The purpose of the study is to investigate and identify the factors that affect utilisation of prevention mother to child transmission of HIV services and propose measures to promote utilisation of services by HIV positive pregnant women in Onitsha, Anambra State, Nigeria. Mother-to-child transmission of HIV accounts for over 90% of infections in children under 15 years. Infected pregnant women can pass on the infection to their babies during pregnancy, delivery or through breastfeeding. There are effective interventions now reduce of the infection to the baby. However some infected women still do not avail themselves of these services due to several reasons. A quantitative descriptive study, using the Health Belief Model as the conceptual framework was used to conduct the research. A structured interview schedule was used to interview 102 pregnant women at two health facilities in Onitsha, Anambra state, Nigeria. The findings from the study reveal that majority of the respondents knew about HIV transmission but not about ways the infection can be transmitted from mother-to-child. The respondents recognise that HIV/AIDS is a very serious threat in Nigeria and the study site and were of the opinion that all pregnant women should know their HIV status. The attitude of health care workers and fears about disclosure of HIV status to others was a setback. Revealing their status to the spouse was feared.

Women and children are often the most affected by pandemics which have swept through the world, and in this regard the HIV/AIDS pandemics is not an exception. The most common route of HIV infection in HIV positive children under 5 years of age is through Mother-To-Child Transmission (MTCT). In spite of the seriousness of this pandemic, the Constitutional Court has found that the measures taken by the South African government with regard to the Prevention of Mother-To-Child Transmission (PMTCT) has fallen short of what the Constitution requires. This dissertation critically reviews the management of the South African PMTCT programme, and discusses the relevant Court decisions. The study finally clarifies the obligations of the South Africa government in the context of PMTCT under the 1996 Constitution and in terms of international law. / Constitutional,International & Indigenous Law / LL.M. (Legal aspects of HIV/AIDS)

This study sought to determine if ANC and PMTCT services are utilized within the first trimester of pregnancy by the women in East Ekurhuleni sub-district. Quantitative descriptive research was conducted on 390 eligible pregnant women and data collection was done using structured questionnaires. The results indicated that women start ANC late despite their knowledge of first trimester as the best time to start ANC. Actions that would motivate them to start ANC early were explored and barriers were identified. / Health Studies / MA (Public Health)

The purpose of the study was to identify factors associated with the HIV transmission rate in 18 to 24 month-old children enrolled in the PMTCT programme at two selected City of Tshwane clinics. Mother-to-child transmission of HIV during labour and breastfeeding accounts for 40% of all HIV infection in children. The prevention of mother-to-child transmission of HIV programme is one effective strategy to reduce the rate of HIV infection in children. The HIV transmission rate was low at six weeks of age but increases at 18 to 24 months of age due to several factors. The researcher selected a descriptive retrospective correlational research design. A structured questionnaire was used to collect data from 60 mothers of children aged 18 to 24 months on the PMTCT programme and a data-collection form to collect data from 152 clinic records of children of the same age on the programme. The study found that the PMTCT guidelines were not properly adhered to by the nurses and the respondents. Prophylactic treatment was not provided as required and mixed feeding was prominent. The uptake of HIV test at 18 to 24 months was low compared to at 6 weeks. The transmission rate was high at 18 to 24 months compared to at 6 weeks. No factors were associated with the transmission rate / Health Studies / M.A. (Public Health)

The purpose of the study is to investigate and identify the factors that affect utilisation of prevention mother to child transmission of HIV services and propose measures to promote utilisation of services by HIV positive pregnant women in Onitsha, Anambra State, Nigeria. Mother-to-child transmission of HIV accounts for over 90% of infections in children under 15 years. Infected pregnant women can pass on the infection to their babies during pregnancy, delivery or through breastfeeding. There are effective interventions now reduce of the infection to the baby. However some infected women still do not avail themselves of these services due to several reasons. A quantitative descriptive study, using the Health Belief Model as the conceptual framework was used to conduct the research. A structured interview schedule was used to interview 102 pregnant women at two health facilities in Onitsha, Anambra state, Nigeria. The findings from the study reveal that majority of the respondents knew about HIV transmission but not about ways the infection can be transmitted from mother-to-child. The respondents recognise that HIV/AIDS is a very serious threat in Nigeria and the study site and were of the opinion that all pregnant women should know their HIV status. The attitude of health care workers and fears about disclosure of HIV status to others was a setback. Revealing their status to the spouse was feared.

Women and children are often the most affected by pandemics which have swept through the world, and in this regard the HIV/AIDS pandemics is not an exception. The most common route of HIV infection in HIV positive children under 5 years of age is through Mother-To-Child Transmission (MTCT). In spite of the seriousness of this pandemic, the Constitutional Court has found that the measures taken by the South African government with regard to the Prevention of Mother-To-Child Transmission (PMTCT) has fallen short of what the Constitution requires. This dissertation critically reviews the management of the South African PMTCT programme, and discusses the relevant Court decisions. The study finally clarifies the obligations of the South Africa government in the context of PMTCT under the 1996 Constitution and in terms of international law. / Constitutional,International and Indigenous Law / LL.M. (Legal aspects of HIV/AIDS)

Introduction: Evidences indicate that human immuno-deficiency virus (HIV) and diabetes (DM) impact pregnancy outcomes but no experience on the integrated service delivery of HIV, DM and pregnancy care. This study explored the domains and levels of integration among DM, HIV and pregnancy care to prepare a service delivery model in Ethiopia. Methods: A sequential exploratory mixed method and the integration theoretical framework guided the study. An exploratory qualitative phase used focused group discussion, in-depth interview and observation to explore the level of integration and to refine a questionnaire for the quantitative phase. The data were transcribed and coded for theme-based analysis. The descriptive quantitative phase described HIV, DM and pregnancy care services, and determined the burden of DM among HIV patients and the prevalence of pregnancy and pregnancy outcomes. Data was analysed using Epi-info. The findings were triangulated, discussed and interpreted. Results: Seven themes were generated: joint plan, shared budget, monitoring system, structural location, the need of policy guide, the practice of integrated service delivery and suggested integration approaches. A coordinated HIV and pregnancy care services were noted. There was a linkage between diabetes and HIV, and diabetes and pregnancy care. The 1.5% of diabetes among HIV, the low number of pregnancies per a mother in diabetes (1.8) and HIV (1.3); the high adverse pregnancy outcomes among HIV (13.4% abortion, 12.4% low birth weight (LBW), 3.5% pre-term birth, 2.1% congenital malformation) and diabetes (3.2% big baby, 3.2% LBW, 3.1% Cesarean-section); the respective absent and low (16.2%) diabetes screening service at anti-natal and HIV clinics, the absent pregnancy care service for diabetic females justified the development of the tripartite integrated service delivery model of diabetes, HIV and pregnancy care. Conclusions: The model suggests active diabetes screening, evaluation and treatment at HIV and antenatal clinics. It considers the coordination between non-communicable diseases (NCD), HIV and maternal health units. Pregnancy care could be coordinated at HIV and NCD units. Full integration can be practiced between HIV and pregnancy care units. Preparing policy guide, building the capacity of health providers, advocating and piloting the model may be prioritized before the implementation of the model. / Health Studies / D. Litt. et Phil. (Health Studies)

The main aim of this study was to explore the extent of freedom or lack thereof in the relationships of HIV positive pregnant women and their partners. These women were attending antenatal care in two Soweto clinics, run by the Perinatal HIV Research Unit. A semi-structured interview schedule was developed and used as the data collection tool. A theoretical framework based on Amartya Sen's theory of Development as Freedom and Isabel Apawo Phiri's theological reflections on women's freedom, was used to analyze data collected from the participants of the study. The ideas of the two theorists complemented each other with regard to the sources of "unfreedom" for women from an economic point of view and from the cultural and religious points of view. Sen highlighted lack of basic freedoms and human rights as the core causes of lack of freedom, which is both a primary means and principal ends of development. Phiri advocated for the liberation of women from the oppressive cultural and religious practices brought about by patriarchy. Removal of all those key sources of unfreedom would provide an ideal situation in which women would be less vulnerable to HIV infection. The analysis of the participants' responses in this study suggested a lack of freedom in their relationships with the fathers of their unborn babies. This had an adverse effect in their ability to disclose their HIV positive status, negotiate safer sex and contraception. Economic dependency on the partners was found to be the major cornerstone that kept women in bondage in their relationships. The churches in Soweto did not seem to have any plausible impact in the lives of the participants and as a result all of them had very loose links with the church. This was another major gap in the initiatives to reduce HIV infection which challenges the churches in Soweto to strengthen their prophetic ministry in terms of women's freedom and their dignity both in the church and in society. / Thesis (M.A.)-University of KwaZulu-Natal, Pietermaritzburg, 2007

Thesis (MPhil)--Stellenbosch University, 2005. / ENGLISH ABSTRACT: This research provides some insight into some of the socio-cultural barriers hindering the implementation of MTCT programmes in Eastern Cape. In most parts of the world today, HIV infection is increasing faster among women more than men. The resulting infection of women is that many babies born to HIV mother become automatically infected. Mother-to-Child transmission (MTCT) of HIV is most significant source of HIV infection in children. Of the estimated 36 million people living with HIV/AIDS, 1.4 million are children (UNAIDS, 2002). The devastating effect of MTCT, prompted the South African government to initiate an urgent programme. In 2000, the SA government set up 18 pilot sites, including 2 sites in Eastern-Cape; the East London Complex, to curb children HIV infection. However, four years after the inception of the programme its success still depends largely on many factors, one of which is the socio-cultural barrier. This research therefore set out to explore some aspect of these socio-cultural barriers that is hindering the PMTCT programme in Eastern Cape. The research report consists of five chapters. Chapter 1. Deals with the introduction into the topic. Chapter 2. Summarises the literature on PMTCT associated with the research, as well as risk factors associated with PMTCT and possible interventions that were identified in various literature that attempts to reduce MTCT. Chapter 3. Focus on the research methodology. It explains the study design, the research aim and objectives, the study population and data analysis resulting from the research. Chapter 4. The results of the research findings is discussed in-dept in this chapter. An overarching theme of high level of societal stigma emerged as the key socio-cultural barrier. Chapter 5. This chapter discusses the identified socio-cultural barrier as well as possible recommendations as to how to address some of these barriers and also suggestion for further research. / AFRIKAANSE OPSOMMING: Hierdie navorsing bied ‘n mate van insig tot sommige van die sosiokulturele beperkinge wat die implementering van sogenaamde MTCT-programme in die Ooskaap kortwiek. In die meeste wêrelddele styg die voorkoms van die HIV-virus onder vroue tans vinniger as onder mans. Die resultaat daarvan is dat die babas van geïnfekteerde vroue outomaties ook geïnfekteer word. Moeder-tot-kind-oordrag MTKO (Mother-to-child transmission –MTCT) van MIV is die hoofsaaklike bron van infeksie in kinders. Van die geskatte 36 miljoen mense wat tans met MIV/VIGS lewe, is 1, 4 miljoen kinders (UNAIDS, 2002). Die vernietigende effek van MTKO het die Suidafrikaanse regering daartoe genoop om ‘n dringende program van stapel te stuur. Gedurende die jaar 2000, het die SA regering beslag gegee aan 18 loodsterreine, waarvan 2 in die Ooskaap-Oos-Londen-kompleks, om MIV-infeksies onder kinders te begin beperk. Vier jaar na die aanvang van die program, egter, is die sukses daarvan steeds afhanklik van ‘n veeltal faktore, een waarvan die sosio-kulturele grens is. Om hierdie rede was hierdie navorsing daarop ingestel om sommige aspekte van hierdie sosio-kulturele grense wat die VMTKO-programme (Voorkomig van MTKO) in die Ooskaap bemoeilik, van nader te ondersoek. Die navorsingsverslag bestaan uit vyf hoofstukke. Hoofstuk 1. Handel oor die inleiding tot die onderwerp. Hoofstuk 2. Som die bestaande literatuur oor VMTKO op sover dit op die navorsing van toepassing is; insluitende risikofaktore wat met VMTKO geassosieer word asook moontlike intervensies met die oog op pogings om MTKO te verlaag, soos geïdentifiseer in verskeie bronne in die literatuur. Hoofstuk 3. Fokus op die navorsings metodologie. Dit verduidelik die ontwerpbeginsels van die studie, die navorsingsdoelstellings en oogmerke, die teikengroep van die studie en die data-analise voortspruitend uit die navorsing. Hoofstuk 4. Die navorsingsresultate word hierin in diepte bespreek. ‘n Oorheersende tema van stigma binne gemeenskapsverband tree as sentrale sosiokulturele grens na vore. Hoofstuk 5. Die geïdentifiseerde sosiokulturele grense word bespreek en moontlike aanbevelings gemaak ten opsigte van hoe sulke grense aangespreek kan word, asook voorstelle vir verdere navorsing.

Abstract:<p>Background. This dissertation focuses on HIV-1 mother-to-child transmission (MTCT) as a major global public health issue. It consists of three papers that were published in international peer review journals. We initiated the study to answer the following research question: what was the impact of socioeconomic, clinical and biological risk factors on HIV-1 mother-to-child transmission incidence at Muhima health centre, in the specific context of Rwanda health sector reforms?<p>Methods. A prospective cohort study in Muhima health centre (Rwanda) was used to address the study objectives, with a follow up of 700 mother-infants pairs (2007-2010).<p>Results. The observed overall transmission rate was 3.2% (CI 1.9% – 4.5%) at age 6 weeks of life and 3.7% (CI 2.3% – 5.1%) at 6 months of age. Among the 679 exposed and followed-up infants, a higher risk of HIV-1 MTCT was significantly associated with the following factors: non-disclosure of HIV status to partner; high viral load (HIV-1 RNA); infant mixed feeding before 6 months of age; low mother’s CD4 count and low hemoglobin level during pregnancy.<p>Conclusions. The health sector reforms were found to have led to a conducive environment that was favorable to scaling up of maternal health services in Rwanda (2000-2010).<p>The observed overall MTCT rate of 3.2% (CI 1.9% – 4.5%) at age 6 – weeks postnatal in the Muhima cohort is a significant reduction of MTCT incidence towards achieving the elimination target of < 5% for breastfeeding populations in developing setting.<p>The most relevant factors independently associated with increased risk of mother – to – child transmission of HIV-1 included non-disclosure of HIV status to partner and high HIV-1 RNA. Members of this cohort also showed socioeconomic inequalities, with unmarried status carrying higher risk of undisclosed HIV status. <p>Integrated service delivery for PMTCT/MCH interventions, including community-based approach, task shifting and subsidized membership fees for people living with HIV, were the key national policies implemented to support optimal access to and delivery of evidence – based interventions for prevention of mother – to – child transmission of HIV in Muhima.<p><p>Résumé:<p>Contexte<p><p>Cette thèse porte sur la transmission mère-enfant du VIH-1 comme un problème majeur de santé publique au niveau mondial. Il est composé de 3 publications dans des revues internationales à comité de lecture. Nous avons initié l’étude pour pouvoir répondre à la question de recherche suivante :quel a été l’impact des facteurs de risque socio-économiques, cliniques et biologiques sur l’incidence de la transmission du VIH-1de la mère à l’enfant au centre de santé de Muhima, dans le contexte spécifique des réformes du secteur de la santé au Rwanda.<p>Cadre méthodologique<p><p>Une étude cohorte prospective a été menée au centre de santé de Muhima pour pouvoir répondre aux objectifs de l’étude, avec un suivi de 700 couples mères-enfants éligibles (2007-2010).<p>Résultats<p><p>L’incidence cumulée de transmission mère-enfant du VIH-1 a été de 3,2% (IC 1,9% – 4,5%) à 6 semaines et 3,7% (IC 2,3% – 5,1%) à 6 mois de vie. Parmi les 679 nourrissons exposés et suivis, un risque plus élevé de transmission mère-enfant du VIH-1 était significativement associé aux facteurs suivants :non divulgation du statut séropositif au VIH-1 entre partenaires ;charge virale élevée (ARN-VIH-1) ;allaitement mixte de l’enfant avant 6 mois d’âge ;CD4 bas et taux d’hémoglobine bas pendant la grossesse. <p><p><p><p><p>Conclusions<p><p>Les réformes du secteur ont pu créer un environnement favorable à l’extension des services de santé maternelle (2007-2010).<p>Le taux global 3,2% (IC 1,9 – 4,5) à 6 semaines de vie représente une réduction significative de l’incidence de transmission mère-enfant du VIH-1 pour atteindre le niveau de <5% comme indicateur relatif au plan d’élimination des nouvelles infections VIH chez l’enfant au sein des populations avec allaitement maternel comme pratique universelle.<p>Les facteurs les plus pertinents indépendamment associés à un risque élevé de transmission mère-enfant du VIH-1sont représentés par la non-divulgation du statut séropositif au VIH-1 entre partenaires et la charge virale élevée (ARN-VIH-1). Au sein de cette cohorte, l’on a également pu identifier l’existence d’inégalités socio-économiques, avec le statut de femme seule associé au risque plus élevé de non-divulgation du statut séropositif au VIH-1 entre partenaires.<p>Le service intégré de PTME / interventions de santé de la mère et de l’enfant, y compris l'approche communautaire, l’approche de délégation des tâches et la subvention des frais d'adhésion à la mutuelle de santé pour les personnes vivant avec le VIH, ont été les principales politiques nationales mises en œuvre pour favoriser l'accès optimal et la prestation des interventions basées sur les preuves pour la prévention de la transmission du VIH-1 de la mère à l’enfant au centre de santé de Muhima.<p> / Doctorat en Sciences de la santé publique / info:eu-repo/semantics/nonPublished