This item was digitized as part of the Million Books Project led by Carnegie Mellon University and supported by grants from the National Science Foundation (NSF). Cornell University coordinated the participation of land-grant and agricultural libraries in providing historical agricultural information for the digitization project; the University of Arizona Libraries, the College of Agriculture and Life Sciences, and the Office of Arid Lands Studies collaborated in the selection and provision of material for the digitization project.

This item was digitized as part of the Million Books Project led by Carnegie Mellon University and supported by grants from the National Science Foundation (NSF). Cornell University coordinated the participation of land-grant and agricultural libraries in providing historical agricultural information for the digitization project; the University of Arizona Libraries, the College of Agriculture and Life Sciences, and the Office of Arid Lands Studies collaborated in the selection and provision of material for the digitization project.

No description available.

Syftet med det här utvecklingsarbetet var att planera och genomföra språkstimulerande aktiviteter i utomhusmiljö för att se om det främjade barns lärande i språk, samt se vilken roll lärarens arbete hade. Vi planerade och genomförde tio aktiviteter i en förskoleklass och i en årskurs fyra med totalt 32 elever. Aktiviteterna genomfördes i växelverkan mellan inomhusmiljö och utomhusmiljö. De metoder som användes för dokumentation var observationer och loggbok samt studerande av tidigare forskning och litteratur. Resultatet visade att utemiljön var en språkstimulerande miljö för eleverna vilket synliggjordes under arbetsprocessen samt i elevernas slutprodukter. De elever som deltog visade ett engagemang och nyfikenhet inför aktiviteterna. Vår slutsats är att vi kommer att använda oss av utemiljön som ett komplement till det traditionella klassrummet eftersom vi anser att det gav både oss och eleverna inspiration. Vi har insett vikten av att våga använda varierande lärandemiljö

Ring is a composition for orchestra (piccolo [doubling flute], two flutes, two oboes, English horn, two clarinets in B-flat, bass clarinet, two bassoons, contra-bassoon, four horns, four trumpets, two tenor trombones, bass trombone, tuba, three percussion parts [including glockenspiel, vibraphone, tubular bells, snare drum, toms, bass drum, suspended cymbal, drum kit, triangle, and gong], timpani, harp, piano, and standard strings) and spatially separated women's choir (SA right, SA left). This arrangement of media is intended to "ring" the audience with performers. At the notated tempo of two quarter-notes per second, the duration of the piece is exactly 17'40". The title of Ring comes from a poem of the same name written by the composer which is the principal text sung by the choir in the piece. The text of the poem is as follows: Wendy is a ring / A beginning and an end / Connected / The finest gold / Melted by touch / Cooled by breath / She fits my every finger / Without constraint / But permanent / Priceless, Precious, Beautiful / Alone / She clothes me. The poem and composition were written for, and dedicated to, the composer's wife. The ring metaphor ("ring" meaning cyclical, unending, complete) underlies many of the compositional choices in the work. Much of the surface of the music and its deeper structural elements are palindromes, which, because they end as they begin, have a circular nature. Also, the pitch structure of the piece involves the climactic completion of the "cycle" of the twelve available equal-tempered pitch classes. A further organizational element is the Fibonacci series, a mathematical construct which is used to determine small-scale rhythms and the duration of the larger sections of the work. These components, taken together, have resulted in a composition filled with variety and contrasts, which, nonetheless, is quite organically cohesive.

With the development of the computer networks, mainly the Internet, it became easier to develop applications where the execution is shared between a local computer, the Client, and one located on the other side of the network communication channel, the Server. The hardware advancements in the recent years made it possible to display 3D graphics (games, map navigation, virtual worlds) on mobile devices. However, executing these complex applications on the client terminal is not possible without reducing the quality of the displayed graphics or lowering its processing requirements. Different solutions have already been proposed in academic publications; however none of them satisfies all requirements. The objective of this thesis is to propose an alternative solution for a new client-server architecture where the connectedness of the mobile devices is fully exploited. Several main requirements are addressed: - Minimize the network traffic, - Reduce the required computational power on the terminal, and - Preserve the user experience compared with local execution. First a formal framework is designed that can effectively define and model distributed applications for 3D graphics. Then a model of new architecture is presented, that overcomes the disadvantages of the architectures presented in the state of the art. The core of the architecture is the MPEG-4 standard, which is used to transfer the data between the server and the client in a compressed manner. The last part of explores the design of architectures optimized for running on mobile devices. The design of the new client-server architecture is validated by implementing a game and running simulations.

?4 phosphoprotein (also known as IGBP1) is a component of the mammalian target-of-rapamycin (mTOR) pathway that controls the initiation of translation and cell-cycle progression in response to nutrients and growth factors. Aberrant signaling of the mTOR pathway has been reported in many cancers. ?4 interacts with the catalytic subunit of protein phosphtase 2A (PP2Ac) to mediate the dephosphorylation of eukaryotic initiation factor 4E-binding protein1 (4E-BP1) and p70S6 kinase (p70S6K). Our laboratory has reported that EDD E3 ubiquitin ligase (EDD/UBR5) and poly(A)-binding protein (PABP) are novel binding partners of ?4 phosphoprotein. In the present study, the interaction of EDD and PABP with ?4 was confirmed in human MCF-7 breast cancer and African green monkey COS-1 kidney cell lines, using immunoprecipitation and immunoblotting (IP/IB) analysis. However, co-IP of total MCF-7 cell lysates with anti-EDD antibodies revealed that EDD does not physically interact with PP2Ac. Several ?4 deletion constructs, that contained either the N-terminal or C-terminal regions of ?4, were transfected into MCF-7 and COS-1 cells. Co-IP studies with anti-EDD and PABP antibodies revealed that EDD interacts with the C-terminal region of ?4 whereas PABP, like PP2Ac, binds to the N-terminal region. EDD and PABP were found to interact with ?4 in both quiescent and actively growing cells. EDD is known to ubiquitinate poly(A)-binding protein-interacting protein 2 (Paip2), targeting it for proteosomal degradation. Paip2 is an antagonist of PABP activity. When ?4 levels in MCF-7 cells were knocked down using small interfering RNA (siRNA), there was no effect on EDD protein levels. There was also no effect on Paip2 levels, indicating that ?4 is not involved in the EDD- mediated ubiquitination of Paip2. Knockdown of EDD gene expression by siRNA did not alter mono-ubiquitination of ?4, indicating that ?4 is not a substrate of EDD. However, knockdown of EDD gene expression decreased poly-ubiquitination of PP2Ac and increased the overall cellular levels of PP2Ac, suggesting PP2Ac as a novel substrate of EDD. The present study suggests a potential role for ?4 in PABP-mediated initiation of mRNA translation. Furthermore, this study suggests a role for EDD in regulating PP2Ac levels through its interaction with ?4. In summary, the ?4 partners EDD, PABP and PP2Ac interact at specific regions of ?4. PP2Ac, but not ?4, is a substrate of EDD. The interaction of PABP with ?4 suggests a potential role for ?4 in PABP-mediated initiation of mRNA translation.

No description available.

No description available.

No description available.