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no / A breakthrough theory that tools and technology are the real drivers of human evolution. Although humans are one of the great apes, along with chimpanzees, gorillas, and orangutans, we are remarkably different from them. Unlike our cousins who subsist on raw food, spend their days and nights outdoors, and wear a thick coat of hair, humans are entirely dependent on artificial things, such as clothing, shelter, and the use of tools, and would die in nature without them. Yet, despite our status as the weakest ape, we are the masters of this planet. Given these inherent deficits, how did humans come out on top?

Great ape gesture is an elaborate, flexible system of intentional communication. It has been suggested that human language originated in gesture, thus, the gestural communication of great apes is of great interest for questions on the origin of language. To date, systematic studies of great ape gesture have been limited to restricted captive settings, supplemented by the study of a few specific gestures in wild populations. To address questions about gestural communication from an evolutionary perspective it is necessary to extend the systematic study of gesture into a wild ape population. I therefore undertook a 22-month study of gesture in the wild Sonso chimpanzee community in Budongo, Uganda. Sonso chimpanzees employ a large repertoire of species-typical gestures in intentional communication; a proportion of this repertoire appears to be ape-typical, as would be expected with a biologically given trait. Chimpanzees can acquire new behavioural patterns through imitation; however, this apparently does not represent a significant means of acquiring gestures. Gesturing was employed regularly in an intentional manner from the end of the first year, and was used by chimpanzees of all ages to communicate across a range of contexts, including the evolutionarily urgent context of consortship. Immature chimpanzees used a wide range of gestures, which they combined into rapid sequences. With maturity, use of the repertoire was ‘tuned’ to focus on the most effective gestures, which were then used individually. Despite the evidence for referential pointing in captive chimpanzees, there was little evidence for the regular use of it in wild chimpanzees. Gestures were used to communicate a range of imperative requests that regulated social behaviour. Chimpanzee gestures vary from the ambiguous to the highly specific in meaning; and, while gestures were used flexibly, they tended to be associated with a single dominant meaning.

The mitochondrial control region (MCR) has played an important role as a population genetic marker in many taxa but sequencing of complete eukaryotic genomes has revealed that nuclear integrations of mitochondrial DNA (numts) are abundant and widespread across many taxa. If left undetected, numts can inflate mitochondrial diversity and mislead interpretation of phylogenetic relationships. Comparative analyses of complete genomes in humans, orangutans and chimpanzees, and preliminary studies in gorillas have revealed high numt prevalence in great apes, but rigorous comparative analyses across taxa have been lacking. The present study aimed to systematically compare the evolutionary dynamics of MCR numts in great apes. Firstly, an inventory numts derived from the region containing the MCR subdomains was carried out by genomic BLAST searches. Secondly, presence/absence of each candidate numt was determined in great ape taxa to estimate numt insertion rate. Thirdly, alternative mechanisms of numt insertion, either through direct mitochondrial integration or post-insertional duplications, were also assessed. Fourthly, the effect of nuclear and mitochondrial environment on patterns of nucleotide composition and substitution was assessed through sequence comparisons of nuclear and mitochondrial paralogous sequences. Finally, numts in the gorilla genome were identified through two experimental methods and their use as polymorphic genetic markers was then evaluated in a sample of captive gorillas from U.S. zoos. A deficit of MCR numts covering two particular mitochondrial subdomains was detected in all three apes examined, and is largely attributed to rapid loss of mitochondrial and nuclear sequence identity in the mitochondrial genome. Insertion rates have varied during the great ape evolution and exhibit substantial differences even between related taxa. The most likely mechanism of numt insertion is direct mitochondrial integration through Non-Homologous-End-Joining Repair. Transition/transversion ratios differed significantly between both mitochondrial and nuclear sequences and between numts from coding and non-coding mitochondrial regions. A previously documented upward bias in the GC content of the primate mitochondrial genome was confirmed and the extent of this bias relative to the corresponding numt sequences increased with numt age. Five gorilla-specific numts were isolated, including three exhibiting insertional polymorphisms that will be used in future population genetic studies in free-range gorilla.

Im Rahmen dieser vorliegenden Arbeit soll untersucht werden, welche Möglichkeiten zur Sicherung einer möglichst hohen Verfügbarkeit (High-Availability), Mechanismen zur Lastverteilung mittels des ZEO-Produkts oder ähnlichem sowie welche Strategien des Cachings sinnvoll an einem ZOPE-Server zum Einsatz kommen können. Die Arbeit untersucht dabei die Einsatzmöglichkeiten von bereits vorhandenen und die eventuelle Notwendigkeit der Eigenimplementierung weiterer Produkte der ZOPE-Entwicklung. Den Rahmen der Arbeit bildet die Serverstruktur des Bildungsmarktplatzes Sachsen.

Cette thèse propose une évaluation des effets potentiels de l’Accord de partenariat économique (APE) entre l’Union européenne (UE) et l’Afrique de l’Ouest sur l’agriculture et les ménages sénégalais. En effet, après plus de 12 ans de discussions, la Communauté Économique des États de l’Afrique de l’Ouest (CEDEAO) dans sa majorité a signé l’APE avec l’UE, le volet commercial de l’Accord de Cotonou. L’APE est ainsi devenu le nouveau cadre de coopération économique et commercial entre l’UE et le Sénégal avec l’établissement à terme d’une zone de de libre-échange réciproque entre l’UE et les pays ACP, cependant asymétrique et mettant ainsi fin au régime des conventions de Lomé, qui était basé sur les préférences commerciales non réciproques. Cette étude est basée sur le modèle d’équilibre général calculable (MEGC) uni-pays développé par Bouët et al (2001). Il s’agit à la base d’un modèle statique avec l’hypothèse de concurrence parfaite et non monétaire qui décrit une petite économie ouverte comme le Sénégal. En effet, le Sénégal est un pays en développement importateur net de produits alimentaires et très dépendant du commerce international notamment pour couvrir ses besoins alimentaires. Ce MEGC a été enrichi par l’introduction de l’approche théorique « Dual-Dual » élaborée par Stifel et Thorbecke (2003) pour tenir compte des spécificités de la plupart des économies africaines comme le Sénégal notamment un secteur informel très développé et la migration rural-urbain d’une part et d’autre part parce que la quasi-totalité des MEGC utilisés pour étudier l’économie sénégalaise n’intègre pas ces aspects structurels. De plus, pour bien prendre en compte l’APE dans nos simulations nous avons rajouté deux étages au niveau des exportations et des importations pour bien distinguer les origines/destinations CEDEAO et UE. Le modèle utilisé est calibré sur une matrice de comptabilité sociale (MCS) pour l’année 2006 construite dans le cadre de cette thèse. Pour appréhender les effets sur les ménages, trois enquêtes ménages ont été utilisées pour identifier 78 ménages représentatifs. Pour les données tarifaires, le nouveau tarif extérieur commun de la CEDEAO (TEC CEDEAO) en vigueur depuis le 1er janvier 2015 a été utilisé. Les résultats ont révélé que l’APE est une réforme commerciale qui n’offre pas des perspectives de gains réels pour le Sénégal car elle implique essentiellement une ouverture de l'économie sénégalaise aux seuls produits européens et n'améliore pas l'accès de l'économie sénégalaise aux économies du reste du monde. Sur le plan des analyses de bien-être, l’APE ne permet pas de réduire la pauvreté et les inégalités / This PHD thesis proposes an assessment of the potential effects of the Economic Partnership Agreement (EPA) between the European Union (EU) and West Africa on Senegalese agriculture and households. Indeed, after 12 years of negotiations, the Economic Community of West African States (ECOWAS) in its majority signed the EPA with the EU, the trade component of the Cotonou Agreement. Thus, the EPA has become the new framework for economic and trade cooperation between the EU and Senegal. The objective to the end is the establishment of a reciprocal free trade area between the EU and ACP countries, however asymmetrical and putting an end to the Lome Agreement, which was based on non-reciprocal trade preferences. This study is based on the Single country computable general equilibrium model (CGE) developed by Bouët et al (2001). It is a static model with the assumption of perfect competition and non-monetary, which describes a small open economy such as Senegal. Indeed, Senegal is a net food-importer developing country and very dependent on international trade specially to cover its food needs. This CGE was enriched by the introduction of the "Dual-Dual" theoretical approach developed by Stifel and Thorbecke (2003) to reflect the specificities of most African economies like Senegal i.e. a large informal sector and migration rural-urban firstly and secondly because almost all the CGE models used to study the Senegalese economy does not incorporate these structural aspects. In addition, to better capture the EPA in our simulations we added two stages in exports and imports modelling to distinguish the origins / destinations ECOWAS and EU. The model is calibrated on a 2006 Social Accounting Matrix (SAM) built as part of this thesis. To understand the effects on households, three household surveys were used to identify 78 representative households. For tariff data, the new ECOWAS Common External Tariff (ECOWAS CET) launched on January 1st 2015 was used. The results revealed that the EPA is a trade reform that offers no real earnings prospects for Senegal because it essentially implies openness of the Senegalese economy only to European products and does not improve the access of Senegalese economy to other economies of the World. In terms of welfare analysis, the EPA did not reduce poverty and inequality.

As a result of drastically improved machine translation quality in recent years, machine translation followed by manual post-editing is currently a trend in the language industry that is slowly but surely replacing manual translation from scratch. In this thesis, the applicability of machine translation to product descriptions of clothing items is studied. The focus lies on determining whether automatic post-editing is a viable approach for improving baseline translations when new training data becomes available and finding out if there is an existing quality estimation system that could reliably assign quality scores to machine translated texts. It is shown that machine translation is a promising approach for the target domain with the majority of systems experimented with being able to generate translations that on average are of almost publishable quality according to the human evaluation carried out, meaning that only light post-editing is needed before the translations can be published. Automatic post-editing is shown to be able to improve the worst baseline translations but struggles with improving the overall translation quality due to its tendency to overcorrect good translations. Nevertheless, one of the trained post-editing systems is still rated higher than the baseline by human evaluators. A new finding is that training a post-editing model on more data using worse translations leads to better performance compared to training on less but higher-quality data. None of the quality estimation systems experimented with shows a strong correlation with human evaluation results which is why it is suggested not to provide the confidence scores of the baseline model to the human evaluators responsible for correcting and approving translations. The main contributions of this work are showing that the target domain of product descriptions is suitable for integrating machine translation into the translation workflow, proposing an approach for that translation workflow that is more automated than the current one as well as the finding that it is better to use more data and poorer translations compared to less data and higher-quality translations when training an automatic post-editing system.

付記する学位プログラム名: 霊長類学・ワイルドライフサイエンス・リーディング大学院 / 京都大学 / 新制・課程博士 / 博士(理学) / 甲第23054号 / 理博第4731号 / 新制||理||1678(附属図書館) / 京都大学大学院理学研究科生物科学専攻 / (主査)准教授 足立 幾磨, 准教授 後藤 幸織, 教授 高田 昌彦 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM