In this dissertation, three experiments were conducted that examined the influence of task demands on manual asymmetries for the performance of reaching movements to tools. In all three experiments, the difference between the hands (in terms of preference for Experiment 1 and performance for Experiments 2 and 3) was studied in response to varying task demands for grasping movements to tools. In the first experiment, 82 right-handed and 60 left-handed university students performed reaching movements to tools and dowels at five positions within working space. Differences in the reaching patterns of the left and right hands to the tools and dowels were examined, as well as the effect of task demands (lift, use) and type of object (tool, dowel) on the reaching patterns. Dowels were used in order to examine if participants would treat a neutral object as if it were a tool in terms of their reaching patterns in working space. Results confirmed and extended prior research on the influence of task demands on reaching patterns within working space. Overall, there were more similarities in the general reaching patterns of left- and right-handed participants than differences. However key differences between the handedness groups emerged in the treatment of the dowel and the frequency of switches (reaching to lift the object with the non-preferred hand and transferring it to the preferred hand to use). Results also showed that tools enjoy a privileged association with the preferred hand, and that the intent of the movement has a very real goal on movement planning. The first experiment examined patterns of hand use across working space in response to differing task demands. In the next experiments performance differences between the hands in terms of movement planning and initiation were examined through the use of reaction time and movement time. In these experiments, reaction time represented the time from the presentation of a go signal to when the participant first lifted their hand, and movement time was the time between lifting the hand to lifting a tool off a sensor. Movement time represented the time to pick up the tool, and did not include the time to use the tool to perform a particular task and complete the reaching movement. In the second experiment, reaction time and movement time to tools placed at the midline position were examined under varying degrees of advance information using a precue paradigm. Three precue conditions were used which presented advance information on the hand to use to perform the movement (left or right) and/or the task (lift, use, or pantomime) to be performed: (1) both hand and task were cued in advance (Both precue); (2) task only was cued in advance (Task precue); and (3) neither hand nor task were cued in advance (No precue). Twenty-four right-handed university students performed reaching movements to tools under the three different precue conditions. The results of Experiment 2 showed that reaction time was sensitive to the amount of advance information presented in the precue. For reaction time manual asymmetries were observed in one condition only – a right hand advantage was present in the No precue condition. In contrast manual asymmetries in favor of the right hand were clearly observed with the movement time results. Experiment 2 was the first experiment reported in the literature to systematically examine reaction time for reaching and grasping movements to tools. In order to further explore these results, in Experiment 3 a fourth precue condition (in which the hand to be used was cued in advance; the Hand precue) was added to the precue paradigm used in Experiment 2. An additional variable called replacement time, which represented the time spent interacting with the tool, was also examined. Forty-two right-handed university students participated in Experiment 3. The results of Experiment 3 largely replicated the findings of Experiment 2, and indicated that both the amount and type of precue information had an effect on reaction time. The addition of the Hand precue condition suggested that having advance knowledge of the hand to be used to perform the task was of greater importance for movement planning than was advance knowledge of the task to be performed. Regarding the movement time results, Experiment 3 was one of the first experiments to show the influence of task demands on the magnitude of manual asymmetries. The lack of differences between the hands for the replacement time results also suggested that the initial execution of the movement (represented by movement time) was most sensitive to manual asymmetries. Overall, these experiments provided further insight into manual asymmetries for the performance of reaching movements, and illustrated how simple manipulations of task demands led to differences between the hands in measures of both preference and performance when interacting with tools.

This thesis explores the various discursive strategies that black women employ when they encounter street harassment from men. To investigate the ways in which these women choose to respond to men’s attention during social interactions, I examine their perception of social situations to understand how they view urban spaces and strangers within these spaces. Drawing on qualitative interviews that I conducted with 10 black women, I focus on how the unique convergence of this group’s racial and gender identities can expose them to sexist and racist street harassment. Thus, I argue that black women face street harassment as a result of gendered and racialized power asymmetries. I found that black women rely on a variety of discursive strategies, including speech and silence, to neutralize and negotiate these power asymmetries. They actively resist reproducing racialized and gendered sexual stereotypes of black women by refusing to talk back to men who harass. Understanding silence as indicative of black women’s agency, not oppression, remains a key finding in this research.

Faraday modulation spectroscopy (FAMOS) is a laser-based spectroscopic dispersion technique for detection of paramagnetic molecules in gas phase. This thesis presents both a new theoretical description of FAMOS and experimental results from the ultra-violet (UV) as well as the mid-infrared (MIR) regions. The theoretical description, which is given in terms of the integrated linestrength and Fourier coefficients of modulated dispersion and absorption lineshape functions, facilitates the description and the use of the technique considerably. It serves as an extension to the existing FAMOS model that thereby incorporates also the effects of lineshape asymmetries primarily originating from polarization imperfections. It is shown how the Fourier coefficients of modulated Lorentzian lineshape functions, applicable to the case with fully collisionally broadened transitions, can be expressed in terms of analytical functions. For the cases where also Doppler broadening needs to be included, resulting in lineshapes of Voigt type, the lineshape functions can be swiftly evaluated (orders of magnitude faster than previous procedures) by a newly developed method for rapid calculation of modulated Voigt lineshapes (the WWA-method). All this makes real-time curve fitting to FAMOS spectra feasible. Two experimental configurations for sensitive detection of nitric oxide (NO) by the FAMOS technique are considered and their optimum conditions are determined. The two configurations target transitions originating from the overlapping Q22(21=2) and QR12(21=2) transitions in the ultra-violet (UV) region (227nm) and the Q3=2(3=2)-transition in the fundamental rotational-vibrational band in the mid-infrared (MIR) region (5.33 µm). It is shown that the implementations of FAMOS in the UV- and MIR-region can provide detection limits in the low ppb range, which opens up the possibility for applications where high detection sensitivities of NO is required.

In this dissertation, three experiments were conducted that examined the influence of task demands on manual asymmetries for the performance of reaching movements to tools. In all three experiments, the difference between the hands (in terms of preference for Experiment 1 and performance for Experiments 2 and 3) was studied in response to varying task demands for grasping movements to tools. In the first experiment, 82 right-handed and 60 left-handed university students performed reaching movements to tools and dowels at five positions within working space. Differences in the reaching patterns of the left and right hands to the tools and dowels were examined, as well as the effect of task demands (lift, use) and type of object (tool, dowel) on the reaching patterns. Dowels were used in order to examine if participants would treat a neutral object as if it were a tool in terms of their reaching patterns in working space. Results confirmed and extended prior research on the influence of task demands on reaching patterns within working space. Overall, there were more similarities in the general reaching patterns of left- and right-handed participants than differences. However key differences between the handedness groups emerged in the treatment of the dowel and the frequency of switches (reaching to lift the object with the non-preferred hand and transferring it to the preferred hand to use). Results also showed that tools enjoy a privileged association with the preferred hand, and that the intent of the movement has a very real goal on movement planning. The first experiment examined patterns of hand use across working space in response to differing task demands. In the next experiments performance differences between the hands in terms of movement planning and initiation were examined through the use of reaction time and movement time. In these experiments, reaction time represented the time from the presentation of a go signal to when the participant first lifted their hand, and movement time was the time between lifting the hand to lifting a tool off a sensor. Movement time represented the time to pick up the tool, and did not include the time to use the tool to perform a particular task and complete the reaching movement. In the second experiment, reaction time and movement time to tools placed at the midline position were examined under varying degrees of advance information using a precue paradigm. Three precue conditions were used which presented advance information on the hand to use to perform the movement (left or right) and/or the task (lift, use, or pantomime) to be performed: (1) both hand and task were cued in advance (Both precue); (2) task only was cued in advance (Task precue); and (3) neither hand nor task were cued in advance (No precue). Twenty-four right-handed university students performed reaching movements to tools under the three different precue conditions. The results of Experiment 2 showed that reaction time was sensitive to the amount of advance information presented in the precue. For reaction time manual asymmetries were observed in one condition only – a right hand advantage was present in the No precue condition. In contrast manual asymmetries in favor of the right hand were clearly observed with the movement time results. Experiment 2 was the first experiment reported in the literature to systematically examine reaction time for reaching and grasping movements to tools. In order to further explore these results, in Experiment 3 a fourth precue condition (in which the hand to be used was cued in advance; the Hand precue) was added to the precue paradigm used in Experiment 2. An additional variable called replacement time, which represented the time spent interacting with the tool, was also examined. Forty-two right-handed university students participated in Experiment 3. The results of Experiment 3 largely replicated the findings of Experiment 2, and indicated that both the amount and type of precue information had an effect on reaction time. The addition of the Hand precue condition suggested that having advance knowledge of the hand to be used to perform the task was of greater importance for movement planning than was advance knowledge of the task to be performed. Regarding the movement time results, Experiment 3 was one of the first experiments to show the influence of task demands on the magnitude of manual asymmetries. The lack of differences between the hands for the replacement time results also suggested that the initial execution of the movement (represented by movement time) was most sensitive to manual asymmetries. Overall, these experiments provided further insight into manual asymmetries for the performance of reaching movements, and illustrated how simple manipulations of task demands led to differences between the hands in measures of both preference and performance when interacting with tools.

The origin and development of human cerebral asymmetries is yet a debated issue. One prominent manifestation of cerebral asymmetry is handedness with humans showing a dextral population bias. Handedness in humans is not fully established before the age of six. However, head turning preference in newborns is thought to be an important factor in the development of later handedness. If this head turning preference did not disappear completely during development but would prevail into adulthood it might, thus, be associated with handedness. Therefore, this study aimed to assess head turning preference in adults and to relate a possibly emerging bias to handedness. Forty-two adults (6 females, aged 23- 63, mean age = 35) participated in the study. Head turning preference was assessed by means of a move during Ju Jutsu martial arts training, which requires the trainee to move the head to either left or right. The direction of head movement is not specified for this move, leaving the choice to the trainee. Handedness was measured by the Edinburgh Handedness Inventory. Results did not reveal a profound head turning bias in adults. Contrary to the dextral bias in handedness, in this study a leftward bias in head turning emerged from those participants who showed a head turning preference. Head turning bias did not depend on handedness. The finding of a nearly absent and predominantly leftward head turning bias in this sample is discussed in the context of the Ju Jutsu task, training experience and trainer bias. It is concluded that the Ju Jutsu move is not a sufficient task to assess head turning preference in humans. Thus, to further illuminate the relation between head turning preference and handedness, studies are needed which assess head turning preference in adults in an un-trainable and unbiased situation.

The rates and patterns at which nucleotide substitutions occur vary significantly across the genome sequence of vertebrates. A prominent example is the difference in the rate of evolution of functional sequences versus nonfunctional (neutrally evolving) sequences, which is explained by the influence of natural selection on functional sequences. However, even within neutrally evolving sequences there is striking variation in the rates and patterns of nucleotide substitutions. Unraveling the underlying processes that induce this variation is necessary to understand the basic principles of variation in neutral substitution profiles, which in turn is crucial for the identification of regions in the genome where natural selection acts. This research question builds the main focus of the present thesis. I have studied the causes and consequences of variation in different patterns of nucleotide substitutions. In particular, I have investigated substitutional strand asymmetries in mammalian genes and could show that they result from the asymmetric nature of DNA replication and transcription. Comparative analysis of substitutional asymmetries then suggested that the organization of DNA replication and the level of transcription are conserved among mammals. Further, I have examined the variation in CpG mutation rate among human genes and could show that beside DNA methylation also GC content plays a decisive role in CpG mutability. In addition, I have studied the signatures of GC-biased gene conversion and its impact on the evolution of the GC isochore structure in chicken. By comparison of the results in chicken to previous results in human I found evidence that karyotype stability is critical for the evolution of GC isochores. Finally, beside the empirical studies, I have performed theoretical investigations of substitution rates in functional sequences. More precisely, I have explored the temporal dynamics of estimates of the ratio of non-synonymous to synonymous substitution rates dN/dS in a phylogentic-population genetic framework.

A large number of studies in psychology and cognitive neuroscience suggest that the left and right cerebral hemispheres have differences in specialization of processing. The left hemisphere tends to be specialized for complex capacities such as language and numbers, whereas the right hemisphere typically shows advantages for visuospatial attention and recognition of nonverbal form. The present study was designed to investigate whether these functional cerebral asymmetries would extend to working memory tasks. It was hypothesized that the left hemisphere would have more advantage for accurate responses to a Number-based memory task, whereas the right hemisphere would be relatively advantaged for accurate responses on a Color-based memory task. For the Color-based memory task, we used a Corsi-Block memory task (4x4 grid). For the Number-based memory task, we used a string of 8 digits. In each case, to-be-remembered stimuli were constructed sequentially, such that participants (N = 39) had to form and maintain the image in working memory. Participants then compared these remembered stimuli with flashed images that appeared either on the left or right edge of the screen. We recorded the correct responses and the response time. The left hemisphere appears to be advantaged for accurate responses when the memory stimuli are numerical in nature, whereas the right hemisphere has more advantage for accurate responses on the color-memory task.

Made available in DSpace on 2014-06-11T19:33:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2004-07-01Bitstream added on 2014-06-13T20:44:49Z : No. of bitstreams: 1 grehs_ra_dr_arafo.pdf: 1198034 bytes, checksum: 2be2545e38cb4c3436e2561d7816c44b (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Esta pesquisa de natureza prospectiva foi realizada com base numa amostra não casualizada constituída de 23 indivíduos portadores de má oclusão Classe II, 1ª Divisão, Subdivisão na fase da dentadura mista. O propósito do estudo foi avaliar um novo procedimento para o tratamento precoce da Classe II Subdivisão com envolvimento mandibular, método proposto por Sakima 85 em 2003. A amostra foi dividida em: Grupo 1 - Portadores de má oclusão Classe II Subdivisão com mordida cruzada posterior unilateral (D) ou (E) e Grupo 2 - Portadores de má oclusão Classe II Subdivisão sem cruzamento. Todos os indivíduos foram submetidos a tratamento ortodôntico de interceptação para correção da subdivisão, sendo que o Grupo 1 teve procedimento prévio para descruzamento da mordida cruzada posterior unilateral (MCPU). A avaliação dos resultados foi realizada mediante tomada de radiografias extra-orais Submento-vertex, os cefalogramas foram traçados e os dados compilados para análise em computador. Os traçados cefalométricos obtidos das imagens radiográficas da Submento-vertex (SMV) foram digitalizados no programa Radiocef. Os dados analisados, submetidos à metodologia estatística e os resultados discutidos. O método estatístico empregado, além da utilização da média e desvio padrão, contou com o Teste t de Student, Teste F de Snedecor e probabilidade p, utilizou-se também o teste não paramétrico de Mann-Whitney-Wilcoxon, os dados estatísticos foram utilizados para avaliar os resultados do tratamento ortodôntico realizado. Após a discussão dos resultados, concluiu-se que: 1)Houve presença de rotação mandibular significante para ambos os grupos estudados quando relacionada maxila e mandíbula; 2) A evolução dos grupos estudados foi semelhante tanto clínica como cefalométrica; 3) Os movimentos dentários constatados melhoram o... . / The purpose of this study was to evaluate a new approach to the early orthodontic treatment of Class II, division 1, subdivision, in the mixed dentition and determined the utility of approach. The sample consisted of 23 subjects divided in two groups (group 1 and group 2). The average was 9.3 years considered in both groups. Measurements were obtained with the use of Submento-vertex Cephalometric Radiographs. The Submento-vertex Radiographs symmetry was assessed by measuring the differences in the spatial positions of dental and Skeletal landmarks between right and left side, determined asymmetric (A) and normal (N) sides. The Angle's 2 Class II subdivision was evaluated in the mixed dentition. Statistic method was based on the skewness statistics, the distributions were normal, allowing means and standard deviations to be used to describe central tendencies and dispersion. We also used the Student t test, the Snedecor p test and Mann-Whitney-Wilcoxon tests were used to statistically comparation.The results showed lower jaw replacement and dento-alveolar displacement in order to correct this malocclusion. The conclusions about the present study were: 1) There was significant mandibular rotation from the asymmetric side to the symmetric side in the two groups when maxilar and mandibular relation was investigated; 2) The two groups evolution was clinical and cephalometrical similar; 3) The teeth movements provide evidence to better relation of the occlusion; 4) The midline line of the teeth has a clinically consistent to normalization and this can better investigated with other evaluation methods.

Change of direction speed (CODS) is an important determinant of performance in many sports. Greater stiffness of the lower limb should be beneficial to CODS, but this had not been well investigated. The purpose of this thesis was to establish the relationship between vertical stiffness, vertical stiffness asymmetries and CODS, with a view to augmenting CODS performance. The pilot study and studies 1-2 sought to determine the most reliable and ecologically valid method to assess stiffness in athletes required to perform changes of direction. The pilot study reported that the use of ultrasonography to determine Achilles tendon stiffness did not demonstrate appropriate reliability for inclusion in subsequent studies. Coefficients of variation (CVs) in excess of 27% were reported during an isometric plantar flexion task. Study 1 reported that CVs for vertical stiffness were lower when assessed during unilateral drop jumping (~7%) than during bilateral drop jumping (~12%) or bilateral hopping (~14%). Study 2 reported that the expression of vertical stiffness (P = 0.033) and vertical stiffness symmetry angle (P = 0.006) was significantly different across three performance tasks: unilateral drop jumping, bilateral drop jumping and bilateral hopping. Asymmetry percentages between compliant and stiff limbs were 5.6% (P < 0.001; d: 0.22), 23.3% (P = 0.001; d = 0.86) and 12.4% (P = 0.001; d = 0.39), respectively. Given the findings of studies 1 and 2, this thesis demonstrated the reliability and validity of a novel method by which to assess vertical stiffness - the unilateral drop jump. This task was used in subsequent studies to measure vertical stiffness. Study 3 sought to determine if vertical stiffness and vertical stiffness asymmetries influenced CODS performance determined during a 90o cutting task. Multiple regression analyses reported that mean vertical stiffness and asymmetry in jump height explained 63% (r2 = 0.63; P = 0.001) of CODS performance. Study 3 was the first investigation to demonstrate the importance of vertical stiffness to CODS performance. Study 4 sought to determine if acute exercise interventions designed to augment vertical stiffness would improve CODS. Unilateral and bilateral ‘stiffness’ interventions were evaluated against a control condition. CODS performances following the unilateral intervention were significantly faster than control (1.7%; P= 0.011; d = -1.08), but not significantly faster than the bilateral intervention (1.0% faster; P = 0.14; d = -0.59). Versus control, vertical stiffness was 14% greater (P = 0.049; d = 0.39) following the unilateral intervention. Study 4 demonstrated that a novel unilateral ‘stiffness’ intervention improved vertical stiffness and CODS performance. This highlights that the potential applicability of unilateral stiffness interventions in the pre-performance preparation of athletes.

abstract: It is commonly known that the left hemisphere of the brain is more efficient in the processing of verbal information, compared to the right hemisphere. One proposal suggests that hemispheric asymmetries in verbal processing are due in part to the efficient use of top-down mechanisms by the left hemisphere. Most evidence for this comes from hemispheric semantic priming, though fewer studies have investigated verbal memory in the cerebral hemispheres. The goal of the current investigations is to examine how top-down mechanisms influence hemispheric asymmetries in verbal memory, and determine the specific nature of hypothesized top-down mechanisms. Five experiments were conducted to explore the influence of top-down mechanisms on hemispheric asymmetries in verbal memory. Experiments 1 and 2 used item-method directed forgetting to examine maintenance and inhibition mechanisms. In Experiment 1, participants were cued to remember or forget certain words, and cues were presented simultaneously or after the presentation of target words. In Experiment 2, participants were cued again to remember or forget words, but each word was repeated once or four times. Experiments 3 and 4 examined the influence of cognitive load on hemispheric asymmetries in true and false memory. In Experiment 3, cognitive load was imposed during memory encoding, while in Experiment 4, cognitive load was imposed during memory retrieval. Finally, Experiment 5 investigated the association between controlled processing in hemispheric semantic priming, and top-down mechanisms used for hemispheric verbal memory. Across all experiments, divided visual field presentation was used to probe verbal memory in the cerebral hemispheres. Results from all experiments revealed several important findings. First, top-down mechanisms used by the LH primarily used to facilitate verbal processing, but also operate in a domain general manner in the face of increasing processing demands. Second, evidence indicates that the RH uses top-down mechanisms minimally, and processes verbal information in a more bottom-up manner. These data help clarify the nature of top-down mechanisms used in hemispheric memory and language processing, and build upon current theories that attempt to explain hemispheric asymmetries in language processing. / Dissertation/Thesis / Ph.D. Speech and Hearing Science 2013