abstract: The analysis of clinical workflow offers many challenges to clinical stakeholders and researchers, especially in environments characterized by dynamic and concurrent processes. Workflow analysis in such environments is essential for monitoring performance and finding bottlenecks and sources of error. Clinical workflow analysis has been enhanced with the inclusion of modern technologies. One such intervention is automated location tracking which is a system that detects the movement of clinicians and equipment. Utilizing the data produced from automated location tracking technologies can lead to the development of novel workflow analytics that can be used to complement more traditional approaches such as ethnography and grounded-theory based qualitative methods. The goals of this research are to: (i) develop a series of analytic techniques to derive deeper workflow-related insight in an emergency department setting, (ii) overlay data from disparate sources (quantitative and qualitative) to develop strategies that facilitate workflow redesign, and (iii) incorporate visual analytics methods to improve the targeted visual feedback received by providers based on the findings. The overarching purpose is to create a framework to demonstrate the utility of automated location tracking data used in conjunction with clinical data like EHR logs and its vital role in the future of clinical workflow analysis/analytics. This document is categorized based on two primary aims of the research. The first aim deals with the use of automated location tracking data to develop a novel methodological/exploratory framework for clinical workflow. The second aim is to overlay the quantitative data generated from the previous aim on data from qualitative observation and shadowing studies (mixed methods) to develop a deeper view of clinical workflow that can be used to facilitate workflow redesign. The final sections of the document speculate on the direction of this work where the potential of this research in the creation of fully integrated clinical environments i.e. environments with state-of-the-art location tracking and other data collection mechanisms, is discussed. The main purpose of this research is to demonstrate ways by which clinical processes can be continuously monitored allowing for proactive adaptations in the face of technological and process changes to minimize any negative impact on the quality of patient care and provider satisfaction. / Dissertation/Thesis / Doctoral Dissertation Biomedical Informatics 2018

Thesis. 1976. M.S.--Massachusetts Institute of Technology. Dept. of Aeronautics and Astronautics. / Microfiche copy available in Archives and Aero. / Includes bibliographical references. / M.S.

Este trabalho tem por objetivo apresentar novos desenvolvimentos e a evolução do conceito de manobras de paralelismo entre alimentadores aéreos primários de distribuição, bem como os efeitos eletromagnéticos provocados por manobras em tempo real, visando a segurança operacional dos equipamentos e operadores de campo. São apresentadas propostas para fechamento de subestações transformadoras de transmissão em anel, através de alimentadores aéreos primários, além de algoritmo simplificado para a operação e despacho do sistema. Uma nova metodologia de operação em tempo real foi desenvolvida através de algoritmo de viabilidade usando dados do SCADA (Supervisory Control and Data Acquisition). Esta metodologia de operação oferece algumas vantagens como o restabelecimento de cargas interrompidas, o isolamento de trechos defeituosos na rede de distribuição aérea, bem como o atendimento de serviços programados no sistema elétrico de potência. Para essa metodologia é feita uma análise das grandezas elétricas e capacidades dos equipamentos envolvidos, bem como dos ajustes e parâmetros dos dispositivos de proteção, de forma a obter sucesso na operação da rede em tempo real. O estudo foi baseado em manobras reais em alimentadores aéreos de distribuição da AES Eletropaulo. A validação do modelo que direcionou para o sucesso das manobras em tempo real foi baseada principalmente em simulações de transitórios eletromagnéticos, fluxo de carga e curto-circuito através dos programas ATP e CYMDIST. / This work aims to present new developments and the evolution of the parallelism switch operation concept among distribution primary overhead feeders, as well as the electromagnetic effects caused by switch operations in real time, in order to keep field operators and equipments in safety. Hereby are presented some proposals for closed-loop arrangement between two power transmission substations through overhead feeders and a simplified algorithm for the system\'s operation and dispatch as well. A new real time operation methodology was developed through viability algorithm using the SCADA\'s (Supervisory Control and Data Acquisition) database. This operation methodology offers some advantages such as restoration of interrupted loads, isolation of the faulty section in the overhead distribution network as well as scheduled services. For this methodology was made an analysis of the electric magnitudes and of the involved equipment capabilities, as well as the protection devices\' adjustments and parameters, so as to obtain successful in real time operation. The study was based on actual switch operations over the distribution overhead feeders of AES Eletropaulo. The validation of the model that drove to the real time switch operations success was mainly based on electromagnetic transients simulations, load flow and short-circuit in ATP (Alternative Transient Program) and CYMDIST softwares.

This thesis describes the development of the real-time convolution system (RTCS) for a little-studied talker/listener in virtual acoustic environments. We include descriptions of the high-resolution directivity measurements of human speech, the RTCS system components, the measurement and characterization of oral-binaural room impulse responses (OBRIRs) for a variety of acoustic environments, and the compensation filter necessary for its validity. In addition to incorporating the high-resolution directivity measurements, this RTCS improved on that developed by Cabrera et al. [1] through the derivation and inclusion of the compensation filter. Objective measures in the time- and frequency-domains, as well as subjective measures, were developed to asses the validity of the RTCS. The utility of the RTCS is demonstrated in the study on vocal effort, and the results of an initial investigation into the vocal effort data are presented.

No description available.

In the agricultural state of Iowa, water quality research is of great importance for monitoring and managing the health of aquatic systems. Among many water quality parameters, water temperature is a critical variable that governs the rates of chemical and biological processes which affect river health. The main objective of this thesis is to develop a real-time high resolution predictive stream temperature model for the entire state of Iowa. A statistical model based solely on the water-air temperature relationship was developed using logistic regression approach. With hourly High Resolution Rapid Refresh (HRRR) air temperature estimations, the implemented stream temperature model produces current state-wide estimations. The results are updated hourly in real-time and presented on a web-based visualization platform: the Iowa Water Quality Information System, Beta version (IWQIS Beta). Streams of 4th order and up are color-coded according to the estimated temperatures. Hourly forecasts for lead time of up to 18 hours are also available. A model was developed separately for spring (March to May), summer (June to August), and autumn (September to November) seasons. 2016 model estimation results generate less than 3 °C average RMSE for the three seasons, with a summer season RMSE of below 2 °C. The model is transferrable to basins of different catchment sizes within the state of Iowa and requires hourly air temperature as the only input variable. The product will assist Iowa water quality research and provide information to support public management decisions.

Das humanes WU Polyomavirus wurde im Jahr 2007 als ein neues Virus in Proben des Respirationstraktes beschrieben und gehört zur Familie der Polpymaviridae. Das Ziel der Arbeit war es, eine WUPyV-rea-time-PCR zu etablieren und zu evaluieren und mit dieser neuen Methode WUPyV-DNA in Nasenrachenskreten (NRS) zu detektieren und zu quantifizieren. Insgesamt wurden 1232 NRS von Patientin mit akuten respiratoischen Erkrankungen, die an der Universitätskinderklinik Würzburg im Zeitraum von Januar 2002 bis September 2005 und Januar 2007 bis July 2007 stationär behandelt worden waren, auf WUPyV-DNA getestet. Zusätzlich wurden 14 Serum- und 14 Stuhlproben von Kindern mit WUPyV-DNA-pos. NRS getestet. Mit der real-time PCR wurde WUPyV-DNA in 5,2 % der 1232 NRS detektiert. Der Viruslastmedian aller WUPyV-positiven NRS betrug 950 Kopien/m. Neben einigen sehr hohen Viruslasten (4,7 % > E9 Kopien/ml) wurden vor allem niedirge Viruslaten (51,6 % < 1000 Kopien/ml) mit der WUPyV-real-time PCR nachgewiesen. Es ergaben sich keine statistisch signifikanten Zusammenhänge zwischen der Viruslast und der Koinfektionen mit anderen respiratorischen Viren, mit klinischer Diagnose, mit dem Alter der infizierten Kinder und mit dem jahreszeitlichen Auftreten. In 3 der 14 Serum und 2 der 14 Stuhlproben konnte WUPyV-DNA detektiert werden. Virämische Kinder hatten tendenzen zu höhrer Viruslast im NRS.Weitere Studien sind notwendig um die pathogenetische Relevanz des WUPyV für den Menschen zu untersuchen. Die in dieser Arbeit etablierte real-time PCR zur WUPyV-Quantifizierung kann dabei zur Anwendung kommen. / The human WU polyomavirus (WUPyV) has been recently described as a novel virus in respiratory tract samples. To investigate the viral load of WUPyV in nasopharyngeal aspirates (NPA´s), stool samples, and serum samples of pediatric patients with acute respiratory tract diseases, obtained between 2002 and 2007, we etablished a real-time PCR for WUPyV DNA. WUPyV was found in 5,2 % of 1232 NPA. The median viral load in the NPA was 950 copies/ml (maximun: 3.4 E10 copies/ml). The WUPyV load in NPA was neither associated wtih the coinfection status nor with the clinical diagnoses. WUPyV was found in 3 of 14 serum samples and 2 of 14 stool samples. The WUPyV load in NPA tended to be hihger in viremic children. Further stuies are necessary to determine whether WUPyV is a human pathogen.

Processing real-world data requires the ability to analyze data in real-time. Data processing engines like Hadoop come short when results are needed on the fly. Apache Spark's streaming library is increasingly becoming a popular choice as it can stream and analyze a significant amount of data. To showcase and assess the ability of Spark various metrics were designed and operated using data collected from the USGODAE data catalog. The latency of streaming in Apache Spark was measured and analyzed against many nodes in the cluster. Scalability was monitored by adding and removing nodes in the middle of a streaming job. Fault tolerance was verified by stopping nodes in the middle of a job and making sure that the job was rescheduled and completed on other node/s. A full stack application was designed that would automate data collection, data processing and visualizing the results. Google Maps API was used to visualize results by color coding the world map with values from various analytics.

Fieldbuses are defined as a family of communication media specified for industrial applications. They usually interconnect embedded systems. Embedded systems exist everywhere in the modern world, they are included in simple personal technology as well as the most advanced spaceships. They aid in producing a specific task, often with the purpose to generate a greater system functionality. These kinds of implementations put high demands on the communication media. For a medium to be applicable for use in embedded systems, it has to reach certain requirements. Systems in industry practice react on real-time events or depend on consistent timing. All kinds are time sensitive in their way. Failing to complete a task could lead to irritation in slow monitoring tasks, or catastrophic events in failing nuclear reactors. Fieldbuses are optimized for this usage. This thesis aims to research fieldbus theory and connect it to industry practice. Through interviews, requirements put on industry are explored and utilization of specific types of fieldbuses assessed. Based on the interviews, guidelines are put forward into what fieldbus techniques are relevant to study in preparation for future work in the field. A discussion is held, analysing trends in, and synergy between, state of the art and the state of practice. A strong momentum is identified. The traditional communication media Ethernet, not originally intended for time-sensitive industry appliances, are expanding throughout the field, both in research and, maybe most interestingly, in practice. It is mainly motivated through qualities of somewhat lesser technical significance. A plethora of methods have emerged trying to optimize Ethernet for real-time purposes, each one resulting in some drawbacks, which are in turn addressed. In the end of this paper, the large-scale trend of Real-Time Ethernet is questioned and discussed.

Seafood substitution is a worldwide problem due to factors such as limited monitoring coupled with complex supply chains. Red snapper (Lutjanus campechanus) is a highly valued and overfished species that is commonly substituted with other fish, such as tilapia, rockfish, and other snapper species. DNA barcoding is typically used by regulatory agencies to detect seafood substitution; however, it is expensive and time-consuming. A rapid, real-time PCR assay targeting red snapper was developed previously for use in fisheries management; however, it has not been tested for its ability to detect red snapper species substitution. The objective of this study was to assess the ability of the real-time PCR assay to identify red snapper fillets and differentiate red snapper from common substitute fish species in combination with DNA barcoding. A total of 21 fresh/frozen fillets labeled as “red snapper” were tested with real-time PCR, along with 57 fresh/frozen fillets representing 15 of the most common categories of fish mislabeled as red snapper. All samples were tested with DNA barcoding to confirm the identity of fish species. Real-time PCR parameters were optimized to reduce background signals associated with cross-reactivity. Overall, real-time PCR identified 4 samples as red snapper: 3 were authenticated as red snapper with DNA barcoding and 1 was identified as mahi-mahi. Overall, 40% of all samples and 91% of “red snapper” samples were considered mislabeled according to DNA barcoding. Red snapper was substituted with other snapper species (e.g., Lutjanus malabaricus, Lutjanus peru, Ocyurus chrysurus, and Rhomboplites aurorubens), rockfish (Sebastes flavidus and Sebastes brevispinis), sea bream (Pagrus major/Pagrus auratus), and mahi-mahi (Coryphaena hippurus). The real-time PCR assay tested in this study can serve as a rapid screening test for the detection of mislabeled species, which can then be confirmed with sequencing techniques. This species identification technique has the potential to be used by regulatory agencies to rapidly determine the authenticity of red snapper on-site.