Study area, the UruS province, is located 70 km WNW of city of Ankara. Major settlements in the study area are two counties, UruS and G&uuml / d&uuml / l / and there are a number of villages, such as, from W to E, Macun, Yogunpelit, Kabaca, &Uuml / regil, &Ouml / zk&ouml / y, Tahtaci&ouml / rencik, Kirkkavak, Kavak&ouml / z&uuml / , Kayi and Karaca&ouml / ren. The study area is 189 km2 in size and included in 1/25000-scaled topographic quadrangles of H28a3, a4, d1 and d2. The G&uuml / d&uuml / l- UruS section of the &Ccedil / eltik&ccedil / i morphotectonic depression (&Ccedil / eltik&ccedil / i Basin) drained by the Antecedent Kirmir River and its second-order drainage system was first mapped in detail in the present study, and faults determining northern margin of the &Ccedil / eltik&ccedil / i depression were named as the UruS fault set comprising the SW part of the &Ccedil / eltik&ccedil / i Fault Zone / and the mechanism of the master fault of the UruS fault set was determined as left lateral oblique-slip fault with reverse component by the morphologic markers such as the deformed drainage system and pressure ridges. This was also supported by the fault plane solutions of the 2000.08.22 UruS earthquake. Three fault plane solutions, of which two of them for the 2000.08.22 UruS earthquake, and one of them for the 2003.02.27 &Ccedil / amlidere earthquake, were done to determine nature of the source. Ground material underlying the city of Ankara were divided into three categories: (a) well-lithified basement rocks, (b) Pliocene fluvio-lacustrine v sedimentary sequence, and (c) unconsolidated terrace and alluvial sediments of Quaternary age. Quaternary unconsolidated sediments are densely populated in Ankara. These sediments are fine-grained and have a maximum thickness of 200 m or more. Inside these sediments, static ground water level is very close (as on average: 6 m) to ground surface. These conditions are quite suitable for liquefaction of these unconsolidated alluvial sediments. In addition, basement rocks are full of zone of weakness. Even if, the city of Ankara is characterized by the shallow focus and small earthquakes (M&amp / #8804 / 5), it is open to the risk of large earthquakes to be sourced from the North Anatolian Fault System and the Seyfe Fault Zone located 110 km and 80 km, respectively, owing the ground material conditions beneath the city of Ankara. This point has to be taken out in constructions and site selection solution.

Dans le monde, 350 000 leucémies sont diagnostiquées chaque année. La rechute reste un problème majeur des leucémies aiguës myéloïdes (LAM) et le métabolisme oxydatif pourrait jouer un rôle essentiel dans la réponse au traitement. Un faible niveau des espèces réactives de l’oxygène (ROS) est associé à des propriétés des cellules souches leucémiques et la quiescence alors qu’un niveau plus élevé caractérise les leucoblastes proliférants. L’homéostasie des ROS repose sur un équilibre entre les systèmes oxydants et antioxydants. Les antioxydants sont bien documentés dans les LAM alors que les connaissances sur l’activité oxydante sont encore limitées. Dans ce travail nous avons choisi d’étudier les sept complexes NADPH oxydases (NOX) dans 25 lignées issues de LAM humaines et des LAM primaires. L’analyse des ARNm et des protéines montre des profils d’expression variables entre les lignées avec une expression plus forte des sous-unités du complexe NOX2 dans les lignées correspondant à des stades de différenciation myéloïde plus avancés. L’activité enzymatique des NOX est cependant équivalente entre les lignées. Deux inhibiteurs, DPI et VAS3947, ont été utilisés pour connaître la contribution des NOX à la production des ROS cellulaires. Alors qu’ils ont inhibé l’activité, ils ont aussi généré un stress oxydatif majeur conduisant à une diminution de la prolifération cellulaire et une forte apoptose, le DPI en augmentant les ROS mitochondriaux et VAS3047 les ROS cytoplasmiques. Afin de connaitre les sous-unités impliquées et de mieux comprendre les mécanismes, les sous-unités NOX2 et p22phox ont été inhibée par ARN interférence. Celle-ci n’ont pas affecté la prolifération mais ont montré des effets compensatoires. Nos data montrent qu’inhiber les NOX pourrait s’avérer une stratégie thérapeutique en augmentant le stress oxydatif dans les cellules leucémiques. / 350,000 leukaemia are diagnosed each year worldwide. In acute myeloid leukaemia (AML), relapse remains a major problem and the oxidative metabolism might play a crucial role in the therapeutic response. Low level of reactive oxygen species (ROS) is associated with properties of leukemic stem cells and quiescence whereas higher level promotes leukoblasts proliferation. ROS homeostasis relies on a tightly regulated balance between the oxidant and antioxidant systems. Although the antioxidant system is extensively studied in AML, the oxidant system remains poorly documented. In this work we aimed to study the seven NADPH oxidases (NOX) complexes in 25 AML human cell lines and primary samples. NOX transcriptional and protein profiles are variable with a higher expression of NOX2 in cell lines belonging to mature differentiation stages. An equivalent level of enzymatic activity was observed across all the cell lines. To reveal the contribution of NOX to global ROS production in the cells, two NOX inhibitors, DPI and VAS3947, were then used. Although both inhibitors efficiently blocked NOX activity they unexpectedly triggered strong oxidative stress leading to reduced cell proliferation and strong apoptosis, DPI by increasing mitochondrial ROS while VAS3947 by increasing cytoplasmic ROS production. To highlight which of the subunits were involved and to understand the mechanisms, NOX2 and p22phox subunits were inhibited using shRNA strategy. These did not affect cell proliferation but revealed a compensation effect. Our data suggest that NOX inhibition might be potential therapeutic strategy by increasing oxidative stress in leukemic cells.

A presente tese de doutorado está inserida dentro do contexto da área de AOSE – Agent-Oriented Software Engineering, uma área surgida recentemente voltada para a engenharia de software de sistemas multi-agentes que mescla conceitos tanto da Inteligência Artificial como da Engenharia de Software. Esta nova área surgiu devido aos novos desafios enfrentados pelos engenheiros de software ao projetar sistemas multi-agentes, uma vez que este tipo de sistema apresenta características que os diferenciam de outros tipos de software, precisamente o fato de possuírem agentes de software, entidades autônomas e pró-ativas que executam funções no sistema, possuidoras de objetivos próprios e capazes de perceber e agir sobre o ambiente que os cerca sem a intervenção de usuários externos. Este trabalho descreve um metamodelo UML desenvolvido para a modelagem de requisitos funcionais específicos para projetos de sistemas multi-agentes. O seu desenvolvimento baseou-se na constatação de que, apesar de já existirem linguagens derivadas da UML para o projeto de sistemas multi-agentes, nenhuma das linguagens estudadas desenvolveu mecanismos para a modelagem dos requisitos deste tipo de software, o que levou-nos a criar um metamodelo UML para este propósito. No decorrer desta tese serão descritas as linguagens estudadas derivadas da UML para ser aplicadas no projeto de sistemas multi-agentes, o metamodelo desenvolvido, sua adaptação aos princípios de projeto de Vicari (2007), três estudos de caso onde o metamodelo foi aplicado, além de uma proposta de mapeamento dos conceitos definidos no metamodelo para os conceitos das linguagens MAS-ML e AML, bem como uma proposta para a validação do metamodelo e dos diagramas criados por meio dele. / This PhD thesis is inserted within the context of the AOSE (Agent-Oriented Software Engineering) area, a recently-emerged field dealing with the software engineering of multi-agent systems which mixes concepts of Artificial Intelligence and Software Engineering together. This new area emerged from new challenges faced by the software engineers when designing multi-agent systems, since this kind of system presents characteristics that set them apart from other types of software, precisely for including software agents, autonomous and proactive entities that execute functions in the system, owning their own goals and able to perceive and act upon the surrounding environment without the intervention of external users. This work describes a UML metamodel developed for the modeling of the specific functional requirements for multi-agent systems projects. Its development was based on the perception that among the studied UML-derived languages for the multi-agent systems project, none of them had developed mechanisms for requirements modeling on this kind of software, leading us to create a UML metamodel for this purpose. Along this thesis we shall describe the UML-derived languages we studied to be applied in the multi-agent systems project, the developed metamodel, its adaptation to the Vicari (2007) design principles, three case studies on which the metamodel was applied, plus a mapping proposal for the concepts defined in the metamodel into MASML and AML languages concepts, as well as a validation proposal for the metamodel and the diagrams created by means of it.

A presente tese de doutorado está inserida dentro do contexto da área de AOSE – Agent-Oriented Software Engineering, uma área surgida recentemente voltada para a engenharia de software de sistemas multi-agentes que mescla conceitos tanto da Inteligência Artificial como da Engenharia de Software. Esta nova área surgiu devido aos novos desafios enfrentados pelos engenheiros de software ao projetar sistemas multi-agentes, uma vez que este tipo de sistema apresenta características que os diferenciam de outros tipos de software, precisamente o fato de possuírem agentes de software, entidades autônomas e pró-ativas que executam funções no sistema, possuidoras de objetivos próprios e capazes de perceber e agir sobre o ambiente que os cerca sem a intervenção de usuários externos. Este trabalho descreve um metamodelo UML desenvolvido para a modelagem de requisitos funcionais específicos para projetos de sistemas multi-agentes. O seu desenvolvimento baseou-se na constatação de que, apesar de já existirem linguagens derivadas da UML para o projeto de sistemas multi-agentes, nenhuma das linguagens estudadas desenvolveu mecanismos para a modelagem dos requisitos deste tipo de software, o que levou-nos a criar um metamodelo UML para este propósito. No decorrer desta tese serão descritas as linguagens estudadas derivadas da UML para ser aplicadas no projeto de sistemas multi-agentes, o metamodelo desenvolvido, sua adaptação aos princípios de projeto de Vicari (2007), três estudos de caso onde o metamodelo foi aplicado, além de uma proposta de mapeamento dos conceitos definidos no metamodelo para os conceitos das linguagens MAS-ML e AML, bem como uma proposta para a validação do metamodelo e dos diagramas criados por meio dele. / This PhD thesis is inserted within the context of the AOSE (Agent-Oriented Software Engineering) area, a recently-emerged field dealing with the software engineering of multi-agent systems which mixes concepts of Artificial Intelligence and Software Engineering together. This new area emerged from new challenges faced by the software engineers when designing multi-agent systems, since this kind of system presents characteristics that set them apart from other types of software, precisely for including software agents, autonomous and proactive entities that execute functions in the system, owning their own goals and able to perceive and act upon the surrounding environment without the intervention of external users. This work describes a UML metamodel developed for the modeling of the specific functional requirements for multi-agent systems projects. Its development was based on the perception that among the studied UML-derived languages for the multi-agent systems project, none of them had developed mechanisms for requirements modeling on this kind of software, leading us to create a UML metamodel for this purpose. Along this thesis we shall describe the UML-derived languages we studied to be applied in the multi-agent systems project, the developed metamodel, its adaptation to the Vicari (2007) design principles, three case studies on which the metamodel was applied, plus a mapping proposal for the concepts defined in the metamodel into MASML and AML languages concepts, as well as a validation proposal for the metamodel and the diagrams created by means of it.

A presente tese de doutorado está inserida dentro do contexto da área de AOSE – Agent-Oriented Software Engineering, uma área surgida recentemente voltada para a engenharia de software de sistemas multi-agentes que mescla conceitos tanto da Inteligência Artificial como da Engenharia de Software. Esta nova área surgiu devido aos novos desafios enfrentados pelos engenheiros de software ao projetar sistemas multi-agentes, uma vez que este tipo de sistema apresenta características que os diferenciam de outros tipos de software, precisamente o fato de possuírem agentes de software, entidades autônomas e pró-ativas que executam funções no sistema, possuidoras de objetivos próprios e capazes de perceber e agir sobre o ambiente que os cerca sem a intervenção de usuários externos. Este trabalho descreve um metamodelo UML desenvolvido para a modelagem de requisitos funcionais específicos para projetos de sistemas multi-agentes. O seu desenvolvimento baseou-se na constatação de que, apesar de já existirem linguagens derivadas da UML para o projeto de sistemas multi-agentes, nenhuma das linguagens estudadas desenvolveu mecanismos para a modelagem dos requisitos deste tipo de software, o que levou-nos a criar um metamodelo UML para este propósito. No decorrer desta tese serão descritas as linguagens estudadas derivadas da UML para ser aplicadas no projeto de sistemas multi-agentes, o metamodelo desenvolvido, sua adaptação aos princípios de projeto de Vicari (2007), três estudos de caso onde o metamodelo foi aplicado, além de uma proposta de mapeamento dos conceitos definidos no metamodelo para os conceitos das linguagens MAS-ML e AML, bem como uma proposta para a validação do metamodelo e dos diagramas criados por meio dele. / This PhD thesis is inserted within the context of the AOSE (Agent-Oriented Software Engineering) area, a recently-emerged field dealing with the software engineering of multi-agent systems which mixes concepts of Artificial Intelligence and Software Engineering together. This new area emerged from new challenges faced by the software engineers when designing multi-agent systems, since this kind of system presents characteristics that set them apart from other types of software, precisely for including software agents, autonomous and proactive entities that execute functions in the system, owning their own goals and able to perceive and act upon the surrounding environment without the intervention of external users. This work describes a UML metamodel developed for the modeling of the specific functional requirements for multi-agent systems projects. Its development was based on the perception that among the studied UML-derived languages for the multi-agent systems project, none of them had developed mechanisms for requirements modeling on this kind of software, leading us to create a UML metamodel for this purpose. Along this thesis we shall describe the UML-derived languages we studied to be applied in the multi-agent systems project, the developed metamodel, its adaptation to the Vicari (2007) design principles, three case studies on which the metamodel was applied, plus a mapping proposal for the concepts defined in the metamodel into MASML and AML languages concepts, as well as a validation proposal for the metamodel and the diagrams created by means of it.

Le CD81 est une molécule de surface appartenant à la superfamille des tetraspanines. Son rôle pronostique a été précédemment étudié dans les pathologies lymphoïdes, dont le myélome multiple où son expression est associée à un pronostic péjoratif. A ce jour, ce marqueur n'a pas été étudié dans les leucémies aiguës myéloïdes (LAM). Nous avons étudié l'expression membranaire du CD81 sur les blastes de LAM au diagnostic, son association aux autres caractéristiques des LAM et sa potentielle influence sur la survie des patients sur une cohorte de 134 patients traités par chimiothérapie intensive.Le CD81 a été retrouvé chez 92 patients sur 134 (69%). Les patients exprimant ce marqueur avaient une leucocytose initiale plus élevée (p=0.02) et présentaient une cytogénétique intermédiaire ou défavorable (p<0.001). L'expression du CD81 avait un impact négatif sur la survie des patients (survie sans évènements (EFS), survie globale (OS), survie sans rechute (RFS)) en analyse uni- (p<0.001) et multivariées (p=0.003, 0.002 and <0.001 respectivement).De plus, le CD81 avait un impact négatif sur l'OS des patients avec une mutation de NPM1 (p=0.01) et chez les patients du groupe cytogénétique favorable (p=0.002) selon la classification ELN.Les anomalies du cycle cellulaire étant associées à la chimiorésistance, la croissance tumorale et l'agressivité de la pathologie, nous avons étudié l'expression du Ki67 sur les blastes de LAM au diagnostic. Ainsi, 10 prélèvements médullaires de patients avec une faible expression du CD81 par les blastes (moins de 20% de positivité) et 10 prélèvements avec une forte expression du marqueur ont été étudiés. Nous avons pu démontrer une expression significativement inférieure du Ki67 sur les blastes CD81 positifs par rapport aux blastes CD81 négatifs (p<0.001), suggérant ainsi un rôle potentiel du CD81 dans le contrôle du cycle cellulaire. De plus, nous nous sommes intéressés au rôle du CD81 dans la chimiorésistance et sur les différentes voies de signalisation cellulaire en étudiant le profil d'expression génique.En conclusion, le CD81 semble être un nouveau marqueur pronostique des LAM ainsi qu'une cible potentielle de traitement de ces pathologies. / CD81 is a cell surface protein which belongs to the tetraspanin family. While in multiple myeloma its expression on plasma cells is associated with worse prognosis, this has not yet been explored in acute myeloid leukemia (AML). We measured membrane expression of CD81 on AML cells at diagnosis, evaluated its association with AML characteristics and its influence on patient outcome after intensive chemotherapy in a cohort of 134 patients. CD81 was detected in 92/134 (69%) patients. Patients with AML expressing CD81 had elevated leukocyte count (p=0.02) and were more likely classified as intermediate or adverse-risk by cytogenetics (p<0.001). CD81 expression had a negative impact on survival (event-free [EFS], overall [OS] and relapse-free survival [RFS]) in univariate (p<0.001) and in multivariate analyses (p=0.003, 0.002 and <0.001, respectively). CD81 has a negative impact on OS in patients with NPM1 mutation (p=0.01) and in favorable risk patients by European Leukemia Net (ELN) classification (p=0.002).Since aberrations in cell cycle signaling can cause drug resistance, tumor growth and aggressiveness we measured Ki67 on primary blast cells from AML patients. We considered 10 bone marrow samples from AML patients with either weak CD81 expression (less than 20% of blast cells) or 10 bone marrow samples with strong CD81 expression on blasts. We found a significant lower ki67 expression on blast cells from CD81 positive patients compared with those from CD81 negative patients (p<0.001), indicating a potential role of CD81 in cell cycle control. Furthermore, we investigated the role of CD81 in chemotherapy resistance and investigated potentially implicated signaling pathways by gene expression profiling.In conclusion, the cell surface marker CD81 may be a new prognostic marker for diagnostic risk classification and a new potential therapeutic target for drug development in AML.

Main focus of the thesis lies in the corporate management decision support deploying and using IT / ICT. Specific technology described is Business Activity Monitoring. The contribution of the work lies primarily in two planes. The first plane is to create as far as the most comprehensive view of the BAM. The findings are collected from different directions and areas. The first direction of research is focused on the development of Business Intelligence and description of BAM as a trend of BI, including the stages of development and projections into the future. The second direction focuses primarily on a detailed circumscribe of BAM. Its definition, deployment assumptions, basic models, the way how business can benefit from BAM usage. The third guideline shows the classification of BAM surrounded by the other / similar technologies and business solutions -- BI and BSM, and the search key differences. The second level of the work is to support the AML implementation in a specific environment of banks using BAM. This is a practical demonstration of the possibility of using BAM in practice. Basic design solution lies in the analysis of risks arising from the law and the current state of the solution. By mapping of banking processes and searching for points of risk it is then possible to deploy these risks BAM tools for their management. Motion of support lies mainly in conceptual terms.

The diploma thesis aims to the problem of money laundering in Czech's law. At the beginning are explained the most frequent terms that are used in this work. The next part is dedicated to the analysis of law environment, institutions and international treaties. The last part contains information about actual methods used in legitimization of the proceeds. The aim of the thesis is to analyze methods of money laundering used in present and assess the quality of instruments used against it in the Czech Republic.

This dissertation examines a bank’s right to unilaterally terminate its contractual relationship with a customer on the basis of reputational risk. The law of contract allows a bank to terminate the bank-customer agreement when the customer is in serious breach of the contract. Over the years, however, a pattern has started to develop by which a bank can unilaterally terminate the bank-customer relationship of high-risk customers based on reputational risk. Banks are reluctant to facilitate the transactions of individuals surrounded by negative publicity, due to fears of how the bank’s investors, customers or counterparts might perceive the bank. Compliance with anti-money laundering (AML) and counter financing of terrorism (CFT) requirements, as set out by both domestic and foreign legislation, results in higher costs for the bank. As such, the profitability of a particular bank-customer relationship may ultimately decline to such an extent that the bank rather decides to make an appropriate business decision by terminating the relationship. Correspondent banking relationships are agreements in terms of which one bank will provide services for another in jurisdictions where the first bank lacks a physical presence. As such, whenever there is a perception that a local bank does not comply with the relevant AML/CFT laws as set out by its domestic legislation, the correspondent bank might decide to terminate its relationship with the local bank, leaving the latter financially excluded from the correspondent banking market. Such a situation would hinder the growth of the South African economy and may also cause a systemic event in the financial industry. Adequate customer due diligence (CDD) measures assist a bank in formulating a clear understanding of the business of its customers. The information obtained through CDD may also assist the bank in determining the reputation of a particular customer. This information can also assist law enforcement in combatting financial crimes. In this regard, it is recommended that a bank should be able to trace the information that was shared with Financial Intelligence Units (FIUs) and law enforcement agencies, so that the bank may reasonably determine the level of reputational risk involved in the relationship. / Mini Dissertation (LLM)--University of Pretoria, 2020. / Mercantile Law / LLM / Unrestricted

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