Unlike RNA viruses, which typically encode their own RNA-dependent RNA polymerases, DNA viruses typically utilize host RNA Polymerase II (RNAPII) to transcribe their genes. Therefore, host factors that interact with RNAPII often maintain important regulatory roles during DNA virus infections. Senataxin (SETX) is a ubiquitously expressed 303 kDa RNA:DNA helicase that associates with RNAPII. It is involved in the resolution of R-loops and plays a role during the DNA damage response. Mutations in SETX are implicated in the neurodegenerative diseases Type 2 Ataxia with Oculomotor Apraxia (AOA2) and juvenile Amyotrophic Lateral Sclerosis (ALS4). Recent work from our group has demonstrated that SETX also acts as an antagonist of the antiviral response during RNA virus infections. Infections, including those caused by Herpes Simplex Virus type I (HSV-1), have been identified as potential environmental triggers of neurodegenerative diseases. Therefore, we elected to study the role of SETX during DNA virus infections since, in addition to regulating host genes, it may also play a role in viral transcription and/or DNA replication. Our data suggests that SETX is involved in the regulation of viral gene expression, and that SETX facilitates DNA replication and contributes to viral biogenesis. SETX attenuates the antiviral response, and in mouse models of infection, is protective against HSV-1 disease pathogenesis. These studies have enhanced our understanding of the role played by SETX during viral infection and may shed light on the mechanism(s) through which SETX dysfunction results in neurodegenerative diseases. / Thesis / Master of Health Sciences (MSc) / DNA viruses utilize host proteins in gene expression, therefore, associated factors play roles during DNA virus infections. Senataxin (SETX) is a RNA:DNA helicase associated with these proteins. SETX mutations are implicated in the neurodegenerative diseases Type 2 Ataxia with Oculomotor Apraxia (AOA2) and juvenile Amyotrophic Lateral Sclerosis (ALS4). Recently, our group demonstrated SETX antagonizes antiviral responses to RNA virus infections. Infections, including those caused by Herpes Simplex Virus type I (HSV-1), are identified as potential triggers of neurodegenerative diseases. We elected to study the role of SETX during DNA virus infections. Our data suggests that SETX is involved in the regulation of viral gene expression, facilitates HSV-1 DNA replication, attenuates the antiviral response, and in mouse models of infection, is protective against HSV-1 disease pathogenesis. These studies enhance understanding of the role of SETX during viral infection and may shed light on the mechanism(s) of SETX role in neurodegenerative disease.

Orientadora: Profa. Dra. Maria de Lourdes Merlini Giuliani / Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Matemática, 2014.

Esse trabalho trata um pouco da teoria de A-loops comutativos finitos. No primeiro captulo estudamos propriedades básicas de loops em geral e exi- bimos exemplos de loops não associativos. No captulo 2 falamos de A-loops em geral e mesmo sem assumirmos comutatividade obtivemos resultados importantes, um exemplo é que A-loop associa potências. Também determinamos quando um isótopo e K -holomorfo de um A-loop é um A-loop. No captulo 3, nossos únicos objetos de estudo foram os A-loops comutativos finitos. Vimos que tais estruturas têm proriedades muito interessantes, por exemplo, para um A-loop comutativo finito valem os teoremas de Lagrange, Cauchy. Também, um A-loop comutativo finito, Q, tem ordem potência de um primo p se e somente se todo elemento de Q tem ordem potência de p. Mais ainda, todo A-loop comutativo finito de ordem mpar é solúvel. No último captulo, apresentamos algumas maneira de se construir um A-loop. / In the first chapter we studied basic properties of general loops and we showed some examples of nonassociative loops. In chapter 2, we talked about general A-loops (without commutativity) and even that we obtained important results, for instance, that any A-loop is power-associative. We also determined when an isotope and a K -holomorph of an A-loop is an A-loop. In chapter 3 we dealt only with finite commutative A-loops. We saw that such structures have very interesting properties, for example, for a finite commutative A- loop, Lagrange, Cauchys theorems apply. Also a finite commutative A-loop, Q, has order a power of a prime p if and only if every element of Q has order a power of p. Moreover, finite commutative A-loops of odd order are solvable. In the last chapter we introduce some ways to construct a commutative A-loop

Neste trabalho classificamos, a menos de isomorfismos, as álgebras de Bol de dimensão 2 sobre um corpo de característica 0. Também determinamos suas álgebras de Lie envolvente e, mostramos que existem álgebras de Bol não isomorfas cujas álgebras de Lie envolventes coorrespondentes são isomorfas. Calculamos os grupos algébricos (locais) correspondentes a cada uma das álgebras de Lie envolventes e provamos que todo loop de Bol analítico (algébrico) global de dimensão 2 sobre um corpo de característica 0 é um grupo. Exibimos exemplos de loops de Bol algébricos globais de dimensão n, para todo n > 2, e fornecemos uma condição necessária e suciente para a existência de um loop de Bol algébrico global quando a álgebra de Bol tem uma álgebra de Lie envolvente nilpotente de índice 2 sobre um corpo de característica diferente de 2. / In this work, we classify up to isomorphism, the Bol algebras of dimension 2 over a eld of characteristic 0. We also determine their enveloping Lie algebras and we exhibit two non-isomorphic Bol algebras which have isomorphic enveloping Lie algebras. We determine the (local) correspondent algebraic groups of each of those enveloping Lie algebras and we show that every global analytic (algebraic) Bol loop of dimension 2 over a eld of characteristic 0 is a group. We exhibit examples of non-nilpotent solvable algebraic Bol loops in dimension n for every n > 2, and we were able to give a necessary and sucient condition to decide if a local algebraic Bol loop is global when its enveloping Lie algebra is nilpotent of index 2 and char(F) 6= 2:

Neste trabalho classificamos, a menos de isomorfismos, as álgebras de Bol de dimensão 2 sobre um corpo de característica 0. Também determinamos suas álgebras de Lie envolvente e, mostramos que existem álgebras de Bol não isomorfas cujas álgebras de Lie envolventes coorrespondentes são isomorfas. Calculamos os grupos algébricos (locais) correspondentes a cada uma das álgebras de Lie envolventes e provamos que todo loop de Bol analítico (algébrico) global de dimensão 2 sobre um corpo de característica 0 é um grupo. Exibimos exemplos de loops de Bol algébricos globais de dimensão n, para todo n > 2, e fornecemos uma condição necessária e suciente para a existência de um loop de Bol algébrico global quando a álgebra de Bol tem uma álgebra de Lie envolvente nilpotente de índice 2 sobre um corpo de característica diferente de 2. / In this work, we classify up to isomorphism, the Bol algebras of dimension 2 over a eld of characteristic 0. We also determine their enveloping Lie algebras and we exhibit two non-isomorphic Bol algebras which have isomorphic enveloping Lie algebras. We determine the (local) correspondent algebraic groups of each of those enveloping Lie algebras and we show that every global analytic (algebraic) Bol loop of dimension 2 over a eld of characteristic 0 is a group. We exhibit examples of non-nilpotent solvable algebraic Bol loops in dimension n for every n > 2, and we were able to give a necessary and sucient condition to decide if a local algebraic Bol loop is global when its enveloping Lie algebra is nilpotent of index 2 and char(F) 6= 2:

Call number: LD2668 .T4 1984 S33 / Master of Science

International Telemetering Conference Proceedings / October 25-28, 1999 / Riviera Hotel and Convention Center, Las Vegas, Nevada / In this paper, a new coherent correlation-loop architecture for tracking direct-sequence spread-spectrum signals is proposed. In the proposed correlation loop model, the mean-square tracking error is minimized by varying the cross-correlation function between the received signal and the locally generated signal. The locally generated signal is produced by passing a replica of the transmitted signal through a linear time-invariant filter, which is termed the VCC filter. The issue of bandwidth of a correlation loop is addressed and a bandwidth definition for comparative purposes is introduced. The filter characteristics to minimize the tracking errors are determined using numerical optimization algorithms. This work demonstrates that the amplitude response of the VCC filter is a function of the input signal-to-noise ratio (SNR). In particular, the optimum filter does not replicate a differentiator at finite signal-to-noise ratio as is sometimes assumed. The optimal filter characteristics and the knowledge of the input SNR can be combined to produce a device that has very low probability of loosing lock.

No description available.

published_or_final_version / Electrical and Electronic Engineering / Doctoral / Doctor of Philosophy

No description available.