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Calamity of the White Picket is a collection of essays that portray how perfection-whether a perfect image, perfect relationship, perfect friendship, or perfect family-becomes withered down, destroyed, and turned into something else. They explore how the idealized image of a family surrounded by a cute white picket fence is dismantled and rearranged through theft, addiction, and a disintegrated family. The essays explore drug addictions, childhood nostalgia, the relationship between heritage and property, innocence, and a stolen best friend. The collection is a train ride of family problems, broken friendships, lying and stealing, and hidden secrets about love and sex. Through these essays, I let go of my versions of the white picket fence, and embrace the new and complicated life that replaces it, ultimately still trying to maintain happiness.

The purpose of this paper was to examine how people experience the practice of Cannabis in daily life. The study was based on interviews with five individuals who have experience with cannabis use. They do not represent a bigger population only themselves. We chose these particular individuals because all of them began using cannabis at a young age- everyone before they were twenty. But they have been using cannabis because of different reasons. The results of the interviews were analyzed with the thesis of Howard Becker and the new developed thesis of Hallstone about social control. The thesis explains the pattern of becoming a drug addict and what the steps are. The final results of this study contain answers about how much cannabis they have been using, how often, with whom and with what purpose. We compared these answers to the patterns to see if there was any truth to them and then we explained the function the drug has in their lives. For further explaining we used former researches about cannabis use in different areas of life. In the discussion we try to understand what these answers mean, what the thought behind cannabis use is and if these people really have the control over it.

Syftet med denna studie är att undersöka varför många i Sverige betraktar missbruk avsubstanser såsom alkohol och narkotika men även sexmissbruk, spelmissbruk m.m.som en sjukdom, samt vad detta synsätt grundar sig i. Studien är inriktad på en kritiskgranskning av den litteratur, texter och forskning som finns i ämnet. Studiensempiriska material bygger främst på den litteratur som tillhandahålls av anonymaalkoholister och anonyma narkomaner, och ställer deras syn mot forskningsresultatinom medicin och socialvetenskap. Analysen av materialet har gjorts utifrånsocialkonstruktivism och diskursens makt, i enlighet med Foucault. Resultatet avlitteraturstudien är att majoriteten av tillgängliga behandlingar för missbrukare,speciellt inom tolvstegprogrammen tillskriver beteendet fel kausalitet, dvs isubstanserna. Därför missar de att se bortom symtomen, och den underliggandeförklaringen till beroendet går förlorad tillsammans med dess lösning. / The main objective of this study is to investigate why many view addiction to alcoholand narcotics as well as sex addiction, gambling etc. as a disease, and the origins ofthis explanation. This study aims to critically look at the texts and science produced bythose who claim that addiction is a disease. The empirical material for this study ismainly that which is provided by Alcoholics Anonymous and Narcotics Anonymous.This material is compared to updated science and our knowledge regarding addictiontoday. The analysis of this material has been made using theories based in socialconstructivism and discourse analysis, as presented by Foucault. The results from mystudy is that a majority of the available treatments for addicts, especially within thetwelve-step programs seem to treat the wrong thing, i.e. the substance, and thereforefailing to see beyond the symptoms and missing the bigger picture, that is theunderlying explanations of addiction and its solution.

The Rowing Coaches is about friendship, money, love, loss, and rowing. It chronicles the turning point in the lives of three friends who are professional rowing coaches. The friends are Don Bestos, Bill Maxwell, and Bergman, men who are or were at the very top of their sport, and now question their friendships with each other and where their lives are headed. The story takes place on a weekend in the summer of 2000 at the USRowing Convention in Las Vegas, the big blow-out for everyone in the sport of rowing. The Rowing Coaches also offers a look at an esoteric and often misunderstood sport. The main character is Don Bestos, a fifty-year-old head coach from Northeastern University. Don is recently divorced and has yet to move on from the failure of his marriage. The memory of his ex-wife Annie causes him physical pain and occasionally haunts him. Don is in crisis and he questions what he has done with his life and whether he can continue with his chosen career. Don's concerns are compounded by his alcoholism. He grapples with his addiction throughout the story. Don also has a peculiar gift; upon touching certain inanimate objects, such as a boat, he can sense if the object has a soul. Don's best friend is Bergman, the obese head coach from the University of Pennsylvania. Bergman's team has been losing for years and he has lost the drive to continue as an elite rowing coach. Bergman is a loyal friend and he watches out for his friends. The one coach who appears to be on the upswing is Billy Maxwell, Don's assistant coach at Northeastern. Billy is a former Olympian and he is considered one of the rising stars in the coaching profession. Billy has been a winner at every level in the sport and he is willing to sacrifice everything to win, even friendship. Other characters include Stacy Kookla, a sociable sales representative for the top rowing boat manufacturer in the country; Andy Carr, the head coach of Yale University; and Missy Krajcik, the fastest female rower in the world.

A number of research studies have highlighted the importance of using empirically supported treatment (evidence-based practices (EBPs)) as the most effective means to reduce addiction. Even though significant federal funding has been committed to support implementation of EBPs in community-based treatment organizations (CBOs) (Glasner-Edwards & Rawson, 2010; NIDA, 2006; IOM, 2003) systematic study of the policy-components of EBP implementation is limited to date. This study examined whether the federal-funder-specific activities (measured as: recommending specific EBPs rather than promoting CBO selection of EBPs, activities associated with specific funding mechanisms, and providing training through ATTCs) were associated with staff perception of level of barriers to implementing federally-funded EBPs. Data sources included interviews with 510 clinical staff from CBOs nationwide who received SAMHSA funding (2003-2008) to implement EBPs. Bivariate analysis and regression modeling methods examined the relationship between federal-funder specific activities and three dependent variables: level of barriers experienced when implementing the EBP, level of modifications made to the EBP that was implemented, and a series of questions regarding attitudes about the usefulness of EBPs. In the regression models, the study controlled for staff, geographic and treatment unit characteristics. It also controlled for variables related to organizational capacity. Findings include: 1. whether or not federal-funders promoted the use of a specific EBP or whether the organization self-selected the EBP to implement was not significantly associated with the level of barriers experienced, the modifications made to the EBP or the attitudes about EBPs. 2. Staff receiving funding from different federal funding mechanisms was associated with reporting different levels of barriers, modifications and attitudes toward EBP implementation. 3. Finally, having received ATTC training was not significantly associated with having more positive attitudes about specific EBPs or the level of modifications or barriers to EBP implementation.

BACKGROUND: Theories suggest two motivations that drive people to consume alcohol at pathological levels: (1) seeking of short-term pleasurable effects and (2) alleviation of unpleasant states. The former is associated with binge drinking (BD; i.e. high intake during fewer occasions) and the latter with heavy drinking (HD; substantial intake during more occasions). Although direct comparisons have not been made, BD has been associated with impairments in top-down executive control (related to frontal-parietal regions) and HD has been linked to bottom-up changes in internal mentation (related to the default mode network anatomical structure and function). This dissertation compares the two drinking patterns with the goal of testing for differential neurocognitive and neuroanatomical characteristics that would be indicative of two disorder subtypes. METHODS: The sample consisted of adult participants with a history of adolescent onset: BD (N = 16), HD (N = 15), and Healthy Controls (HC; N = 21). All groups were equated on age, education, amount of lifetime alcohol consumed (BD and HD groups), as well as other factors. The study compared group performance on an affective go/no go task and group differences in brain volume and cortical thickness based on structural MRI. RESULTS: Behavioral results showed a higher number of errors for the HD group, in comparison to other groups. Volumetric results indicated a smaller bilateral ventral diencephalon in both BD and HD, in comparison to the HC, and smaller bilateral globus pallidus in BD only. Cortical thickness analyses revealed a thinner left superior parietal region (overlapping with the dorsal attention and fronto-parietal networks) in BD, whereas a left medial occipito-parietal region was thicker in HD (overlapping mainly with the visual network). CONCLUSION: These data, interpreted in the context of prior studies, suggest that BD findings might be indicative of an executive control dysregulation that could contribute to continued BD. HD findings might be indicative of tissue damage due to frequent drinking. Prior research has found the occipital region to have the highest concentration γ-Aminobutyric acid receptors that are affected by alcohol, which might explain the thicker occipital region findings in the HD group.

Alcohol use disorder (AUD) is a chronic, relapsing condition with a complex etiology and heritable susceptibility factors interact with environmental factors to produce and maintain the disease. One goal of current neuroscience research is to identify the neuroadaptations mediating the propensity to consume high amounts of alcohol, of either innate or environmental origin. Dysfunctional neuronal communication between prefrontal cortical regions and the nucleus accumbens (NAcc) have been implicated in excessive alcohol drinking and proposed to play a critical role in AUD. However, the exact mechanism by which altered prefrontostriatal transmission may perpetuate excessive drinking is poorly understood. In addition, the exact role of dopamine receptor 1 (D1R) or dopamine receptor 2 (D2R)-expressing medium spiny neurons in the NAcc is unclear and adds another layer of complexity to this framework. This thesis concerns pituitary adenylate cyclase-activating polypeptide (PACAP), a highly conserved 38 amino acid neuropeptide, and its receptor PAC1R. Studies in rodents and humans have implicated PACAP and PAC1R in the actions of drugs of abuse, including more recently, alcohol. Notably, the PACAP/PAC1R system has also been shown to increase glutamatergic neurotransmission in several circuits. The overall hypothesis of this project was that the PACAP/PAC1 system in the prefrontal cortex-NAcc pathway regulates excessive drinking and the long-lasting neuroplastic changes observed in alcohol addiction, via the modulation of the glutamatergic system. Using alcohol-preferring rats, a hereditary model of AUD, we found that intracerebroventricular administration of a PAC1R antagonist blocked excessive alcohol drinking, motivation to drink, and alcohol seeking behavior selectively in this line and not in outbred rats. Alcohol-preferring rats displayed a higher number of PAC1R positive cells in the NAcc Core. Blockade of PAC1R in the NAcc Core, via pharmacology or gene knockdown, resulted in reduced alcohol drinking. Conversely, we found that knockdown of the PAC1R in the NAcc Shell led to increased alcohol drinking and motivation to drink in alcohol-preferring rats, suggesting that the PACAP/PAC1R system may play an opposite role in these two NAcc subregions. Using a mouse exposure model of excessive drinking, a glutamatergic projection from PACAP-expressing cells in the prelimbic portion of the prefrontal cortex (PrL) to the NAcc Core circuit was found to be recruited by alcohol exposure. Inhibition of these neurons, as well as PACAP neuron ablation or PACAP deletion, led to decreased alcohol intake that was specific to male mice. Systemic PAC1R antagonism, and specific knockdown of PAC1R in the NAcc Core, also decreased alcohol intake in male mice. Using slice electrophysiology and channelrhodopsin assisted circuit mapping, we found that this pathway is biased to D1R-expressing neurons in the NAcc Core following alcohol exposure in males, and that PACAP application increases post-synaptic measures of glutamatergic transmission in this circuit. Overall, these data describe a key role for the corticostriatal PACAP/PAC1R system in aberrant alcohol drinking in both hereditary- and exposure-based models of AUD and give novel insights into the underlying mechanisms of alcohol addiction. / 2025-01-23T00:00:00Z

Partners of sex addicts report symptoms similar to those of post-traumatic stress disorder in a mental health crisis known as betrayal trauma. Behaviors that constitute sexual addiction include viewing pornography, a behavior often claimed to affect no one but the user. This article presents an analysis of 1,191 qualitative responses to an item on the Trauma Inventory for Partners of Sex Addicts (TIPSA), with particular emphasis on respondents’ self-reported disruption to relationships outside of the marriage/romantic relationship (e.g., with their children, employers, friends) following discovery of betrayal. Phenomenological analysis was conducted on participants’ responses to determine if other relationships are/are not being significantly affected. Seven themes of disruption were found, including impairment to functioning, difficulty fulfilling roles, preoccupation, loss of identity, shame, getting stuck, and moving on. A discussion is included on the implications of these findings, including the implications for therapists who work with sex addicts and their partners and recommendations for policy changes.