Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2016-08-05T14:27:22Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação_.pdf: 1522093 bytes, checksum: bb2928d81ecdfb4d866a999cf07f0b76 (MD5) / Made available in DSpace on 2016-08-05T14:27:22Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação_.pdf: 1522093 bytes, checksum: bb2928d81ecdfb4d866a999cf07f0b76 (MD5) Previous issue date: 2016-02-29 / CNPq / A escolha de uma estratégia adequada de manutenção para os sistemas produtivos de uma organização é um pré-requisito para a sua efetividade. Destaca-se que esta escolha é um processo decisório que utiliza modelos matemáticos para encontrar uma estratégia que otimize a relação custo-benefício das ações de manutenção. Tal estratégia deve levar em conta períodos para a execução das intervenções, bem como a existência de metas de produção. Embora seja comum a inclusão de paradas para manutenção entre períodos de operações dos sistemas nos planos de produção, geralmente aqueles modelos ignoram a finitude da duração de tais paradas; o mesmo acontece com relação à escassez dos recursos de manutenção. Entretanto, esses fatores restringem a quantidade de ações que podem ser executadas a cada parada e, portanto, não devem ser desprezados. Em virtude disso, é necessário identificar, dentre as ações de manutenção passíveis de serem executadas no sistema, aquelas que são críticas para seu(s) indicador(es) de performance. Isso é uma prerrogativa dos modelos de manutenção seletiva. Não obstante, a resolução desses modelos é tarefa árdua, já que problemas combinatórios necessitam de métodos heurísticos para serem solucionados. Neste trabalho, ambas as necessidades foram trabalhadas. O fim principal da investigação foi contribuir com os modelos de manutenção seletiva dedicados a sistemas orientados a múltiplas missões. Para isso, expandiu-se um modelo de manutenção seletiva voltado a sistemas orientados a multimissões e desenvolveu-se um algoritmo genético para resolver o problema. Estes foram postos à prova em uma aplicação numérica. Atestados a efetividade do método e a aplicabilidade do modelo, fez-se análises de sensibilidade e formulou-se modelos alternativos. Ainda se fez recomendações para a canalização de esforços em trabalhos futuros. No todo, a pesquisa configura-se como tendo natureza básica e aplicada, bem como caráter explicativo. Quanto à abordagem, é quantitativa e utiliza o método da modelagem e simulação. / The choice of a suitable maintenance strategy for productive systems of an organization is a requirement for its effectiveness. It is emphasized that this choice is a decision-making process that uses mathematical models to find a strategy that optimizes the cost-effectiveness of maintenance actions. This strategy must take into account periods for the implementation of assistance, as well as the existence of production goals. Although it is common to include maintenance downtime between periods of systems operations in production schedules, generally those models ignore the finite length of these stops; the same applies regarding to the shortage of maintenance resources. However, these factors constrain the number of actions that can be performed at each break and, therefore, should not be neglected. As a result, it is necessary to identify, among the maintenance actions that can be performed on the system, those that are critical to the performance indicator(s). This is a prerogative of selective maintenance models. Nevertheless, the resolution of these models is a difficult task, as combinatorial problems require heuristic methods to be solved. In this work, both requirements were addressed. The main purpose of the research was to contribute to the selective maintenance models dedicated to multiple mission’s oriented systems. For this it has been expanded a multiple mission oriented maintenance model and was developed a genetic algorithm for solving the problem. These were tested in a numerical application. Attested the effectiveness of the method and the applicability of the model, a sensitivity analysis were performed and alternative models were developed. Still it has made recommendations for concentrating efforts in future work. Overall, the research is characterized as having basic and applied nature, as well as explanatory character. As for the approach, it is quantitative and uses the modeling and simulation method.

Ce travail de thèse s’inscrit dans un contexte d’explosion des nanoparticules et de leur très grand potentiel pour des applications en cancérologie. Ainsi, deux classes de nanoparticules ont été étudiées afin de valider et de caractériser biologiquement ce potentiel. Premièrement les Nanodiamants hydrogénés (H-NDs) dont l’interaction avec les photons de l’irradiation comme générateur de stress oxidatif était au cœur du postulat physico-chimique. Nous avons non seulement validé cette hypothèse dans plusieurs lignées cellulaires de cancer du rein et du sein notamment, insensibles aux doses d’irradiation étudiées ; mais également identifié la sénescence comme étant la voie activée par le double traitement H-NDs et irradiation. Les Solides hybrides poreux sont également des matériaux prometteurs grâce à leur haut pouvoir d’encapsulation de molécules actives. Nous avons ainsi démontré l’absence de toxicité de ces composés seuls dans quatre lignées de cancer du poumon et du foie, élément essentiel avant d’envisager leur utilisation, chargés avec des principes actifs. Enfin, à l’heure où la réglementation internationale encourage le développement et l’utilisation de modèles alternatifs à l’expérimentation animale, nous avons mis au point un modèle de culture tridimensionnelle d’adénocarcinome mucosécrétant de poumon. Il est utilisé pour l’étude de la progression tumorale ainsi que pour la découverte de nouvelles molécules de chimiothérapie. / The present work focuses on nanoparticles and their great skills for oncology therapies. Two kinds of nanoparticles have been studied in order to biologically validate and characterize their features. The use of hydrogenated Nanodiamonds (H-NDs) as radio sensitizer is based on a physic-chemical postulate where they act as oxidative stress generator through interaction with irradiation. Thus we validated this hypothesis in radio resistant kidney and breast cancer cell lines and identify senescence as the main pathway after co-treatment with H-NDs and irradiation. Metal organic frameworks are also of particular interest for drug delivery because of their very important loading capacities. Here we demonstrate the biocompatibility of the empty compounds in four lung and hepatic cancer cell lines, a main point before their involvement in drug delivery strategies. Finally, following international guidelines encouraging to make animal testing more ethic, we developed a new 3D cell culture mimicking mucinous lung adenocarcinoma. This well characterized model will be used for the study of cancer development and drug screening.

<p>In 2007, at its 52nd Conference in Polokwane, the African National Congress (ANC) called for the implementation of a National Health Insurance (NHI) scheme. The announcement resulted in much debate, with critics voicing concerns about the state of the public health system, lack of consultation and the expense of a NHI scheme. However, little attention has been paid to the&nbsp / human resource (HR) needs, despite the fact that 57% of recurrent expenditure on health1 is on HR. This research aimed to identify the HR requirements to support the implementation of an effective and equitable health system funded by a NHI in South Africa. An overview of the current burden of disease and distribution of HR is provided. Through interviewing key stakeholders the study attempted to elicit information about factors which will hamper or assist in developing such a health system, specifically looking at the HR situation and needs. The research explores HR&nbsp / odels and proposes key HR requirements for implementation of a health system funded by a NHI in South Africa, including skills mix and projected numbers of health workers and&nbsp / proposes ways to improve the deficient HR situation. Exploratory qualitative research methods were used comprising in-depth individual interviews, with a purposive sample of key informants, including: public health professionals and health managers (working in rural and urban areas) / researchers / academics and NGO managers. The contents of the interviews were analysed to identify common responses about and suggestions for HR requirements within the framework of a NHI. 1 Personal communication Dr Mark Blecher, Director Social Services (Health), National Treasury, 17 July 2009 The literature review includes policy documents, position papers and articles from journals and bulletins. Key informants were asked to identify literature and research material to support recommendations. The research findings indicate that despite the South African Government&rsquo / s expressed commitment to Primary Health Care (PHC), the National Department of Health has continued to support and sustain a clinical model of health service delivery (Motsoaledi, 2010), primarily utilising doctors and nurses. The clinic based services are limited in their ability to reach community level, and, being focused on curative aspects, are often inadequate with regard to prevention, health promotion and rehabilitation services. While the curricula of health professionals have been through some changes, the training has continued to be curative in focus and the clinical training sites have not been significantly expanded to include peripheral sites. While there are many Community Health Workers in the country, they remain disorganised and peripheral to the public health system. The mid level worker category&nbsp / has not been fully explored. Finally there are no clear strategies for recruitment and retention of health workers in rural and under-resourced areas. In addition to the continued use of a clinical model, transformation of the health system hasbeen hampered by inadequate numbers of health workers, particularly in the rural and periurban townships and informal settlements. There is no clear strategy for addressing the critical&nbsp / health worker shortage in under-resourced areas, particularly rural areas. The last section makes recommendations, which will be submitted to the relevant task teams working on the NHI. It is intended that recommendations arising out of the research will influence the process and decisions about HRH within a NHI funded health system.</p>

<p>In 2007, at its 52nd Conference in Polokwane, the African National Congress (ANC) called for the implementation of a National Health Insurance (NHI) scheme. The announcement resulted in much debate, with critics voicing concerns about the state of the public health system, lack of consultation and the expense of a NHI scheme. However, little attention has been paid to the&nbsp / human resource (HR) needs, despite the fact that 57% of recurrent expenditure on health1 is on HR. This research aimed to identify the HR requirements to support the implementation of an effective and equitable health system funded by a NHI in South Africa. An overview of the current burden of disease and distribution of HR is provided. Through interviewing key stakeholders the study attempted to elicit information about factors which will hamper or assist in developing such a health system, specifically looking at the HR situation and needs. The research explores HR&nbsp / odels and proposes key HR requirements for implementation of a health system funded by a NHI in South Africa, including skills mix and projected numbers of health workers and&nbsp / proposes ways to improve the deficient HR situation. Exploratory qualitative research methods were used comprising in-depth individual interviews, with a purposive sample of key informants, including: public health professionals and health managers (working in rural and urban areas) / researchers / academics and NGO managers. The contents of the interviews were analysed to identify common responses about and suggestions for HR requirements within the framework of a NHI. 1 Personal communication Dr Mark Blecher, Director Social Services (Health), National Treasury, 17 July 2009 The literature review includes policy documents, position papers and articles from journals and bulletins. Key informants were asked to identify literature and research material to support recommendations. The research findings indicate that despite the South African Government&rsquo / s expressed commitment to Primary Health Care (PHC), the National Department of Health has continued to support and sustain a clinical model of health service delivery (Motsoaledi, 2010), primarily utilising doctors and nurses. The clinic based services are limited in their ability to reach community level, and, being focused on curative aspects, are often inadequate with regard to prevention, health promotion and rehabilitation services. While the curricula of health professionals have been through some changes, the training has continued to be curative in focus and the clinical training sites have not been significantly expanded to include peripheral sites. While there are many Community Health Workers in the country, they remain disorganised and peripheral to the public health system. The mid level worker category&nbsp / has not been fully explored. Finally there are no clear strategies for recruitment and retention of health workers in rural and under-resourced areas. In addition to the continued use of a clinical model, transformation of the health system hasbeen hampered by inadequate numbers of health workers, particularly in the rural and periurban townships and informal settlements. There is no clear strategy for addressing the critical&nbsp / health worker shortage in under-resourced areas, particularly rural areas. The last section makes recommendations, which will be submitted to the relevant task teams working on the NHI. It is intended that recommendations arising out of the research will influence the process and decisions about HRH within a NHI funded health system.</p>

Submitted by FERNANDO DE MORAES TOLLER (fmtoller@mdbrasil.com.br) on 2018-04-27T10:30:21Z No. of bitstreams: 1 DISSERTAÇÃO DE MESTRADO - TOLLER - FERNANDO DE MORAES.pdf: 1413904 bytes, checksum: 6e7e2ac853fe24092590a80cb4919d82 (MD5) / Approved for entry into archive by Jacqueline de Almeida null (jacquie@franca.unesp.br) on 2018-04-27T19:28:18Z (GMT) No. of bitstreams: 1 Toller_FM_me_fran.pdf: 1413904 bytes, checksum: 6e7e2ac853fe24092590a80cb4919d82 (MD5) / Made available in DSpace on 2018-04-27T19:28:18Z (GMT). No. of bitstreams: 1 Toller_FM_me_fran.pdf: 1413904 bytes, checksum: 6e7e2ac853fe24092590a80cb4919d82 (MD5) Previous issue date: 2018-03-09 / O presente trabalho tem por objetivo o estudo do regime da progressão continuada implantado na rede pública de ensino do Estado de São Paulo a partir do ano de 1998. Para tanto foi necessário realizar pesquisa que trata dos aspectos históricos, legais e educacionais do regime de progressão continuada e sua relação com o direito à educação e à democratização do ensino público. Outro aspecto fundamental nesta pesquisa será a análise das relações entre o regime de progressão continuada e uma política entendida como neoliberalismo com reflexos na formação de uma nova escola, mediante a racionalidade de recursos públicos proporcionados por um sistema de avaliação onde procuram-se índices baixos de retenção e de evasão escolar. Sobre o neoliberalismo, foram abordados conceitos, teorias e o processo histórico entre a política econômica neoliberal e o regime de progressão continuada. Após, o trabalho realizou análise crítica de parte da bibliografia teórico-científica sobre o regime de progressão continuada, dispondo para tanto de criteriosa classificação sobre as abordagens em relação ao citado regime, levando-se em consideração suas propostas, perspectivas e tendências teóricas. Por derradeiro, a pesquisa vai propor modelos alternativos ou proposta de aprimoramento do regime de progressão continuada. / The present study aims to study the regime of continuous progression implanted in the Public School network of the State of São Paulo since 1998. It was necessary to carry out research that deals with the historical, legal and educational aspects of the progression regime and its relationship with the right to education and democratization of public education. Another fundamental aspect in this research will be the analysis of the relations between the regime of continuous progression and a politics understood as neoliberalism with reflexes in the formation of a new school, through the rationalization of public resources provided by an evaluation system that pursues low levels of retention and low levels of school dropout. On neoliberalism, concepts, theories and the historical process between neoliberal economic policy and the regime of continuous progression were approached. Afterwards, the work carried out a critical analysis of part of the theoretical / scientific bibliography on the regime of the continuous progression, having for that reason a careful classification on the approaches in relation to the mentioned regime, taking into consideration its proposals, perspectives and theoretical tendencies. Lastly, the research proposes alternative models or ways to improve the regime of continuous progression.

Magister Public Health - MPH / In 2007, at its 52nd Conference in Polokwane, the African National Congress (ANC) called for the implementation of a National Health Insurance (NHI) scheme. The announcement resulted in much debate, with critics voicing concerns about the state of the public health system, lack of consultation and the expense of a NHI scheme. However, little attention has been paid to the human resource (HR) needs, despite the fact that 57% of recurrent expenditure on health1 is on HR. This research aimed to identify the HR requirements to support the implementation of an effective and equitable health system funded by a NHI in South Africa. An overview of the current burden of disease and distribution of HR is provided. Through interviewing key stakeholders the study attempted to elicit information about factors which will hamper or assist in developing such a health system, specifically looking at the HR situation and needs. The research explores HR odels and proposes key HR requirements for implementation of a health system funded by a NHI in South Africa, including skills mix and projected numbers of health workers and proposes ways to improve the deficient HR situation. Exploratory qualitative research methods were used comprising in-depth individual interviews, with a purposive sample of key informants, including: public health professionals and health managers (working in rural and urban areas); researchers; academics and NGO managers. The contents of the interviews were analysed to identify common responses about and suggestions for HR requirements within the framework of a NHI. 1 Personal communication Dr Mark Blecher, Director Social Services (Health), National Treasury, 17 July 2009 The literature review includes policy documents, position papers and articles from journals and bulletins. Key informants were asked to identify literature and research material to support recommendations. The research findings indicate that despite the South African Government’s expressed commitment to Primary Health Care (PHC), the National Department of Health has continued to support and sustain a clinical model of health service delivery (Motsoaledi, 2010), primarily utilising doctors and nurses. The clinic based services are limited in their ability to reach community level, and, being focused on curative aspects, are often inadequate with regard to prevention, health promotion and rehabilitation services. While the curricula of health professionals have been through some changes, the training has continued to be curative in focus and the clinical training sites have not been significantly expanded to include peripheral sites. While there are many Community Health Workers in the country, they remain disorganised and peripheral to the public health system. The mid level worker category has not been fully explored. Finally there are no clear strategies for recruitment and retention of health workers in rural and under-resourced areas. In addition to the continued use of a clinical model, transformation of the health system hasbeen hampered by inadequate numbers of health workers, particularly in the rural and periurban townships and informal settlements. There is no clear strategy for addressing the critical health worker shortage in under-resourced areas, particularly rural areas. The last section makes recommendations, which will be submitted to the relevant task teams working on the NHI. It is intended that recommendations arising out of the research will influence the process and decisions about HRH within a NHI funded health system. / South Africa