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The current study examined the social factors that have influenced the rising female incarceration rates in Japan between 1970 and 2011, based on two theoretical explanations: Women's behavioral change thesis (women's liberation thesis and economic marginalization thesis), and policy change thesis (arrest and prosecutorial effect). Based on the secondary data obtained from the Japanese government's statistics, time series analysis was conducted. The results didn't support liberation thesis, whereas economic marginalization thesis and policy change thesis (prosecutorial effect) were supported to explain the rising female incarceration rate for special law crimes in Japan. On the other hand, two general indicators of ecoomic and political conditions in Japan had strong impact on the female incarceration rate for both penal code and special law crimes. Implications were discussed, basing on the cultural backgrounds of gender stratification, criminal justice processing and the broader economic and political conditions in Japan.

By implementing Albert O. Hirschman’s theory about reactions, the purpose of this thesis is to analyse the arguments against carbon offsetting presented in Swedish media. More specifically, I will structure and analyse the counter-arguments I find in the articles about carbon offsetting presented by the Swedish paper Dagens Nyheter between October 2019 and January 2020. Hirschman’s theory of the reactionary rhetoric is based on the notion that every social action is followed by a reaction. To illustrate this, Hirschman introduces three types of theses –arguments -deployed by those who oppose a new idea or reform. The three principal arguments Hirschman identifies is the futility thesis, the perversity thesis and the jeopardy thesis. The futility thesis suggests that an action aiming to improve the society in any way won’t have any effect, the perversity thesis claims that the action will result in the opposite outcome of what was intended and the jeopardy thesis implies that the action will result in intolerable consequences in other areas. Hirschman suggests that a debate where any of these theses are present both is a danger for democracy and is likely to result in suffering in other ways as well. In that way, his theory provides a tool for identifying dangerous arguments in order to take a step towards a more democracy friendly discussion. By analysing 85 arguments against carbon offsetting I find that 51 of them easily can be categorized as either one of the theses, while 22 can’t be categorized at all. The remaining 12 arguments can either partly or in full be placed in the model. The majority of the 51 arguments fitting in Hirschman’s model are futility theses, which implies that the Swedish debate in this area largely consists of arguments claiming that carbon offsetting doesn’t make any difference. My conclusion based on Hirschman’s theory and the analysis of the arguments is that the Swedish debate about carbon offsetting unarguably contains signs of the polarized discussion Hirschman claims to be a democratic danger and that both the debate itself and the climate overall probably would benefit from a more nuanced and balanced debate.

The hippocampus, in humans and rats, plays crucial roles in spatial tasks and nonspatial tasks involving episodic-type memory. This thesis presents a novel computational model of the hippocampus (CA1, CA3 and dentate gyrus) which creates a framework where spatial memory and episodic memory are explained together. This general model follows the approach where the memory function of the rodent hippocampus is seen as a “memory space” instead of a “spatial memory”. The innovations of this novel model are centred around the fact that it follows detailed hippocampal architecture constraints and uses spiking networks to represent all hippocampal subfields. This hippocampal model does not require stable attractor states to produce a robust memory system capable of pattern separation and pattern completion. In this hippocampal theory, information is represented and processed in the form of activity patterns. That is, instead of assuming firing-rate coding, this model assumes that information is coded in the activation of specific constellations of neurons. This coding mechanism, associated with the use of spiking neurons, raises many problems on how information is transferred, processed and stored in the different hippocampal subfields. This thesis explores which mechanisms are available in the hippocampus to achieve such control, and produces a detailed model which is biologically realistic and capable of explaining how several computational components can work together to produce the emergent functional properties of the hippocampus. In this hippocampal theory, precise explanations are given to why mossy fibres are important for storage but not recall, what is the functional role of the mossy cells (excitatory interneurons) in the dentate gyrus, why firing fields can be asymmetric with the firing peak closer to the end of the field, which features are used to produce “place fields”, among others. An important property of this hippocampal model is that the memory system provided by the CA3 is a palimpsest memory: after saturation, the number of patterns that can be recalled is independent of the number of patterns engraved in the recurrent network. In parallel with the development of the hippocampal computational model, a simulation environment was created. This simulation environment was tailored for the needs and assumptions of the hippocampal model and represents an important component of this thesis.

There is much interest in the study of midbrain dopaminergic (mDA) neurons as their functions include the regulation of motor function, emotion and reward pathways. Furthermore the dysfunction of these neurons is implicated in a number of human disorders such as Parkinson’s disease (PD), addiction and schizophrenia. PD is characterised by the degeneration of mDA neurons of the substantia nigra pars compacta (SNc), therefore, research into the specification and development of mDA neurons is of particular interest in relation to this disease. An understanding of the development of mDA neurons may lead to new methods of preventing their degeneration or potentially a human ES cell derived source of mDA neurons that could be used for transplantation in PD patients. Pitx3 is a bicoid-related homeodomain protein with an expression pattern restricted to the mDA neurons of the SNc and ventral tegmental area (VTA), within the central nervous system. To directly investigate a role for Pitx3 in mDA neuron development, I have analysed a line of transgenic mice with a green fluorescent protein (GFP) reporter under the control of the endogenous Pitx3 promoter. Use of the targeted GFP reporter as a midbrain dopaminergic lineage marker in the phenotypically normal heterozygous mice identified previously unrecognised ontogenetically distinct subpopulations of dopaminergic cells within the ventral midbrain. These subpopulations were detectable at E12.5 based on their temporal and topographical expression of Pitx3 and TH. Analysis of the Pitx3 null mice revealed that Pitx3 is required for the survival of a subset of nascent mDA neurons at the beginning of their terminal differentiation. The loss of mDA neurons via apoptosis continued throughout development resulting in a complete absence of SNc neurons whilst the VTA remained relatively intact in adult Pitx3 null mice. In addition, during embryonic development Pitx3 deficiency caused a loss of tyrosine hydroxylase (TH) expression specifically in the SNc dopaminergic neurons. Analysis of chimeric mice made with Pitx3 null and Pitx3 heterozygous ES cells revealed that Pitx3 acts in a cell autonomous manner. These findings point to two roles for Pitx3 in SNc mDA neurons, one in their survival and the other in regulation of TH expression. Taken together, these studies suggest that the ontogenetically distinct subpopulations may provide the molecular basis for the specific dependence of substantia nigra DA neurons on Pitx3. In addition, to establish whether the subpopulations identified at E12.5 do form the SNc and VTA, respectively, a strategy to track the fate of the earliest Pitx3- expressing cells has been initiated. In order to achieve this I have created transgenic mice in which a tamoxifen inducible form of Cre recombinase is under the control of the endogenous Pitx3 promoter. These mice can be crossed with existing mice which contain a ubiquitously expressed Cre-inducible reporter, such as LacZ or GFP, to give a temporally and spatially restricted reporter expression.

The diagnosis and treatment of depressive and anxiety disorders has changed rapidly in the past century. Western medicine has produced diagnostic criteria, pharmaceuticals, and different therapies, increasing public awareness of these conditions. This research investigates the potential and perceived cultural, familial, and political influences on anxiety and depressive disorders in the current biomedical system; analyzes the effects of this system on the patients within it; and compares the causality, diagnosis, and treatment of these conditions cross-culturally. To accomplish these research goals, I conducted in-depth interviews with people affected by depression and anxiety in the Atlanta area. I will present my analysis of the interview data collected, focusing on the extent to which each participants' familial and cultural backgrounds and attitudes towards biomedicine affected their choices and experiences with treatment. I also explore the role of pharmaceutical advertising and marketing strategies in patients’ perceptions of their disorder and treatment options.

The importance of spiritual care by nurses for health and recovery has become increasingly topical in the last decade. However, there is little research into why nurses should give spiritual care. Whilst bodily caring has always been associated with nurses and nursing, spiritual care has been seen as the concern of religious ministers. The steady decline of people belonging to conventional religions in secular British society is paralleled by an upsurge of interest in spiritualities. But why nurses should give spiritual care is unclear. This qualitative, interdisciplinary study aims to explore why nurses are asked to give spiritual care to patients by considering whether there is something amiss with nursing care that would be remedied by the addition of spiritual care. To investigate this, spiritualities and bodily caring are considered in tension with each other. By using feminist standpoint epistemological approaches I propose to: a) allow the everyday experiences of nurses in giving nursing care to be expressed; b) demonstrate that themes of nursing care as comforting, compassionate caring challenge claims that the addition of spiritual care is necessary; c) show that nurses conform to the perverse body/spirit dualisms of dominant patriarchal institutions and cultural norms in describing bodily nursing care as spiritual and d) present living models of nurses and nursing care as meaningful materialist world views. Material for the study was obtained in semi-structured, one-to-one conversational interviews with eighteen experienced practising nurses. Stories of nursing care were interpreted and analysed within nursing theories of spiritual care as either imperative or integral to nursing care. Body/spirit critiques in feminist informed theologies provided a further theoretical framework for analysis. The thesis describes the everyday distress that nurses experience. The feminist design created a vehicle for fresh constructs of care by nurses not previously identified in studies of spiritual care by nurses. The findings provide an evidence base for practising nurses to validate their own skills; for managers and policy makers in planning support for nurses to give nursing care, as well as for chaplains and others to listen and respond to care matters.

Book designers and manuscript artists have inserted illustrations into narrative works for centuries now. This practice is an intelligent behaviour that requires specialised knowledge of the text and the external parameters affecting the selection and placement criteria. This thesis offers a model for automation of illustration insertion into a narrative discourse. The model presented here is a significant improvement to the crudest method of dividing the text into equal parts and inserting one illustration into each part. This study starts from the position that narratives are expressions of mental representations of a sequence of events in various modes of discourse. Here, this mental representation is referred to as ‘the story’. When coupled with a mode of discourse, the story becomes a narrative. Thus, a story can be expressed as oral, written, pictorial, or film narratives. If they all express the same sequence of events, they are telling the same story. In an illustrated narrative, while the written discourse expresses the event sequence in the form of sentences, illustrations depict them using pictorial elements. The insertion of illustration into written narrative is analogous to collating two texts into one, based on their event content. In this process, sentential representation of events are collated against the pictorial expressions of the same events. Thus, for the purposes of automation, this study claims that an investigation into the locations of events can lead to potential locations for illustration insertions. However, the list of potential illustration locations can be improved further through eliminating the events that are not depictable. This model is also able to further improve on the insertion policy by incorporating event constraints as parameters for event priorities. If a set of event types is given preference in the illustration policy, the model is able to prioritise the list accordingly. Furthermore, the model is able to allow the samedegree of customisation for preferred characters, locations, or time in the story. The prioritisation can be applied to the entire narrative, or smaller chunks of the narrative text such as chapters or sections. The model is developed via the study of the verb roots of sentences – denoting the event types – in the discourse of Mohl’s critical edition of the Shāhnāma, the Persian epic composed by Abu al Qāsium Firdausī in 400/1010. A collection of 109 illustrated manuscripts of the Shāhnāma was considered in this study. These manuscripts come from various traditions of Persian paintings and cover a long period from the early 14th century to the late 19th century. A population of nearly 6,000 Shāhnāma illustrations were annotated. Each illustration is linked to a sentence in the narrative. The bottom-up approach to the study of verb distribution in the written discourse against the illustration location distribution indicates that illustration distribution follows the same trend as that of the depictable event distribution in the discourse. Particular event tokens displayed a high rate of illustration rendering them as all time favourite events. In summary, this study claims that investigation into the distribution of events in a narrative discourse provides a model for the insertion of illustrations into a narrative work.

Abstraction concepts based on process groups have largely dominated the design and implementation of communication patterns in message passing systems. Although such an approach seems pragmatic—given that participating processes form a ‘group’—in this dissertation, we discuss subtle issues that affect the qualitative and quantitative aspects of this approach. To address these issues, we introduce the concept of a ‘communication structure,’ which defines a communication pattern as an implicit runtime composition of localised patterns, known as ‘roles.’ During application development, communication structures are derived from the algorithm being implemented. These are then translated to an executable form by defining process specific data structures, known as ‘branching channels.’ The qualitative advantages of the communication structure approach are that the resulting programming model is non-ambiguous, uniform, expressive, and extensible. To use a pattern is to access the corresponding branching channels; to define a new pattern is simply to combine appropriate roles. The communication structure approach therefore allows immediate implementation of ad hoc patterns. Furthermore, it is guaranteed that every newly added role interfaces correctly with all of the existing roles, therefore scaling the benefit of every new addition. Quantitatively, branching channels improve performance by automatically overlapping computations and communications. The runtime system uses a receiver initiated communication protocol that allows senders to continue immediately without waiting for the receivers to respond. The advantage is that, unlike split-phase asynchronous communications, senders need not check whether the send operations were successful. Another property of branching channels is that they allow communications to be grouped, identified, and referenced. Communication structure specific parameters, such as message buffering, can therefore be specified immediately. Furthermore, a ‘commit’ based interface optimisation for send-and-forget type communications—where senders do not reuse sent data—is presented. This uses the referencing property of branching channels, allowing message buffering without incurring performance degradation due to intermediate memory copy.

We present an investigation into the design of an evolutionary mechanism for multiagent protocol constraint optimisation. Starting with a review of common population based mechanisms we discuss the properties of the mechanisms used by these search methods. We derive a novel algorithm for optimisation of vectors of real numbers and empirically validate the efficacy of the design by comparing against well known results from the literature. We discuss the application of an optimiser to a novel problem and remark upon the relevance of the no free lunch theorem. We show the relative performance of the optimiser is strong and publish details of a new best result for the Keane optimisation problem. We apply the final algorithm to the multi-agent protocol optimisation problem and show the design process was successful.