A associação entre doenças periodontais e desfechos adversos durante a gestação tem ganho grande atenção nos últimos anos. Apesar da maior parte dos estudos mostrar uma relação entre doença periodontal e parto prematuro, estudos que avaliam o impacto do tratamento periodontal nem sempre tem encontrado reduções nas taxas de prematuridade. A explicação para este fato pode estar no impacto do tratamento periodontal sobre mediadores inflamatórios relacionados aos mecanismos dos desfechos adversos durante a gestação. Por este motivo, o estudo de marcadores inflamatórios, como a proteína C-reativa, é de suma importância para a melhor compreensão do impacto inflamatório sistêmico do tratamento periodontal em gestantes. O objetivo deste estudo foi comparar os níveis sistêmicos de PCR em gestantes que receberam ou não tratamento periodontal. Esta dissertação consiste na avaliação dos níveis de PCR de 89 gestantes que receberam tratamento periodontal durante (grupo teste, n=44) ou após a gestação (grupo controle, n=45). Foram realizados dois exames periodontais completos, o primeiro em um momento anterior à 20° semana de gestação e o segundo entre a 26a e a 28a semanas de gestação. As pacientes do grupo teste receberam tratamento periodontal que incluiu raspagem e alisamento supra e subgengivais e instrução para higiene bucal. Consultas de controle para deplacagem profissional e instrução de higiene bucal foram realizadas após o tratamento até o exame final, de acordo com necessidades individuais. Os níveis de PCR foram avaliados através de imunoturbidimetria. Nenhuma diferença estatisticamente significante foi encontrada entre os grupos nos níveis de PCR nos exames inicial e final (p=0.06 e p=0.19, respectivamente). A redução média encontrada nos níveis de PCR foi de 1.93mg/L (±9.69) e 0.44mg/L (±5.44) nos grupos teste e controle, respectivamente. Essas diferenças não foram estatisticamente significativas (p=0.38). O tratamento periodontal durante a gestação reduziu significativamente os parâmetros clínicos periodontais. Esta melhora clínica não apresentou um impacto significativo sobre os níveis sistêmicos de PCR. / The association between periodontal diseases and adverse pregnancy outcomes has been subject of great attention in recent years. Although most studies have shown an association between periodontal diseases and premature birth, studies assessing the impact of periodontal treatment have not found a reduction in these figures. The explanation for this may lie on the impact of periodontal treatment on inflammatory mediators associated with the mechanisms of adverse pregnancy outcomes. For this reason, the study of inflammatory markers such as C-reactive protein is of paramount importance for better comprehension of the impact of systemic inflammatory periodontal treatment in pregnant women. The aim of this study was to compare the systemic levels of CRP in pregnant women who received or not periodontal treatment. This paper was based in the assessment of CRP levels of 89 pregnant women who received periodontal treatment during (test group, n = 44) or after pregnancy (control group, n = 45). Two periodontal examinations were performed, before of 20 weeks of gestation and the second between the 26th and 28th weeks of gestation. Patients in the test group received treatment that included periodontal scaling and root planing and hygiene instructions. Professional cleaning and oral hygiene instruction were performed after treatment until the final exam, according to individual needs. CRP levels were evaluated by immunoturbidimetry. No statistically significant difference was found between the groups for the levels of CRP in the initial and final examinations (p=0.06 and p=0.19, respectively). The average reduction found in CRP was 1.93mg / L (± 9.69) and 0.44mg / L (± 5.44) in test and control groups, respectively. These differences were not statistically significant (p = 0.38). The periodontal treatment during pregnancy significantly reduced the clinical periodontal parameters, but this clinical improvement did not result in a significant reduction on the systemic levels of CRP.

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An adequate nutritional status may therefore be protective in delaying the onset from latent infection to active disease. In South Africa, very little data is available on the nutritional status of adults who present with tuberculosis. This study therefore aims to compare the nutritional status of newly diagnosed pulmonary tuberculosis patients with TB-free controls.</span> <b style="mso-bidi-font-weight: normal"><span lang="EN-GB">Study population &amp / Design</span></b><span lang="EN-GB">: This is a community based case-control study. Forty-three newly diagnosed pulmonary tuberculosis patients were recruited as cases and matched according to age, gender and race to 43 TB-free close contacts. HIV positive subjects were excluded from the study.</span> <b style="mso-bidi-font-weight: normal"><span lang="EN-GB">Methods</span></b><span lang="EN-GB">: Each participant was interviewed and completed a structured questionnaire to obtain demographic information. Weight was measured to the nearest 0.1kg and height to the nearest 1mm. A 24-hr dietary recall method was used to obtain dietary information. Biochemical analysis was carried out to measure&nbsp / concentrations of transferrin, albumin, CRP, ferritin, zinc, copper, vitamin A and E.</span> <b style="mso-bidi-font-weight: normal"><span lang="EN-GB">Results</span></b><span lang="EN-GB">: The median Body Mass Index (BMI) for cases was 18.80kg/m&sup2 / (IQR 14.35, 32.11) and TB-free contacts 21.17 kg/m&sup2 / (IQR 16.75, 34.98) with a significant difference between the groups of p=0.001. There was significant difference in weight (p=0.002) and MUAC (p=0.000) between groups. No significant difference in dietary intake of energy (KJ) (p=0.695), protein (p=0.804), CHO (p=0.801) and fat ( p=0.796) was found between groups. There was a statistically significant increase in ferritin (p=0.000) and C-reactive protein (CRP) (p=0.000) in TB patients, while albumin (p=0.000), serum zinc (p=0.000) and serum vitamin A (p=0.000) were statistically significantly lower among cases.</span> <b style="mso-bidi-font-weight:normal"><span lang="EN-GB">Conclusion</span></b><span lang="EN-GB">: There was no significant difference in the macronutrient intake of TB cases and TB-free contacts, although a significant difference was seen in BMI, MUAC and weight between groups, with all these parameters being lower in TB patients. Ferritin and CRP levels were markedly increased in TB cases while serum zinc, vitamin A and albumin are all significantly lower in&nbsp / TB patients than TB free contacts.</span> <b style="mso-bidi-font-weight:normal"><span lang="EN-GB">&nbsp / </span></b></p> <p>&nbsp / </p>

Haptoglobin is an acute phase protein with important biological role because of its capacity to bind to haemoglobin. Haptoglobin exists in three major genetic polymorphism types: Hp1-1, Hp2-1 and Hp2-2, the distribution of which has been associated with abdominal aortic aneurysm (AAA), an asymptomatic aortic disease common among men older than 65 years.    Five different electrophoretic methods were tested according to their ability to separate the haptoglobin phenotypes. The detection was based on a produced hemolysate of blood in which haemoglobin binds to haptoglobin thereby forming a complex that can be detected by specific haemoglobin staining using TMB-dihydrochloride and hydro peroxide as substrate resulting in an azure-green color of the bands. Samples from 15 patients who had suffered surgery for not broken AAA, that is more than5.0 cmaortic diameter, and 15 samples from matched controls were analyzed.    Among the five tested electrophoretic methods best migration and separation was seen on the pre-cast agarosgel Hydragel HR on the instrument Hydrasys. The other four methods gave less successful results. This pilot investigation showed the following distribution of the phenotypes of haptoglobin among AAA patients; 7 % Hp1-1, 40 % Hp2-1 and 53 % Hp2-2 and for the controls; 13 % Hp1-1, 33 % Hp2-1 and 53 % Hp2-2.    In conclusion, the used techniques has to be further optimized and more patients have to be included in the study before it can be ascertained if the phenotypes of Haptoglobin play any role in the progress of the AAA disease.

The purpose of this study was to investigate whether or not gender differences may be present in the expression of a number of urinary proteins which may serve as markers of inflammation and oxidative stress. Males and females have different patterns of illness and different life spans, suggesting basic biological traits exert significant control on the incidence of rhabdomyolysis, renal failure, atherosclerosis, myocardial ischemia, myocardial contraction band formation, autoimmune disorders and general inflammatory diseases. Men are at greater risk for cardiovascular disease; however women, particularly elderly women, have higher fatality rates due to heart failure. Renal diseases progress far more quickly in men, possibly due to testosterone. Men also have higher kidney bulk related to androgen expression. Gender disparity may be most obvious in autoimmune disorders; of the estimated 8.5 million people diagnosed with autoimmune disorders, approximately 80% are women. Hashimoto’s thyroiditis, the most common form of hypothyroidism, is up to 10 times more common in women. Systemic Lupus Erythematosus (SLE), an autoimmune disease characterized by acute and chronic inflammation, is 9 times more common in women. Rheumatoid arthritis (RA), an autoimmune disease affecting approximately 1.3 million people in the United States, is four times more common in women. Diabetes mellitus (DM), affecting more than 17 million people – the majority of which are women, is linked to microvascular and macrovascular diseases such as kidney failure, strokes and atherosclerosis. These conditions are linked to physiological changes that may alter the expression of certain biomarkers of inflammation and oxidative stress. Over the past several decades, it has become increasingly clear that the role of diet, smoking, and other lifestyle choices clearly influence the etiology and pathophysiology of these diseases. The use of drugs, both licit and illicit, has been clearly linked to many of these diseases. Illicit substances, particularly cocaine, have been demonstrated to produce pathophysiological changes to many systems in the body which can greatly influence the progression of existing and drug-induced disease states leading to systemic damage. A relationship between the expression of markers of inflammation, oxidative stress, cardiac damage, or other systemic injury, gender and cocaine use has not been clearly established. Urine is an important medium for assessment of general health status. It has classically been used to monitor disease states; glucosuria as an indicator of diabetes and renal dysfunction, microorganisms signifying urinary tract or bladder infection, and biomarkers such as human chorionic gonadotropin to confirm pregnancy. Recently urine has been used to assess biomarker expression and disease states. Urine is an ideal clinical tool for toxicological screens; it is readily accessible, non invasive and typically supplied in sufficient quantity to accommodate multiple tests. In this study, urine specimens were collected and analyzed for creatinine, cocaine, total protein, aldosterone, c-reactive protein (hsCRP), myeloperoxidase (MPO), microalbumin (MAB), neutrophil gelatinase-associated lipocalin (NGAL), heat shock protein 90α (hsp90α), vascular endothelial growth factor (VEGF), myoglobin, pro atrial natriuretic peptide (proANP) and interleukins 1α, 1 β , and 6 using ELISA and colorimetric assays. Urine specimens that tested negative for all illicit substances in the standard National Institute on Drug Abuse (NIDA) 10 panel showed differences in a number of these biomarkers which strongly suggested significant differences between males and females for aldosterone, IL1α and IL1β. In addition, significance is suggested for MPO and CRP. Although sex specific differences in serum expression have been noted for some of the markers in both animal and human models, this has not been previously demonstrated in human urine. This may have implications for what is typically referred to as ‘normal’ values. Gender specific differences were not apparent in urine specimens that tested positive for cocaine. Also, in males only, the levels of myoglobin and aldosterone significantly increased.

The overarching aim of the thesis research was to investigate mechanisms altered by protein-energy malnutrition (PEM), a common stroke co-morbidity factor that could affect the extent of brain damage and recovery following stroke. To model stroke, the rat 2-vessel occlusion model of global brain ischemia was employed. To characterize the effects of PEM, three states of malnutrition were assessed: PEM co-existing with brain ischemia (Study 1), effects of PEM independent of brain ischemia (Study 2), and PEM developing after brain ischemia (Study 3). The first hypothesis tested was co-existing PEM triggers an exacerbated glial response to global brain ischemia. The failure to achieve a consistent model of global ischemia prevented us from drawing conclusions on whether co-existing PEM exacerbates reactive gliosis. Nonetheless, this study demonstrated that mean temperature and temperature fluctuation are increased within the first 24hr of exposure to a low protein diet. The second hypothesis tested was PEM causes sustained changes in core temperature that are associated with an inflammatory response. Exposure to a low protein diet caused an immediate small and transient increase in mean temperature and a larger sustained increase in temperature amplitude. As malnutrition evolved, mean temperature declined. PEM stimulated an acute-phase response, characterized by an increase in the positive acute-phase protein, alpha-2-macroglobulin (A2M), and a decrease in the negative acute-phase protein, albumin. This response appeared to be aberrant, since the positive acute-phase protein, alpha-1-acid glycoprotein (AGP), was decreased with PEM. The final hypothesis tested was PEM developing after global brain ischemia exacerbates systemic and hippocampal inflammation, which is associated with diminished neuroplasticity. The effects of PEM on the acute-phase response are persistent following brain ischemia, as demonstrated by decreased serum albumin and increased serum A2M. A decrease in the positive acute-phase protein, haptoglobin, strengthened the evidence that PEM triggers an atypical reaction. The strong glial response elicited by global ischemia was unaltered by PEM. However, PEM influenced hippocampal neuroplasticity mechanisms, as GAP-43 and synaptophysin were significantly lower at d21. In summary, it has been demonstrated that PEM affects core temperature, the systemic acute-phase reaction and the neuroplasticity response to global brain ischemia.

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mso-ascii-font-family:Calibri / mso-ascii-theme-font:minor-latin / mso-hansi-font-family:Calibri / mso-hansi-theme-font:minor-latin / mso-bidi-font-family:"Times New Roman" / mso-bidi-theme-font:minor-bidi / mso-ansi-language:EN-US / mso-fareast-language:EN-US / } </style> <![endif]--><b style="mso-bidi-font-weight: normal"><span lang="EN-GB">Background</span></b><span lang="EN-GB">: Malnutrition is a risk factor for the development of pulmonary tuberculosis (TB) and may be responsible for the premature deaths of patients with active disease. An adequate nutritional status may therefore be protective in delaying the onset from latent infection to active disease. In South Africa, very little data is available on the nutritional status of adults who present with tuberculosis. This study therefore aims to compare the nutritional status of newly diagnosed pulmonary tuberculosis patients with TB-free controls.</span> <b style="mso-bidi-font-weight: normal"><span lang="EN-GB">Study population &amp / Design</span></b><span lang="EN-GB">: This is a community based case-control study. Forty-three newly diagnosed pulmonary tuberculosis patients were recruited as cases and matched according to age, gender and race to 43 TB-free close contacts. HIV positive subjects were excluded from the study.</span> <b style="mso-bidi-font-weight: normal"><span lang="EN-GB">Methods</span></b><span lang="EN-GB">: Each participant was interviewed and completed a structured questionnaire to obtain demographic information. Weight was measured to the nearest 0.1kg and height to the nearest 1mm. A 24-hr dietary recall method was used to obtain dietary information. Biochemical analysis was carried out to measure&nbsp / concentrations of transferrin, albumin, CRP, ferritin, zinc, copper, vitamin A and E.</span> <b style="mso-bidi-font-weight: normal"><span lang="EN-GB">Results</span></b><span lang="EN-GB">: The median Body Mass Index (BMI) for cases was 18.80kg/m&sup2 / (IQR 14.35, 32.11) and TB-free contacts 21.17 kg/m&sup2 / (IQR 16.75, 34.98) with a significant difference between the groups of p=0.001. There was significant difference in weight (p=0.002) and MUAC (p=0.000) between groups. No significant difference in dietary intake of energy (KJ) (p=0.695), protein (p=0.804), CHO (p=0.801) and fat ( p=0.796) was found between groups. There was a statistically significant increase in ferritin (p=0.000) and C-reactive protein (CRP) (p=0.000) in TB patients, while albumin (p=0.000), serum zinc (p=0.000) and serum vitamin A (p=0.000) were statistically significantly lower among cases.</span> <b style="mso-bidi-font-weight:normal"><span lang="EN-GB">Conclusion</span></b><span lang="EN-GB">: There was no significant difference in the macronutrient intake of TB cases and TB-free contacts, although a significant difference was seen in BMI, MUAC and weight between groups, with all these parameters being lower in TB patients. Ferritin and CRP levels were markedly increased in TB cases while serum zinc, vitamin A and albumin are all significantly lower in&nbsp / TB patients than TB free contacts.</span> <b style="mso-bidi-font-weight:normal"><span lang="EN-GB">&nbsp / </span></b></p> <p>&nbsp / </p>

No description available.

A associação entre doenças periodontais e desfechos adversos durante a gestação tem ganho grande atenção nos últimos anos. Apesar da maior parte dos estudos mostrar uma relação entre doença periodontal e parto prematuro, estudos que avaliam o impacto do tratamento periodontal nem sempre tem encontrado reduções nas taxas de prematuridade. A explicação para este fato pode estar no impacto do tratamento periodontal sobre mediadores inflamatórios relacionados aos mecanismos dos desfechos adversos durante a gestação. Por este motivo, o estudo de marcadores inflamatórios, como a proteína C-reativa, é de suma importância para a melhor compreensão do impacto inflamatório sistêmico do tratamento periodontal em gestantes. O objetivo deste estudo foi comparar os níveis sistêmicos de PCR em gestantes que receberam ou não tratamento periodontal. Esta dissertação consiste na avaliação dos níveis de PCR de 89 gestantes que receberam tratamento periodontal durante (grupo teste, n=44) ou após a gestação (grupo controle, n=45). Foram realizados dois exames periodontais completos, o primeiro em um momento anterior à 20° semana de gestação e o segundo entre a 26a e a 28a semanas de gestação. As pacientes do grupo teste receberam tratamento periodontal que incluiu raspagem e alisamento supra e subgengivais e instrução para higiene bucal. Consultas de controle para deplacagem profissional e instrução de higiene bucal foram realizadas após o tratamento até o exame final, de acordo com necessidades individuais. Os níveis de PCR foram avaliados através de imunoturbidimetria. Nenhuma diferença estatisticamente significante foi encontrada entre os grupos nos níveis de PCR nos exames inicial e final (p=0.06 e p=0.19, respectivamente). A redução média encontrada nos níveis de PCR foi de 1.93mg/L (±9.69) e 0.44mg/L (±5.44) nos grupos teste e controle, respectivamente. Essas diferenças não foram estatisticamente significativas (p=0.38). O tratamento periodontal durante a gestação reduziu significativamente os parâmetros clínicos periodontais. Esta melhora clínica não apresentou um impacto significativo sobre os níveis sistêmicos de PCR. / The association between periodontal diseases and adverse pregnancy outcomes has been subject of great attention in recent years. Although most studies have shown an association between periodontal diseases and premature birth, studies assessing the impact of periodontal treatment have not found a reduction in these figures. The explanation for this may lie on the impact of periodontal treatment on inflammatory mediators associated with the mechanisms of adverse pregnancy outcomes. For this reason, the study of inflammatory markers such as C-reactive protein is of paramount importance for better comprehension of the impact of systemic inflammatory periodontal treatment in pregnant women. The aim of this study was to compare the systemic levels of CRP in pregnant women who received or not periodontal treatment. This paper was based in the assessment of CRP levels of 89 pregnant women who received periodontal treatment during (test group, n = 44) or after pregnancy (control group, n = 45). Two periodontal examinations were performed, before of 20 weeks of gestation and the second between the 26th and 28th weeks of gestation. Patients in the test group received treatment that included periodontal scaling and root planing and hygiene instructions. Professional cleaning and oral hygiene instruction were performed after treatment until the final exam, according to individual needs. CRP levels were evaluated by immunoturbidimetry. No statistically significant difference was found between the groups for the levels of CRP in the initial and final examinations (p=0.06 and p=0.19, respectively). The average reduction found in CRP was 1.93mg / L (± 9.69) and 0.44mg / L (± 5.44) in test and control groups, respectively. These differences were not statistically significant (p = 0.38). The periodontal treatment during pregnancy significantly reduced the clinical periodontal parameters, but this clinical improvement did not result in a significant reduction on the systemic levels of CRP.

A contagem de células somáticas (CCS) é o padrão ouro de avaliação da integridade da glândula mamária e da qualidade do leite. A haptoglobina (Hp) é uma das principais proteínas de fase aguda que se eleva em processos inflamatórios, infecciosos e de estresse em ruminantes. Este estudo avaliou a relação entre os níveis séricos de Hp e a CCS, através de coletas de amostras de leite e sangue de vacas leiteiras de rebanhos do Noroeste do estado do Rio Grande do Sul. As amostras foram obtidas, entre fevereiro e outubro de 2008 de 150 animais da raça Holandesa, sem distinção de idade e número de lactação, divididos em três grupos de 50 animais separados conforme o valor da CCS. O grupo 1 (G1) incluiu vacas com CCS abaixo de 600.000 cel/mL; o grupo 2 (G2), vacas com CCS superior a 600.000 cel/mL e, o grupo 3 (G3), vacas que apresentavam sinais clínicos de mastite. Para cada amostra de leite, foi determinada a CCS, a contagem bacteriana total (CBT) e os níveis de proteína, gordura, lactose e sólidos totais. Coletouse 5 mL de sangue através de punção da veia coccígea para avaliar contagem total e diferencial de leucócitos, fibrinogênio, hematócrito, proteínas plasmáticas totais e haptoglobina. A análise estatística demonstrou diferença significativa entre os três grupos quanto à CCS, CBT e lactose. A proteína apresentou diferença significativa entre G1 para G2 e G3. Nos sólidos totais, G1 e G2 apresentaram diferença significativa para G3. A gordura não apresentou diferença significativa entre os grupos. Análises não paramétricas demonstraram forte correlação positiva entre CCS e CBT (r=0,852, P<0,005). Quanto às análises hematológicas, o leucograma e as proteínas plasmáticas totais não apresentaram diferença significativa entre os grupos. Fibrinogênio e hematócrito se diferenciaram estatisticamente nos grupos 1 e 3. Na análise do diferencial, os monócitos do G1 e G3 apresentaram diferença estatística para G2. Além disso, o fibrinogênio apresentou correlação leve, mas significativa (r= 0,270, P<0,001), em relação ao valor de CCS. Análises não paramétricas apresentaram correlação média entre CCS e concentração de Hp (r= 0,357, P<0,001), demonstrando associação entre as variáveis. Quanto à concentração de Hp, houve diferença significativa do G1 (0,41 g/L) e G2 (0,41 g/L) para G3 (0,70 g/L), ou seja, se comprovou a elevação dos níveis séricos de Hp em vacas com processo inflamatório instalado; entretanto, a Hp não se mostrou sensível para detecção de mastite subclínica. Sugere-se que estudos adicionais possam elucidar tais associações. / Somatic cell count (SCC) is the gold standard of both the mammalian gland and milk quality evaluation. The haptoglobin (Hp) is one of the main acute phase proteins, which increase in inflammation, infectious and stress processes of ruminants. This work evaluated the relation between Hp serum level and SCC, through the analysis of milk and blood samples from dairy cows from herds in the northwest Rio Grande do Sul state. Samples were obtainned, between February and October 2008, from 150 Holstein cows, without age or milking number discrimination and that were separate in three different groups with 50 animals each, according SCC value. Group 1 (G1) included cows with SCC below 600.000 cells/mL; group 2 (G2), cows with SCC above 600.000 cells/mL and group 3 (G3), cows with signs of clinical mastitis. For each milk sample, it was determined SCC, total bacteria count (TBC), and the protein, fat, lactose, and total solid contents. A 5 mL blood sample was collected by puncturing coccigeal vein to evaluate total and differential leucocytes counts, fibrinogen, hematocrit, total serum protein, and haptoglobin. Statistic analysis showed significant differences among the three groups for SCC, TBC, and lactose. The protein average showed significant difference among G1 to G2 and G3. Total solid contents from G1 and G2 were significantly different to that from G3. Fat content had not significant differences among groups. Not parametric analysis demonstrated strong positive association between SCC and TBC (r= 0,852, P< 0,005). For the hematological analysis, leucograma and total serum protein had no significant differences among groups. Both, fibrinogen and hematocrit showed statistical differences in G1 and G3. Regarding the differential analysis, the monocytes of G1 and G3 showed statistical differences to that of G2. Moreover, although short, there was significant correlation (r= 0,270, P<0,001) between fibrinogen and SCC. Not parametric analysis displayed mean correlation between SCC and Hp concentration (r= 0,357, P<0,001), demonstrating association between the variables. For the concentration of Hp, there was significant differences between G1 (0,41 g/L) and G2 (0,41 g/L) to G3 (0,70 g/L) proving the Hp increase in cows affected by clinical mastitis; nevertheless, the Hp was not a sensible marker to subclinical mastitis. It is suggested that further studies may elucidate those associations.

A associação entre doenças periodontais e desfechos adversos durante a gestação tem ganho grande atenção nos últimos anos. Apesar da maior parte dos estudos mostrar uma relação entre doença periodontal e parto prematuro, estudos que avaliam o impacto do tratamento periodontal nem sempre tem encontrado reduções nas taxas de prematuridade. A explicação para este fato pode estar no impacto do tratamento periodontal sobre mediadores inflamatórios relacionados aos mecanismos dos desfechos adversos durante a gestação. Por este motivo, o estudo de marcadores inflamatórios, como a proteína C-reativa, é de suma importância para a melhor compreensão do impacto inflamatório sistêmico do tratamento periodontal em gestantes. O objetivo deste estudo foi comparar os níveis sistêmicos de PCR em gestantes que receberam ou não tratamento periodontal. Esta dissertação consiste na avaliação dos níveis de PCR de 89 gestantes que receberam tratamento periodontal durante (grupo teste, n=44) ou após a gestação (grupo controle, n=45). Foram realizados dois exames periodontais completos, o primeiro em um momento anterior à 20° semana de gestação e o segundo entre a 26a e a 28a semanas de gestação. As pacientes do grupo teste receberam tratamento periodontal que incluiu raspagem e alisamento supra e subgengivais e instrução para higiene bucal. Consultas de controle para deplacagem profissional e instrução de higiene bucal foram realizadas após o tratamento até o exame final, de acordo com necessidades individuais. Os níveis de PCR foram avaliados através de imunoturbidimetria. Nenhuma diferença estatisticamente significante foi encontrada entre os grupos nos níveis de PCR nos exames inicial e final (p=0.06 e p=0.19, respectivamente). A redução média encontrada nos níveis de PCR foi de 1.93mg/L (±9.69) e 0.44mg/L (±5.44) nos grupos teste e controle, respectivamente. Essas diferenças não foram estatisticamente significativas (p=0.38). O tratamento periodontal durante a gestação reduziu significativamente os parâmetros clínicos periodontais. Esta melhora clínica não apresentou um impacto significativo sobre os níveis sistêmicos de PCR. / The association between periodontal diseases and adverse pregnancy outcomes has been subject of great attention in recent years. Although most studies have shown an association between periodontal diseases and premature birth, studies assessing the impact of periodontal treatment have not found a reduction in these figures. The explanation for this may lie on the impact of periodontal treatment on inflammatory mediators associated with the mechanisms of adverse pregnancy outcomes. For this reason, the study of inflammatory markers such as C-reactive protein is of paramount importance for better comprehension of the impact of systemic inflammatory periodontal treatment in pregnant women. The aim of this study was to compare the systemic levels of CRP in pregnant women who received or not periodontal treatment. This paper was based in the assessment of CRP levels of 89 pregnant women who received periodontal treatment during (test group, n = 44) or after pregnancy (control group, n = 45). Two periodontal examinations were performed, before of 20 weeks of gestation and the second between the 26th and 28th weeks of gestation. Patients in the test group received treatment that included periodontal scaling and root planing and hygiene instructions. Professional cleaning and oral hygiene instruction were performed after treatment until the final exam, according to individual needs. CRP levels were evaluated by immunoturbidimetry. No statistically significant difference was found between the groups for the levels of CRP in the initial and final examinations (p=0.06 and p=0.19, respectively). The average reduction found in CRP was 1.93mg / L (± 9.69) and 0.44mg / L (± 5.44) in test and control groups, respectively. These differences were not statistically significant (p = 0.38). The periodontal treatment during pregnancy significantly reduced the clinical periodontal parameters, but this clinical improvement did not result in a significant reduction on the systemic levels of CRP.