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Made available in DSpace on 2016-08-19T18:16:02Z (GMT). No. of bitstreams: 1 NAIME DIANE SAUAIA HOLANDA SILVA.pdf: 2473346 bytes, checksum: 07e67a7f1132d9fe7f4754bac958aa45 (MD5) Previous issue date: 2010-09-24 / Conselho Nacional de Desenvolvimento Científico e Tecnológico / Objective: To compare the results with the Scale of Alberta (Alberta Infant Motor Scale), applied at three months of corrected gestational age (IGC), with those Scale Bayley (Bayley Scales of Infant Development - 3rd edition) in premature infants, discharged from the Neonatal Intensive Care Unit-NICU of University Hospital Maternal Child Unit - UFMA. Methods: We studied 42 premature infants in the outpatient clinics ("Follow up") Unit, University Hospital Maternal Child Unit - UFMA between March and August 2009. In the study of concurrent validity and agreement of the 42 premature infants at 3 months of IGC were assessed by AIMS and the motor scale of the Bayley Scales of Infant Development, 3rd edition, using the correlation coefficient of Pearson and the concordance test Bland & Altman to analyze the results. Results: In the study of concurrent validity, correlation found between the two scales was high (r = 0.86) and statistically significant (p <0.01) in the total population of infants. In concordance analysis showed that most of the measures is in the range between ± 1.96 standard deviation is thus the two tests agree. Conclusion: The AIMS is a valid and consistent with the standard measures can be recommended for evaluation of motor development of premature infants in the population of public health in Brazil. / Objetivo: Comparar os resultados obtidos com a Escala de Alberta (Alberta Infant Motor Scale), aplicada com três meses de idade gestacional corrigida (IGC), com aqueles da Escala de Bayley (Bayley Scales of Infant Development - 3ª edição) em lactentes nascidos prematuros, egressos da UTIN do Hospital Universitário Unidade Materno Infantil - UFMA. Métodos: Foram avaliados 42 lactentes nascidos prematuros no do Ambulatório de Seguimento ( Follow up ) do Hospital Universitário Unidade Materno Infantil - UFMA entre Março e Agosto de 2009. No estudo de validade concorrente e concordância os 42 lactentes prematuros com 3 meses de IGC foram avaliados pela AIMS e pela escala motora da Bayley Scales of Infant Development- 3ª edição, utilizando-se o coeficiente de correlação de Pearson e o teste de concordância Bland & Altman para analise dos resultados. Resultados: No estudo de validade concorrente, a correlação encontrada entre as duas escalas foi alta (r = 0,86) e estatisticamente significativa (p < 0,01) na população total de lactentes. Na análise de concordância observou-se que a maioria das medidas está na faixa compreendida entre ± 1,96 desvio padrão sendo, portanto, os dois testes concordantes. Conclusão: A AIMS é uma escala válida e concordante com as medidas padrões podendo ser indicada para avaliação do desenvolvimento motor de lactentes prematuros na população da rede publicam de saúde brasileira.

Carências nutricionais são ocorrências comuns em grande proporção de crianças do mundo e reconhecidamente um dos grandes problemas da saúde pública brasileira. Alguns estudos têm relatado que os escores mental e motor de crianças com carências nutricionais são mais baixos do que aqueles obtidos pelas crianças sem carências. As Escalas Bayley, publicadas pela primeira vez em 1969 e revisadas em 1993, constituem-se em instrumento adequado para a avaliação de crianças de um a quarenta e dois meses de idade, e são amplamente utilizadas em estudos que avaliam efeitos de carências nutricionais. Desta forma, o objetivo deste trabalho foi verificar a aplicabilidade da Escala de Avaliação do Comportamento Infantil (BRS), uma das três escalas que constituem as Escalas Bayley, na avaliação de crianças de creche com carência nutricional. A amostra foi constituída por 50 crianças de ambos os sexos, com idades que variaram entre 7 e 41 meses, provenientes de duas creches filantrópicas do município de Ribeirão Preto – SP. Um grupo de 23 crianças com deficiência proteico-calórica ou de ferro, consideradas de leve a moderada, segundo o Z-score < +1, proposto pela OMS e níveis de hemoglobina acima de 8 mg/dL, foi comparado a outro de 27 crianças sem estas deficiências. Através da avaliação do comportamento foram obtidos índices referentes ao comportamento geral, o controle emocional, a atenção/exitabilidade, a orientação/engajamento e a qualidade motora das crianças. Tais índices são apresentados em forma de percentil, sendo possível, segundo Bayley (1993), a classificação em: comportamento dentro dos limites normais (índice ? percentil 26), ou seja, esperado para sua idade; comportamento questionável (índice entre o percentil 11 e o 25), que sugere possível prejuízo e merece maior investigação; e comportamento não-ótimo (índice ? percentil 10), que evidencia atraso ou prejuízo em uma ou mais áreas importantes. Os resultados obtidos revelaram que o grupo controle era de maior faixa etária (30 meses) que o grupo carente nutricional (23 meses), e que as crianças do grupo controle apresentavam um comportamento geral frente a situação de teste melhor que do que as crianças do grupo carente nutricional (p=0.03), principalmente no fator Orientação/Engajamento (p=0.01): Afeto positivo (p=0.03), Energia (p=0.005), Entusiasmo acerca das tarefas (p=0.04), Engajamento social (p=0.03); e nos itens Afeto negativo (p=0.04) e Movimento lento e atrasado (p=0.005). Estes resultados são consistentes com aqueles já apresentados na literatura, nos quais as crianças com carências nutricionais são descritas como menos ativas, mais inibidas e tímidas, menos responsivas, atentas, vocalizando e movimentando-se menos. Concluiu-se que os itens relacionados à avaliação comportamental, aplicados e cotados como proposto originalmente, foram sensíveis para diferenciar grupos com e sem alterações nutricionais leves ou moderadas, embora as Escalas Bayley do Desenvolvimento Infantil requeiram ainda adaptação às condições sociais e culturais brasileiras. Tais resultados sugerem ainda que esta escala pode ser útil em outras condições clínicas, assim como para a avaliação do desempenho de grupos pós procedimentos de recuperação nutricional. / Nutritional deficiencies are common occurrences among a large proportion of children all over the world and are recognized to be one of the great public health problems in Brazil. Some studies have reported that the mental and motor scores of children with nutritional deficiencies are lower than those of children with no deficiencies. The Bayley Scales, first published in 1969 and revised in 1993, are an appropriate instrument for the evaluation of children aged one to forty months and are widely used in studies that evaluate the effects of nutritional deficiencies. Thus, the objective of the present study was to determine the applicability of the Behavioral Rating Scale (BRS), one of the three scales forming the Bayley Scales, for the evaluation of day-care center children with nutritional deficiencies. The sample consisted of 50 children of both sexes aged 7 to 41 months, from two philanthropic day-care centers in the municipality of Ribeirão Preto – SP. A group of 23 children with protein-calorie or iron deficiency considered to be mild to moderate according to a Z-score < +1 proposed by the WHO and with hemoglobin levels above 8 mg/dL, was compared to a group of children without these deficiencies. Indices referring to general behavior, emotional control, attention/excitability, orientation/engagement, and motor quality of the children were obtained by behavioral evaluation. These indices are presented in percentile form and, according to Bayley (1993), it is possible to classify them as behavior within normal limits (index ? 26th percentile), i.e., expected for age, questionable behavior (index between the 11th and 25th percentile), suggesting possible impairment and requiring more investigation, and non-optimal behavior (index ? 10th percentile), which demonstrates delay or impairment in one or more important areas. The results obtained revealed that the control group was in an older age range (30 months) than the group with nutritional deficiency (23 months), and that the children in the control group presented a better general behavior in the test situation than the children in the group with nutritional deficiency (p=0.03), especially regarding the Orientation/Engagement factor (p=0.01): Positive affect (p=0.03), Energy (p=0.005), Enthusiasm about tasks (p=0.04), Social engagement (p=0.03); and in the items Negative affect (p=0.04) and Slow and delayed movement (p=0.005). These results are consistent with those reported in literature studies in which children with nutritional deficiencies are described as less active, more inhibited and shy, less responsive and attentive, and vocalizing and moving less. We conclude that the items related to behavioral evaluation, applied and scored as originally proposed, were sensitive in differentiating between groups with and without mild or moderate nutritional alterations, although the Bayley Scales for Childhood Development still require adaptation to the Brazilian social and cultural conditions. These results also suggest that this scale can be useful for other clinical conditions and for the evaluation of performance of groups submitted to procedures or nutritional recovery.

Carências nutricionais são ocorrências comuns em grande proporção de crianças do mundo e reconhecidamente um dos grandes problemas da saúde pública brasileira. Alguns estudos têm relatado que os escores mental e motor de crianças com carências nutricionais são mais baixos do que aqueles obtidos pelas crianças sem carências. As Escalas Bayley, publicadas pela primeira vez em 1969 e revisadas em 1993, constituem-se em instrumento adequado para a avaliação de crianças de um a quarenta e dois meses de idade, e são amplamente utilizadas em estudos que avaliam efeitos de carências nutricionais. Desta forma, o objetivo deste trabalho foi verificar a aplicabilidade da Escala de Avaliação do Comportamento Infantil (BRS), uma das três escalas que constituem as Escalas Bayley, na avaliação de crianças de creche com carência nutricional. A amostra foi constituída por 50 crianças de ambos os sexos, com idades que variaram entre 7 e 41 meses, provenientes de duas creches filantrópicas do município de Ribeirão Preto – SP. Um grupo de 23 crianças com deficiência proteico-calórica ou de ferro, consideradas de leve a moderada, segundo o Z-score < +1, proposto pela OMS e níveis de hemoglobina acima de 8 mg/dL, foi comparado a outro de 27 crianças sem estas deficiências. Através da avaliação do comportamento foram obtidos índices referentes ao comportamento geral, o controle emocional, a atenção/exitabilidade, a orientação/engajamento e a qualidade motora das crianças. Tais índices são apresentados em forma de percentil, sendo possível, segundo Bayley (1993), a classificação em: comportamento dentro dos limites normais (índice ? percentil 26), ou seja, esperado para sua idade; comportamento questionável (índice entre o percentil 11 e o 25), que sugere possível prejuízo e merece maior investigação; e comportamento não-ótimo (índice ? percentil 10), que evidencia atraso ou prejuízo em uma ou mais áreas importantes. Os resultados obtidos revelaram que o grupo controle era de maior faixa etária (30 meses) que o grupo carente nutricional (23 meses), e que as crianças do grupo controle apresentavam um comportamento geral frente a situação de teste melhor que do que as crianças do grupo carente nutricional (p=0.03), principalmente no fator Orientação/Engajamento (p=0.01): Afeto positivo (p=0.03), Energia (p=0.005), Entusiasmo acerca das tarefas (p=0.04), Engajamento social (p=0.03); e nos itens Afeto negativo (p=0.04) e Movimento lento e atrasado (p=0.005). Estes resultados são consistentes com aqueles já apresentados na literatura, nos quais as crianças com carências nutricionais são descritas como menos ativas, mais inibidas e tímidas, menos responsivas, atentas, vocalizando e movimentando-se menos. Concluiu-se que os itens relacionados à avaliação comportamental, aplicados e cotados como proposto originalmente, foram sensíveis para diferenciar grupos com e sem alterações nutricionais leves ou moderadas, embora as Escalas Bayley do Desenvolvimento Infantil requeiram ainda adaptação às condições sociais e culturais brasileiras. Tais resultados sugerem ainda que esta escala pode ser útil em outras condições clínicas, assim como para a avaliação do desempenho de grupos pós procedimentos de recuperação nutricional. / Nutritional deficiencies are common occurrences among a large proportion of children all over the world and are recognized to be one of the great public health problems in Brazil. Some studies have reported that the mental and motor scores of children with nutritional deficiencies are lower than those of children with no deficiencies. The Bayley Scales, first published in 1969 and revised in 1993, are an appropriate instrument for the evaluation of children aged one to forty months and are widely used in studies that evaluate the effects of nutritional deficiencies. Thus, the objective of the present study was to determine the applicability of the Behavioral Rating Scale (BRS), one of the three scales forming the Bayley Scales, for the evaluation of day-care center children with nutritional deficiencies. The sample consisted of 50 children of both sexes aged 7 to 41 months, from two philanthropic day-care centers in the municipality of Ribeirão Preto – SP. A group of 23 children with protein-calorie or iron deficiency considered to be mild to moderate according to a Z-score < +1 proposed by the WHO and with hemoglobin levels above 8 mg/dL, was compared to a group of children without these deficiencies. Indices referring to general behavior, emotional control, attention/excitability, orientation/engagement, and motor quality of the children were obtained by behavioral evaluation. These indices are presented in percentile form and, according to Bayley (1993), it is possible to classify them as behavior within normal limits (index ? 26th percentile), i.e., expected for age, questionable behavior (index between the 11th and 25th percentile), suggesting possible impairment and requiring more investigation, and non-optimal behavior (index ? 10th percentile), which demonstrates delay or impairment in one or more important areas. The results obtained revealed that the control group was in an older age range (30 months) than the group with nutritional deficiency (23 months), and that the children in the control group presented a better general behavior in the test situation than the children in the group with nutritional deficiency (p=0.03), especially regarding the Orientation/Engagement factor (p=0.01): Positive affect (p=0.03), Energy (p=0.005), Enthusiasm about tasks (p=0.04), Social engagement (p=0.03); and in the items Negative affect (p=0.04) and Slow and delayed movement (p=0.005). These results are consistent with those reported in literature studies in which children with nutritional deficiencies are described as less active, more inhibited and shy, less responsive and attentive, and vocalizing and moving less. We conclude that the items related to behavioral evaluation, applied and scored as originally proposed, were sensitive in differentiating between groups with and without mild or moderate nutritional alterations, although the Bayley Scales for Childhood Development still require adaptation to the Brazilian social and cultural conditions. These results also suggest that this scale can be useful for other clinical conditions and for the evaluation of performance of groups submitted to procedures or nutritional recovery.

Malgré les avancées médicales, la prédiction précoce du devenir développemental des enfants nés prématurément demeure un défi. Ces enfants sont à risque de séquelles plus ou moins sévères telles l'infirmité motrice d'origine cérébrale, les déficiences intellectuelles et sensorielles ainsi que les difficultés d'apprentissage. Afin de diminuer l’impact fonctionnel de ces séquelles, l’identification de marqueurs précoces devient un enjeu important. Dans le contexte actuel de ressources financières et humaines limitées, seuls les enfants nés avant 29 semaines de gestation ou avec un poids de naissance (PN) <1250g sont systématiquement suivis, laissant pour compte 95% des enfants prématurés. L’identification de marqueurs précoces permettrait de cibler les enfants nés après 28 semaines de gestation porteurs de séquelles. Le principal objectif des présents travaux visait à évaluer l’utilité de l’Évaluation neurologique d’Amiel-Tison (ENAT) dans l’identification et le suivi des enfants nés entre 29 et 37 semaines de gestation et qui présenteront des problèmes neurodéveloppementaux à l’âge corrigé (AC) de 24 mois. Plus précisément, la fidélité inter-examinateurs, la stabilité ainsi que la validité prédictive de l’ENAT ont été évaluées. La cohorte était composée initialement de 173 enfants nés entre 290/7 et 370/7 semaines de gestation, avec un PN<2500g et ayant passé au moins 24 heures à l’unité de soins néonatals du CHU Sainte-Justine. Les enfants étaient évalués avec l’ENAT à terme et aux AC de 4, 8, 12 et 24 mois. À l’AC de 24 mois, leur développement était évalué à l’aide du Bayley Scales of Infant Development–II. Les principaux résultats révèlent une excellente fidélité inter-examinateurs ainsi qu’une bonne stabilité au cours des deux premières années de vie du statut et des signes neurologiques. Des différences significatives à l’AC de deux ans ont été relevées aux performances développementales en fonction du statut neurologique à terme, qui constitue l’un des meilleurs facteurs prédictifs de ces performances. Les résultats encouragent l’intégration du statut neurologique tel que mesuré par l’ENAT comme marqueur précoce dans le cours d’une surveillance neurodéveloppementale des enfants les plus à risque. / Despite the progress in medicine, early prediction of neurodevelopmental outcome for infants born preterm still remains a challenge. Infants born preterm are at risk of mild to severe disabilities such as cerebral palsy, mental retardation, sensory impairments or learning disabilities. To reduce the functional impact of those disabilities, identification of valid early markers of neurodevelopmental disabilities becomes important. As financial and human resources are limited, only those infants with a gestational age (GA) <29 weeks and a birth weight (BW) <1250 are systematically followed, leaving 95% of the preterm population without surveillance. The identification of early markers would allow targeting infants born after 28 weeks of GA the more at risk. The main objective of the present work was to assess the use of the Amiel-Tison Neurological Assessments (ATNA) in the identification and the follow-up of infants with a GA between 29 and 37 weeks who will present neurodevelopmental problems at two years of corrected age (CA). Specifically, the inter-examiner reliability, the stability during the first two years of life and the predictive validity of the ATNA were assessed. The cohort was composed of 173 children born between 290/7 and 370/7 weeks of GA, with a BW<1250g and who stayed at least 24 hours in the neonatal intensive care unit at the CHU Sainte-Justine. The children were assessed with the ATNA at term age and at 4, 8, 12 and 24 months CA. At 24 months CA, their development was assessed with the Bayley Scales of Infant Development–II. The results revealed excellent inter-examiners reliability and good stability during the first two years of age of the neurological status and signs. Significant differences according to the neurological status at term age were observed at 24 months CA for developmental performance. Moreover, this status was one of the main predictive variables of developmental performance at two years CA. Results incite the integration of the neurological status as assessed by the ATNA as an early marker for the surveillance of infants the more at risk.

Malgré les avancées médicales, la prédiction précoce du devenir développemental des enfants nés prématurément demeure un défi. Ces enfants sont à risque de séquelles plus ou moins sévères telles l'infirmité motrice d'origine cérébrale, les déficiences intellectuelles et sensorielles ainsi que les difficultés d'apprentissage. Afin de diminuer l’impact fonctionnel de ces séquelles, l’identification de marqueurs précoces devient un enjeu important. Dans le contexte actuel de ressources financières et humaines limitées, seuls les enfants nés avant 29 semaines de gestation ou avec un poids de naissance (PN) <1250g sont systématiquement suivis, laissant pour compte 95% des enfants prématurés. L’identification de marqueurs précoces permettrait de cibler les enfants nés après 28 semaines de gestation porteurs de séquelles. Le principal objectif des présents travaux visait à évaluer l’utilité de l’Évaluation neurologique d’Amiel-Tison (ENAT) dans l’identification et le suivi des enfants nés entre 29 et 37 semaines de gestation et qui présenteront des problèmes neurodéveloppementaux à l’âge corrigé (AC) de 24 mois. Plus précisément, la fidélité inter-examinateurs, la stabilité ainsi que la validité prédictive de l’ENAT ont été évaluées. La cohorte était composée initialement de 173 enfants nés entre 290/7 et 370/7 semaines de gestation, avec un PN<2500g et ayant passé au moins 24 heures à l’unité de soins néonatals du CHU Sainte-Justine. Les enfants étaient évalués avec l’ENAT à terme et aux AC de 4, 8, 12 et 24 mois. À l’AC de 24 mois, leur développement était évalué à l’aide du Bayley Scales of Infant Development–II. Les principaux résultats révèlent une excellente fidélité inter-examinateurs ainsi qu’une bonne stabilité au cours des deux premières années de vie du statut et des signes neurologiques. Des différences significatives à l’AC de deux ans ont été relevées aux performances développementales en fonction du statut neurologique à terme, qui constitue l’un des meilleurs facteurs prédictifs de ces performances. Les résultats encouragent l’intégration du statut neurologique tel que mesuré par l’ENAT comme marqueur précoce dans le cours d’une surveillance neurodéveloppementale des enfants les plus à risque. / Despite the progress in medicine, early prediction of neurodevelopmental outcome for infants born preterm still remains a challenge. Infants born preterm are at risk of mild to severe disabilities such as cerebral palsy, mental retardation, sensory impairments or learning disabilities. To reduce the functional impact of those disabilities, identification of valid early markers of neurodevelopmental disabilities becomes important. As financial and human resources are limited, only those infants with a gestational age (GA) <29 weeks and a birth weight (BW) <1250 are systematically followed, leaving 95% of the preterm population without surveillance. The identification of early markers would allow targeting infants born after 28 weeks of GA the more at risk. The main objective of the present work was to assess the use of the Amiel-Tison Neurological Assessments (ATNA) in the identification and the follow-up of infants with a GA between 29 and 37 weeks who will present neurodevelopmental problems at two years of corrected age (CA). Specifically, the inter-examiner reliability, the stability during the first two years of life and the predictive validity of the ATNA were assessed. The cohort was composed of 173 children born between 290/7 and 370/7 weeks of GA, with a BW<1250g and who stayed at least 24 hours in the neonatal intensive care unit at the CHU Sainte-Justine. The children were assessed with the ATNA at term age and at 4, 8, 12 and 24 months CA. At 24 months CA, their development was assessed with the Bayley Scales of Infant Development–II. The results revealed excellent inter-examiners reliability and good stability during the first two years of age of the neurological status and signs. Significant differences according to the neurological status at term age were observed at 24 months CA for developmental performance. Moreover, this status was one of the main predictive variables of developmental performance at two years CA. Results incite the integration of the neurological status as assessed by the ATNA as an early marker for the surveillance of infants the more at risk.

Background: Oruro is a mining city in the Bolivian highlands. Most of its citizens are exposed to polymetalic cocktails. This study aims to determine whether the neuropsychological development of one year-old children can be associated with 1) polymetalic exposures and/or 2) growth patterns. Methods: The thesis builds from data collected by the ToxBol multidisciplinary project. The health task was centred on the follow-up of a birth-cohort that set to evaluate child development. Children were examined at 11 and 12 months of age using the Bayley Scale of Infant Development (BSID). Results: 1) Analyses revealed no high concentrations of metals in the blood of pregnant women. 2) No neuropsychological anomalies were observed in association with metal concentrations or growth patterns. 3) A positive association was observed between low lead values in blood and the neuropsychological development of children. 4) During the first 6 months of life, growth rate was negatively associated with weight at birth and positively associated with the BMI at 12 months of age. Conclusion: Although heavy metallic pollution was demonstrated by environmental studies, unexpected low levels of exposure were registered from pregnant women. Neither the level of exposure to metals nor the growth patterns appear to have an impact on child neuropsychological development. We argue that the positive effect that was observed in association to lead might be caused by factors such as diet. / Antecedentes: Oruro es una ciudad minera del altiplano boliviano. Muchos de sus habitantes están expuestos a un cóctel polimetálico. El objetivo principal es el de determinar si existe una asociación entre desarrollo neuropsicológico de los niños de un año y 1) la exposición polimetálica y/o 2) los patrones de crecimiento. Métodos: Esta tesis está basada en los datos recogidos del Proyecto multidisciplinario ToxBol. Se realizó el seguimiento de una cohorte de niños para evaluar su desarrollo. Para evaluar el desarrollo neuropsicológico de los niños se utilizaron las escalas de Bayley de desarrollo infantil (BSID). Resultados: 1) No se observaron altas concentraciones de metales en sangre de las mujeres embarazadas. 2) No se observaron anormalidades neuropsicológicas en relación con concentraciones de metales o patrones de crecimiento. 3) Se observó una asociación positiva entre exposiciones bajas de plomo y el desarrollo neuropsicológico del niño al año de vida. 4) La velocidad de crecimiento, desde el nacimiento hasta los 6 meses, se asoció negativamente con el peso al nacer y positivamente con el BMI a los 12 meses. Conclusión: A diferencia de lo demostrado en otros estudios epidemiológicos, se observó una inesperada baja exposición. No se observó una relación entre el grado de exposición a metales- o los patrones de crecimiento -y el desarrollo neuropsicológico del niño. El efecto positivo del plomo creemos que se debe a otros factores como la dieta. / Antecedents: Oruro es una ciutat minera del altiplà Bolivià. La població es troba es contacte amb fonts de contaminación polimetàlica. L’objectiu principal es el de determinar si existeix una associació entre el desenvolupament neuropsicològic dels nens d’un any i 1) la exposició polimetálica i/o 2) patrons de creixement. Mètodes: Esta tesi està basada en dades del Projecte multidisciplinari ToxBol. La tasca de salut es va centrar en el seguiment del desenvolupament d’una cohort de nens. El desenvolupament neuropsicològic infantil es va avaluar amb les escales de Baley de Desenvolupament infantil (BSID). Resultats: 1) No es van observar concentracions altes de metalls en sang de les dones embarassades. 2) No es va observar anormalitats neuropsicològiques en realció amb les concentracions de metalls o patrons de creixement. 3) Es va observar una associació positiva entre concentracions baixes de plom en sang i el desenvolupament neuropsicològic dels nens d’un any. 4) La velocitat de creixement, des del naixement fins els 6 mesos, es va associar negativament amb el pes al néixer i positivament amb el BMI als 12 mesos. Conclusió: A diferencia del que esperàvem, es van registrar baixes concentracions de metalls a les dones embarassades. Tampoc s’observa una relació entre el grau d’exposició a metalls, o patrons de creixement, i el desenvolupament neuropsicològic del nens. El efecte positiu que observem del plom, pensem que es deu a altres factors com la dieta.