- About
-
The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 301 to 310 of 1132 (0.034 seconds)Spelling suggestions: "subject:"angiogenesis"" "subject:"ngiogenesis""
| 301 |
Extracellular vesicles secreted from bone metastatic renal cell carcinoma promote angiogenesis and endothelial gap formation in bone marrow in a time-dependent manner in a preclinical mouse model / 骨転移指向性腎細胞癌由来の細胞外小胞は前臨床モデルにおいて時間依存性に骨髄での血管新生、血管内皮ギャップ形成を促進するTakeda, Masashi 24 July 2023 (has links)
京都大学 / 新制・課程博士 / 博士(医学) / 甲第24840号 / 医博第5008号 / 新制||医||1068(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 藤田, 恭之, 教授 松田, 道行, 教授 柳田, 素子 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
|
| 302 |
Ponatinib-induced Cardiac Toxicity is Mediated by Impaired AngiogenesisAltiokka, Imran 01 January 2023 (has links) (PDF)
Ponatinib is a third-generation tyrosine kinase inhibitor approved for Chronic Myelogenous Leukemia and Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia and it is the only tyrosine kinase inhibitor able to bind T315I mutation of BCR-ABL1 (Breakpoint Cluster Region and Abelson1) kinase protein. However, the cardiotoxic adverse reactions related to Ponatinib treatment can result in serious health problems and discontinuation of the therapy. The underlying mechanisms of Ponatinib-induced cardiotoxicity are not known. This study hypothesized that Ponatinib downregulates leptin and serpine-1 expressions and inhibits angiogenesis through the adipokine-induced p38 MAPK signaling pathway in mouse hearts. To evaluate this proposed pathway C57BL/6J mice were divided into two groups: control and ponatinib. After 14 days of the injections, mice were sacrificed and the heart samples were collected for histological analysis and evaluation of mRNA and protein expression levels. The RNA sequence analysis of heart samples was used to detect the main angiogenic markers affected by the treatment. Further analysis was done by Western Blot, RT-PCR, and immunohistochemistry. The heart function was assessed by echocardiography. Overall, the data indicated that the angiogenic response was inhibited by Ponatinib treatment through leptin and serpine-1-mediated p38 MAPK pathway. The anti-angiogenic response is an important underlying pathological mechanism that could lead to disruption of heart function and the echocardiography data confirmed that ponatinib-treated mice showed impaired heart function. Our study suggested that the potential underlying mechanism of Ponatinib-induced cardiotoxicity can be explained by serpine-1 and leptin-mediated angiogenic pathways.
|
| 303 |
Oxygen Sensing, Hypoxia Inducible Factor 1 (HIF-1) Expression, and Hypoxia-Induced Angiogenesis in the Aged Rat BrainNdubuizu, Obinna I. January 2011 (has links)
No description available.
|
| 304 |
The Role of CD36 in Thrombospondin-1 Mediated Antiangiogenesis: A Study of Regulation of CD36 Ecto-phosphorylation and Mechanisms of VEGF InhibitionChu, Ling-yun 22 May 2012 (has links)
No description available.
|
| 305 |
The Mechanisms of Carboxyalkylpyrrole Induced AngiogenesisWest, Xiaoxia Z. 19 June 2012 (has links)
No description available.
|
| 306 |
A novel peptide derived from the functional domain of AGGF1 has anti-angiogenic activityPasupuleti, Vinay 19 July 2011 (has links)
No description available.
|
| 307 |
Crim1 Maintains Retinal Vascular Stability during Development by Regulating Endothelial Cell Vegfa Autocrine SignalingFan, Jieqing 28 October 2014 (has links)
No description available.
|
| 308 |
Synthesis and Characterization of Novel Inorganic Nanoparticles for Diagnostic and Therapeutic ApplicationsPerera, Vindya S. 18 November 2014 (has links)
No description available.
|
| 309 |
Transcriptional Regulation of Developmental and Tumor-Induced Angiogenesis by Etv2 and Fli1bCraig, Michael P. 02 June 2015 (has links)
No description available.
|
| 310 |
The Ron Receptor Tyrosine Kinase in Prostate CancerThobe, Megan 06 August 2010 (has links)
No description available.
|
Page generated in 0.0391 seconds