Analysis of spontaneous adverse events reports of Infanrix hexa vaccine Author: Klára Kovaříková Supervisor: PharmDr. Eva Zimčíková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Infanrix hexa vaccine is used for vaccination of infants and toddlers against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and disease caused by Haemophilus influenzae type b. Analysis of spontaneous adverse drug reactions (ADRs) reports is one of the most important sources of information to evaluate drug-related risks. Objective: The aim of this study was to analyse spontaneous ADRs reports of Infanrix hexa vaccine, which were sent to the State Institute for Drug Control (SÚKL) database in the period from 2004 to 2017. Methods: The data was analysed using descriptive statistic in MS Excel. ADRs were classified according to the MedDRA. Seriousness and expectedness of ADRs were evaluated. Results: Overall 1288 reports were obtained containing 4334 ADRs, approximately 3.4 ADRs per report. Infanrix hexa vaccine was the only suspected drug in most of the reports (75.9%). Physicians were the most frequent reporters (70.2%). Serious ADRs were found in 84.3% of reports. The most frequent ADRs were general disorders and administration site...

Aromatherapy and Pharmacies in the Czech Republic Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, The Czech Republic Author: Anna Hamrová Thesis supervisor: PharmDr. Jitka Pokladníková, Ph.D. Introduction and objective: Aromatherapy represents a method of alternative and complementary medicine. However, up to date, there have not been published any studies which would focus on pharmacists' and pharmacy technicians' opinion on this particular treatment method. This has provided us an incentive to investigate given topic. The main objective of this thesis is thus to further specify the attitudes, knowledge and awareness of Czech pharmacists and pharmacy technicians of aromatherapy. Methods: The thesis draws from pilot research project. For the research the method of cross-sectional questionnaire survey was used. The data was collected during the period of mid-September till end of October 2020. The data was subsequently analytically processed in Microsoft Excel. Results: The questionnaire was filled by 246 respondents (192 pharmacists and 54 pharmacy technicians). The data collected indicated that respondents more often did not consider aromatherapy as a very effective medical treatment. Data demonstrated a significant difference...

This diploma thesis deals with one of the most frequently used addictive stuffs - alcohol. The theoretical part contains the characteristics of the addiction and the syndrom of risky behaviour in the adolescent age, it deals with the topic of drugs and drug addiction. Later, it investigates alcohol - its characteristics, metabolism and intake, its effects on single organ systems, the levels and types of alcohol addiction. It focuses on the prevention of using addictive stuffs and alcohol and on the treatment of alcohol addiction. The practical part of the thesis settles the targets and the questions of the research. The main goal of the practical part, eventually of the whole thesis, was to analyze the basic school students' (sixth grade and higher) awareness of alcohol, its effects and the risk of it being consumed. As well as this, the aim was to find out whether the pupils have any experience with preventive programs and where they get in touch with these. The method of quantity research was used to hit these targets - semi-structured questionnaires for the pupils of basic schools (sixth grade and higher), followingly, school prevention methodologists were asked written questions. The questionnaries were filled in by 120 pupils of the 6th up to the 9th class of chosen basic schools. The results...

This thesis deals with the manipulating practices in the political media coverage in the period before the elections to the House of Parliament of the Czech Republic in May 2010. It describes the types of communication in terms of its ability to influence and focuses on the effects of the media and its impact on the audience. It also deals with the theoretical framework of the issues of manipulating methods and techniques and their causes. It defines the function of media in terms of intentions and evaluates the current situation in the Czech Republic, including the existing control mechanisms. A part of this thesis is a comparative analysis that focuses on a detailed qualitative analysis of texts published in the dailies Mladá fronta Dnes and Právo and their comparison during the period under consideration.

The diploma thesis Comparative study of a presentation of women's beauty in lifestyle magazines for men and women suggests the hypothesis that the image of women's beauty is modified according to the target group of the media. As to support or falsify the thought, there are analysed chosen photographs of women in four Czech lifestyle magazines, specifically in ELLE, ForMen, Cosmopolitan and Esquire. Chosen method of semiotic analysis and description helps define the differences between image of women's beauty in the pictures. In order to interpret the pictures in broader context, the first half of work deals with the development of aesthetic theories and various scientific views of beauty as well as theories about presumed media influence. The results of the analysis are interpreted and explained on the grounds the theoretical base. Besides the evaluation of the primary hypotheses there are also noted other theoretical findings. The document is closed by comments of authoress on the issue based on already written theories.

Iveta Šteflová Drug induced imbalance of sodium Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Pharmacy Department of Biological and Medical Science Supervisor: Doc.MUDr. Josef Herink, DrSc. Sodium (Na+ ) is the major extracellular cation. It plays an important role in maintaining membrane potential and depolarization that is the basic mechanism of transmission of the nerve impulse. It is involved in maintaining acid-base balance, osmotic pressure, water retention in the body. The largest part of the sodium is in the extracellular fluid where it is stored about 50 % of sodium. Plasma concentration of sodium is 140 ± 5 mmol/l. Drug-induced electrolyte disorders are increasingly reported and may be associated with considerable morbidity and mortality. The risk of drug-induced hyponatremia is generally higher than the risk of drug-induced hypernatremia. Hyponatremia is a common electrolyte disorder defined as a decrease plasma sodium concentration below 135 mmol/l. It is classified by the state of volume - hypovolemic, euvolemic and hypervolemic hyponatremia. It reflects the relative rate between sodium and water in the body. The most common cause is the syndrome of inappropriate secretion of antidiuretic hormone that induces euvolemic hyponatremia. Hypernatremia is...

HORMONAL CONTRACEPTION - USERS̕ KNOWLEDGE Student: Křiklánová, J. Tutor: Marešová, H. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Hormonal contraception is a broadly used and very reliable birth control method. Nonetheless, it is not entirely risk-free. This thesis deals with the awareness of those risks in women who are currently using hormonal contraception or have ever used it before. Aim of the thesis: The main aim was to determine the extent of the users' awareness of hormonal contraception and its risks, undesirable side effects and contraindications, as well as their source of information. Furthermore, the awareness of the environmental impact, the reasons for using hormonal contraception and user satisfaction were examined. Methodology: The research was carried out by means of online questionnaires, which were spread among current or former users of hormonal contraception regardless of age, educational background or place of residence. 148 completed questionnaires were gathered and the data which were obtained were statistically evaluated. Results: It was discovered that women feel informed (25 %) or rather informed (44,6 %) more often than uninformed; the most frequent source of information is patient...

Title: Effect of sauna on muscle tone after physical excersise Topic definition: This thesis presents a pilot theoretical - empirical two-factor experiment, where the main subject of the experiment is to evaluate the effect of sauna on increased muscle tension after sport and its potential for use in physical therapy and recovery. Aim of the thesis: To provide a summary of theoretical knowledge related to the subject and to assess the impact of sauna usage on muscle tension occurred after short term maximal anaerobic excercise and compare it with passive rest. Methods: This thesis will be processed at the Faculty of Physical Education and Sport on 6 individuals, who will be randomly divided into two equally large groups. The first three-person group will be a research one, the second three-member group will be the control group. Afterwards they will be subjected to a Wingate stress test. The experimental group will participate in sauna treatments and the control group in passive rest. Muscle tension will be measured before the load, after the load, and after the sauna / passive rest. Measurements will take place in a kinesiology lab at the Faculty of Physical Education and Sports. Measurements will be done by using a myotonometer and the data will be gathered via an analogue-digital converter and...

Title of thesis: Ballistic cavity origin characterisation; auxiliary materials of a standardised or a special military ammunition. Aim of thesis: The goal of this work is to provide a regularising framework suggesting structural changes of the auxiliary materials in the impact zone of the various ammunition. Methods: A ballistic experiment based upon the piercing test of various ammunition types. For these tests different barrier materials were used (e.g. glycerine, soap, ballistic gel). A comparative study of the various physical aspects of the cavities was exercised. Several diagnostic methods such as dimensions verification, water volume measurement, projectile speed radar check, computer tomography or the high speed camera were used to determine the secondary cavity specifics. Results: This thesis identified several key parameters determining projectile behaviour in the auxiliary materials. The major determinants were: speed, position or homogeneity of the projectile on the impact. However the major parameter defining the "injury level" was the concluded that the highest Injury level has the prohibited "fragmentation effect ammunition". On the other hand it was pointed out that so called "Black Mamba" projectiles have lower injury effect, although manufactore claims otherwise. Key words:...

Vendula Dvořáčková Attitudes of patients toward antidepressant medication Master's thesis Charles University in Prague, the Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Pharmacy Background: The master's thesis deals with evaluation of attitudes of inpatients in the psychiatric clinic of Military University Hospital Prague. The main task was to clarify the relation between therapy attitude and the prescribed medication, diagnosis and sociodemographic characteristics. Methods: The data were collected using the Drug Attitude Inventory questionnaire (Czech version by Masopust) where sum of negative and positive answers was used to determine the patient's general attitude. Patients' characteristics were acquired from a data-entry form, specific medication from the medical records. Results: In the observed group women seemed to have a more positive attitude toward the treatment compared to men, similarly to people with a higher level of education and patients between 31 - 40 years of age in comparison with other age groups. The most positive responses were observed in patients who were prescribed agomelatine, trazodone and paroxetine. People diagnosed with personal disorders or affective bipolar disorder inclined to positive answers as well, on the other hand most negative...