Syfte Syftet med studien är att undersöka om det finns ett samband mellan motorisk färdighet ochmängd fysisk aktivitet av olika intensiteter hos barn med diagnosen ADHD. Frågeställningar 1. Hur många barn med ADHD har motoriska nedsättningar utifrån Movement ABC? 2. Hur många barn med ADHD når upp till de Nordiska rekommendationerna för fysiskaktivitet? 3. Hur ser sambandet mellan motorisk färdighet och fysisk aktivitetsnivå ut hos barn medADHD? Metod I studien ingick fem pojkar i åldern 9-12 år med diagnosen ADHD. I studien mättes denfysiska aktivitetsgraden med accelerometrar av modellen ActiGraph GT3X somtestpersonerna bar under sju efterföljande dagar. Den motoriska förmågan hos testpersonernamättes med hjälp av de kvantitativa motoriktesterna i Movement ABC. Testerna genomfördesi en lokal på testpersonernas skolor och accelerometrarna samt ett medföljandeinformationsbrev delades ut vid samma tillfälle. Resultat Av resultaten av motoriktesterna framgår att endast en testperson hade ett resultat som visarpå tillfredsställande motorisk förmåga, tre testpersoner låg i riskzonen för motoriskanedsättningar och en testperson hade uppenbara brister i sin motoriska färdighet. Fyra av de fem testpersonerna uppnådde de Nordiska rekommendationerna om minst 60 minuters fysiskaaktivitet per dag, inkluderad både måttlig till hård aktivitet. Inga signifikanta samband kundeses mellan fysisk aktivitetsnivå och motorisk färdighet. Slutsats Studien kunde inte finna något samband mellan motorisk färdighet och mängd fysisk aktivitetav olika intensiteter hos barn med diagnosen ADHD. På grund av testgruppens ringa storlekbör man ej betrakta studiens resultat som generaliserbara, studien kan dock ses som enpilotstudie. / Aim The purpose of this study was to investigate whether there is a correlation between motorskills and amount of physical activity of various intensities in children diagnosed with ADHD. Questions 1. How many children with ADHD have motor impairments based on Movement ABC? 2. How many children with ADHD reaches the Nordic recommendations for physicalactivity? 3. What is the relationship between motor skills and level of physical activity in childrenwith ADHD? Method The study included five boys aged 9-12 years diagnosed with ADHD. The study is study inwhich the physical activity level was measured using ActiGraph GT3X accelerometers whichtest subjects wore for seven subsequent days. The motor skills of the test subjects were measured using the quantitative motor tests in Movement ABC. The tests were carried out ina room at the test subjects schools and accelerometers, and accompanying instruction were distributed at the same time. Results The results of motor tests showed that only one person had test results showing satisfactorymotor skills, three test persons were at risk of motor impairments and a test person hadobvious defects in their motor skills. Four of the five test persons achieved the nordicrecommendations for at least 60 minutes of physical activity per day, including both moderateto heavy activity. No significant correlation was seen between physical activity level andmotor skills. Conclusions The study could not find any correlation between motor skills and amount of physical activityof various intensities in children diagnosed with ADHD. Due to the small test group theresults of the current study should be taken with precaution, but can be regarded as a pilotstudy.

Bakgrund: I slutet av 1980-talet slog de aktivitetsbaserade tankegångarna igenom, i form av ABC-kalkylering. Dock visade sig metoden vara komplex att använda i praktiken och därför introducerades tankegångar kring att istället använda den aktivitetsbaserade informationen i styrningssyften, ABM. Trots detta är det ABC som har fått störst genomslag i svensk tillverkningsindustri. Syfte: Syftet med denna studie är att undersöka om svenska företag använder sig av ABM och i så fall hur de använder ABM. Dessutom är syftet att studera hur sambandet mellan ABM och ABC ser ut för att utröna om det föreligger något beroende dem emellan. Metod: Denna uppsats har genomförts med en kombinerad forskningsdesign. Det har utförts både en enkätundersökning och en fallstudie, därmed har såväl kvantitativ som kvalitativ metod använts. Slutsatser: Resultatet av föreliggande studie visar på att företag i svensk tillverkningsindustri inte känner till begreppet ABM men trots det används den aktivitetsbaserade informationen i styrningssyften. Det finns ett fåtal företag som uttryckligen säger sig använda ABM. De vanligaste användningsområdena inom ABM är kostnadsreducering och ständiga förbättringar. Dessutom visar resultaten att det inte föreligger något beroende mellan ABM och ABC. / Background: The activity-based ideas made its breakthrough in the late 1980's with the Activity-Based Costing, ABC. But the method proved to be difficult and complex to use in practice and that's the reason to the introduction of alternative ways to use the activity-based ideas, namely Activity-Based Management, ABM. But it is although ABC that has had the greatest breakthrough in the Swedish manufacturing industry. Purpose: In this study, the purpose is to investigate if companies in the Swedish manufacturing industry use ABM and if, how do they use ABM. The purpose is also to study the relation between ABM and ABC to investigate if there is any dependence between them. Method: This study has been carried out with a mixed method. Both a survey and a case study has been made, which means that both quantitative as well as qualitative research method has been used. Conclusions: The result of this study shows that the term ABM is unknown to companies in the Swedish manufacturing industry, but although use the activity-based information in control purposes, ABM. There are though a few companies that explicitly express the use of ABM. The most common used applications of ABM is cost reducing and continuous improvement. The result also shows that there are no dependence between ABM and ABC.Keywords: ABM (Activity-Based Management), ABC (Activity-Based Costing) and the ABCM-cross.

<p>This degree project is based on identifying and allocation of costs in a packaging section at Electrolux Distriparts in Torsvik.</p><p>The purpose of this thesis is to identify the costs that emerge when packaging different articles and show how the costs are allocated. The report also contains improvement suggestions about how the company can use the current computer system more efficient.</p><p>The methods that have been used in order to approach the problem and the collection of information have mainly been literature study, interviews and observation.</p><p>The work started with answering the questions; which expenditure cost and direct cost exist in the section, how can they be allocated, if improvement can be done and how the flow of information is supposed to happen.</p><p>In order to answer the questions we used our former experience and the knowledge we achieved by reading literature, interview relevant persons in the company and observations carried out in the section.</p><p>Through our studies, we came up with an Excel file, which is the groundwork for a template that can be used by the company in different occasions depending on the situation and need. It is important to remember to modify the template if the presumptions change. In the template, we have identified the different kind of costs that emerge when packaging different articles and we have also allocated the costs. In addition formulas and estimations that are necessary for the cost calculation are presented.</p><p>The work consisted in making the groundwork for a template. That means there is a lot of work for the company left to do until the template is ready to be used in working routine.</p><p>The template includes estimations that are not tested with real figures and therefore can contain hidden defects. The company could not supply us with the figures on the relevant costs, because of secrecy reason. Therefore it is very difficult to eliminate the risk for hidden defects in the template. In order to distinguish obvious defects, made up figures were used. These can differ essential from the real figures, but the purpose is to minimise the defects and help the company to see how the template works.</p><p>An improvement suggestion is that the company should use the proposed flow of information in order to save time and therefore be able to spend more time with the main operations. The flow of information saves time by:</p><p>• Using more the current computer system</p><p>• Being simple</p><p>• Identifying unnecessary activities, so that it can be removed or modified</p>

This degree project is based on identifying and allocation of costs in a packaging section at Electrolux Distriparts in Torsvik. The purpose of this thesis is to identify the costs that emerge when packaging different articles and show how the costs are allocated. The report also contains improvement suggestions about how the company can use the current computer system more efficient. The methods that have been used in order to approach the problem and the collection of information have mainly been literature study, interviews and observation. The work started with answering the questions; which expenditure cost and direct cost exist in the section, how can they be allocated, if improvement can be done and how the flow of information is supposed to happen. In order to answer the questions we used our former experience and the knowledge we achieved by reading literature, interview relevant persons in the company and observations carried out in the section. Through our studies, we came up with an Excel file, which is the groundwork for a template that can be used by the company in different occasions depending on the situation and need. It is important to remember to modify the template if the presumptions change. In the template, we have identified the different kind of costs that emerge when packaging different articles and we have also allocated the costs. In addition formulas and estimations that are necessary for the cost calculation are presented. The work consisted in making the groundwork for a template. That means there is a lot of work for the company left to do until the template is ready to be used in working routine. The template includes estimations that are not tested with real figures and therefore can contain hidden defects. The company could not supply us with the figures on the relevant costs, because of secrecy reason. Therefore it is very difficult to eliminate the risk for hidden defects in the template. In order to distinguish obvious defects, made up figures were used. These can differ essential from the real figures, but the purpose is to minimise the defects and help the company to see how the template works. An improvement suggestion is that the company should use the proposed flow of information in order to save time and therefore be able to spend more time with the main operations. The flow of information saves time by: • Using more the current computer system • Being simple • Identifying unnecessary activities, so that it can be removed or modified

Šiame darbe yra trumpai apžvelgiami dalelių spiečių sistemų algoritmai, maršrutų optimizavimo uždaviniai ir jų formuluotės, bei praktinės interpretacijos. Plačiau apžvelgiami dirbtinių bičių kolonijų algoritmai ir jų pritaikymas keliaujančio pirklio uždaviniams spręsti. Taip pat šiame darbe galima rasti dirbtinių bičių kolonijų algoritmo pritaikymą keliaujančio pirklio uždaviniams spręsti, bei sukurtos programos skaičiavimo rezultatų analizę. / This paper consists of short description of swarm systems algorithms, route optimisation problems overview and longer description of artificial bee colony algorithms adaptation for traveling salesman problem. Moreover, you can find an artificial bee colony algorithm's application to traveling salesman problem and analysis of computational results.

Dans cette étude, le transporteur ABC de zinc de Streptococcus agalactiae, première cause d’infections materno-foetale en France, a été caractérisé. Nous avons montré que ce transporteur se compose, du complexe perméase-ATPase AdcCB, associé à trois protéines membranaires Lmb, AdcA et AdcAII redondantes dans la fixation de zinc. Ce transporteur comporte également deux protéines Sht et ShtII, retrouvées au niveau de la paroi, et nécessaires aux protéines Lmb et AdcAII pour la capture de zinc. L’absence d’un transporteur fonctionnel, par la triple délétion des gènes lmb, adcA et adcAII ou du complexe adcCB, a révélé une inhibition de la croissance et une perturbation de la division de la bactérie lorsqu’elle se trouve dans un environnement carencé en zinc. De plus, nous avons montré que ce transporteur de zinc participe à la survie de la bactérie en milieux biologiques humains, comme le liquide amniotique ou le LCR, où la bactérie est retrouvée lors d’infections, suggérant l’importance du transporteur lors du processus infectieux. Ces résultats ont mis en évidence, pour la première fois, que le zinc assure des fonctions biologiques vitales pour S. agalactiae et que, dans des conditions de forte carence en zinc, le transporteur Adc/Lmb représente le principal système d’acquisition de zinc de la bactérie. / In this study, the zinc-ABC transporter of Streptococcus agalactiae, the first cause of materno-foetal infections in France, was characterized. We showed that this transporter is composed of an AdcCB permease-ATPase complex in association with three membrane-associated proteins Lmb, AdcA and AdcAII, which are redundant in zinc-binding. This transporter also possesses two proteins Sht and ShtII, which are associated to the cell wall, and that are necessary for the Lmb and AdcAII proteins for zinc capture. The absence of a functional transporter, by the triple deletion of the lmb, adcA and adcAII genes or the adcCB complex, revealed a growth inhibition and a disruption of the division of the bacterium when it is in a zinc-restricted environment. Furthermore, we showed that the zinc-ABC transporter contributes to the survival of the bacterium in human biological fluids, as the amniotic fluid or the cerebrospinal fluid, where the bacterium is found during infections, suggesting the importance of the transporter during the infectious process. These results hightlighted, for the first time, that zinc has biologically vital functions in S. agalactiae and that, under high zinc deficiency conditions, the Adc/Lmb transporter is the main zinc acquisition system of the bacterium.

This thesis is called "Stock Management in the Store". The main aim of the thesis is to determine the optimal size and composition of inventory assortment in the store. The thesis consists of two parts - theoretic and practic one. The first part was focused on stock management in the business unit. The selected store was characterized in the practical part. Subsequently, was selected five specific samples of goods selected assortment categories - meat products, dairy products, pasta and drinks. On these groups of products was accomplished optimization. This optimization was accomplished by analysis of selected products, Economic Order Quantity and Direct Product Profilitability.

The aim of the diploma thesis was optimization of the warehouse system according to suitability for use in assortment in a selected production company focusing on material and information flows, decay processes, warehouse technology, logistic costs and relevant logistics indicators. The partial objective was to determine the critical factors in terms of management and operation in the warehouse of the selected manufacturing enterprise.

Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Lukáš Slatinský Supervisor: Assoc. prof. PharmDr. Martina Čečková, Ph.D. Title of diploma thesis: Interactions of selected anticancer drugs of the MAPK/ERK signaling pathway inhibitors group with the ABC drug transporters ABCB1 (Pgp, P-glycoprotein) and ABCG2 (BCRP, breast cancer resistance protein) are members of a transmembrane efflux ATP dependent transporter family, so called ATP-binding cassettes (ABC). Physiologicaly they are expressed in the cellular membrane and protect body tissues against potentially toxic xenobiotics including drugs. They represent also one of the tumor defense mechanisms when being able to efflux a wide variety of cytotoxic drugs out of the cancer cells leading to treatment failure. BRAF protein plays an important regulatory and signal role in MAPK/ERK pathway affecting cell division, differentiation and secretion. Mutations of BRAF lead to overactivity in MAPK/ERK pathway in many cancer cells and can be therefore targeted by anticancer therapy. Cobimetinib and dabrafenib are relatively new anticancer therapeutics inhibiting the signal pathway mentioned above and they are used in treatment of melanoma carrying the BRAF mutation. The aims of this project were to...

Made available in DSpace on 2016-08-02T21:42:31Z (GMT). No. of bitstreams: 1 Kerg.pdf: 559651 bytes, checksum: 16dbc6bf7bf63787553b8330addf07f3 (MD5) Previous issue date: 2013-10-02 / Standards of tax transparency (Law 101/00, LC131/09, Decree 7185/10) provide that all federal entities of the three spheres of power make available on the Internet, in real time, detailed information on the budgetary and financial execution. The federal entity closest to the citizen is the county where your living space is made. The transparency of county information enables better monitoring of public accounts. Thus, the citizen may exercise more effectively their right to accountability. The research objective is to assess the level of transparency of the budget of ABC Paulista´s county, based on compliance with legal standards of fiscal transparency. The research´s nature is exploratory and descriptive, with a quantitative approach. Scores were constructed according to municipalities, allowing classifying them into four categories of transparency: transparent, translucent, transparent and opaque. Data collection was conducted in the period from February to June of 2013 by observing the transparency homepages of each county. Empirical evidence suggests that portals are not in full compliance with legal requirements. Regarding accountability advances are still modest, informational asymmetry persists and published content is very technical. / As normas da transparência fiscal (LC 101/00, LC131/09, Decreto 7185/10) determinam que todos os entes da federação das três esferas de poder disponibilizem na internet, em tempo real, informações pormenorizadas sobre a execução orçamentária e financeira. O ente federativo mais próximo do cidadão é o município, onde o seu espaço de vida é constituído. A transparência das informações municipais possibilita um melhor acompanhamento das contas públicas. Dessa forma, o cidadão poderá exercer de forma mais eficaz o seu direito de accountability. O objetivo da pesquisa é avaliar o nível de transparência do orçamento público dos municípios do ABC Paulista, com base na conformidade com as normas legais da transparência fiscal. A pesquisa é exploratória e de natureza descritiva, com abordagem quantitativa. Foram construídos escores de conformidade para os municípios, permitindo classificá-los em quatro categorias de transparência: transparente, translúcido, diáfano e opaco. A coleta de dados foi realizada no período de fevereiro a junho de 2013 por meio da observação nos portais eletrônicos da transparência de cada município. As evidências empíricas apontam que os portais não estão em total conformidade com as exigências legais. No que tange a accountability os avanços ainda são modestos, a assimetria informacional ainda persiste e o conteúdo divulgado é muito técnico.