Graduate / 0485

Graduate / 0485

Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 5 uppsatser.

abstract: Gait and balance disorders are the second leading cause of falls in the elderly. Investigating the changes in static and dynamic balance due to aging may provide a better understanding of the effects of aging on postural control system. Static and dynamic balance were evaluated in a total of 21 young (21-35 years) and 22 elderly (50-75 years) healthy subjects while they performed three different tasks: quiet standing, dynamic weight shifts, and over ground walking. During the quiet standing task, the subjects stood with their eyes open and eyes closed. When performing dynamic weight shifts task, subjects shifted their Center of Pressure (CoP) from the center target to outward targets and vice versa while following real-time feedback of their CoP. For over ground walking tasks, subjects performed Timed Up and Go test, tandem walking, and regular walking at their self-selected speed. Various quantitative balance and gait measures were obtained to evaluate the above respective balance and walking tasks. Total excursion, sway area, and mean frequency of CoP during quiet standing were found to be the most reliable and showed significant increase with age and absence of visual input. During dynamic shifts, elderly subjects exhibited higher initiation time, initiation path length, movement time, movement path length, and inaccuracy indicating deterioration in performance. Furthermore, the elderly walked with a shorter stride length, increased stride variability, with a greater turn and turn-to-sit duration. Significant correlations were also observed between measures derived from the different balance and gait tasks. Thus, it can be concluded that aging deteriorates the postural control system affecting static and dynamic balance and some of the alterations in CoP and gait measures may be considered as protective mechanisms to prevent loss of balance. / Dissertation/Thesis / M.S. Bioengineering 2014

Abstract The topic of this thesis is superconducting electric circuits. Technical advances have made possible the experimental study of Josephson junction based circuit elements which sustain quantum mechanical properties long enough to be denoted as quantum devices. The quantum state can be controlled with electronic variables and measured using standard electrical setups. The research is motivated by the possibility to examine quantum phenomena in circumstances that can be customized, prospects of new quantum devices, and the development of quantum information processing. This thesis presents theoretical studies on the nonlinear and stochastic driving of a superconducting quantum two-level system (qubit). We first investigate the energy level shifts a single-Cooper-pair transistor under large amplitude driving realized via the inherently nonlinear Josephson energy by using an external magnetic flux. The effective driving field substantially deviates from a circular polarization and linear coupling. The energy level shifts are compared to the cases of a vanishing and a weak driving field, measured as the Stark shift and the generalized Bloch-Siegert shift, respectively. We describe criteria for the natural basis of the analytical and the numerical calculations. In addition to that, we develop a formalism based on the Floquet method for the weak probe measurement of the strongly driven qubit. In the latter part of the thesis research, we study utilization of a stochastic driving field whose time evolution is not regular but follows probabilistic laws. We concentrate on the motional averaging phenomenon and show that it can be measured with an unparalleled accuracy by employing a flux-modulated transmon qubit. As the stochastically modulated qubit is simultaneously measured with a moderate driving field, we develop a theoretical description accounting the possible interference effects between the modulation and the drive. The comparison with experimental results shows good agreement. Motional averaging phenomenon can be applied to estimate the properties of fluctuation processes occurring in qubits, e.g., the quasiparticle tunneling or the photon shot noise. Resting on the motional averaging, we anticipate that the qubit dephasing times can be improved if one can accelerate the dynamics of two-level fluctuators. We apply a semiclassical formalism where the qubit is treated with quantum mechanical concepts whereas the driving fields are classical. In the solution procedure, the numerical results support the main analytical understanding. As the theoretical results are extensively compared to reflection measurements, we construct an explicit connection between the dynamics of the studied quantum devices and the measured reflection coefficient.

Climate change is an important contributor to the modification of many bumblebee species’ range boundaries. It was linked to widespread decline at the southern edge of their distribution and to their inability to colonize new areas at the northern edge. Additionally, bumblebee decline is aggravated by other anthropogenic threats like land use change, agricultural practices and pathogen spillover. Predicted consequences are numerous, and could lead to severe economic and ecological impacts on human populations. A species-specific assessment of potential climate change impacts on North American bumblebees, based on the most recent global change scenarios as used in the Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC), was done for the first time. Using a massive dataset of georeferenced bumblebee observations and general circulation models, a series of species distribution models explore the impact of different climate change scenarios on climatically suitable areas of 30 bumblebee species. Northward range shifts occur in most bumblebee species’ projected climatic niches, revealing potential hotspots – places projected to be climatically suitable to multiple species – under future climate scenarios. Areas where species are likely to be lost in the absence of intervention are substantial, particularly in eastern parts of the continent. Models showed significant contractions of current ranges even under the very optimistic scenario in which all species disperse at 10 km/year. Results indicate that managed relocation as well as habitat management should be considered as a conservation strategy for some species. This research serves as a foundation for broader discussion and research in a nascent research area. It may assist in establishing localities where first conservation efforts could be directed for vulnerable bumblebee species.

Coral reefs are priority habitats which are vulnerable to natural and anthropogenic disturbances. These can cause phase shifts from coral habitat to degraded algal-dominated states – and consequent changes in the distribution, abundance and activity of associated fish species. In the eastern Red Sea, human-induced reef degradation is likely to increase with planned development of the Saudi Arabian coast and the changing climate. The present study therefore investigates the ecological effects of coral-algal phase shifts in reef-associated fish communities, using naturally occurring within-reef benthic zones as proxies for levels of habitat health - with a focus on how these responses differ temporally. These zones were dominated by: hard coral (coral zone), coral and turf algae (transition zone), and macroalgal canopies (algal zone). Six inshore reef areas, were studied in periods with low and high densities of Sargassum in the algal zones (May and November respectively). Community composition was assessed via visual census and predation activity predicted using two proxies: in situ experiments and biomass of carnivores. In both periods, we observed distinct fish communities in each zone - with reduced species richness, Shannon-Wiener diversity and predation intensity, from the coral to the algal zones. Decreases in the abundance and biomass of fish also occurred from the coral to algal zones in May but a spike, as well as a shift in community composition, occurred in the algal zone in November. This shift is attributed to the vast increases in grazer biomass, predominantly Siganus luridus, associated with the November bloom of Sargassum canopies. The present study established, the composition and functioning of Red Sea fish communities is spatially and temporally affected by increased macroalgal dominance. This finding supports the need for herbivorous fish to be made a conservation priority in the management and conservation of reef systems in order to prevent phase shifts to algal dominated states. We conclude that if Red Sea reefs are allowed to shift to alternate states, depending on the density of macroalgal canopies, reefs may support high biomass and abundance of fish but the functioning of the fish community will be altered and the diversity lost.

Understanding the factors that make non-native species successful invaders is an important step towards mitigating spread. At the same time, species invasions can serve as natural experiments to test range-limit theory. Range-limit theory postulates declines in local abundance (abundant center model) and genetic diversity (central-peripheral hypothesis) towards range edges because of underlying environmental gradients. Such declines constrain adaptation to marginal habitats via gene swamping. However, broader evolutionary theory predicts intermediate rates of immigration into range-edge populations can relieve genetic drift and improve adaptive potential. I tested hypotheses generated from theory while illuminating aspects affecting of the invasion of the Asian tiger mosquito (Aedes albopictus Skuse) into the US. Using reciprocal distribution modeling, I found US populations occupied significantly different climate and habitat than in their native range (SE Asia). Most inconsistencies were found in the northern US range, where Ae. albopictus has recently crept northward, providing an opportunity to test range-limit theory as the range reaches its limit. Because of its limited natural dispersal ability, rapid spread after the 1985 US introduction pointed to human-aided dispersal. I tested the current role of human-aided versus natural dispersal using a landscape genetics framework, and found that natural dispersal dominated current patterns. Some distant localities were highly genetically similar, indicating potential human-aided transport in limited cases. Asymmetric gene flow from core to edge localities supported the abundant center model, but uniformly high genetic diversity contrasted with the central-marginal hypothesis. I detected a significant signature of local adaptation by overwintering diapause-induced eggs in multiple field sites using reciprocal transplants. Surprisingly, most genotypes from throughout the range produced large offspring when overwintered at the range edge. Relative offspring mass between home and away winters peaked at an intermediate immigration rate. These results show that rapid adaptation has occurred in US populations of Ae. albopictus and highlight the potential for further spread. Genetic admixture from multiple introductions may explain high genetic diversity throughout the US range and contribute to high offspring size for all genotypes overwintered at the range edge. Finally, my work highlights the need for a better understanding of contemporary ecological and evolutionary processes leading to range-limits (or expansion) to more accurately reflect processes occurring in a human-dominated world.

Yes / The 13C NMR chemical shifts of the three Edaravone tautomers (keto, enol, and amine) were calculated using a combined molecular mechanics (Pcmod 9.1/MMFF94) and ab initio (GIAO (B3LYP/DFT, 6–31 + G(d)) model. This method gave such good agreement with experiment that the assignment of the complex spectrum of Edaravone in solution, which is a mixture of the three tautomers could be made. This has been attempted previously by various methods with diverse results. In CDCl3 solution, the observed spectra show only one form, the keto tautomer, and this is also the case with acetonitrile solvent. Acetone solvent reacts with Edavarone in the NMR tube. In the other solvents studied, methanol, pyridine, DMSO, trifluoroethanol (TFE), there is a mixture of the tautomers with populations which vary with the solvent. The application of the shift predictions allows the assignment of the 13C spectra to the three tautomers and from this the proportions of the tautomers in the solution. The results at times differ significantly from previous studies, and this is discussed.

No description available.