<p>Elevated blood pressure (BP) is a significant risk factor for cardiovascular diseases (CVD), which are the leading cause of morbidity and mortality. Dietary minerals such as sodium (Na) and potassium (K) play a crucial role in overall health and play a specific function in regulating blood pressure in the human body. Numerous studies have been conducted on the association between blood pressure and dietary intervention. While many nutritional intervention studies have shown adverse effects of excessive Na intake and the beneficial impact of supplemental K in humans, less is understood on Na and K tissue retention and health outcomes of such retention. The most commonly used biomarkers to study Na retention and regulation is urine Na. However, the use of urine Na concentration as an indicator of Na retention has its limitations and has been recently questioned. In-vivo neutron activation analysis (IVNAA) is a unique and powerful technique for elemental analysis in the human body that has the potential to quantify Na and K retention and monitor their bio-kinetics. This research work designed an in vivo neutron irradiation system with high sensitivity and minimal radiation dose to measure Na/K and monitor Na/K bio-kinetics. The system was characterized, tested, and validated for K measurement in mice and rats. Moreover, we developed a methodology for in vivo quantification of Na in pigs in bone and soft tissue after dietary intervention. The project's overall goal is to exploit the potential of a compact DD neutron generator-based neutron activation analysis system for in vivo quantification of Na and K in humans and small animals.</p>

Several novel techniques for controlling, managing and utilizing high power diode lasers are described. Low pressure water spray cooling for a high heat flux system is developed and proven to be an ideal cooling method for high power diode laser arrays. In order to enable better thermal and optical performance of diode laser arrays, a new and simple optical element, the beam control prism, is invented. It provides the ability to accomplish beam shaping and beam tilting at the same time. Several low thermal resistance diode packaging designs using beam control prisms are proposed, studied and produced. Two pump cavity designs using a diode laser array to uniformly pump rod shape gain media are also investigated.

Laser beam welding has been widely applied in different industrial sectors due to its unique advantages. However, there are still challenges, such as beam positioning in T-joint welding, and gap bridging in butt joint welding,especially in the case of varying gap width along a joint. It is expected that enabling more advanced control to a welding system, and obtaining more in-depth process knowledge could help to solve these issues. The aim of this work is to address such welding issues by a laser beam shaping technology using a novel deformable mirror together with computer vision methods and also to increase knowledge about the benefits and limitations with this approach. Beam shaping in this work was realized by a novel deformable mirror system integrated into an industrial processing optics. Together with a wave front sensor, a controlled adaptive beam shaping system was formed with a response time of 10 ms. The processes were monitored by a coaxial camera with selected filters and passive or active illumination. Conduction mode autogenous bead-on-plate welding and butt joint welding experiments have been used to understand the effect of beam shaping on the melt pool geometry. Circular Gaussian, and elliptical Gaussian shapes elongated transverse to and along the welding direction were studied. In-process melt pool images and cross section micrographs of the weld seams/beads were analyzed. The results showed that the melt pool geometry can be significantly modified by beam shaping using the deformable mirror. T-joint welding with different beam offset deviations relative to the center of the joint line was conducted to study the potential of using machine learning to track the process state. The results showed that machine learning can reach sufficient detection and estimation performance, which could also be used for on-line control. In addition, in-process and multidimensional data were accurately acquired using computer vision methods. These data reveal weaknesses of current thermo-fluid simulation model, which in turn can help to better understand and control laser beam welding. The obtained results in this work shows a huge potential in using the proposed methods to solve relevant challenges in laser beam welding. / Lasersvetsning används i stor utsträckning i olika industrisektorer på grund av dess unika fördelar. Det finns emellertid fortfarande utmaningar, såsom rätt positionering av laserstrålen vid genomträngningssvetsning av T-fogar och hantering av varierande spaltbredd längs fogen vid svetsning av stumfogar. Sådana problem förväntas kunna lösas med avancerade metoder för automatisering, metoder som också förväntas ge fördjupade kunskaper om processen. Syftet med detta arbete är att ta itu med dessa problem med hjälp av en teknik för lasereffektens fördelning på arbetsstycket, s.k. beam shaping. Det sker med hjälp av en ny typ av i realtid deformerbar spegel tillsammans med bildbehandling av kamerabilder från processen. För- och nackdelar med detta tillvägagångssätt undersöks.Beam shaping åstadkoms med hjälp av ny typ av deformerbart spegelsystem som integreras i en industriell processoptik. Tillsammans med en vågfrontsensor bildas ett adaptivt system för beam shaping med en svarstid på 10 ms. Processen övervakas av en kamera linjerad koaxialt med laserstrålen. För att kunna ta bilder av svetspunkten belyses den med ljus av lämplig våglängd, och kameran är försedd med ett motsvarande optiskt filter. Försök har utförts med svetsning utan tillsatsmaterial, direkt på plåtar, svetsning utan s.k. nyckelhål, för att förstå effekten av beam shaping på svetssmältans geometri. Gauss fördelade cirkulära och elliptiska former, långsträckta både tvärs och längs svetsriktningen har studerats. Bilder från svetssmältan har analyserats och även mikrostrukturen i tvärsnitt från de svetsade plåtarna. Resultaten visar att svetssmältans geometri kan modifieras signifikant genom beam shaping med hjälp av det deformerbara spegelsystemet. Genomträngningssvetsning av T-fogar med avvikelser relativt foglinjens centrum genomfördes för att studera potentialen i att använda maskininlärning för att fånga processens tillstånd. Resultaten visade att maskininlärning kan nå tillräcklig prestanda för detektering och skattning av denna avvikelse. Något som också kan användas för återkopplad styrning. Flerdimensionell processdata har samlats i realtid och analyserats med hjälp av bildbehandlingsmetoder.  Dessa data avslöjar brister i nuvarande simuleringsmodeller,vilket i sin tur hjälper till med att bättre förstå och styra lasersvetsning.Resultaten från detta arbete uppvisar en god potential i att använda de föreslagna metoderna för att lösa relevanta utmaningar inom lasersvetsning. / <p>Till licentiatuppsats hör 2 inskickade artiklar, som visas inte nu.</p>

Un faisceau de Bessel est un champ électromagnétique résistant à la diffraction. il peut se propager en préservant son profile transversal d'intensité même en régime de filamentation. Ceci est très avantageux pour les applications laser de haute puissance, en particulier parce qu’ils permettent de générer des canaux de plasma homogènes dans les diélectriques. Cependant, à haute intensité, les impulsions laser ultracourtes subissent, dans certaines conditions expérimentales (faible focalisation), des instabilités non linéaires entraînant la modulation d’intensité du lobe central au cours de la propagation, ce qui peut être néfaste pour ces applications comme l’usinage des matériaux transparents. L’objectif de cette thèse est de contrôler la génération de canaux de plasma par impulsions de Bessel via le contrôle du profil spatial de ces impulsions. Nous avons dans une première partie, développé une méthode expérimentale pour manipuler le profil d’intensité axiale en régime linéaire. La seconde partie concerne l’étude et le contrôle des instabilités non linéaires induites par l’effet Kerr. Nous avons développé un modèle théorique du mélange à quatre ondes dans les faisceaux de Bessel et avons démontré une nouvelle approche pour manipuler ces instabilités par une mise en forme appropriée de l’intensité axiale des faisceaux de Bessel. Nous avons ensuite étudié la validité des modèles de filamentation basés l’équation non linéaire de Schrödinger et le modèle de Drude. Les résultats expérimentaux de la filamentation des faisceaux de Bessel dans le verre ont montré un comportement invariant par propagation, contrairement aux modèles numériques. Nous avons testé et amendé les modèles de dynamiques de plasma et de propagation. Nos simulations sont comparées à des résultats expérimentaux. Nous montrons que les corrections que nous avons pu apporter par rapport à l’état de l’art sont insuffisantes et rendent nécessaire une autre forme de modèle. / Bessel beams are solutions of Helmholtz equation. They can propagate while conserving their transverse intensity profile in space even in filamentation regime. This feature is very advantageous in high power laser applications such as plasma waveguide generation and laser ablation because they can generate homogeneous plasma channels in dielectrics. However, for moderate to low focusing conditions, Bessel pulses can sustain nonlinear instabilities, which consist in the modulation of the central core intensity along the propagation. Such a feature can prevent efficient energy deposition which hampers the applicability of Bessel pulses. The aim of this thesis is to investigate the possibility to control laser-generated plasma channels using spatially-reshaped Bessel pulses. In a first part, we have developed an experimental method based on a spatial light modulator to modify the evolution of the on-axis intensity of Bessel beams in the linear propagation regime. To study and control Kerr-induced instabilities, we developed, in a second part, a novel model based on four wave mixing interactions in Bessel beams. We have then demonstrated a novel approach to control these instabilities via on-axis intensity shaping. Bessel filamentation models in transparent media were then studied. Most models used in literature are based on nonlinear Schrödinger equation for light propagation and Drude model for laser-matter coupling. Experimental results on Bessel filamentation in glass showed propagation-invariant features in contrast with numerical simulations. Several corrections to this model were discussed. Our results show that such models are insufficient to explain our experimental results and thus the need to develop a more suitable one.

In this thesis, an investigation into the modal characteristics of novel beam shapes is presented. Sculpting the phase profile of a Gaussian beam can result in the generation of a beam with unique properties. Described in this thesis are Laguerre-Gaussian (LG), Hermite-Gaussian (HG) and Bessel beams (BBs). The diffraction of LG beam modes from a triangular aperture is explored and this effect can be used for the efficient measurement of the azimuthal mode index l that indicates the number of multiples of 2π of phase changes that the field displays around one circumference of the optical axis. In this study, only LG beams with zero radial mode index p, with p + 1 denoting the number of bright high intensity concentric rings around the optical axis, were considered. Then, a powerful approach to simultaneously determine both mode indices of a pure LG beam using the principal component analysis (PCA) algorithm on the observed far-field diffraction patterns was demonstrated. Owing to PCA algorithm, the shape of the diffracting element used to measure the mode indices is in fact of little importance and the crucial step is ‘training' any diffracting optical system and transforming the observed far-field diffraction patterns into the uncorrelated variables (principal components). Our PCA method is generic and it was extended to other families of light fields such as HG, Bessel and superposed beams. This reinforces the widespread applicability of this method for various applications. Finally, both theoretically and experimentally investigations using interferometry show the definitive linkage between both the radial and azimuthal mode indices of a partially coherent LG beam and the dislocation rings in the far-field cross-correlation function (CCF).

This thesis exploits so called “Optical Eigenmodes” (OEi) in the focal plane of an optical system. The concept of OEi is introduced and the OEi operator approach is outlined, for which quadratic measures of the light field are expressed as real eigenvalues of an Hermitian operator. As an example, the latter is employed to locally minimise the width of a focal spot. The limitations of implementing these spots with state of the art spatial beam shaping technique are explored and a selected spot with a by 40 % decreased core width is used to confocally scan an in focus pair of holes, delivering a two-point resolution enhanced by a factor of 1.3. As a second application, OEi are utilised for fullfield imaging. Therefore they are projected onto an object and for each mode a complex coupling coefficient describing the light-sample interaction is determined. The superposition of the OEi weighted with these coefficients delivers an image of the object. Compared to a point-by-point scan of the sample with the same number of probes, i.e. scanning points, the OEi image features higher spatial resolution and localisation of object features, rendering OEi imaging a compressive imaging modality. With respect to a raster scan a compression by a factor four is achieved. Compared to ghost imaging as another fullfield imaging method, 2-3 orders of magnitude less probes are required to obtain similar images. The application of OEi for imaging in transmission as well as for fluorescence and (surface enhanced) Raman spectroscopy is demonstrated. Finally, the applicability of the OEi concept for the coherent control of nanostructures is shown. For this, OEi are generated with respect to elements on a nanostructure, such as nanoantennas or nanopads. The OEi can be superimposed in order to generate an illumination of choice, for example to address one or multiple nanoelements with a defined intensity. It is shown that, compared to addressing such elements just with a focussed beam, the OEi concept reduces illumination crosstalk in addressing individual nanoelements by up to 70 %. Furthermore, a fullfield aberration correction is inherent to experimentally determined OEi, hence enabling addressing of nanoelements through turbid media.

This thesis describes an electrically thin surface used for electromagnetic applications in the microwave regime. The surface is free-standing and its primary purpose is to modify the phase distribution, or the phase and amplitude distribution of electromagnetic fields propagating through it: it is called phase shifting surface (PSS) in the first case, and phase and amplitude shifting surface (PASS) in the second case. For practical applications, the surface typically comprises three or four layers of metallic patterns spaced by dielectric layers. The patterns of the metallic layers are designed to locally alter the phase (and amplitude in the case of the PASS) of an incoming wave to a prescribed set of desired values for the outgoing wave. The PSS/PASS takes advantage of the reactive coupling by closely spacing of the metallic layers, which results in a larger phase shift range while keeping the structure significantly thin. The PSS concept is used to design components such as gratings and lens antennas which are presented in this document. The components are designed for an operating frequency of 30 GHz. The PSS phase grating gives high diffraction efficiency, even higher than a dielectric phase grating. Several types of lens antennas are also presented, which show comparable performance to that of a conventional dielectric plano-hyperbolic lens antenna with similar parameters. The PASS concept is used in a beam shaping application in which a flat-topped beam antenna is designed. This work demonstrates the potential for realising thin, lightweight and low-cost antennas at Ka band, in particular for substituting higher-gain antenna technologies such as conventional dielectric shaped lens antennas.

This thesis describes an electrically thin surface used for electromagnetic applications in the microwave regime. The surface is free-standing and its primary purpose is to modify the phase distribution, or the phase and amplitude distribution of electromagnetic fields propagating through it: it is called phase shifting surface (PSS) in the first case, and phase and amplitude shifting surface (PASS) in the second case. For practical applications, the surface typically comprises three or four layers of metallic patterns spaced by dielectric layers. The patterns of the metallic layers are designed to locally alter the phase (and amplitude in the case of the PASS) of an incoming wave to a prescribed set of desired values for the outgoing wave. The PSS/PASS takes advantage of the reactive coupling by closely spacing of the metallic layers, which results in a larger phase shift range while keeping the structure significantly thin. The PSS concept is used to design components such as gratings and lens antennas which are presented in this document. The components are designed for an operating frequency of 30 GHz. The PSS phase grating gives high diffraction efficiency, even higher than a dielectric phase grating. Several types of lens antennas are also presented, which show comparable performance to that of a conventional dielectric plano-hyperbolic lens antenna with similar parameters. The PASS concept is used in a beam shaping application in which a flat-topped beam antenna is designed. This work demonstrates the potential for realising thin, lightweight and low-cost antennas at Ka band, in particular for substituting higher-gain antenna technologies such as conventional dielectric shaped lens antennas.

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This thesis describes an electrically thin surface used for electromagnetic applications in the microwave regime. The surface is free-standing and its primary purpose is to modify the phase distribution, or the phase and amplitude distribution of electromagnetic fields propagating through it: it is called phase shifting surface (PSS) in the first case, and phase and amplitude shifting surface (PASS) in the second case. For practical applications, the surface typically comprises three or four layers of metallic patterns spaced by dielectric layers. The patterns of the metallic layers are designed to locally alter the phase (and amplitude in the case of the PASS) of an incoming wave to a prescribed set of desired values for the outgoing wave. The PSS/PASS takes advantage of the reactive coupling by closely spacing of the metallic layers, which results in a larger phase shift range while keeping the structure significantly thin. The PSS concept is used to design components such as gratings and lens antennas which are presented in this document. The components are designed for an operating frequency of 30 GHz. The PSS phase grating gives high diffraction efficiency, even higher than a dielectric phase grating. Several types of lens antennas are also presented, which show comparable performance to that of a conventional dielectric plano-hyperbolic lens antenna with similar parameters. The PASS concept is used in a beam shaping application in which a flat-topped beam antenna is designed. This work demonstrates the potential for realising thin, lightweight and low-cost antennas at Ka band, in particular for substituting higher-gain antenna technologies such as conventional dielectric shaped lens antennas.