This thesis acknowledges that the philosophical basis of the novels and short stories of Vidia Naipaul bears a significant resemblance to the tenets of Absurdity set out in Albert Camus' The Myth of Sisyphus and witnessed in various other Absurdist writings. At the same time it attempts to demonstrate that Naipaul's Absurdist vision reflects a Zeitgeist fundamental to the West Indies. It in no way suggests, however, that Naipaul consciously imitated the thoughts of Camus or others, or that he deliberately set out to circumscribe West Indian feelings. Chapter One attempts to demonstrate that Naipaul's most crucial perceptions of life have been those of disorientation and futility. It then shows where awareness of an inharmonious existence has been especially prevalent in the twentieth century, and it goes on to examine in some detail the discovery of the Absurd Conjunction between the world and individual consciousness articulated by Camus in The Myth of Sisyphus. In addition it describes the alternatives which Camus and other Absurdist writers advance to counter-act the anguish of Absurd Discovery. The second chapter begins by revealing the relationship between the absurd as "ridiculous" and the Absurd as "anguish", demonstrating that while Naipaul's perception of the irreducibility of the world is more central to his later works, it begins already in his earlier ones. It then goes on to discuss various aspects of Absurd Discovery which appear in Naipaul’s fiction: discovery of the isolation of man; discovery of the hostility of the world to the desires of man; and discovery of the disparity between the possible and the actual. Chapter Three shows how Naipaul's characters respond to the challenge of meaninglessness with both negation and affirmation. Although his characters frequently submit to despondency, this is in most cases only an initial reaction. In a vein similar to that of Camus, Naipaul implies that the Absurd would best be confronted by rebellion, creativity, personal involvement or, barring all else, ironic assessment. The final chapter demonstrates that the world of Vidia Naipaul - the disorder to which he attests and the alternatives he offers - while exhibiting sentiments essential to the European Absurdists, also mirrors experiences general to the West Indies.. Rather than dissecting with dispassionate superiority a background from which he has had occasion to feel alienated, Naipaul has sensitively illuminated a geographical region which, both historically and sociologically, has come to encompass its own especial Sisyphean sphere. / Arts, Faculty of / English, Department of / Graduate

tA/v\Am (the Audio/Video Analysis Machine) is an interactive analysis engine optimized for audio/visual mediums, such as film, video games, and music. I designed tA/v\Am to allow users to pace the playback speed of videos containing sub-title style analytical text, without affecting the pitch content of the audio. The software affords writers the opportunity to display the relevant sensory data (i.e., analytical text and sound/visual media) more efficiently than the paper format. It also serves as a flexible medium; the writer may, for example, compress extensive text into a short amount of time, causing the reader to pause or slow down the rate of the video and thus suspending him/her in the sensorial moment which the writer describes. G®¡ND for Alto Saxophone, Percussion & Electronics is an exploration of the tipping point between signal and noise. Through tablature notation, MIR tools, granular synthesis, and the deconstruction of the saxophone, I have assembled a palette of inordinately contrasting sounds and threaded them together based on action profiles obtained by computer assisted analysis. With them, I have set varying physical conditions of friction that dictates whether the sonic energy is to become focused to one resonant point, or distributed equally/randomly throughout the spectrum as noise. In my critical essay, I use the software to analyze independent video games, showing how tA/v\Am is a highly appropriate tool for such analysis as it is an analogous medium. I then show the software's capabilities as a multimedia platform in analyzing acoustic music, as well as my own electroacoustic work, G®¡ND. In doing so, I advocate for a media-driven analyses, and maintain that one can communicate nuanced ideas using minimal verbal/textual explanation.

0 / SPK / specialcollections@tulane.edu

Film screenings in painting In his theoretical work and film storyboard artwork I had the opportunity to prepare the philosophical basis for the practical part of the thesis. I was inspired by many authors with different approaches to film and film footage contemplation. For me as a creator, it was important to work with what is well-known. I dealt with the question of whether he could reality that surrounds us, filmic look when she make her over. After previous experience of seeing the painting, which draws on the film composition and borrowing of foreign ideas, I decided - as well as a film director - search for compositions which can be seen in the reality around us. Following my bachelor thesis, which was purely monochromatic cycle, I now chose a color theme and I returned to the activities that precede the making of the film. Our eye can function as a film lens. A seemingly ordinary reality is for me a pretext for building atmospheric film scene. For a long time I wore a camera with me, which was ready to use the moment I discovered an interesting space or situation. Patterns for paintings I naturally found in my travels around the city. I specifically sought location, which could be part of an imaginary film. For me, the composition under sunny streets huddled different feeling and unfinished, something that comes and works below the surface of each image in parallel. I hope linking reality and personal paintings will boost the atmosphere as value added. Name Film screenings in painting refers to the vocabulary filmmakers, the author looks at the experiences around film composition. In my work I wanted to simulate the Czech local, peculiar atmosphere of the place. During the work, there was a change from the original plan, and that the originals are really own, nevypůjčené. Heroes paintings are everyday people with their personal stories. However, there is a blending and assimilation of different film genres. For example, an image with the workers and the working machine has a compositional compliance with the sci-fi film, light and story recall something that we could ever see. Compared painters who have the means to extensive designed templates, I worked with a range that can be found only through accurate observation of reality. Construction patterns and Figures, therefore, actor scene, I could not prepare in advance. I counted with the fact that something interesting camera ready to capture and scene appeared before me. A crucial part of the process of my work was therefore observation and effort as possible to capture the genius loci.

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This diploma thesis engages in theme: Quality evaluation of dairy products made from goat milk. In literature summary of the thesis is described composition and characteristics of goat milk. There is basic information about goat dairy products, especially about cheeses. Practical part of the thesis deals with measuring pH, titrating acidity, content of proteins, fat, salt, dry matter and fat in dry matter in samples of goat cheeses. All results are compared in its group of goat cheese and simultaneously with other groups of goat cheeses. Measured values of analysis are compared with data on packaging. The lowest value in majority of the analysis reach group of spreadable cheeses. The highest values in majority of the analysis were found in semi-hard cheeses made only from goat milk and from mixture of goat, cow and ewe milk. When the results are being compared with the packaging, the most values correspond with dry matter and content of proteins. The lowest corresponding results were found in fat in matter and content of salt of goat cheese.

Die erwiesene Verbindung der V-ATPase mit Krankheiten wie Osteoporose oder Krebs erfordert die umfassende Analyse des Enzyms und seiner Inhibitoren, um entsprechende therapeutische Ansätze zu ermöglichen. V-ATPasen befinden sich sowohl in Endomembranen eukaryotischer Zellen als auch in Plasmamembranen vieler tierischer Zellen. Strukturell gliedern sie sich in einen membranständigen, protonentranslozierenden VO-Komplex und einen peripheren, ATP-hydrolysierenden V1-Komplex. Über die Kopplung von ATP-Hydrolyse und Protonentransport energetisiert die V-ATPase viele transmembrane Transportprozesse und reguliert den pH-Wert in Organellen und Zellen. Die etablierten Plecomakrolid-Inhibitoren Bafilomycin und Concanamycin, welche schon seit den 1980er Jahren untersucht werden, hemmen die V-ATPase spezifisch in nanomolaren Konzentrationen. In vorangegangenen Arbeiten war der Hauptteil ihrer Bindestelle bereits der c-Untereinheit des VO-Komplexes zugeordnet worden, wobei aber auch die VO-Untereinheit a an der Bindung beteiligt zu sein scheint. In der vorliegenden Arbeit wurde die Bindestelle mit Hilfe von Photoaffinitätsmarkierungen mit neuen Plecomakrolid-Derivaten und der V-ATPase aus Manduca sexta weiter charakterisiert. Dabei wurde bestätigt, dass die Plecomakrolide an die VO-Untereinheit c binden. Außerdem konnte die Beteiligung der VO-Untereinheit a erstmals direkt gezeigt werden. Sie ist vermutlich auf die engen Interaktionen der Untereinheiten innerhalb des VO-Komplexes zurückzuführen, weshalb ein Inhibitionsmechanismus naheliegt, bei dem Bafilomycin und Concanamycin als „Stöckchen im Getriebe“ die Rotation des c-Rings relativ zur a-Untereinheit verhindern. Mit dem Inhibitor Apicularen wurde in dieser Arbeit erstmals die Bindestelle eines Benzolacton Enamids an der V-ATPase bestimmt. Eine Besonderheit der Benzolacton Enamide ist die Tatsache, dass sie als erste Inhibitor-Klasse die V-ATPasen von Pilzen nicht hemmen. Nach Kenntnisstand zu Beginn dieser Arbeit binden die Benzolacton Enamide zwar innerhalb des VO-Komplexes, aber an anderer Stelle als die Plecomakrolide und der Inhibitor Archazolid. Überraschenderweise wurden aber bei Photoaffinitätslabelversuchen mit einem Diazirinyl-Derivat von Apicularen ebenfalls die VO-Untereinheiten a und c markiert. Es konnte bestätigt werden, dass sich die Apicularen-Bindestelle deutlich von der des Archazolids unterscheidet, sie jedoch teilweise mit der Plecomakrolid-Bindestelle überlappt. Für die weitere Untersuchung der Apicularen-Bindung wurden Komplementationsstudien mit Deletionsmutanten von Saccharomyces cerevisiae und VO-Untereinheiten Apicularen-sensitiver Organismen durchgeführt. Während der funktionelle Austausch der a-Untereinheit gegen Hybrid-a-Untereinheiten aus S. cerevisiae und Homo sapiens nicht glückte, resultierte der Austausch der c-Untereinheit gegen Homologe von H. sapiens und M. sexta in vollständig assemblierten und aktiven Hybrid-V-ATPasen. Damit gelang es erstmals, eine humane V-ATPase-Untereinheit in Hefe funktionell zu exprimieren. Dadurch, dass die Hybrid-V-ATPasen nicht durch Apicularen gehemmt werden, kann angenommen werden, dass die Apicularen-Bindestelle zumindest nicht von der c-Untereinheit allein gebildet wird, sondern dass im Umkehrschluss die VO-Untereinheit a einen erheblichen Beitrag zur Bindung beisteuert.

Design of national theatre in city centre of a capital. The building plot is defined by block of existing buildings. With my propose i am defining new theatre squere.

The newly built office building in an exclusive residential suburb of Brno is a worthy partner to the villa from the thirties of the last century. The layout is based on the contrast of the surrounding built-up area. Its sharp and clean lines are dissimilar from the round forms of the neighbouring villa. The minimalist concept frees of the classical façade articulation. However it most respects other neighbouring buildings with its dimension arrangement.

Master 's thesis Městská knihovna v Přerově is developing the new city library for town Přerov. This project is based on semestral project strategy for library, which was searching for the best place for the building. Master's thesis is situating the new city library in waterfront area Na Marku, near the new Tyršův most.