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Producing names with a bizarre voice does not improve memory for face–name pairsPatel, Payal 11 1900 (has links)
Most social interactions require correct identification of an individual’s face and name; however, this can be a rather challenging task. The present study examined whether a mnemonic proposed by pop-culture can enhance memory for face–name associations. More specifically, we tested whether vocalizing names in an unusual voice can improve subsequent memory for an individual’s face and name. The memory literature has examples of enhanced memory for items that require bizarre mental imagery as opposed to normal mental imagery, and separate evidence of enhanced memory for items that are said aloud, as opposed to items read silently. However, it is unclear whether bizarre production of names compared to regular production of names will lead to enhanced memory for faces, names, or face–name associations. In the present study, participants studied face–name pairs while vocalizing the names in a bizarre voice or a normal voice. Memory for face–name associations was tested using cued recall tests and a recognition test. The results suggest that using a bizarre voice disrupts memory performance compared to using a normal voice. Contrary to suggestions in pop-culture, the production of a bizarre voice appears to make it harder to associate face–name pairs during learning. / Thesis / Master of Science (MSc)
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Exploration of brand equity measures : linking customer mind-set measure to product-market performance measureHuang, Rong, 1973- January 2008 (has links)
No description available.
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A study of the Buddha's epithets in the Khuddaka Nikāya /Paknys, Kristyna January 1987 (has links)
No description available.
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Private-label versus corporate brands : a qualitative studyArendse, Garron Mark 03 1900 (has links)
Thesis (MBA)--Stellenbosch University, 2008. / ENGLISH ABSTRACT: Competition in food retailing has become a noticeable cosmopolitan
phenomenon. Competitiveness filters down from retailers and their private-label
brands to the suppliers and their manufacturer brands. Furthermore, the
proliferation of food retailing has evolved into a double-edged sword for suppliers
and manufacturers of both private-label and manufacturer/supplier-branded
goods. Therefore, these suppliers, in comparison to those that solely
manufacture national-brand goods, has to continuously maintain a favourable
status quo on shelf with regard to brand performance, product quality and price
of both retailer and supplier brands. Moreover, in store and on shelf, consumers
of these brands are overloaded with choices between different packaging, prices
and product statements. All relevant and eye catching, but do the supplier
brands get the worst of the bargain? The objective of this study was to perform a
qualitatively analysis on the supplier value of being a supplier of both privatelabel
and manufacturer brands to the food-retail industry.
The empirical study encompassed one-an-one and electronic interviews with key
participants from specific food retailers to obtain answers validly, objectively and
economically. The researcher employed a qualitative research approach
together with a non-probability sampling strategy to explore the retail
environment and interview participants. The three retailers that participated in
the qualitative study were SPAR and Shoprite from South Africa and Morrisons
from the United Kingdom. Interviews were scheduled with each participant that
was available to participate and actively contribute to the outcome of this study.
Interviews were conducted with a pre-set list of open-ended questions that was
prepared in a discussion guide. Content analysis was then done on the interview
feedback and this was used to formulate major findings and provide justification
for the research objectives and propositions of this study. From the major
findings in this study five themes were identified: growth, challenges, competitive
environment, brand differentiation and supplier-retailer relationship.
Findings indicated that retailers - regardless of their global location, consumer
base and competitive environment - were mostly focused on growing their
company and their respective private-label brand. Depending on the volatility of
the supplier-retailer relationship, this growth focus could even come at the
expense of a manufacturer's brand. The study also revealed that retailers are
faced with a number of different challenges, which include deciding whether a
product is fit to be sold under their private-label brand and if a supplier's strategy
supports their own company strategy. The challenges encompass dependability
of supply, quality of product and delivery reliability. Additionally, prime area for
retailing is becoming more condensed in South Africa and as a result competition
between the four major South African retailers is more vibrant. The study has
noted that major retailers are also seeking expansion into emerging markets
outside the metropolitan areas in South Africa, which will increase demand and
create new customer expectations. Competitiveness and a point of difference
would then be underpinned by innovation , creating a favourable shopping
experience and service delivery, but with no compromise on quality and price.
When considering brand differentiation, the study revealed that retailers were
using this differentiation to increase private-label market share among the
national brands whereas suppliers use it to create aspirational brands that attract
and sustain consumer loyalty. It was concluded from this study that the growing
availability and presence of private-label products in all categories on retailer
shelves will become a serious threat for growing national brands that have not
yet established themselves as market leaders. This threat will be further
enhanced by the fact that retailers are using real estate and shelf space as
leverage to negotiate. Regarding supplier-retailer relationship, this study showed
that a retailer's focus will always be biased with the balance of power tilting in
favour of the retailer, speCifically where a supplier is considered to be a supplier
of both private-label and manufacturer brands. Although the latter is an industry
norm, the power balance is complicated by the fact that no contract exists
between supplier and retailer. As a result, a show of goodwill and a hand shake
will seldom have the one-sided situation swing in favour of a supplier.
Nonetheless, retailers' feedback indicated that they would rather develop
relationships with suppliers that either have brands with smaller market share or
only manufacture private-label products. / AFRIKAANSE OPSOMMING: Mededinging in die voedselkleinhandel het 'n merkbare kosmopolitaanse
verskynsel geword. Mededingendheid syfer van kleinhandelaars en hul private
handelsmerke na verskaffers en hul vervaardigershandelsmerke deur. Voorts
het uitbreiding in die voedselkleinhandel in 'n tweesnydende swaard vir
verskaffers en vervaardigers van goedere vir sowel private as vervaardigersIverskaffershandelsmerke
ontwikkel. Daarom moet hierdie verskaffers,
vergeleke met diegene wat slegs goedere vir nasionale handelsmerke
vervaardig, voortdurend 'n gunstige status quo op die rak handhaaf ten opsigte
van die handelsmerkprestasie, produkgehalte en prys van sowel private as
verskaffershandelsmerke. Origens word verbruikers van hierdie handelsmerke,
in die winkel en op die rak, oorlaai met keuses tussen verskillende verpakking,
pryse en produkverklarings. Dit is alles tersaaklik en treffend, maar trek die
verskaffershandelsmerke aan die kortste end? Die oogmerk van hierdie studie
was om 'n kwalitatiewe ontleding te doen van die waarde vir die verskaffer om 'n
verskaffer van sowel private as vervaardigershandelsmerke vir die
voedselkleinhandel te wees.
Die empiriese studie het persoonlike en elektroniese onderhoude met
sleuteldeelnemers van spesifieke voedselkleinhandelaars behels om op geldige,
objektiewe en ekonomiese wyse antwoorde te bekom. Die navorser het 'n
kwalitatiewe navorsingsbenadering gevolg tesame met 'n niewaarskynlikheidsteekproefnemingstrategie
om die kleinhandelomgewing te verken en
onderhoude met deelnemers te voer. Die drie kleinhandelaars wat aan die
kwalitatiewe studie deelgeneem het, was SPAR en Shoprite van Suid-Afrika en
Morrisons van die Verenigde Koninkryk. Onderhoude is geskeduleer met elke
deelnemer wat vir deelname beskikbaar was en aktief tot die uitkoms van die
studie wou bydra. Onderhoude is gevoer met 'n voorafbepaalde lys oop vrae wat
in 'n besprekingsgids saamgevat is. Inhoudsontleding is daarna gedoen ten
opsigte van die terugvoering wat tydens die onderhoude ontvang is. Dit is gebruik om hoofbevindinge te formuleer en motivering vir die
navorsingsoogmerke en stellings van die studie te bied. Op grond van die
hoofbevindinge van die studie is vyf temas geïdentifiseer: groei, uitdagings,
mededingende omgewing, handelsmerkdifferensiasie en verhouding tussen
verskaffer en kleinhandelaar.
Die bevindinge het getoon dat kleinhandelaars - ongeag waar hulle hul in die
wêreld bevind, hul verbruikersbasis en mededingende omgewing - meestal op
hul maatskappy en hul private handelsmerk se groei toegespits is. Na gelang
van die wisselvalligheid van die verhouding tussen verskaffer en kleinhandelaar
kan hierdie fokus op groei selfs ten koste van 'n vervaardigershandelsmerk
plaasvind. Die studie het ook getoon dat kleinhandelaars voor verskeie
uitdagings te staan kom, waaronder die besluit of 'n produk geskik is om onder
hul private handelsmerk verkoop te word en of 'n verskaffer se strategie hul eie
maatskappystrategie ondersteun. Die uitdagings sluit ook betroubaarheid ten
opsigte van voorraad, produkgehalte en lewering in. Daarby word die
eersteklasgebied vir klein handel in Suid-Afrika toenemend digter en as gevolg
daarvan is mededinging tussen die vier vernaamste Suid-Afrikaanse
kleinhandelaars lewendiger. Die studie het bevind dat vername kleinhandelaars
ook na ontluikende markte buite die metropolitaanse gebiede in Suid-Afrika wil
uitbrei, wat die vraag sal vergroot en nuwe verbruikersverwagtinge sal skep.
Mededingendheid en 'n verskilpunt sal dan deur innovering, die skepping van 'n
aangename inkopie-ervaring en dienslewering - sonder benadeling van gehalte
en prys - ondersteun word. Ten opsigte van handelsmerkdifferensiasie het die
studie getoon dat kleinhandelaars hierdie differensiasie gebruik om die
markaandeel van private handelsmerke onder nasionale handelsmerke te
verhoog, terwyl verskaffers dit gebruik om aspirasie-handelsmerke te skep wat
verbruikerslojaliteit lok en behou. Daar is van die studie afgelei dat die
toenemende beskikbaarheid en teenwoordigheid van produkte onder private
handelsmerke in alle kategorieë op kleinhandelaars se rakke 'n ernstige
bedreiging sal word vir groeiende nasionale handelsmerke wat hulle nog nie as
markleiers gevestig het nie. Hierdie bedreiging sal versterk word deur die feit dat
kleinhandelaars eiendom en rakruimte vir mag in onderhandeling sal gebruik.
Ten opsigte van die verhouding tussen verskaffer en kleinhandelaar het hierdie
studie getoon dat 'n kleinhandelaar se fokus altyd partydig sal wees, met die
magsbalans ten gunste van die kleinhandelaar, veral indien 'n verskaffer as
verskaffer van sowel private as vervaardigershandelsmerke beskou word.
Alhoewel laasgenoemde 'n bedryfsnorm is, word die magsbalans bemoeilik deur
die feit dat daar geen kontrak tussen die verskaffer en die kleinhandelaar
bestaan nie. As gevolg daarvan sal 'n welwillendheidsgebaar en 'n handdruk
selde daartoe lei dat die eensydige situasie ten gunste van die verskaffer sal
draai. Kleinhandelaars se terugvoering het nietemin aangedui dat hulle eerder
verhoudings met verskaffers sal ontwikkel wat of handelsmerke met 'n kleiner
markaandeel het of produkte vir private handelsmerke vervaardig .
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An investigation into the impact of the Internet on brand building strategies in the physical and virtual worldPienaar, Hannelie 12 1900 (has links)
Thesis (MBA)--Stellenbosch University, 2001. / ENGLISH ABSTRACT: With the emergence of the Internet in the early 1990's, traditional principles of
building brand equity, as they were applied in physical markets, were challenged.
This happened because brands were traditionally built using passive media such as
radio, television and print magazines and newspapers. The Internet introduced
interactive media where the consumer is not only highly informed because of the
exponential expansion of technology especially on the Internet, but also because the
consumer could now choose to be a participant, or not, in marketing and brand
building initiatives.
Theoretically, it is possible to establish certain principles to build brands in virtual
markets. The best solution is however to look at past studies of different companies
that present various challenges that relate directly to the Internet and its brand
building initiatives, and then combine this practical knowledge with a theoretical
background.
In the case studies, eight success drivers were identified as being crucial to build a
brand firstly in a virtual market, but also secondly in physical markets. The success
drivers that were implemented by companies that managed to build strong brands on
the Internet include: using a multimedia mixture to differentiate and build the brand;
focusing on supreme customer commitment: entering into distribution and content
alliances; moving first, fast and keeping up the pace; developing intimate customer
and market knowledge; building a reputation for excellence; delivering outstanding
value and in respect of cross-over marketers, respecting core brand attributes,
improving on the offline brand experience online and leveraging key offline assets in
favour of the online brand.
Brand building on the Internet, should be clear, consistent and reflecting leadership
not only in the implementation of the above success drivers, but also in respect of the
overall construction of the brand. / AFRIKAANSE OPSOMMING: Met die bekendstelling van die Internet in die vroeë negentiger jare, is die
tradisionele beginsels van "brand building" soos toegepas in tradisionele markte
bevraagteken. Dit het gebeur omrede "brands" tradisioneel gebou was deur
passiewe media soos radio, televisie, tydskrifte en koerante te gebruik. Die Internet
het nie net interaktiewe media bekend gestel waar die kliënt oor baie inligting beskik
as gevolg van die eksponensiële uitbreiding van tegnologie op die Internet nie, maar
ook het die kliënt nou die keuse om deel te neem of nie aan bemarkings en "brand
building" insentiewe.
Dit is moontlik om deur middel van 'n teoretiese studie sekere beginsels vas te stel
ten opsigte van hoe "brands" gebou moet word op die Internet. Die beste oplossing is
egter om na gevallestudies te kyk wat betrekking het op 'n paar maatskappye wat 'n
verskeidenheid van uitdagings daarstel wat direk van toepassing is op "branding"
insentiewe op die Internet. Die kennis verkry van die gevallestudies kan dan
gekombineer word met die teoretiese kennis om 'n raamwerk daar te stel vir
"branding" op die Internet.
Die gevallestudies het agt sukses drywers geïdentifiseer wat krities is vir die
ontwikkeling van "brand building" insentiewe in fisiese markte sowel as markte op die
Internet. Die sukses drywers deur die maatskapye geïmplimenteer wat sterk "brands"
of die Internet gebou het, sluit in: die gebruik van 'n multimedia mengsel om die
"brand" te differensïeer en te bou; konsentrasie op uitstekende ktïente diens; sluit van
verspreidings en inhouds vennootskappe, om eerste in die mark te wees en aan te
hou beweeg; ontwikkel intieme klïente en mark kennis; bou 'n uitstekende reputasie;
lewer uitstaande waarde en ten opsige van oorbruggings bemarkers, respekteer die
basis van die "brand", verbeter die Internet "brand" se ervaring in vergelyking met die
fisiese "brand" en gebruik die bates van die fisiese "brand" ten gunste van die
Internet "brand". Die bou van 'n "brand" moet eenvouding, deursigtig en konstant
wees sowel as leierseienskappe toon wat nie net betrekking het op die bogemelde
sukses drywers nie, maar ook op die algehele "brand" projeksie en implimentasie.
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An exploratory analysis of the global brand perceptions of SABMiller's global beer brands in AfricaNdisengei, Charity 04 1900 (has links)
Thesis (MBA)--Stellenbosch University, 2015. / ENGLISH ABSTRACT: David Ogilvy stated that ‘I have seen one advertisement actually sell not twice as much, not three times as much, but 19 ½ times as much as another. Both advertisements occupied the same space. Both were run in the same publication. Both had photographic illustrations. Both had carefully written copy. The difference was that one used the right appeal and the other used the wrong appeal’, Ogilvy (1983, 9) He then goes on to say that, the wrong advertising can actually reduce the sales of products.
It is with this quote in mind that the researcher took to this research study. The objective of this study is to understand why the current advertising for SABMiller’s Global brands does not resonate with its intended target audience and based on these findings make recommendations that can be implemented by SABMiller.
The design of this report is qualitative and exploratory. Participants of this study included a sample of fifteen individuals made up of SABMiller customers, and employees from Tanzanian brewery’s marketing and sales departments.
The findings confirmed that Global brand advertising does not currently resonate with consumers in Tanzania. The perception generally is that these brand’s communication does not compel consumers to want to interact with them, let alone drive the propensity for purchase. Factors such as a mismatch in culture, language and relevance were identified as drivers to advertising relevance, all of which were lacking in Global brand advertising.
The practical impact of this study is that SABMiller marketers can use this information to develop robust brand positioning strategies as well as communications strategies that will better resonate with their intended target audience and help to increase consumer’s propensity to purchase these brands.
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Místní jména v Norsku / Norwegian place-namesZirhutová, Martina January 2011 (has links)
This thesis, called "Norwegian Place-Names", deals with place-names of all types (for example names of rivers, towns and cities, mountains, lakes, roads) in Norway. The main goal is to explore the names from different points-of-view, provide information about major place-name groups, analyze the best-known names and compare Norwegian and Czech place-names. The language aspects have been emphasized.
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Branding in financial services with special reference to banks in the retail market18 March 2015 (has links)
M.Com. (Business Management) / Branding has been used for many years to differentiate products and verify quality. Although the notion of branding has become more complicated over the centuries, the idea of ownership nevertheless continuous to lie at the heart of the brand. For far too long, banks seemed indifferent to building and maintaining a strong brand. But the stakes are getting higher to differentiate from the crowd and the success of some banks in building brand equity will transfer indistinct players to commodity status. The challenge for banks is to position themselves more strongly in the mirid of the consumer, in terms of awareness, relevance, quality and, most importantly, competitive differentiation. Banks need to establish brand strength by measuring and then managing these dimensions. The main purpose of the study is to provide a comprehensive and up-to-date overview on branding especially in the retail banking market. This study firstly examines the literature on branding in general and then focuses more specifically on branding in banking institutions. It then considers brand equity and the sources of brand equity comprising brand awareness, brand loyal, perceived quality and brand associations. The empirical study conducted centres around the awareness of the different brands in the retail banking market and what the consumer perceptions of these brands are. More specifically the research looks at commitment levels of users, including the potential for future growth and where such growth is likely to come from. The results showed that the South African banking industry has remained relatively consistent during 1998 and 1999. The only notable exception is ABSA, which has significantly improved its position and, along with Standard Bank, currently maintains the strongest position in the market...
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Participação do óxido nítrico na expressão de vasopressina e ocitocina durante sepse polimicrobiana experimental / Involvement of nitric oxide in vasopressin and oxytocin expression during experimental polymicrobial sepsis.Pelegrin, Gabriela Ravanelli de Oliveira 18 June 2009 (has links)
Sepse induz exagerada produção de mediadores inflamatórios, como o óxido nítrico (NO), e causa alterações cardiovasculares, neuroendócrinas e de temperatura corporal (Tc). Na fase tardia da sepse existe liberação basal de vasopressina (AVP), apesar da hipotensão persistente. Uma hipótese para isso seria a inibição da síntese de AVP pelo aumento da produção de NO. Nosso objetivo foi investigar a possível participação do NO, produzido centralmente pelas isoformas de NO sintase (NOS), na expressão de AVP e ocitocina (OT), na resposta cardiovascular e de Tc durante sepse experimental. Ratos Wistar receberam injeção i.c.v. de L-NAME, inibidor não seletivo de NOS (250g/L), ou de aminoguanidina (AG,250g/L), inibidor seletivo da isoforma induzida (NOSi). Outro grupo recebeu inibidor da guanilato ciclase solúvel (ODQ,0,25g/L). Grupos controles receberam veículos (salina ou DMSO1%). Trinta minutos após as injeções, foi induzido sepse por ligadura e perfuração cecal (CLP) ou operação fictícia. Os animais foram divididos em 4 grupos: 1) avaliação da sobrevida, 2) determinação da Tc, 3) aferição da pressão arterial (PAM) e frequência cardíaca (FC) e 4) avaliação de parâmetros hidroeletrolíticos e secreção de AVP e OT. A CLP promoveu alta mortalidade, aumentou NO progressivamente, diminuiu PAM e aumentou FC. A concentração plasmática de AVP (AVPp) aumentou na fase inicial da sepse e por seu efeito antipirético pode ter contribuído para a hipotermia observada. A razão de expressão para ambos os hormônios diminuiu nos núcleos supraóticos (SON) e paraventriculares (PVN). Na fase tardia AVPp estava basal e sua expressão nos SON e PVN mais diminuída do que na fase inicial. A expressão de OT diminuiu somente no SON. O pré-tratamento com L-NAME aumentou a sobrevida, reduziu a produção de NO até 20h, aumentou PAM e Tc, e manteve a FC semelhante ao grupo veículo. AVPp aumentou simultaneamente à diminuição da razão de expressão em ambos os núcleos. Na fase tardia, o grupo L-NAME apresentou NO aumentado e expressão de AVP diminuída, aparentemente contribuindo para AVPp basal e hipotensão. O L-NAME diminuiu a razão de expressão de OT na fase inicial, mas aumentou na fase tardia. A inibição de NOSi pela AG aumentou ainda mais a sobrevida e Tc. Apesar de não bloquear a produção de NO a AG aumentou a expressão de AVP e OT e manteve AVPp constante e acima da basal. Injeção i.c.v de AG aumentou PAM somente na fase inicial da sepse. O pré-tratamento com ODQ foi o mais eficiente em aumentar a sobrevida e Tc após CLP. Entretanto, não alterou o aumento progressivo de NO, e ainda diminuiu a expressão de AVP e OT. A AVPp basal após ODQ contribuiu para a hipotensão observada durante todo o período. Esses resultados mostram que aumento central de NO após CLP inibe a expressão de AVP e OT independente de GMPc no SON e parcialmente dependente no PVN. A inibição da expressão de AVP na fase tardia da sepse resulta em concentração basal do hormônio contribuindo para a hipotensão. Em nossos experimentos o controle da temperatura corporal teve maior contribuição no aumento da sobrevida durante sepse polimicrobiana do que a regulação neuroendócrina e/ou cardiovascular. / Sepsis induces massive production of inflammatory mediators, such as nitric oxide (NO), and causes cardiovascular, neuroendocrine and body temperature (Tb) alterations. In the late phase of sepsis there is a basal vasopressin (AVP) release despite the persisting hypotension. One reason could be the inhibition of AVP synthesis by the increase in NO production. Our aim was to investigate the possible involvement of NO, produced centrally by NO synthase (NOS) isoforms, on AVP and oxytocin (OT) expression, cardiovascular response and Tb during experimental sepsis. Male Wistar rats received an i.c.v. injection of the non-selective NOS inhibitor L-NAME (250g/L), or of aminoguanidine (AG,250g/L), a selective inhibitor of its inducible isoform (iNOS). Another group received soluble guanylate cyclase inhibitor (ODQ,0.25µg/L). Control groups received vehicles (saline or DMSO1%). Thirty minutes after the injections, sepsis was induced by cecal ligation and puncture (CLP), or the rats were sham operated. The animals were divided into 4 groups for: 1) assessment of survival, 2) determination of Tb, 3) measurement of blood pressure (MAP) and heart rate (HR), and 4) evaluation of hydroelectrolytic parameters and AVP and OT secretion. The CLP promoted high mortality and progressive increase in NO levels. It also decreased MAP and increased HR. The AVP plasma concentration (AVPp) increased in the early phase of sepsis and its antipyretic effect may have contributed to the observed hypothermia. The expression ratio of both hormones was reduced in the supraoptic (SON) and paraventricular (PVN) nuclei. In the late phase, AVPp was basal and its expression decreased in both nuclei more than in the initial phase. The OT expression decreased only in the SON. L-NAME pretreatment increased the survival and reduced the NO production until 20h. MAP and Tb were increased, while HR remained similar to that observed in the vehicle control group. AVPp increased simultaneously to the decrease of its expression ratio in both nuclei. In the late phase, the L-NAME group showed NO levels increased and decreased AVP expression, apparently contributing to basal AVPp and hypotension. The L-NAME decreased OT expression ratio in the initial phase, but increased in the late phase. Inhibition of iNOS by AG further increased the survival and Tb. Even though AG did not block NO production, it increased AVP and OT expression and kept AVPp constant and above the baseline. AG pretreatment increased MAP only in the initial phase of sepsis. The ODQ pretreatment was more efficient to increase survival and Tb after CLP. However it neither altered the progressive NO increase nor the decrease in AVP and OT expression ratio. The basal AVPp after ODQ contributed to hypotension observed during the studied period. These results show that the increased central NO levels observed after CLP inhibit cGMP-independent hormone expression in the SON and partially dependent in the PVN. Inhibition of AVP expression, in the late phase of sepsis, results in basal concentrations of this hormone further contributing to hypotension. In our experiments the control of body temperature during polymicrobial sepsis had greater contribution in survival than the neuroendocrine and/or cardiovascular regulation.
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Corpo carotídeo e hipertensão: alterações celulares e da matriz extracelular / Carotid body and hypertension: cellullar and extracellular matrix alterationAlyne Souza Félix Fonseca 21 February 2011 (has links)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro / O aumento de doenças cardiovasculares possui como fator primordial e, mais comum, o aumento da pressão arterial (PA). Esta, pode gerar complicações em outros órgãos e acarretar diversas patologias, podendo levar a morte. A hipertensão é uma síndrome multifatorial, cuja maior incidência ocorre em indivíduos obesos, sedentários e consumidores em excesso de bebidas alcoólicas e sal. O corpo carotídeo (CC) é um órgão quimiorreceptor localizado na bifurcação da artéria carótida, formado de estruturas básicas chamadas glomus. Cada glomus carotídeo é constituído de células tipo 1 envoltas por células tipo 2 ou sustentaculares. Este trabalho teve como objetivo analisar as alterações morfofuncionais que ocorrem no CC, causada por hipertensão arterial induzida pelo L-NAME, um inibidor da enzima óxido nítrico sintase. Para isso, o estudo utilizou 20 ratos Wistar divididos em dois grupos: controle (C) e L-NAME (LN). Após a administração de 40mg/kg/dia de L-NAME por 45 dias, o CC foi coletado. Observou-se aumento significativo da pressão arterial a partir da segunda semana de administração de L-NAME. Análise quantitativa mostrou uma redução no número de núcleos do glomus carotídeo e o aumento na área total do órgão no grupo LN. Não foi encontrado diferença significativa no número de núcleos totais do corpo carotídeo entre os grupos. Na análise morfológica do grupo LN, observamos a formação de vacúolos nas células tipo 1 do glomus, bem como uma redução do número total de núcleos das células de cada glomus carotídeo. A análise qualitativa sugeriu um aumento no número de fibras colágenas e fibras do sistema elástico na matriz extracelular e grânulos no grupo LN. Imunomarcações com anticorpo anti VEGF e NF-kB e nNOS mostram-se aumentadas e dispersas por todo CC no grupo LN em relação ao grupo C. Além disso, marcações para Substância-P também foram observadas em maior quantidade nas células tipo 1 do grupo LN. Quanto à marcação para PGP 9.5, houve a redução desta marcação caracterizada dentro do glomus carotídeo grupo LN comparado ao grupo C. O estudo sugere que o corpo carotídeo, em resposta à hipertensão induzida pela inibição da enzima óxido nítrico sintase, gera mudanças morfofisiológicas semelhantes as encontradas em hipóxia. / The increased cardiovascular disease as the key features and, more common, increasing blood pressure (BP). This can cause complications in other organs and cause various diseases and may lead to death. Hypertension is a multifactorial syndrome, whose incidence is higher in obese, sedentary and consumers in excess alcohol and salt. The carotid body (CC) is a chemoreceptor organ located in bifurcation carotid artery, consisting of basic structures called carotid glomus. Each is made up of carotid glomus type 1 cells surrounded by sustentacular or type 2 cells. This study aimed to analyze the morphological and functional changes that occur in CC, caused by hypertension induced by L-NAME, an inhibitor of nitric oxide synthase. For that, the study used 20 rats divided into two groups: control (C) and L-NAME (LN). After administration of 40mg/kg/day L-NAME for 45 days, the CC was collected. We observed significantly increased blood pressure starting at second week of administration of L-NAME. Quantitative analysis showed a reduction in the number of cells in the carotid glomus and an increase in the total area of the body in the LN group. No significant difference was found in the nuclei total number in carotid body between the groups. In the morphological analysis of the LN group, we observed the formation of vacuoles in type 1 glomus cells, as well as a reduction in the total number of nuclei of cells from each carotid glomus. The qualitative analysis suggested an increase in collagen and elastic system fibers in the extracellular matrix and cytoplasmic granules in LN group. Immunostainings with anti-VEGF and NFkappa- B and nNOS show was increase and dispersed in the LN group than in group C. In addition, appointments for P substance were also obeservado in greater amounts in type 1 cells of the LN group. The marking for PGP 9.5, there was a reduction of this marking characterized in carotid glomus LN group compared with group C. The study suggests that the carotid body, in response to hypertension induced by inhibition of nitric oxide synthase, produces morphophysiological changes similar to those found in hypoxia.
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