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In der vorliegenden Arbeit wurde die Expression unterschiedlicher Marker für die Vaskularisation in verschiedenen Modifikationen zur Unterkieferaugmentation mit autologem kortikospongiösen Beckenkammtransplantaten in-vivo am Schafmodell untersucht. Wie schon aus Voruntersuchungen bekannt, zeigte vor allem die Modifikation des Transplantatlagers in der Kombination einer resorbierbaren Bio-Gide® Membran mit dem Knochenersatzmaterial (KEM) Bio-Oss® und einem kortikospongiösen Transplantat die geringsten Resorptionsraten. Dieser Konditionierung wurden verschiedene andere Modikifationen des Transplantatlagers gegenübergestellt und jeweils die Expression der Vaskularisationsmarker untersucht und verglichen. Sowohl die Untersuchungen zur Expression von Bone Morphogenetic Protein-2 (BMP-2), Vascular Endothelial Growth Factor (VEGF) und seinen Rezeptor-Isoformen VEGF-Rezeptor 1 und VEGF-Rezeptor 2, sowie den NOS-Isoformen eNOS und iNOS zeigen alle eine signifikant vermehrte Expression in der Konditionierung mit Bio-Oss® als KEM und einer resorbierbaren Bio-Gide® Membran. Lediglich die Expression des von-Willebrand-Faktors (vWF) als Marker des Endothels zeigte keine signifikant vermehrte Expression in der mit Bio-Oss® und Bio-Gide® modifizierten Gruppe. Hier wäre die Tatsache, dass der vWF auch als Marker der endothelialen Dysfunktion beschrieben wird und in den klinisch stärker atrophierten Modifikation vermehrt exprimiert wird, eine Erklärungsmöglichkeit. Die Untersuchungen zur Expression der Vaskularisationsmarker hinsichtlich der Regionen im Augmentat zeigen sowohl bei BMP-2 wie auch bei VEGF und seinen Rezeptorisoformen VEGF-R1 und VEGF-R2 eine signifikant vermehrte Expression im Bereich des Transplantates in der Bio-Oss® Modifikation. Diese Ergebnisse stützen den klinischen Aspekt der guten Vaskularisierung des Transplantates und unterstreichen die Bedeutung der Wachstumsfaktoren für die Vaskularisierung im Transplantat. Bei den Färbungen auf NOS findet sich eine signifikant vermehrte Expression im Transplantatlager. Diese Ergebnisse stellen die Bedeutung von NOS für die Regulation der Osteogenese und die direkten Wirkungen auf Osteoblasten und Osteoklasten. Die Tatsache, dass gerade in der Bio-Oss® Modifikation, in der klinisch die geringste Resorption zu beobachten war, signifikant mehr Vaskularisationsmarker exprimiert wurden, ist Nachweis der besseren Vaskularisation dieser Konditionierung und unterstreicht sowohl den Nutzen von KEM wie Bio-Oss® bei Transplantationen autologen Knochens, wie auch die Möglichkeiten der therapeutischen Verwendung einzelner Wachstumsfaktoren wie z. B. BMP-2. / In this study the expression of various markers for vascularization in different modifications of alveolar ridge augmentation procedures on the mandible with autogenous bone grafts from the iliac crest was analyzed with the help of an in-vivo sheep model. As preliminary investigations suggested, especially the modification of the host side as a combination of a resorbable Bio-Gide® membrane according to the concept of Guided Bone Regeneration (GBR) with Bio-Oss® as a bovine bone substitute, showed the least resorption in clinical findings. This modification of the host side was compared with a control group, in which other modifications of the host side were being used and which showed a way higher rate of resorption during the surveillance period and until the euthanasia of the sheep after 16 weeks. The expression of different vascularization markers was compared between these two groups. The data concerning the expression of Bone Morphogenetic Protein-2 (BMP-2), Vascular Endothelial Growth Factor (VEGF) and its receptor-isoforms VEGF-Receptor 1 and VEGF-Receptor 2, as well as the Nitric Oxide Synthase (NOS) isoforms, the endothelial NOS (eNOS) and the inducible NOS (iNOS) all showed a significantly higher expression within the modification of the host side using GBR and Bio-Oss®. Only the expression of the von-Willebrand-Factor (vWF) as a marker of the endothelium showed no significantly higher expression within this modification but a higher expression within the control group. Hypothetically, the fact that vWF is also a marker of endothelial dysfunction could explain the higher expression within the control group. Taking the different regions of the graft in consideration, BMP-2, VEGF, VEGFR-1 and VEGFR-2 all showed a significantly higher expression within the bone graft of the modification using GBR and Bio-Oss®. These results underline the clinical aspect of the good vascularization of the graft within this modification. NOS showed a significantly higher expression in the region of the host side and could explain the importance of NOS for osteogenesis and its effect on osteoblasts and osteoclasts. In summary, the significantly higher expression of vascularization markers and clincally the lowest rate of atrophy and resorption within the modification of the host side using GBR and Bio-Oss®, underlines the better vascularization of this modification and emphasizes the use of GBR and bone substitues during the transplantation of autogenous bone grafts and suggests the therapeutical use of certain growth factors such as BMP-2 within this modification.

In this thesis, a novel approach is presented for blade loss simulation of an aircraft gas turbine rotor mounted on rolling element bearings with squeeze film dampers, seal rub and enclosed in a flexible housing. The modal truncation augmentation (MTA) method provides an efficient tool for modeling this large order system with localized nonlinearities in the ball bearings. The gas turbine engine, which is composed of the power turbine and gas generator rotors, is modeled with 38 lumped masses. A nonlinear angular contact bearing model is employed, which has ball and race degrees of freedom and uses a modified Hertzian contact force between the races and balls and for the seal rub. This combines a dry contact force and viscous damping force. A flexible housing with seal rub is also included whose modal description is imported from ANSYS. Prediction of the maximum contact load and the corresponding stress on an elliptical contact area between the races and balls is made during the blade loss simulations. A finite-element based squeeze film damper (SFD), which determines the pressure profile of the oil film and calculates damper forces for any type of whirl orbit is utilized in the simulation. The new approach is shown to provide efficient and accurate predictions of whirl amplitudes, maximum contact load and stress in the bearings, transmissibility, thermal growths, maximum and minimum damper pressures and the amount of unbalanced force for incipient oil film cavitation. It requires about 4 times less computational time than the traditional approaches and has an error of less than 5 %.

This paper presents a statistical framework for estimating output-specific efficiencies for the 2-output case based upon a DEA frontier estimate. The key to the approach is the concept of target output-mix. Being usually unobserved, target output-mixes of firms are modelled as missing data. Using this concept the relevant data generating process can be formulated. The resulting likelihood function is analytically intractable, so a data augmented Bayesian approach is proposed for estimation purposes. This technique is adapted to the present purpose. Some implementation issues are discussed leading to an empirical Bayes setup with data informed priors. A prove of scale invariance is provided. (author's abstract) / Series: Department of Economics Working Paper Series

In recent years, numerous methods to aid designers in conceptualizing new products have been developed. These methods intend to give structure to a process that was, at one time, considered to be a purely creative exercise. Resulting from the study, implementation, and refinement of design methodologies is the notion that both the structure of the development process and the structure of the developed product are key factors in creating value in a firm’s product line. With respect to the latter key factor, product architecture, but more specifically, modular product architecture has been the subject of much study. However, prior research in the area of modular product architecture has, with limited exception, focused on the construction of modules that are to be incorporated into a product before it becomes available to its end-users; that is, the modules are incorporated ‘pre-market.’ The research contained in this thesis is focused on two tasks: advancing the notion of a modular product architecture in which modules can be incorporated into a product ‘post-market,’ and creating a method that aids designers in synthesizing these post-market modules. Researchers have examined the idea of post-market modules; however, they do not fully formalize language used to describe these modules, and they also do not give the product space created by post-market modularization well-defined boundaries. Additionally, the prior work gives no method that can be used to create post-market modules. The research presented here addresses these shortcomings in the prior work by first, defining the terms ‘derivative product’ and ‘host product’ to describe the post-market module and the product that the module augments, respectively. Second, by establishing three guidelines that are used to assess the validity of potential derivative products, giving the newly termed host and derivative product space defined boundaries. And lastly, by developing a 7-step, biomimetic-based methodology that can be used to create derivative product concepts (post-market modules). This developed methodology is applied to four case studies in which it is used to create five derivative product concepts for a given host product. Thus, 20 derivative product concepts are developed in this study, demonstrating the qualitative effectiveness of the 7-step methodology.

Thesis--University of Oklahoma. / Bibliography: leaves 97-101.

Film cooling is used in gas turbine engines to cool turbine components. Cooler air is bled from the compressor, routed internally through turbine vanes and blades, and exits through discrete holes, creating a film of coolant on the parts’ surfaces. Cooling the turbine components protects them from thermal damage and allows the engine to operate at higher combustion temperatures, which increases the engine efficiency. Shaped film cooling holes with diffuser exits have the advantage that they decelerate the coolant flow, enabling the coolant jets to remain attached to the surface at higher coolant flow rates. Furthermore, the expanded exits of the coolant holes provide a wider coolant distribution over the surface. The first part of this dissertation provides data for a new laidback, fan-shaped hole geometry designed at Pennsylvania State University’s Experimental and Computational Convection Laboratory. The shaped hole geometry was tested on flat plate facilities at the University of Texas at Austin and Pennsylvania State University. The objective of testing at two laboratories was to verify the adiabatic effectiveness performance of the shaped hole, with the intent of the data being a standard of comparison for future experimental and computational shaped hole studies. At first, measurements of adiabatic effectiveness did not match between the labs, and it was later found that shaped holes are extremely sensitive to machining, the material they are machined into, and coolant entrance effects. In addition, the adiabatic effectiveness was found to scale with velocity ratio for multiple density ratios and mainstream turbulence intensities. The second part of this dissertation measures heat transfer coefficient augmentation (hf/h0) at density ratios (DR) of 1.0, 1.2, and 1.5 using a uniform heat flux plate and the same shaped hole geometry. In the past, heat transfer coefficient augmentation was generally measured at DR = 1.0 under the assumption that hf/h0 was independent of density ratio. This dissertation is the first study to directly measure the wall and adiabatic wall temperature to calculate heat transfer coefficient augmentation at DR > 1.0. The results showed that the heat transfer coefficient augmentation was low while the jets were attached to the surface and increased when the jets started to separate. At DR = 1.0, hf/h0 was higher for a given blowing ratio than at DR = 1.2 and DR = 1.5. However, when velocity ratios are matched, better correspondence was found at the different density ratios. Surface contours of hf/h0 showed that the heat transfer was initially increased along the centerline of the jet, but was reduced along the centerline at distances farther downstream. The decrease along the centerline may be due to counter-rotating vortices sweeping warm air next to the heat flux plate toward the center of the jet, where they sweep upward and thicken the thermal boundary layer. This warming of the core of the coolant jet over the heated surface was confirmed with thermal field measurements. / text

We define a subclass of dynamic linear models with unknown hyperparameters called d-inverse-gamma models. We then approximate the marginal p.d.f.s of the hyperparameter and the state vector by the data augmentation algorithm of Tanner/Wong. We prove that the regularity conditions for convergence hold. A sampling based scheme for practical implementation is discussed. Finally, we illustrate how to obtain an iterative importance sampling estimate of the model likelihood. (author's abstract) / Series: Forschungsberichte / Institut für Statistik

Computations were run to study heat transfer coefficient augmentation with film cooling for a simulated gas turbine blade leading edge. The realizable k-[epsilon] turbulence model (RKE) and Shear Stress Transport k-[omega] turbulence model (SST) were used for the computational simulations. RKE computations completed at a unity density ratio were confirmed to be consistent with experimental measurements conducted by Yuki et al.(1998) and Johnston et al. (1999) whereas SST computations exhibited significant discrepancies. Moreover the effect of the density ratio on heat transfer coefficient augmentation was studied because experimental measurements of heat transfer coefficient augmentation with film cooling are generally constrained to unity density ratio tests. It was shown that heat transfer coefficient augmentation can be simulated using unity density ratio jets, but only when scaled with the momentum flux ratio of the coolant jets. / text

In this thesis, a novel approach is presented for blade loss simulation of an aircraft gas turbine rotor mounted on rolling element bearings with squeeze film dampers, seal rub and enclosed in a flexible housing. The modal truncation augmentation (MTA) method provides an efficient tool for modeling this large order system with localized nonlinearities in the ball bearings. The gas turbine engine, which is composed of the power turbine and gas generator rotors, is modeled with 38 lumped masses. A nonlinear angular contact bearing model is employed, which has ball and race degrees of freedom and uses a modified Hertzian contact force between the races and balls and for the seal rub. This combines a dry contact force and viscous damping force. A flexible housing with seal rub is also included whose modal description is imported from ANSYS. Prediction of the maximum contact load and the corresponding stress on an elliptical contact area between the races and balls is made during the blade loss simulations. A finite-element based squeeze film damper (SFD), which determines the pressure profile of the oil film and calculates damper forces for any type of whirl orbit is utilized in the simulation. The new approach is shown to provide efficient and accurate predictions of whirl amplitudes, maximum contact load and stress in the bearings, transmissibility, thermal growths, maximum and minimum damper pressures and the amount of unbalanced force for incipient oil film cavitation. It requires about 4 times less computational time than the traditional approaches and has an error of less than 5 %.