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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 21 to 24 of 24 (0.009 seconds)| 21 |
Charakterizace extracelulárních a intracelulárních organických látek produkovaných fytoplanktonem ve vztahu k procesům úpravy vody / Characterization of extracellular and intracellular organic matter produced by phytoplankton in relation to water treatmentZezulová, Tereza January 2015 (has links)
This study investigated characteristics of algal organic matter (AOM) derived from four species (cyanobacteria Microcystis aeruginosa and Merismopedia tenuissima, diatom Fragilaria crotonensis and green alga Chlamydomonas geitleri) dominating phytoplanktonic populations in the reservoirs supplying drinking water treatment plants - the water reservoirs Švihov (the Želivka water treatment plant) and Josefův Důl (the Jizerské Mountains), Czech Republic. The four mentioned microorganisms were cultivated under laboratory conditions and the algal growth was quantified by a number of cells, chrorophyll-a and optical density. Production of AOM was evaluated by dissolved organic carbon concentration measurements, by specific UV absorbance, the amount of peptide/protein and non-peptide (carbohydrate) contents, water affinity and molecular weight (MW). AOM of all considered microorganisms are formed predominantly by hydrophilic substances with low values of specific UV absorbance (< 2 L/(m.mg)). Considerable portions of both types of AOM, i.e. extracellular and cellular organic matters are represented by substances with MW < 1 kDa or with MW > 100 kDa. However, the total amount and composition of AOM significantly depend on algal species and their growth. The obtained results imply that the knowledge of AOM...
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Defective IL-23/IL-17 Axis Protects p47phox−/− Mice from Colon CancerRichter, Cornelia, Herrero San Juan, Martina, Weigmann, Benno, Bergis, Dominik, Dauber, Katrin, Muder, Michael H., Baretton, Gustavo B., Pfeilschifter, Josef Martin, Bonig, Halvard, Brenner, Sebastian, Radeke, Heinfried H. 19 July 2017 (has links) (PDF)
In the colon, a sophisticated balance between immune reaction and tolerance is absolutely required. Dysfunction may lead to pathologic phenotypes ranging from chronic inflammatory processes to cancer development. Two prominent modulators of colon inflammation are represented by the closely related cytokines interleukin (IL)-12 and IL-23, which initiate adaptive Th1 and Th17 immune responses, respectively. In this study, we investigated the impact of the NADPH oxidase protein p47phox, which negatively regulates IL-12 in dendritic cells, on colon cancer development in a colitis-associated colon cancer model. Initially, we found that IL-12−/− mice developed less severe colitis but are highly susceptible to colon cancer. By contrast, p47phox−/− mice showed lower tumor scores and fewer high grade tumors than wild-type (WT) littermates. Treatment with toll-like receptor 9 ligand CpG2216 significantly enhanced colitis in p47phox−/− mice, whereas tumor growth was simultaneously reduced. In tumor tissue of p47phox−/− mice, the IL-23/IL-17 axis was crucially hampered. IL-23p19 protein expression in tumor tissue correlated with tumor stage. Reconstitution of WT mice with IL-23p19−/− bone marrow protected these mice from colon cancer, whereas transplantation of WT hematopoiesis into IL-23p19−/− mice increased the susceptibility to tumor growth. Our study strengthens the divergent role of IL-12 and IL-23 in colon cancer development. With the characterization of p47phox as a novel modulator of both cytokines our investigation introduces a promising new target for antitumor strategies.
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Defective IL-23/IL-17 Axis Protects p47phox−/− Mice from Colon CancerRichter, Cornelia, Herrero San Juan, Martina, Weigmann, Benno, Bergis, Dominik, Dauber, Katrin, Muder, Michael H., Baretton, Gustavo B., Pfeilschifter, Josef Martin, Bonig, Halvard, Brenner, Sebastian, Radeke, Heinfried H. 19 July 2017 (has links)
In the colon, a sophisticated balance between immune reaction and tolerance is absolutely required. Dysfunction may lead to pathologic phenotypes ranging from chronic inflammatory processes to cancer development. Two prominent modulators of colon inflammation are represented by the closely related cytokines interleukin (IL)-12 and IL-23, which initiate adaptive Th1 and Th17 immune responses, respectively. In this study, we investigated the impact of the NADPH oxidase protein p47phox, which negatively regulates IL-12 in dendritic cells, on colon cancer development in a colitis-associated colon cancer model. Initially, we found that IL-12−/− mice developed less severe colitis but are highly susceptible to colon cancer. By contrast, p47phox−/− mice showed lower tumor scores and fewer high grade tumors than wild-type (WT) littermates. Treatment with toll-like receptor 9 ligand CpG2216 significantly enhanced colitis in p47phox−/− mice, whereas tumor growth was simultaneously reduced. In tumor tissue of p47phox−/− mice, the IL-23/IL-17 axis was crucially hampered. IL-23p19 protein expression in tumor tissue correlated with tumor stage. Reconstitution of WT mice with IL-23p19−/− bone marrow protected these mice from colon cancer, whereas transplantation of WT hematopoiesis into IL-23p19−/− mice increased the susceptibility to tumor growth. Our study strengthens the divergent role of IL-12 and IL-23 in colon cancer development. With the characterization of p47phox as a novel modulator of both cytokines our investigation introduces a promising new target for antitumor strategies.
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Development of an API for creating and editing openEHR archetypesKlasson, Filip, Väyrynen, Patrik January 2009 (has links)
Archetypes are used to standardize a way of creating, presenting and distributing health care data. In this master thesis project the open specifications of openEHR was followed. The objective of this master thesis project has been to develop a Java based API for creating and editing openEHR archetypes. The API is a programming toolbox that can be used when developing archetype editors. Another purpose has been to implement validation functionality for archetypes. An important aspect is that the functionality of the API is well documented, this is important to ease the understanding of the system for future developers. The result was a Java based API that is a platform for future archetype editors. The API-kernel has optional immutability so developed archetypes can be locked for modification by making them immutable. The API is compatible with the openEHR specifications 1.0.1, it can load and save archetypes in ADL (Archetype Definition Language) format. There is also a validation feature that verifies that the archetype follows the right structure with respect to predefined reference models. This master thesis report also presents a basic GUI proposal.
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