific ligands; Poly (I:C) and flagellin respectively, for 24 hours. The culture media was analysed for elevated cytokine and chemokine levels using cytometric bead array. Results: TLRs, NLRs, RLRs, TLR downstream signalling molecules, cytokines and chemokines involved during implantation event and the hyaluronic system were all found to be positively expressed in the early stages of human embryo development. The expression levels of the above molecules were generally moderate to low (CT 24-34) and varied across the embryonic developmental stages. Stimulation of TLR3 and TLR5 in day 5 blastocysts produced cytokines and chemokines. In addition, there were alterations in gene expression patterns in the Poly (I:C) and flagellin treated blastocysts in comparison to the untreated blastocysts. Conclusion: The varied expression levels of the investigated molecules involved in early embryonic developmental suggests a potential role for these molecules in early pregnancy loss and implantation failure. Specifically, the relationship between the level of TLR expression, function and embryo quality is worth investigating in the future as a potential marker for embryo competence.

A unique process of fabricating a strained layer GexSi1-x on insulator is demonstrated. Such strained heterostructures are useful in the fabrication of high-mobility transistors. This technique incorporates well-established silicon processing technology e.g., ion implantation and thermal oxidation. A dilute GeSi layer is initially formed by implanting Ge+ into a silicon-on-insulator (SOI) substrate. Thermal oxidation segregates the Ge at the growing oxide interface to form a distinct GexSi1-x thin-film with a composition that can be tailored by controlling the oxidation parameters (e.g. temperature and oxidation ambient). In addition, the film thickness can be controlled by implantation fluence, which is important since the film forms pseudomorphically below 2×1016 Ge/cm2. Continued oxidation consumes the underlying Si leaving the strained GeSi film encapsulated by the two oxide layers, i.e. the top thermal oxide and the buried oxide. Removal of the thermal oxide by a dilute HF etch completes the process. Strain relaxation can be achieved by either of two methods. One involves vacancy injection by ion implantation to introduce sufficient open-volume within the film to compensate for the compressive strain. The other depends upon the formation of GeO2. If Ge is oxidized in the absence of Si, it evaporates as GeO(g) resulting in spontaneous relaxation within the strained film. Conditions under which this occurs have been discussed along with elaborated results of oxidation kinetics of Ge-ion implanted silicon. Rutherford backscattering spectrometry (RBS), ion channeling, Raman spectroscopy and scanning electron microscopy (SEM) were used as the characterization techniques.

>Magister Scientiae - MSc / When the spacecrafts orbit in space, it is subjected to significant thermal cycling variation. Thermal regulation of the spacecraft temperature is required to ensure a good operation of the small crafts such as CubeSats and the on-board equipment while minimizing the weight. Three methods employed for the Smart Radiator Devices (SRD) are (i) mechanical louvers, (ii) electrochromic coatings and (iii) thermochromic coatings (which is of interest in this study). Based on the characteristics of the thermochromic coatings, the passive smart radiator device is by far the most efficient option since there are no mechanical moving components and also no electric energy needed for the craft to operate.

Platelet activating factor (PAF) was administered to female mice in order to investigate its effect on ovulation rate and on oocyte quality including their in-vitro embryonic development, implantation and uterine receptivity. In experiment 1, 4-week-old female mice were assigned to receive PAF or phosphate buffered saline for 4 consecutive days. On the second day of this treatment, pregnant mares' serum gonadotrophin was administered and human chorionic gonadotrophin (HCG) 48 h later, after which copulation occurred. Oocytes were collected on the following day and evaluated. The mean number of oocytes and zygotes (two pronuclear stage embryos) recovered from the PAF-treated group was not diffferent from the control group (31 versus 27), but the proportion of zygotes was higher in PAF-treated group than in controls (83 versus 68%, P < 0.05, PAF versus controls). Although the rate of in-vitro first cleavage was not different in the two groups (82 versus 69% respectively), hatching was higher in the PAF-treated group than control mice (99 versus 83%, P < 0.01). In experiment 2, the in-vitro developed blastocysts from experiment 1 were transferred into the uterus of day 3 pseudopregnant PAF-treated or control recipients. Three different combinations of intrauterine transfer were performed; PAF embryo to control recipient (PAF → C: n = 19), control embryo to PAF recipient (C → PAF: n = 19), and control embryo to control recipient (C → C: n = 22). Implantation and abortion were assessed on day 19 post-transfer. The implantation rate of C → PAF (23.7%) was lower than C → C (31.1%, P < 0.05), but was not different from PAF → C (31.2%). Further, C → PAF showed a higher abortion rate per embryo (29.6%) than PAF → C (12.7%, P < 0.05), but was not different from C → C (24.4%). In the present study, PAF administration enables females to produce oocytes with a higher potential for fertilization, in vitro development and implantation, but has a detrimental effect on uterine receptivity to embryos.

Recent data regarding social-emotional challenges indicate elevations in behavior problems (BPs) in deaf and hard of hearing (DHH) children (Austen, 2010; Stevenson et al., 2010; van Eldik et al., 2004). Factors affecting this include family and social contexts, language development (LD), and cochlear implantation (CIs). The purpose of this dissertation was to analyze findings across studies for trends in BPs in DHH children. Specifically, a model of the effect of deafness, CI use, and LD on the emergence of BPs in DHH children as compared to hearing children was examined. Studies were collected through systematic searches of psychology databases supplemented by studies referenced in other sources therein discovered. Random-effects meta-analyses using the restricted maximum likelihood estimation method were non-significant (g = 0.31, SE = 0.20, CI [-0.09, 0.71]), as were subgroup analyses (g = 0.36, SE = 0.22, CI [-0.07, 0.80]). A metaregression using CIs as a predictor evidenced a nonsignificant reduction in BPs for deaf children with CIs and CIs did not significantly predict BPs in deaf children. Unexplained heterogeneity remained elevated in all cases (I2 above 96%). In sensitivity analyses, I2 decreased to 87%, suggesting that designs of included primary studies may have impacted those studies’ data collection, analysis, and interpretation. Unmeasured variables such as LD may explain much of the remaining heterogeneity. Collaborating with researchers worldwide, using more inclusive selection criteria, and enacting a longitudinal design could collect a greater variety of data, creating a more complete understanding of the effect of hearing loss on BPs.

京都大学 / 0048 / 新制・論文博士 / 博士(医学) / 乙第13112号 / 論医博第2130号 / 新制||医||1022(附属図書館) / (主査)教授 浅野 雅秀, 教授 瀬原 淳子, 教授 近藤 玄 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第21012号 / 医博第4358号 / 新制||医||1028(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 戸口田 淳也, 教授 鈴木 茂彦, 教授 開 祐司 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

A research report submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Master of Science / The role of intersite electron correlation effects and the possible occurrence of the metal-insulator transition in carbon-ion implanted type IIa diamond samples have been studied at very low temperatures, using four- and two-point probe contact electrical conductivity measuring techniques. The measurements were extended to ruthenium oxide thin films in the presence and absence of a constant magnetic field of B = 4.0 T down to 100 mK, using a 3He-4He dilution refrigerator. The effect of the Coulomb gap in the variable range hopping regime has been well studied by other workers. The results tend to follow the Efros-Shklovskii behaviour with a trend towards the Mott T- 114 law for diamond samples far removed from the metal insulator transition, on the insulating side at low temperatures. / Andrew Chakane 2019

京都大学 / 新制・課程博士 / 博士(医学) / 甲第24132号 / 医博第4872号 / 新制||医||1059(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 平井 豊博, 教授 湊谷 謙司, 教授 羽賀 博典 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM