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1H NMR spectroscopic elucidation in solution of the kinetics and thermodynamics of spin crossover for an exceptionally robust Fe2+ complexPetzold, Holm, Djomgoue, Paul, Hörner, Gerald, Speck, J. Matthäus, Rüffer, Tobias, Schaarschmidt, Dieter 15 September 2016 (has links)
A series of Fe2+ spin crossover (SCO) complexes [Fe(5/6)]2+ employing hexadentate ligands (5/6) with cis/trans-1,2-diamino cyclohexanes (4) as central building blocks were synthesised. The ligands were obtained by reductive amination of 4 with 2,2′-bipyridyl-6-carbaldehyde or 1,10-phenanthroline-2-carbaldehyde 3. The chelating effect and the rigid structure of the ligands 5/6 lead to exceptionally robust Fe2+ and Zn2+ complexes conserving their structure even in coordinating solvents like dmso at high temperatures. Their solution behavior was investigated using variable temperature (VT) 1H NMR spectroscopy and VT Vis spectroscopy. SCO behavior was found for all Fe2+ complexes in this series centred around and far above room temperature. For the first time we have demonstrated that the thermodynamics as well as kinetics for SCO can be deduced by using VT 1H NMR spectroscopy. An alternative scheme using a linear correction term C1 to model chemical shifts for Fe2+ SCO complexes is presented. The rate constant for the SCO of [Fe(rac-trans-5)]2+ obtained by VT 1H NMR was validated by Laser Flash Photolysis (LFP), with excellent agreement (1/(kHL + kLH) = 33.7/35.8 ns for NMR/LFP). The solvent dependence of the transition temperature T1/2 and the solvatochromism of complex [Fe(rac-trans-5)]2+ were ascribed to hydrogen bond formation of the secondary amine to the solvent. Enantiomerically pure complexes can be prepared starting with R,R- or S,S-1,2-diaminocyclohexane (R,R-trans-4 or S,S-trans-4). The high robustness of the complexes reduces a possible ligand scrambling and allows preparation of quasiracemic crystals of [Zn(R,R-5)][Fe(S,S-5)](ClO4)4·(CH3CN) composed of a 1 : 1 mixture of the Zn and Fe complexes with inverse chirality. / Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
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Influência da rutina na fotoestabilização da avobenzona (filtro UVA) e do ρ-metoxicinamato de octila (filtro UVB) / Influence of rutin in photostabilization of avobenzone (UVA filter) and octyl methoxycinnamate (UVB filter)Pinto, Claudinéia Aparecida Sales de Oliveira 29 May 2014 (has links)
Com o intuito de promover proteção de amplo espectro, na maioria dos protetores solares estão associados pelo menos dois filtros orgânicos (UVA e UVB). A combinação da avobenzona (BMBM), filtro UVA, e do p--metoxicinamato de octila (EHMC), filtro UVB, é conhecida e muito utilizada em formulações manipulas e industrializadas, porém apresenta alteração na absorção espectral após exposição à radiação UV. A estratégia empregada com maior frequência para reduzir a instabilidade da combinação é baseada na adição de agentes fotoestabilizadores. A adição de substâncias naturais em formulações fotoprotetoras vem sendo explorada, especialmente o grupo dos flavonoides, como a rutina, que apresenta resultados positivos em relação à eficácia fotoprotetora. O objetivo principal desta pesquisa foi avaliar o potencial da rutina como substância fotoestabilizadora dos filtros EHMC e BMBM. Foram desenvolvidas formulações contendo os dois filtros associados ou não com rutina de acordo planejamento fatorial em três níveis. As formulações foram avaliadas quanto a eficácia fotoprotetora in vitro aplicadas em placas de PMMA e analisadas por espectrofotometria de refletância com esfera de integração antes e após a exposição à radiação UV. As interações moleculares dos filtros com a rutina foram avaliadas por 1H RMN, DSC, TG e análise qualitativa da supressão do estado energético singleto. A adição de rutina nas formulações contendo 5,0% (p/p) de BMBM e 10,0% (p/p) de EHMC promoveu elevação na conservação do FPS in vitro de 53,9% para 65,8 (0,1% de rutina) e 70,8% (1,0% de rutina). As curvas DSC e TG da rutina apresentaram alterações promovidas pela presença dos filtros BMBM e EHMC, indicando interação entre o flavonoide e os filtros. Após dose de 5760 J cm-2 de radiação UV o valor da razão trans/cis para o filtro EHMC em solução adicionado do filtro BMBM foi elevado de 5,5±0,1, sem adição de rutina, para 12,6±0,4, com adição da rutina. A análise qualitativa da supressão do estado singleto indicou que um dos mecanismos envolvidos na fotoestabilização dos filtros BMBM e EHMC é a supressão do estado energético singleto. Os resultados reportados neste estudo indicaram que a adição da rutina em formulações fotoprotetoras representa um caminho simples e efetivo para elevar a fotoestabilidade da combinação dos filtros BMBM e EHMC. A adição da rutina em formulações fotoprotetoras representa uma estratégia promissora, pois aliada a ação fotoestabilizadora, verificada nesse estudo, esse flavonoide possui propriedades antioxidante e quelante de metais que podem colaborar para o desenvolvimento de formulações fotoprotetoras de amplo espectro com aumento da segurança e eficácia. / In order to promote broad-spectrum protection, most sunscreens are associated with at least two organic filters (UVA and UVB). The combination of avobenzone (BMBM), UVA filter, and octyl methoxycinnamate (EHMC), UVB filter, is well known and widely used in industrial formulations and pharmaceutical compounding, but shows alteration in spectral absorption after UV radiation exposure. The most commonly used strategy to reduce the instability of the combination is based on the addition of photostabilizer agents. The addition of natural substances in sunscreen formulations has been explored, especially the group of flavonoids such as rutin, which shows positive results regarding photoprotective efficacy. The main objective of this research was to evaluate the potential of rutin as a photostabilizer substance of EHMC and BMBM. Formulations were developed containing the two filters associated or not with rutin, according to factorial design at three levels. The formulations were evaluated for in vitro photoprotective efficacy applied on PMMA plates and analyzed by spectrophotometer with integrating sphere reflectance before and after exposure to UV radiation. Molecular interactions of filters with rutin were evaluated by 1H NMR, DSC, TG and qualitative analysis of the suppression of singlet energy state. The addition of rutin in the formulations containing 5.0 % (w/w) BMBM and 10.0 % (w/w) EHMC promoted an increase in the preservation of in vitro SPF of 53.9% to 65.8 (0.1 % rutin) and 70.8 % (1.0% rutin). The DSC and TG curves of rutin showed changes promoted by the presence of BMBM and EHMC filters, indicating interaction between the flavonoid and filters. After 5760 J cm-2 of UV radiation the value of the trans/cis ratio for the EHMC filter added from the BMBM filter was increased from 5.5 ± 0.1 without addition of rutin, to 12.6 ± 0 4,with the addition of rutin. Qualitative analysis of the suppression of the singlet state indicated that one of the mechanisms involved in the photostabilization BMBM and EHMC filters is suppression of singlet excited state.The results reported in this study indicate that the addition of rutin in sunscreen formulations is a simple and effective way to increase the photostability of the combination of BMBM and EHMC. The addition of rutin in sunscreen formulations represents a promising strategy, for allied with the photostabilization action, observed in this study, this flavonoid has antioxidant and chelating properties of metals that can contribute to the development of broad-spectrum sunscreens formulations with increased safety and efficacy.
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Development Of Two Dimensional Correlation And Resolved Methodologies For NMR Spectroscopic Discrimination Of EnantiomersPrabhu, Uday Ramesh 10 1900 (has links) (PDF)
The research work reported in this thesis deals with the development of novel NMR experimental techniques for the spectroscopic discrimination of enantiomers dissolved in a chiral liquid crystalline medium. The information on the chemical shifts and coupling constants pertaining to each enantiomer has been derived on the investigated chiral molecules. The enantiomeric excess (ee), a parameter which is of profound importance in pharmaceutical industry and in asymmetric synthesis, has also been measured. A special attention is paid to the use of high sensitivity of H NMR for chiral discrimination. Typical analyses of H NMR spectra are severely hindered due to enormous spectral inhomogeneous broadening arising from too many unresolved transitions, in addition to superposition of spectra from both the enantiomers. Therefore, the major part of the work is focused on the design and application of pulse sequences to overcome many of these drawbacks. This helps to achieve very high resolution, discerning of overlapped transitions, identification of resonances pertaining to each enantiomer and simplification of the spectrum for easy extraction of spectral parameters, in addition to the accurate measurement of ee.
Initially a brief discussion is provided on enantiomers, diastereomers, basic principles of NMR spectroscopy, the several interaction Hamiltonians responsible for yielding the NMR spectra, introduction to product and polarization operator formalisms that gives insight into the spin dynamics for designing appropriate two-dimensional (2D) NMR experiments. This sets the foundation to understand the complex multiplet structures of the diagonal peaks and cross peaks in the resulting 2D spectrum. Subsequently, a brief introduction is given for the available techniques for NMR spectroscopic discrimination of enantiomers in isotropic medium, where only chemical shifts are employed as a measurable parameter. The limitations of these techniques are circumvented by the introduction of other anisotropic NMR parameters, such as homo-and hetero-nuclear dipolar couplings, quadrupolar couplings and chemical shift anisotropies. To achieve this goal the enantiomers are dissolved in weakly aligning chiral liquid crystalline (CLC) medium. To understand this, a general introduction to liquid crystals and their utility as an alignment medium in NMR spectroscopy and the anisotropic interactions affecting the NMR spectrum has also been provided. The preparation of the CLC phase of Poly-γ-Benzyl-L-Glutamate (PBLG) employed in the present study and its orientational behaviour has been discussed. The detection of NMR spectra of various nuclei and the interaction parameters utilized for chiral discrimination will be enumerated. A brief summary of the experiments employed for the spectral analyses of the enantiomers dissolved in PBLG will also be presented.
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Influência da rutina na fotoestabilização da avobenzona (filtro UVA) e do ρ-metoxicinamato de octila (filtro UVB) / Influence of rutin in photostabilization of avobenzone (UVA filter) and octyl methoxycinnamate (UVB filter)Claudinéia Aparecida Sales de Oliveira Pinto 29 May 2014 (has links)
Com o intuito de promover proteção de amplo espectro, na maioria dos protetores solares estão associados pelo menos dois filtros orgânicos (UVA e UVB). A combinação da avobenzona (BMBM), filtro UVA, e do p--metoxicinamato de octila (EHMC), filtro UVB, é conhecida e muito utilizada em formulações manipulas e industrializadas, porém apresenta alteração na absorção espectral após exposição à radiação UV. A estratégia empregada com maior frequência para reduzir a instabilidade da combinação é baseada na adição de agentes fotoestabilizadores. A adição de substâncias naturais em formulações fotoprotetoras vem sendo explorada, especialmente o grupo dos flavonoides, como a rutina, que apresenta resultados positivos em relação à eficácia fotoprotetora. O objetivo principal desta pesquisa foi avaliar o potencial da rutina como substância fotoestabilizadora dos filtros EHMC e BMBM. Foram desenvolvidas formulações contendo os dois filtros associados ou não com rutina de acordo planejamento fatorial em três níveis. As formulações foram avaliadas quanto a eficácia fotoprotetora in vitro aplicadas em placas de PMMA e analisadas por espectrofotometria de refletância com esfera de integração antes e após a exposição à radiação UV. As interações moleculares dos filtros com a rutina foram avaliadas por 1H RMN, DSC, TG e análise qualitativa da supressão do estado energético singleto. A adição de rutina nas formulações contendo 5,0% (p/p) de BMBM e 10,0% (p/p) de EHMC promoveu elevação na conservação do FPS in vitro de 53,9% para 65,8 (0,1% de rutina) e 70,8% (1,0% de rutina). As curvas DSC e TG da rutina apresentaram alterações promovidas pela presença dos filtros BMBM e EHMC, indicando interação entre o flavonoide e os filtros. Após dose de 5760 J cm-2 de radiação UV o valor da razão trans/cis para o filtro EHMC em solução adicionado do filtro BMBM foi elevado de 5,5±0,1, sem adição de rutina, para 12,6±0,4, com adição da rutina. A análise qualitativa da supressão do estado singleto indicou que um dos mecanismos envolvidos na fotoestabilização dos filtros BMBM e EHMC é a supressão do estado energético singleto. Os resultados reportados neste estudo indicaram que a adição da rutina em formulações fotoprotetoras representa um caminho simples e efetivo para elevar a fotoestabilidade da combinação dos filtros BMBM e EHMC. A adição da rutina em formulações fotoprotetoras representa uma estratégia promissora, pois aliada a ação fotoestabilizadora, verificada nesse estudo, esse flavonoide possui propriedades antioxidante e quelante de metais que podem colaborar para o desenvolvimento de formulações fotoprotetoras de amplo espectro com aumento da segurança e eficácia. / In order to promote broad-spectrum protection, most sunscreens are associated with at least two organic filters (UVA and UVB). The combination of avobenzone (BMBM), UVA filter, and octyl methoxycinnamate (EHMC), UVB filter, is well known and widely used in industrial formulations and pharmaceutical compounding, but shows alteration in spectral absorption after UV radiation exposure. The most commonly used strategy to reduce the instability of the combination is based on the addition of photostabilizer agents. The addition of natural substances in sunscreen formulations has been explored, especially the group of flavonoids such as rutin, which shows positive results regarding photoprotective efficacy. The main objective of this research was to evaluate the potential of rutin as a photostabilizer substance of EHMC and BMBM. Formulations were developed containing the two filters associated or not with rutin, according to factorial design at three levels. The formulations were evaluated for in vitro photoprotective efficacy applied on PMMA plates and analyzed by spectrophotometer with integrating sphere reflectance before and after exposure to UV radiation. Molecular interactions of filters with rutin were evaluated by 1H NMR, DSC, TG and qualitative analysis of the suppression of singlet energy state. The addition of rutin in the formulations containing 5.0 % (w/w) BMBM and 10.0 % (w/w) EHMC promoted an increase in the preservation of in vitro SPF of 53.9% to 65.8 (0.1 % rutin) and 70.8 % (1.0% rutin). The DSC and TG curves of rutin showed changes promoted by the presence of BMBM and EHMC filters, indicating interaction between the flavonoid and filters. After 5760 J cm-2 of UV radiation the value of the trans/cis ratio for the EHMC filter added from the BMBM filter was increased from 5.5 ± 0.1 without addition of rutin, to 12.6 ± 0 4,with the addition of rutin. Qualitative analysis of the suppression of the singlet state indicated that one of the mechanisms involved in the photostabilization BMBM and EHMC filters is suppression of singlet excited state.The results reported in this study indicate that the addition of rutin in sunscreen formulations is a simple and effective way to increase the photostability of the combination of BMBM and EHMC. The addition of rutin in sunscreen formulations represents a promising strategy, for allied with the photostabilization action, observed in this study, this flavonoid has antioxidant and chelating properties of metals that can contribute to the development of broad-spectrum sunscreens formulations with increased safety and efficacy.
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The assessment of intramolecular hydrogen bonding in ortho-substituted anilines by an NMR methodAbraham, M.H., Abraham, R.J., Aghamohammadi, Amin, Afarinkia, Kamyar, Liu, Xiangli 14 August 2020 (has links)
No / We describe the Δlog P method for the assessment of intramolecular hydrogen bonds (IMHBs), and show that it is not a very general method of distinguishing between molecules in which there is an IMHB and molecules in which there is no IMHB. The ‘double’ Δlog P method of Shalaeva et al. is a much more reliable method for the assessment of IMHB but requires the synthesis of a model compound and the determination of no less than four water-solvent partition coefficients. In addition, it is difficult to apply to compounds that contain more than one hydrogen bond acidic group capable of IMHB. We then describe our NMR method of assessing IMHB, based on 1H NMR chemical shifts in solvents DMSO and CDCl3. We have determined 1H NMR chemical shifts for a number of ortho-substituted anilines and show that the only compound we have studied that forms an IMHB is methyl 2-methylaminobenzoate though there is no IMHB present in methyl 2-aminobenzoate. This apparently anomalous result is supported by both MM and ab initio calculations. The NMR method is much simpler and less time consuming than other methods for the assessment of IMHB. It provides a quantitative assessment of IMHB and can be applied to molecules with more than one hydrogen bond acidic group.
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The assessment of intramolecular hydrogen bonding in ortho-substituted anilines by an NMR methodAbraham, M.H., Abraham, R.J., Aghamohammadi, Amin, Afarinkia, Kamyar, Liu, Xiangli 20 July 2020 (has links)
Yes / We describe the Δlog P method for the assessment of intramolecular hydrogen bonds (IMHBs), and show that it is not a very general method of distinguishing between molecules in which there is an IMHB and molecules in which there is no IMHB. The ‘double’ Δlog P method of Shalaeva et al. is a much more reliable method for the assessment of IMHB but requires the synthesis of a model compound and the determination of no less than four water-solvent partition coefficients. In addition, it is difficult to apply to compounds that contain more than one hydrogen bond acidic group capable of IMHB. We then describe our NMR method of assessing IMHB, based on 1H NMR chemical shifts in solvents DMSO and CDCl3. We have determined 1H NMR chemical shifts for a number of ortho-substituted anilines and show that the only compound we have studied that forms an IMHB is methyl 2-methylaminobenzoate though there is no IMHB present in methyl 2-aminobenzoate. This apparently anomalous result is supported by both MM and ab initio calculations.
The NMR method is much simpler and less time consuming than other methods for the assessment of IMHB. It provides a quantitative assessment of IMHB and can be applied to molecules with more than one hydrogen bond acidic group.
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Produção de biodiesel empregando biocatálise via reações de esterificação e transesterificação / Biodiesel production employing biocatalysis by esterification and transesterification reactionsRosset, Isac George 14 March 2011 (has links)
Neste trabalho prepararam-se ésteres de ácidos graxos por esterificação do ácido oléico e transesterificação do óleo de soja e do triéster oléico via catálise enzimática. Determinou-se a composição dos produtos obtidos por RMN 1H e CG-FID. Os padrões dos ésteres do ácido oléico via esterificação ácida foram preparados empregando ácido sulfúrico, os padrões dos ésteres do óleo de soja por transesterificação básica com hidróxido de sódio e o padrão do triéster oléico foi sintetizado utilizando ácido p-tolueno sulfônico como catalisador. A melhor enzima para essas reações foi determinada através de reações de esterificação do ácido oléico e transesterificação do óleo de soja com etanol na ausência de co-solventes, sendo que foi selecionada a lipase de Candida antarctica. A mesma enzima foi empregada nas esterificações enzimáticas do ácido oléico com diversos alcoóis (metanol, etanol, n-propanol e n-butanol), na transesterificação enzimática do óleo de soja e do triéster oléico com etanol. Em ambos os estudos, foram avaliados os fatores que influenciam as reações: quantidade de enzima; tempo de reação; água adicionada ao álcool e reuso do biocatalisador. Na esterificação enzimática do ácido oléico, o uso do etanol forneceu o melhor rendimento (96,5%) com 5,0% (m/m) de enzima em 24 horas de reação. Quando uma quantidade de 4,0% de água foi adicionada ao álcool, a reação utilizando metanol mostrou maior eficiência (98,5%) e os rendimentos com os outros alcoóis não foram alterados significativamente (acima de 90%). Também foi possível utilizar a enzima por até 10 ciclos sem perda de rendimento, com exceção do metanol, onde ocorreu um decréscimo acentuado de rendimentos nos ciclos seguintes. Na transesterificação enzimática do óleo de soja, os mesmos fatores foram avaliados e com 5,0% de enzima, após 24 horas, foi obtido um rendimento de 84,1% e com a adição de água o rendimento não foi significativamente alterado (83%). Na transesterificação, os métodos de quantificação por RMN 1H e CG-FID foram comparados sendo que uma maior diferença foi observada para as reações com baixos rendimentos por RMN 1H, porém em altos rendimentos a diferença entre os dois métodos não foi significativa. Monoglicerídeos e diglicerídeos foram quantificados por CG-FID e por RMN 1H onde foi possível calcular a razão dos produtos formados através de uma equação desenvolvida, sendo que a diferença entre esses tipos de análises foi pequena, de apenas 1,4%. A transesterificação enzimática do triéster oléico foi obtida em bom rendimento (90,4%) e uma pequena quantidade de mono- e diglicerídeos foi produzida. Em todas as reações de transesterificação, o glicerol não foi detectado após a lavagem dos produtos. A metodologia empregando a lipase de Candida antarctica mostrou-se eficiente para a produção de biodiesel a partir do óleo de soja e do ácido oléico com diferentes tipos de alcoóis. / In this work, it was prepared esters of the fatty acid by esterification of the oleic acid and transesterification of the soy oil through enzymatic catalysis. It was determined the composition of the products obtained by 1H NMR and GC-FID. The standards of esters of the oleic acid by acid esterification was prepared employing sulfuric acid, the standards of esters of the soy oil by alkaline transesterification with sodium hydroxide and the standard of the oleic triester was synthesized employing p-toluene sulfonic acid as catalyst. The best enzyme for those reactions was determined through reactions of esterification of the oleic acid and transesterification of the soy oil with ethanol and free co-solvents, and lipase from Candida antarctica was selected. The same enzyme was employed in the enzymatic esterifications of the oleic acid with various alcohols (methanol, ethanol, propanol and butanol), in the enzymatic transesterification of soy oil and the oleic triester with ethanol. In both studies, was assessed the factors that influence the reactions: amount of catalyst, reaction time, water added in the alcohol and the turnover of biocatalyst. In the enzymatic esterification of the oleic acid, the ethanol showed the better yield (96,5%) with 5,0% (m/m) of enzyme at 24 hours of reaction. When 4,0% of water was added to the alcohol, the methanol showed the high efficiency (98,5%) and the yield with another alcohols were not affected. It was also possible to use the enzyme for 10 cycles without lose yield, except for the methanol. In the enzymatic transesterification of the soy oil, the same factors were assessed using 5,0% of enzyme, after 24 hours, a yield of 84,1% was obtained and with the water addition the yield was not modified (83%). On the transesterification, 1H NMR and GC-FID were compared and a great difference was observed for low yields, but on high yields, the difference between methods was small. Monoglycerides and diglycerides were quantified by GC-FID and detected by 1H NMR, it was possible to calculate the ratio between them on the products formed through an equation developed and the difference for this type of analysis was small, only 1.4% . The enzymatic transesterification of the oleic triester was obtained with good yield (90,4%) and a small amount of the monoglycerides and diglycerides was produced. In all the transesterifications reactions, glycerol was not detected after washing mixture of products. The methodology employing Candida antarctica lipase was efficient for biodiesel production by soybean oil and oleic acid with different alcohols.
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Estudos por RMN de 1H das interações de substratos carbonílicos e carboxílicos com agentes de discriminação quiral / 1H NMR investigations of the interactions of carbonyl and carboxyl derivatives with chiral discriminating agentsClaudio, Thais Bezerra 30 June 2010 (has links)
Os sais derivados de alcalóides da Cinchona têm sido muito utilizados como catalisadores de transferência de fase, em reações assimétricas. No entanto, sua performance como agentes de discriminação quiral tem sido pouco explorada. Com o objetivo de melhor compreender as bases moleculares que comandam o reconhecimento quiral dos isômeros ópticos de compostos carbonílicos e carboxílicos, quando em mistura com a quinina ou com sais de alcalóides da Cinchona, foi realizada uma série de experimentos, utilizando a técnica da RMN de 1H. A atribuição dos deslocamentos químicos aos solvatos de cada enantiômero foi feita pelo registro do espectro de RMN de 1H de misturas dos agentes de discriminação quiral com amostras enantiopuras ou enantiomericamente enriquecidas dos substratos. A estabilidade relativa dos solvatos foi estimada utilizando-se modelos moleculares, nos quais foi possível identificar a existência de interações do tipo π-π e de ligações de hidrogênio. As conclusões baseadas nos experimentos de RMN de 1H foram concordantes com as resultantes da análise dos modelos moleculares, construídos para cada par substrato/agente de discriminação quiral / Salts of Cinchone alcaloids are common chiral catalysts for asymmetric phase-transfer reactions. However, studies on their performance as chiral discriminating are still scarce. In order to investigate the molecular basis of chiral recognition for such compounds, the 1H NMR spectra of admixtures of quinine or Cinchone alkaloids salts with carbonyl and carboxyl derivatives were recorded and analyzed. The relative stabilities of the solvated complexes were estimated on the basis of preferential π-π and hydrogen bonding interactions between substrates and the chiral discriminating agent. Conclusions based on results of the 1H NMR experiments were in line with those arising from the analysis of molecular models for the substrate/chiral discriminating agent pairs
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Novel Superacidic Ionic Liquid Catalysts for Arene FunctionalizationAngueira, Ernesto J. 15 August 2005 (has links)
There is a continuing interest in the subject of arene carbonylation, especially in strong acids and environmentally-benign alternatives are sought to HF/BF3 and to AlCl3 as conversion agents. Ionic liquids offer a powerful solvent for useful conversion agents such as aluminum chloride. The ILs permit AlCl3 to be used at lower HCl partial pressures than with other solvents. The superior reactivity demonstrated by acidic, chloroaluminate ILs is probably due to their enhanced solvation power for HCl and CO. Addition of HCl gas increased reactivity of the system by forming Brnsted acids, and toluene carbonylation is a Brnsted demanding reaction. It was found that reaction is stoichiometric in Al species and only intrinsically acidic ILs are active for toluene carbonylation, therefore it was possible to correlate observed conversion with predicted amounts of Lewis + Brnsted acids. Molecular modeling provided information about the different species present in these ILs and predicted 1H NMR, and 27Al NMR spectrum. Predictions suggested that three types of HCl species are present; and these predictions were confirmed using data of 13C-labeled acetone and its 13C-NMR spectra. These data showed that only one of the three types of HCl in the IL were super acidic. Reactivity towards arene formylation can be tuned by adjusting the ligands R and R in the organic cation and by changing the anion. This reactivity tuning can be exploited in a process where high acidity is required for the conversion of substrate but where separation of product from IL is facilitated by low acidity.
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Chromophore Barbitursäure-Derivate als schaltbare opto-chemische Sensoren für Nukleinbasen und verwandte VerbindungenBolz, Ina 29 September 2009 (has links) (PDF)
Gegenstand der vorliegenden Arbeit ist die Synthese und Strukturaufklärung von
neuartigen, chromophoren Barbituraten, welche als selektive Chemosensoren verwendet
werden können. Als Schlüsselverbindungen dienten 5-(4-Nitrophenyl)-barbiturate,
deren Enolisierungsfähigkeit systematisch untersucht wurden. Des Weiteren konnten
SCHIFFschen Basen, Pyridinium-Barbiturat-Betain-Farbstoffe sowie ein fluoreszenzaktive
Naphthalimid synthetisiert werden, in welchen der Barbitursäure-Substituent ebenfalls
elektronenschiebende Eigenschaften aufweist. Die individuelle Interaktion der Barbiturate
mit der Solvensumgebung wurde mittels Lineare-Solvatations-Energie (LSE)-
Beziehungen unter Verwendung der empirischen Lösungsmittelparameter nach KAMLET-TAFT
und CATALÁN untersucht. Besonderes Augenmerk lag auf dem Studium der molekularen
Erkennung von ausgewählten Chromophoren mit Nukleinbasen und strukturell
verwandten Verbindungen. Hierzu gelang es die supramolekularen Bindungsphänomene
über Wasserstoffbrücken und die Beeinflussung des chromophoren Systems sowohl im
Festkörper als auch in Lösung zu verfolgen.
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