Este trabalho consiste no estudo de métodos de otimização aplicados em um problema de controle para sistemas lineares com saltos markovianos (SLSM). SLSM formam uma importante classe de sistemas que têm sido muito úteis em aplicações envolvendo sistemas sujeitos a falhas e outras alterações abruptas de comportamento. Este estudo enfoca diferentes métodos para resolução deste problema. Comparamos o método variacional com o de Newton, sob o ponto de vista do número de problemas resolvidos e pelo nível de sub-otimalidade obtido (relação entre os custos obtidos por estes métodos). Também propomos um novo método, o qual pode ser inicializado com soluções de equações de Riccati acopladas, e o comparamos com o método variacional. Além disso, para a comparação dos métodos, propomos um algoritmo que gerou dez mil exemplos / This work addresses optimizations methods applied to a control problem for linear systems with markovian jumps, which form an important class of systems that have been very useful in applications involving systems subject to failures and other abrupt changes. This study focuses on different methods for solving this problem. We compare the variational approach with the Newton method, in terms of the number of solved problems and the level of sub-optimality (ratio between the costs obtained by these approaches). We also propose a new method, which can be initialized with solutions of coupled Riccati equations, and we compare it with the variational approach. We have proposed an algorithm for creating ten thousand examples for the comparisons

Dans cette thèse, nous développons des méthodes de contrôle pour stabiliser des systèmes quantiques en temps continu sous mesures quantiques non-destructives. En boucle ouverte, ces systèmes convergent vers un état propre de l'opérateur de mesure, mais l'état résultant est aléatoire. Le rôle du contrôle est de préparer un état prescrit avec une probabilité de un. Le nouvel élément pour atteindre cet objectif est l'utilisation d'un mouvement Brownien pour piloter les actions de contrôle. En utilisant la théorie stochastique de Lyapunov, nous montrons stabilité exponentielle globale du système en boucle fermés. Nous explorons aussi la syntèse du contrôle pour stabiliser un code correcteur d'erreurs quantiques en temps continu. Un autre sujet d'intérêt est l'implementation de contrôles efficacement calculables dans un contexte expérimental. Dans cette direction, nous proposons l'utilisation de contrôles et filtres qui calculent seulement les characteristiques classiques du système, correspondant a la base propre de l'opérateur de mesure. La formulation de dites filtres est importante pour adresser les problèmes de scalabilité du filtre posées par l'avancement des technologies quantiques. / In this thesis, we develop control methods to stabilize quantum systems in continuous-time subject to quantum nondemolition measurements. In open-loop such quantum systems converge towards a random eigenstate of the measurement operator. The role of feedback is to prepare a prescribed eigenstate with unit probability. The novel element to achieve this is the introduction of an exogenous Brownian motion to drive the control actions. By using standard stochastic Lyapunov techniques, we show global exponential stability of the closed-loop dynamics. We explore as well the design of the control layer for a quantum error correction scheme in continuous-time. Another theme of interest is towards the implementation of efficiently computable control laws in experimental settings. In this direction, we propose the use control laws and of reduced-order filters which only track classical characteristics of the system, corresponding to the populations on the measurement eigenbasis. The formulation of these reduced filters is important to address the scalability issues of the filter posed by the advancement of quantum technologies.

The field of mathematical modelling for pedestrian dynamics has attracted significant scientific attention, with various models proposed from perspectives such as kinetic theory, statistical mechanics, game theory and partial differential equations. Often such investigations are seen as being a part of a new branch of study in the domain of applied physics, called sociophysics. Our study proposes three models that are tailored to specific scenarios of crowd dynamics. Our research focuses on two primary issues. The first issue is centred around pedestrians navigating through a partially dark corridor that impedes visibility, requiring the calculation of the time taken for evacuation using a Markov chain model. The second issue is posed to analyse how pedestrians move through a T-shaped junction. Such a scenario is motivated by the 2022 crowd-crush disaster took place in the Itaewon district of Seoul, Korea. We propose a lattice-gas-type model that simulates pedestrians’ movement through the grid by obeying a set of rules as well as a parabolic equation with special boundary conditions. By the means of numerical simulations, we investigate a couple of evacuation scenarios by evaluating the mean velocity of pedestrians through the dark corridor, varying both the length of the obscure region and the amount of uncertainty induced by the darkness. Additionally, we propose an agent-based-modelling and cellular automata inspired model that simulates the movement of pedestrians through a T-shaped grid, varying the initial number of pedestrians. We measure the final density and time taken to reach a steady pedestrian traffic state. Finally, we propose a parabolic equation with special boundary conditions that mimic the dynamic of the pedestrian populations in a T-junction. We solve the parabolic equation using a random walk numerical scheme and compare it with a finite difference approximation. Furthermore, we prove rigorously the convergence of the random walk scheme to a corresponding finite difference scheme approximation of the solution.

Yes / This paper investigates the stabilisation problem and consider transient optimisation for a class of the multi-input-multi-output (MIMO) semi-linear stochastic systems. A control algorithm is presented via an m-block backstepping controller design where the closed-loop system has been stabilized in a probabilistic sense and the transient performance is optimisable by optimised by searching the design parameters under the given criterion. In particular, the transient randomness and the probabilistic decoupling will be investigated as case studies. Note that the presented control algorithm can be potentially extended as a framework based on the various performance criteria. To evaluate the effectiveness of this proposed control framework, a numerical example is given with simulation results. In summary, the key contributions of this paper are stated as follows: 1) one block backstepping-based output feedback control design is developed to stabilize the dynamic MIMO semi-linear stochastic systems using a linear estimator; 2) the randomness and probabilistic couplings of the system outputs have been minimized based on the optimisation of the design parameters of the controller; 3) a control framework with transient performance enhancement of multi-variable semi-linear stochastic systems has been discussed. / Higher Education Innovation Fund (No. HEIF 2018-2020), De Montfort University, Leicester, UK.

Yes / This paper presents a new control strategy for stochastic distribution shape tracking regarding non-Gaussian stochastic non-linear systems. The objective can be summarised as adjusting the probability density function (PDF) of the system output to any given desired distribution. In order to achieve this objective, the system output PDF has first been formulated analytically, which is time-variant. Then, the PDF vectorisation has been implemented to simplify the model description. Using the vector-based representation, the system identification and control design have been performed to achieve the PDF tracking. In practice, the PDF evolution is difficult to implement in real-time, thus a data-driven extension has also been discussed in this paper, where the vector-based model can be obtained using kernel density estimation (KDE) with the real-time data. Furthermore, the stability of the presented control design has been analysed, which is validated by a numerical example. As an extension, the multi-output stochastic systems have also been discussed for joint PDF tracking using the proposed algorithm, and the perspectives of advanced controller have been discussed. The main contribution of this paper is to propose: (1) a new sampling-based PDF transformation to reduce the modelling complexity, (2) a data-driven approach for online implementation without model pre-training, and (3) a feasible framework to integrate the existing control methods. / This paper is partly supported by National Science Foundation of China under Grants (61603262 and 62073226), Liaoning Province Natural Science Joint Foundation in Key Areas (2019- KF-03-08), Natural Science Foundation of Liaoning Province (20180550418), Liaoning BaiQianWan Talents Program, i5 Intelligent Manufacturing Institute Fund of Shenyang Institute of Technology (i5201701), Central Government Guides Local Science and Technology Development Funds of Liaoning Province (2021JH6/10500137).

La biología sintética se define como la ingeniería de la biología: el (re)diseño y construcción de nuevas partes, dispositivos y sistemas biológicos para realizar nuevas funciones con fines útiles, que se basan en principios elucidados de la biología y la ingeniería. Para facilitar la construcción rápida, reproducible y predecible de estos sistemas biológicos a partir de conjuntos de componentes es necesario desarrollar nuevos métodos y herramientas. La tesis plantea la optimización multiobjetivo como el marco adecuado para tratar los problemas comunes que surgen en el diseño racional y el ajuste óptimo de los circuitos genéticos sintéticos. Utilizando un enfoque clásico de ingeniería de sistemas, la tesis se centra principalmente en: i) el modelado de circuitos genéticos sintéticos basado en los primeros principios, ii) la estimación de parámetros de modelos a partir de datos experimentales y iii) el ajuste basado en modelos para lograr el desempeño deseado de los circuitos. Se han utilizado dos circuitos genéticos sintéticos de diferente naturaleza y con diferentes objetivos y problemas: un circuito de realimentación de tipo 1 incoherente (I1-FFL) que exhibe la importante propiedad biológica de adaptación, y un circuito de detección de quorum sensing y realimentación (QS/Fb) que comprende dos bucles de realimentación entrelazados -uno intracelular y uno basado en la comunicación de célula a célula- diseñado para regular el nivel medio de expresión de una proteína de interés mientras se minimiza su varianza a través de la población de células. Ambos circuitos han sido analizados in silico e implementados in vivo. En ambos casos, se han desarrollado modelos de estos circuitos basado en primeros principios. Se presta especial atención a ilustrar cómo obtener modelos de orden reducido susceptibles de estimación de parámetros, pero manteniendo el significado biológico. La estimación de los parámetros del modelo a partir de los datos experimentales se considera en diferentes escenarios, tanto utilizando modelos determinísticos como estocásticos. Para el circuito I1-FFL se consideran modelos determinísticos. Aquí, la tesis plantea la utilización de modelos locales utilizando la optimización multiobjetivo para realizar la estimación de parámetros del modelo bajo escenarios con estructura de modelo incompleta. Para el circuito QS/Fb, una estructura controlada por realimentación, el problema tratado es la falta de excitabilidad de las señales. La tesis propone una metodología de estimación en dos etapas utilizando modelos estocásticos. La metodología permite utilizar datos de curso temporal promediados de la población y mediciones de distribución en estado estacionario para una sola célula. El ajuste de circuitos basado en modelos para lograr un desempeño deseado también se aborda mediante la optimización multiobjetivo. Para el circuito QS/Fb se realiza un análisis estocástico completo. La tesis aborda cómo tener en cuenta correctamente tanto el ruido intrínseco como el extrínseco, las dos principales fuentes de ruido en los circuitos genéticos. Se analiza el equilibrio entre ambas fuentes de ruido y el papel que desempeñan en el bucle de realimentación intracelular, y en la realimentación extracelular de toda la población. La principal conclusión es que la compleja interacción entre ambos canales de realimentación obliga al uso de la optimización multiobjetivo para el adecuado ajuste del circuito. En esta tesis además del uso adecuado de herramientas de optimización multiobjetivo, la principal preocupación es cómo derivar directrices para el ajuste in silico de parámetros de circuitos que puedan aplicarse de forma realista in vivo en un laboratorio estándar. Como alternativa al análisis de sensibilidad de parámetros clásico, la tesis propone el uso de técnicas de clustering a lo largo de los frentes de Pareto, relacionando el compr / La biologia sintètica es defineix com l'enginyeria de la biologia: el (re) disseny i construcció de noves parts, dispositius i sistemes biològics per a realitzar noves funcions útils que es basen a principis elucidats de la biologia i l'enginyeria. Per facilitar la construcció ràpida, reproduïble i predictible de aquests sistemes biològics a partir de conjunts de components és necessari desenvolupar nous mètodes i eines. La tesi planteja la optimització multiobjectiu com el marc adequat per a tractar els problemes comuns que apareixen en el disseny racional i l' ajust òptim dels circuits genètics sintètics. Utilitzant un enfocament clàssic d'enginyeria de sistemes, la tesi es centra principalment en: i) el modelatge de circuits genètics sintètics basat en primers principis, ii) l' estimació de paràmetres de models a partir de dades experimentals i iii) l' ajust basat en models per aconseguir el rendiment desitjat dels circuits. S'han utilitzat dos circuits genètics sintètics de diferent naturalesa i amb diferents objectius i problemes: un circuit de prealimentació de tipus 1 incoherent (I1-FFL) que exhibeix la important propietat biològica d'adaptació, i un circuit de quorum sensing i realimentació (QS/Fb) que comprèn dos bucles de realimentació entrellaçats -un intracel·lular i un basat en la comunicació de cèl·lula a cèl·lula- dis-senyat per regular el nivell mitjà d'expressió normal d'una proteïna d'interès mentre es minimitza la seua variació al llarg de la població de cèl·lules. Els dos circuits han estat analitzats in silico i implementats in vivo. En tots dos casos, s'han desenvolupat models basats en primers principis d'aquests circuits. Després es presta especial atenció a delinear com obtenir models d'ordre reduït susceptibles de estimació de paràmetres, però mantenint el significat biològic. L' estimació dels paràmetres del model a partir de les dades experimentals es considera en diferents escenaris, tant utilitzant models determinístics com estocàstics. Per al circuit I1-FFL es consideren models determinístics. La tesi planteja la utilització de models locals utilitzant la optimització multiobjectiu per realitzar l'estimació de parametres del model sota escenaris amb estructura de model incompleta (dinàmica no modelada). Per al circuit de QS/Fb, una estructura controlada per realimentació, el problema tractat és la manca d'excitabilitat dels senyals. La tesi proposa una metodologia de estimació en dues etapes utilitzant models estocàstics. La metodologia permet utilitzar dades de curs temporal promediats de la població i mesures de distribució en estat estacionari d'una sola una cèl·lula. L' ajust de circuits basat en models per aconseguir el rendiment desitjat dels circuits també s' aborda mitjançant la optimització multiobjectiu. Per al circuit QS/Fb, es fa un anàlisi estocàstic complet. La tesi aborda com tenir en compte correctament tant el soroll intrínsec com l' extrínsec, les dues principals fonts de soroll en els circuits genètics sintètics. S' analitza l'equilibri entre dues fonts de soroll i el paper que exerceixen en el bucle de realimentació intracel·lular, les i en la realimentació extracel·lular de tota la població. La principal conclusió es que la complexa interacció entre els dos canals de realimentació fa necessari l' ús de la optimització multiobjectiu per al adequat ajust del circuit. En aquesta tesi, a més de l'ús adequat d'eines d'optimització multiobjectiu, la principal preocupació és com derivar directives per al ajust in silico de paràmetres de circuits que puguin aplicar-se de forma realista en viu en un laboratori estàndard. Així, com a alternativa a l'anàlisi de sensibilitat de paràmetres clàssic, la tesi proposa l'ús de l' tècniques de l'agrupació al llarg dels fronts de Pareto, relacionant el compromís de dessempeny amb les regions en l'espai d'paràmetres. / Synthetic biology is defined as the engineering of biology: the deliberate (re)design and construction of novel biological and biologically based parts, devices and systems to perform new functions for useful purposes, that draws on principles elucidated from biology and engineering. Methods and tools are needed to facilitate fast, reproducible and predictable construction of biological systems from sets of biological components. This thesis raises multi-objective optimization as the proper framework to deal with common problems arising in rational design and optimal tuning of synthetic gene circuits. Using a classical systems engineering approach, the thesis mainly addresses: i) synthetic gene circuit modeling based on first principles, ii) model parameters estimation from experimental data and iii) model-based tuning to achieve desired circuit performance. Two gene synthetic circuits of different nature and with different goals and inherent problems have been used throughout the thesis: an Incoherent type 1 feedforward circuit (I1-FFL) that exhibits the important biological property of adaptation, and a Quorum sensing/Feedback circuit (QS/Fb) comprising two intertwined feedback loops -an intracellular one and a cell-to-cell communication-based one-- designed to regulate the mean expression level of a protein of interest while minimizing its variance across the population of cells. Both circuits have been analyzed in silico and implemented in vivo. In both cases, circuit modeling based on first principles has been carried out. Then, special attention is paid to illustrate how to obtain reduced order models amenable for parameters estimation yet keeping biological significance. Model parameters estimation from experimental data is considered in different scenarios, both using deterministic and stochastic models. For the I1-FFL circuit, deterministic models are considered. In this case, the thesis raises ensemble modeling using multi-objective optimization to perform model parameters estimation under scenarios with incomplete model structure (unmodeled dynamics). For the QS/Fb gene circuit, a feedback controlled structure, the lack of excitability of the signals is the problem addressed. The thesis proposes a two-stage estimation methodology using stochastic models. The methodology allows using population averaged time-course data and steady state distribution measurements at the single-cell level. Model-based circuit tuning to achieve desired circuit performance is also addressed using multi-objective optimization. First, for the QS/Fb feedback control circuit, a complete stochastic analysis is performed. Here, the thesis addresses how to correctly take into account both intrinsic and extrinsic noise, the two main sources of noise in gene synthetic circuits. The trade-off between both sources of noise, and the role played by in the intracellular single-cell feedback loop and the extracellular population-wide feedback is analyzed. The main conclusion being that the complex interplay between both feedback channels compel the use of multi-objective optimization for proper tuning of the circuit to achieve desired performance. Thus, the thesis wraps up all the previous results and uses them to address circuit tuning for desired performance. Here, besides the proper use of multi-objective optimization tools, the main concern is how to derive guidelines for circuit parameters tuning in silico that can realistically be applied in vivo in a standard laboratory. Thus, as an alternative to classical parameters sensitivity analysis, the thesis proposes the use of clustering techniques along the optimal Pareto fronts relating the performance trade-offs with regions in the circuits parameters space. / This work has been partially supported by the Spanish Government (CICYT DPI2014- 55276-C5-1) and the European Union (FEDER). The author was recipient of the grant Formación de Personal Investigador by the Universitat Politècnica de València, subprogram 1 (FPI/2013-3242). She was also recipient of the competitive grants for pre-doctoral stays Erasmus Student Placement-European Programme 2015, and FPI Mobility program 2016 of the Universitat Politècnica de València. She also received the competitive grant for a pre-doctoral stay Becas de movilidad para Jóvenes Profesores e Investigadores 2016, Programa de Becas Iberoamérica of the Santander Bank. / Boada Acosta, YF. (2018). A systems engineering approach to model, tune and test synthetic gene circuits [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/112725

No / This paper presents a novel concept to describe the couplings among the outputs of the stochastic systems which are represented by NARMA models. Compared with the traditional coupling description, the presented concept can be considered as an extension using statistical independence theory. Based on this concept, the decoupling control in statistical sense is established with the necessary and sufficient conditions for complete decoupling. Since the complete decoupling is difficult to achieve, a control algorithm has been developed using the Cauchy-Schwarz mutual information criterion. Without modifying the existing control loop, this algorithm supplies a compensative controller to minimise the statistical couplings of the system outputs and the local stability has been analysed. In addition, a further discussion illustrates the combination of the presented control algorithm and data-based mutual information estimation. Finally, a numerical example is given to show the feasibility and efficiency of the proposed algorithm.

Neste trabalho estudamos as noções de alcançabilidade e controlabilidade para sistemas lineares a tempo contínuo com perturbações aditivas e saltos nos parâmetros sujeitos a uma cadeia de Markov geral. Definimos conceitos de alcançabilidade e controlabilidade médios de maneira natural exigindo que os valores esperados dos gramianos correspondentes sejam definidos positivos. Visando obter uma condição testável para ambos os conceitos, introduzimos conjuntos de matrizes de alcançabilidade e de controlabilidade para esta classe de sistemas e usamos certas propriedades de invariância para mostrar que: o sistema é alcançável em média, e, analogamente, controlável em média, se e somente se as matrizes respectivas, de alcançabilidade e de controlabilidade, têm posto completo. Usamos alcançabilidade média de sistemas para mostrar que a matriz de segundo momento do estado é definida positiva com uma margem uniforme. Uma consequência deste resultado no problema de estimação linear do estado é que a matriz de covariância do erro de estimação é positiva definida em média, no sentido que existe um nível mínimo de ruído nas estimativas. Na sequência, para estimadores lineares markovianos, estudamos a limitação do valor esperado da matriz de covariância do erro para mostrar que o filtro é estável num certo sentido, sendo esta uma propriedade desejável em aplicações reais. Quanto às aplicações da controlabilidade média, usamos este conceito para estabelecer condições necessárias e suficientes que garantem a existência de um processo de controle que leva a componente contínua do estado do sistema para a origem em tempo finito e com probabilidade positiva. / In this work we study the reachability and controllability notions for continuous-time linear systems with exogenous inputs and jump parameters driven by a quite general Markov chain. We define a rather natural average reachability and controllability concepts by requiring that the associated gramians are average positive definite, respectively. Aiming at testable conditions for each concept, we introduce certain sets of matrices linked with the gramians, and employ some invariance properties to find rank-based conditions. We show for average reachable systems that the state second moment is positive definite. One consequence of this result in the context of linear estimation for reachable systems is that the expectation of the error covariance matrix is positive definite. Moreover, for linear markovian filters we study the average boundedness of the error covariance matrix to show that the filter is stable in an appropriate sense, which consists in a property that is desirable in real applications. Regarding the average controllability concept, we show that it is a necessary and sufficient condition for the feasibility of the following control problem: find a control process that drives the continuous component of the state to zero in finite time with positive probability.

Die vorliegende Arbeit umfaßt drei Abhandlungen, welche allgemein mit einer stochastischen Theorie für die Lyapunov-Exponenten befaßt sind. Mit Hilfe dieser Theorie werden universelle Skalengesetze untersucht, die in gekoppelten chaotischen und ungeordneten Systemen auftreten. <br /> <br /> Zunächst werden zwei zeitkontinuierliche stochastische Modelle für schwach gekoppelte chaotische Systeme eingeführt, um die Skalierung der Lyapunov-Exponenten mit der Kopplungsstärke ('coupling sensitivity of chaos') zu untersuchen. Mit Hilfe des Fokker-Planck-Formalismus werden Skalengesetze hergeleitet, die von Ergebnissen numerischer Simulationen bestätigt werden. <br /> <br /> Anschließend wird gezeigt, daß 'coupling sensitivity' im Fall gekoppelter ungeordneter Ketten auftritt, wobei der Effekt sich durch ein singuläres Anwachsen der Lokalisierungslänge äußert. Numerische Ergebnisse für gekoppelte Anderson-Modelle werden bekräftigt durch analytische Resultate für gekoppelte raumkontinuierliche Schrödinger-Gleichungen. Das resultierende Skalengesetz für die Lokalisierungslänge ähnelt der Skalierung der Lyapunov-Exponenten gekoppelter chaotischer Systeme. <br /> <br /> Schließlich wird die Statistik der exponentiellen Wachstumsrate des linearen Oszillators mit parametrischem Rauschen studiert. Es wird gezeigt, daß die Verteilung des zeitabhängigen Lyapunov-Exponenten von der Normalverteilung abweicht. Mittels der verallgemeinerten Lyapunov-Exponenten wird der Parameterbereich bestimmt, in welchem die Abweichungen von der Normalverteilung signifikant sind und Multiskalierung wesentlich wird. / This work incorporates three treatises which are commonly concerned with a stochastic theory of the Lyapunov exponents. With the help of this theory universal scaling laws are investigated which appear in coupled chaotic and disordered systems. <br /> <br /> First, two continuous-time stochastic models for weakly coupled chaotic systems are introduced to study the scaling of the Lyapunov exponents with the coupling strength (coupling sensitivity of chaos). By means of the the Fokker-Planck formalism scaling relations are derived, which are confirmed by results of numerical simulations. <br /> <br /> Next, coupling sensitivity is shown to exist for coupled disordered chains, where it appears as a singular increase of the localization length. Numerical findings for coupled Anderson models are confirmed by analytic results for coupled continuous-space Schrödinger equations. The resulting scaling relation of the localization length resembles the scaling of the Lyapunov exponent of coupled chaotic systems. <br /> <br /> Finally, the statistics of the exponential growth rate of the linear oscillator with parametric noise are studied. It is shown that the distribution of the finite-time Lyapunov exponent deviates from a Gaussian one. By means of the generalized Lyapunov exponents the parameter range is determined where the non-Gaussian part of the distribution is significant and multiscaling becomes essential.

The presence of vibration is an important problem in many engineering applications. Various passive techniques have traditionally been used in order to reduce waves and vibrations, and their harmful effects. Passive techniques are, however, difficult to apply in the low frequency region. In addition, the use of passive techniques often involve adding mass to the system, which is undesirable in many applications. As an alternative, active techniques can be used to manipulate system dynamics and to control the propagation of waves and vibrations. This thesis deals with modeling, estimation and active control of systems that have resonant dynamics. The systems are exposed to stochastic disturbances. Some of them excite the system and generate vibrational responses and other corrupt measured signals. Feedback control of a beam with attached piezoelectrical elements is studied. A detailed modeling approach is described and system identification techniques are employed for model order reduction. Disturbance attenuation of a non-measured variable shows to be difficult. This issue is further analyzed and the problems are shown to depend on fundamental design limitations. Feedforward control of traveling waves is also considered. A device with properties analogous to those of an electrical diode is introduced. An `ideal´ feedforward controller based on the mechanical properties of the system is derived. It has, however, poor noise rejection properties and it therefore needs to be modified. A number of feedforward controllers that treat the measurement noise in a statistically sound way are derived. Separation of overlapping traveling waves is another topic under investigation. This operation also is sensitive to measurement noise. The problem is thoroughly analyzed and Kalman filtering techniques are employed to derive wave estimators with high statistical performance. Finally, a nonlinear regression problem with close connections to unbalance estimation of rotating machinery is treated. Different estimation techniques are derived and analyzed with respect to their statistical accuracy. The estimators are evaluated using the example of separator balancing.