En el presente trabajo, explicamos como un producto que muchas veces es considerado inservible o ya no apto para el uso que se le solía dar debido al avance de la tecnología puede ser reutilizado. La idea de negocio que presentaremos es un reloj hecho a base de discos de vinilo calados, el cual puede ser utilizado para decorar o personalizar un espacio de tu hogar u oficina. Para ello, hemos fijado nuestro target y hemos calculado el tamaño de mercado según la cantidad de personas que cumple con los criterios de nuestra segmentación. Contando con estos datos, hemos validado la intención de compra de nuestro producto mediante encuestas y, finalmente, hemos concretado ventas. Por otro lado, hemos calculamos la inversión que requeriríamos para llevar a cabo este proyecto, así como las ventas proyectadas a 3 año, el VAN de la empresa y otros indicadores financieros que nos ayudan a validar si nuestra idea de negocio es rentable o no. Por los resultados mostrados a lo largo de la investigación, podemos confirmar que Vinyclock si es un proyecto viable. Además, es un proyecto que también contribuye al medio ambiente al reutilizar residuos y darles un nuevo uso. / In the present work, we explain how a product, which is often considered unusable or no longer suitable for the use that was usually given to it due to the advancement of technology, can be reused. Our business idea that we're going to present is a clock made with openwork vinyl records, which can be used to decorate or personalize a space in your home or office. To do this, we have set our target and we have calculated the market size according to the number of people that meet the criteria of our segmentation. With this data, we have validated the purchase intention of our product through surveys and, finally, we have finalized sales. On the other hand, we have calculated the investment that we would need to carry out this project, as well as the projected sales to 3 years, the NPV of the company and other financial indicators that help us validate if our business idea is profitable or not. For the results shown throughout the investigation, we can confirm that Vinyclock is a viable project. In addition, it's a project that also contributes to the environment by reusing waste and giving it a new use. / Trabajo de investigación

Springer and European Journal of Clinical Microbiology and Infectious Diseases, 33, 2014, 1371-79, Seasonal trend and clinical presentation of Bacillus cereus bloodstream infection: association with summer and indwelling catheter, K. Kato & Y. Matsumura & M. Yamamoto & M. Nagao & Y. Ito & S. Takakura & S. Ichiyama, figure number 2, original copyright notice is given to the publication in which the material was originally published, by adding; with kind permission from Springer Science and Business Media / 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第19922号 / 医博第4142号 / 新制||医||1017(附属図書館) / 33008 / 京都大学大学院医学研究科医学専攻 / (主査)教授 中川 一路, 教授 佐藤 俊哉, 教授 玉木 敬二 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Population structure in five African beef cattle breeds in South Africa was investigated, to assess the effect of animal recording in management of genetic diversity and genetic improvement. Pedigree records of 247,173 Afrikaner, 57,561 Boran, 198,557 Drakensberger, 256,692 Nguni and 55,309 Tuli breed were analysed using the online POPREP software system. Pedigree completeness over six generations varied with the lowest completeness in the Boran and the highest in the Afrikaner.The average generation interval ranged between 6.0 to 6.4 years. The rates of inbreeding per year were 0.03%, 0.04%, 0.06%, 0.07% and 0.08% in Boran, Nguni, Afrikaner, Drakensberger and Tuli respectively. Effective population sizes were 89, 107, 122, 191 and 364 in Tuli, Afrikaner, Drakensberger, Nguni and Boran respectively. Inbreeding and effective population size for the Boran was not a true reflection due to poor pedigree recording. These results indicate that none of the breeds are in critical limits of endangerment. Breeding values were regressed on birth year of each breed for weight traits; Kleiber ratio and scrotal circumference from 1986 to 2012. Genetic trends were stable for birth weights except the Afrikaner and Tuli. Genetic progress has been made in weaning and post weaning weights for all the breeds except for limited progress in the Nguni. Kleiber ratio and scrotal circumference in all measured breeds have shown good progress. The results of this study confirmed that recording of pedigree and performance records are effective in maintenance of genetic diversity and genetic improvement through selection based on EBVs of recorded traits. / Dissertation (MScAgric)--University of Pretoria, 2014. / tm2015 / Animal and Wildlife Sciences / MScAgric / Unrestricted

Marketing Mix Modelling has been used since the 1950s, leveraging statistical inference to attribute media investments to sales. Typically, regression models have been used to model the relationship between the two. However, the media landscape evolves at an increasingly rapid pace, driving the need for more refined models which are able to accurately capture these changes. One class of such models are Bayesian structural time series, which are the focal point in this thesis. This class of models retains the relationship between media investments and sales, while also allowing for model parameters to vary over time. The effectiveness of these models is evaluated with respect to prediction accuracy and certainty, both in and out-of-sample. A total of four different models of varying degrees of complexity were investigated. It was concluded that the in-sample performance was similar across models, yet when it came to out-of-sample performance models with time-varying performance outperformed their static counterparts, with respect to uncertainty. Furthermore, the functional form of the intercept influenced the uncertainty of the forecasts on extended time horizons. / Marketing mix modellering har använts sedan 1950-talet för att dra slutsatser om hur mediainvesteringar påverkar försäljning, med hjälp av statistisk inferens. Vanligtvis har regressionmodeller använts för att modellera relationen mellan de två. Men medielandskapet utvecklas allt snabbare, vilket kräver mer sofistikerade modeller som kan fånga upp dessa förändringar på ett mer precist sätt. En klass av sådana modeller är Bayesianska strukturella tidsseriemodeller, som är fokus för detta arbete. Denna klass av modeller bibehåller den strukturella relationen mellan mediainvesteringar och försäljning, samtidigt som de också tillåter modellparametrarna att variera över tid. Effektiviteten hos modellerna bedöms med avseende på noggrannhet och säkerhet, både tränings- och testdata. Totalt fyra olika modeller med varierande komplexitet undersöktes. Det konstaterades att prestandan på träningsdata var likvärdig mellan modellerna, men när det gällde testdata presterade modeller med tidsvarierande parametrar bättre än sina statiska motsvarigheter, med avseende på osäkerhet. Dessutom påverkade den funktionella formen av interceptet osäkerheten hos prognoserna över längre tidshorisonter.

Grades awarded to undergraduate students at Brigham Young University over a 20-year period were analyzed to determine to what extent the mean GPA may have increased. Study variables included enrolled freshman mean ACT, enrolled freshman mean AP credits, faculty research productivity, student evaluations of teaching (SET), and a university policy change regarding course withdrawal dates and calculating students' mean GPA. Other study variables included the overall grading philosophy of the college or school (normative, mastery, or other) and the course level (upper division, lower division). The study employed a regression model with splines for the residual, or yearly trend. Upper division courses have higher mean GPA than lower division courses, and mean GPA in mastery-based grading colleges are higher than in normative-based grading colleges. Mean GPA in upper division courses are consistently higher than mean GPA of lower courses, regardless of college grouping, but the difference between the upper and lower division mean GPA scores of the normative-grading classification is significantly larger than the difference between upper and lower division mean GPA of the other two grading classifications. Faculty research productivity had no impact on mean GPA. SET scores are highly correlated with college grading philosophy and course level and did not further predict mean GPA. The university policy change had no statistically significant effect on most mean GPA, but there is a marginally significant negative local effect on mean GPA of the lower division normative courses, as well as a marginally significant positive effect on mean GPA of lower division mastery courses. Grade trends vary between colleges with differing grading philosophies. They also likely vary across departments within colleges and from course to course within departments. Trends also differ between course level. Except for the non-significant effect of the policy change, mean GPA trends across most categories at the university have leveled off for more than a decade and are likely to remain so. Study results indicate there is no reason for alarm and that no systemic, rampant pattern of grade inflation is evident.

<p> The theory of canonical correlation analysis has been combined with that of trend surface analysis in order to construct a multivariate trend surface which is called a canonical trend surface. </p> <p> A canonical trend surface is a parsimonious summarization of areal variations of a set of geological variates. This trend has a property of maximum correlation between variates and geographic coordinates. It does not show the absolute value of each variate, but it shows the nature of the variation of a linear combination of the variates. The Permian system in western Kansas and eastern Colorado was studied as a numerical example to illustrate the general procedures in solving practical problems and also to demonstrate the validity of this technique. By use of this type of trend it is possible to reveal the underlying pattern of geographic variation common to a set of variates. </p> <p> Other applications of canonical correlation analysis in geology have been explained with illustrative geological examples, namely: the relationships between two sets of variates, matching two factor patterns, Q-technique canonical correlation, and discriminatory analysis. </p> <p> Comparison of canonical correlation analysis and principal factor solution in factor analysis suggests that factor analysis may be more appropriate for suggesting interrelationships among variables, while canonical correlation analysis may be a suitable tool for prediction problems. </p> <p> FORTRAN IV programs for these computations are listed in appendices with instructions for using them. </p> / Thesis / Doctor of Philosophy (PhD)

Many Inuit feel they are not benefitting from research activities that come from colonial research licensing practices and laws enabling state control over research. In Nunavut, research licensing also helped to increase community engagement in research. The Nunavut Research Institute (NRI), based in Iqaluit, Nunavut manages research and issues physical/natural, health, and social science research licenses in the Territory. In partnership with the NRI, we examined social science and Inuit knowledge research licensed between 2004-2019, to understand the scope of research trends in Nunavut. Using the 568 project summaries from social science research licenses, thematic content analysis was conducted to: i) identify research topics in social science and Inuit knowledge projects; ii) determine frequency and diversity of topics according to leadership, location, and timeframe; iii) develop new metrics to improve tracking of research topics; and, iv) contribute to the development of a Nunavut research portal making NRI research applications/reports public. Through this analysis we learned that social science research in Nunavut increased over time. Research projects are predominantly led by Canadian academics, with the highest concentration of research being in Iqaluit. Social science research is mainly focused on cultural topics, conducted using interviews, and shared in peer-reviewed journal articles. Community engagement has also increased over time in Nunavut, and research intensity appears to be connected to the availability of research-related capacity and infrastructure in a community. This research is an important starting point in making research trends more accessible to Nunavummiut (people of Nunavut), and more useable by decision-makers regarding research intensity and potential fatigue in some Nunavut communities. Long term, improving tracking of metrics such as funding sources and reporting mechanisms can contribute to policy reform and to advancing the NRI licensing database. This is an initial step contributing to Nunavut-specific approaches to Inuit self-determination in research. / Thesis / Master of Arts (MA) / Many Inuit feel they are not involved in the research process or seeing benefits from research outcomes. For my MA research, I am working with the Nunavut Research Institute (NRI) licensing database analyzing summaries of social science research applications from 2004-2019. The objectives are to: 1) Identify research topics addressed in social science projects; 2) Determine the variation of research topics across Nunavut over the past 16 years; 3) Develop new metrics to improve tracking of research topics; 4) Contribute to the development of a Nunavut research database making NRI research applications publicly accessible Through this analysis we learned that social science research in Nunavut has increased over time. Research projects are mainly led by Canadian academics, focused on cultural topics, and concentrated in Iqaluit. Community engagement has also increased over time in Nunavut and appears to be linked with the availability of research-related capacity and infrastructure in a community. This research is an important starting point in making research trends more accessible to Nunavummiut (people of Nunavut). This work is also an initial step contributing to Nunavut-specific approaches to Inuit self-determination in research.

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