Motivation In South Africa, various transitional changes parallel detrimental modifications in lifestyle behaviour of especially the lower socio-economic communities. We are currently double-burdened by a high prevalence of communicable and noncommunicable diseases such as diabetes, chronic respiratory and cardiovascular diseases, which is accompanied by a high cardiovascular mortality rate. Healthcare and treatment resources are limited and low-cost intervention strategies to lower this burden are urgently needed. Unhealthy lifestyle behaviours, such as excessive alcohol consumption and tobacco use, are known to augment inflammation as reflected by inflammatory markers such as C-reactive protein and interleukin-6, which are well-known risk factors for cardiovascular disease and mortality. Several studies showed the prognostic value of soluble urokinase plasminogen activator receptor (suPAR) in advanced disease states and that suPAR associates with different types of cancers, infectious diseases, diabetes, coronary artery disease and all-cause mortality. Since the discovery of suPAR in 1991, the role of this less known inflammatory marker in various diseases has been under debate. It was further reported that black individuals have higher suPAR levels than whites. However, whether an unhealthy lifestyle and cardiometabolic risk factors are related to suPAR, whether suPAR plays a role in the development of cardiovascular disease such as hypertension, and whether suPAR could predict all-cause and cardiovascular mortality, especially among the understudied black South African population, remain to be established. Aim The central aim of this thesis was to determine if suPAR associates with cardiovascular disease development in a black South African population. We therefore explored whether suPAR relates to lifestyle and cardiometabolic risk factors, associates with the development of hypertension and has prognostic value for cardiovascular and all-cause mortality over five years. Methodology This five-year prospective sub-study, which is embedded in the international Prospective Urban and Rural Epidemiology study, included black South African volunteers of ages older than 35 years from the North West province, South Africa. Baseline data collection took place in 2005 during which 2 010 men and women from urban and rural areas were examined. A total of 1 292 participants returned for examination and were followed-up for the first time in 2010. Of these participants, 214 were newly identified as being infected with the human immunodeficiency virus (HIV), while 233 died during the five year period. Standardised methods were used to capture all data and included health questionnaires (lifestyle factors, medication use, disease status and history, mortality outcome), cardiovascular and anthropometric measurements, as well as biochemical analyses of inflammatory markers (suPAR, C-reactive protein, interleukin-6), HIV status and relevant metabolic markers. In preparation for statistical analyses, non-Gaussian variables were logarithmically transformed. We compared means and proportions with independent t-tests, analysis of variance, analysis of covariance (for adjustments) and Chi-square tests, while dependent t-tests and McNemar tests were used for analysis of longitudinal data within individual groups. We determined relationships between variables with Pearson’s correlation coefficients. Independent relationships were determined with logistic regression, forward stepwise multiple regression and proportional Cox-regression analyses. Mortality rates were calculated using Kaplan-Meier survival function estimates and log-rank tests. In all cases, p≤0.05 were used to indicate statistical significance. Results and conclusions of each manuscript Three manuscripts were written in order to achieve the aim of this thesis. In the first manuscript we explored the cross-sectional relationships of suPAR with lifestyle and cardiometabolic risk factors in a black South African population. We showed that suPAR was independently associated with lifestyle behaviours, including alcohol consumption, as indicated by gamma-glutamyltransferase levels (β=0.24; p<0.001), tobacco use (β=0.13; p<0.001) and unemployment (β=0.07; p=0.039), despite no direct links with cardiometabolic factors such as blood pressure, dyslipidaemia, glycaemia or adiposity. These findings emphasise the important need to address lifestyle behaviours in order to limit the detrimental effect of modifiable risk factors on the health and mortality rate of this population. Secondly, we determined whether suPAR was associated with the development of hypertension over five years. We found that suPAR was higher and increased more prominently (14.2% vs. 6.94%; p=0.007) in participants that developed hypertensio than in those that remained normotensive. Change in systolic blood pressure was independently associated with baseline suPAR (β=0.14; p=0.043), while becoming hypertensive was associated with an increase in suPAR (odds ratio=1.41; p=0.015). Whether inflammation leads to the development of hypertension or vice versa, remains unclear. Our findings emphasise the need to acknowledge the role of inflammation in hypertension and may permit further investigation of the use of suPAR as a potential marker for early risk identification and intervention. The third manuscript investigated the prognostic value of suPAR, compared to other inflammatory markers C-reactive protein and interleukin-6, in all-cause and cardiovascular mortality. We showed for the first time in a black population that suPAR predicted both all-cause (hazard ratio=1.27; p=0.003) and cardiovascular mortality (hazard ratio=1.40; p=0.026), independent of interleukin-6. Future research is needed to clarify the mechanisms behind the association of suPAR with cardiovascular mortality and to explore the possibility of a suPAR cut-off value for early identification of those with increased risk for cardiovascular morbidity and mortality in this population. General conclusion In this thesis we showed for the first time that suPAR has potential as a marker of cardiovascular disease development in black South Africans. SuPAR associated with hypertension and independently predicted all-cause and cardiovascular mortality over five years. Our findings, that suPAR is independently associated with adverse health behaviours such as alcohol and tobacco use, lend support for the use of suPAR as a novel approach for early risk identification and intervention strategies, which may be effective in combatting the high cardiovascular disease burden among the black South African community. / PhD (Physiology), North-West University, Potchefstroom Campus, 2015

Motivation In South Africa, various transitional changes parallel detrimental modifications in lifestyle behaviour of especially the lower socio-economic communities. We are currently double-burdened by a high prevalence of communicable and noncommunicable diseases such as diabetes, chronic respiratory and cardiovascular diseases, which is accompanied by a high cardiovascular mortality rate. Healthcare and treatment resources are limited and low-cost intervention strategies to lower this burden are urgently needed. Unhealthy lifestyle behaviours, such as excessive alcohol consumption and tobacco use, are known to augment inflammation as reflected by inflammatory markers such as C-reactive protein and interleukin-6, which are well-known risk factors for cardiovascular disease and mortality. Several studies showed the prognostic value of soluble urokinase plasminogen activator receptor (suPAR) in advanced disease states and that suPAR associates with different types of cancers, infectious diseases, diabetes, coronary artery disease and all-cause mortality. Since the discovery of suPAR in 1991, the role of this less known inflammatory marker in various diseases has been under debate. It was further reported that black individuals have higher suPAR levels than whites. However, whether an unhealthy lifestyle and cardiometabolic risk factors are related to suPAR, whether suPAR plays a role in the development of cardiovascular disease such as hypertension, and whether suPAR could predict all-cause and cardiovascular mortality, especially among the understudied black South African population, remain to be established. Aim The central aim of this thesis was to determine if suPAR associates with cardiovascular disease development in a black South African population. We therefore explored whether suPAR relates to lifestyle and cardiometabolic risk factors, associates with the development of hypertension and has prognostic value for cardiovascular and all-cause mortality over five years. Methodology This five-year prospective sub-study, which is embedded in the international Prospective Urban and Rural Epidemiology study, included black South African volunteers of ages older than 35 years from the North West province, South Africa. Baseline data collection took place in 2005 during which 2 010 men and women from urban and rural areas were examined. A total of 1 292 participants returned for examination and were followed-up for the first time in 2010. Of these participants, 214 were newly identified as being infected with the human immunodeficiency virus (HIV), while 233 died during the five year period. Standardised methods were used to capture all data and included health questionnaires (lifestyle factors, medication use, disease status and history, mortality outcome), cardiovascular and anthropometric measurements, as well as biochemical analyses of inflammatory markers (suPAR, C-reactive protein, interleukin-6), HIV status and relevant metabolic markers. In preparation for statistical analyses, non-Gaussian variables were logarithmically transformed. We compared means and proportions with independent t-tests, analysis of variance, analysis of covariance (for adjustments) and Chi-square tests, while dependent t-tests and McNemar tests were used for analysis of longitudinal data within individual groups. We determined relationships between variables with Pearson’s correlation coefficients. Independent relationships were determined with logistic regression, forward stepwise multiple regression and proportional Cox-regression analyses. Mortality rates were calculated using Kaplan-Meier survival function estimates and log-rank tests. In all cases, p≤0.05 were used to indicate statistical significance. Results and conclusions of each manuscript Three manuscripts were written in order to achieve the aim of this thesis. In the first manuscript we explored the cross-sectional relationships of suPAR with lifestyle and cardiometabolic risk factors in a black South African population. We showed that suPAR was independently associated with lifestyle behaviours, including alcohol consumption, as indicated by gamma-glutamyltransferase levels (β=0.24; p<0.001), tobacco use (β=0.13; p<0.001) and unemployment (β=0.07; p=0.039), despite no direct links with cardiometabolic factors such as blood pressure, dyslipidaemia, glycaemia or adiposity. These findings emphasise the important need to address lifestyle behaviours in order to limit the detrimental effect of modifiable risk factors on the health and mortality rate of this population. Secondly, we determined whether suPAR was associated with the development of hypertension over five years. We found that suPAR was higher and increased more prominently (14.2% vs. 6.94%; p=0.007) in participants that developed hypertensio than in those that remained normotensive. Change in systolic blood pressure was independently associated with baseline suPAR (β=0.14; p=0.043), while becoming hypertensive was associated with an increase in suPAR (odds ratio=1.41; p=0.015). Whether inflammation leads to the development of hypertension or vice versa, remains unclear. Our findings emphasise the need to acknowledge the role of inflammation in hypertension and may permit further investigation of the use of suPAR as a potential marker for early risk identification and intervention. The third manuscript investigated the prognostic value of suPAR, compared to other inflammatory markers C-reactive protein and interleukin-6, in all-cause and cardiovascular mortality. We showed for the first time in a black population that suPAR predicted both all-cause (hazard ratio=1.27; p=0.003) and cardiovascular mortality (hazard ratio=1.40; p=0.026), independent of interleukin-6. Future research is needed to clarify the mechanisms behind the association of suPAR with cardiovascular mortality and to explore the possibility of a suPAR cut-off value for early identification of those with increased risk for cardiovascular morbidity and mortality in this population. General conclusion In this thesis we showed for the first time that suPAR has potential as a marker of cardiovascular disease development in black South Africans. SuPAR associated with hypertension and independently predicted all-cause and cardiovascular mortality over five years. Our findings, that suPAR is independently associated with adverse health behaviours such as alcohol and tobacco use, lend support for the use of suPAR as a novel approach for early risk identification and intervention strategies, which may be effective in combatting the high cardiovascular disease burden among the black South African community. / PhD (Physiology), North-West University, Potchefstroom Campus, 2015

The purpose of this study was to determine whether the various categories of giftedness can be adequately identified in an under-resourced rural area. To supplement the literature, a focus group was held and informal interviews were conducted with people in the area of research. Giftedness was ultimately defined as both potential and product which cannot be separated from the community where the person lives. Apart from causes of underachievement such as poverty, illiteracy, lack of equipment, low motivation and difficult home circumstances, it was found that fear is a powerful hindrance in the actualisation of giftedness, as there is a strong belief that learners who stand out amongst their peers could fall prey to witchcraft. In order to adequately identify giftedness, an identification method which is used by the Faculty of Education at Unisa, was applied to 10 learners. Various talents additional to academic talent were found among the respondents. The identification method was finally evaluated according to certain identification criteria. / Psychology of Education / M. Ed. (Psychology of Education)

The original publication is available at http://www.commerce.uct.ac.za/Organisations/Demography/SA_Journal_of_Demography/SAJD/Volume%208/SAJDem_2000_8_1_Bekker.pdf

The problem with which this study is concerned is that of discrimination. Data from the United States Bureau of the Census is used to approach the problem through the concept of economic discrimination. This study has two purposes. First, it tests the hypothesis that blacks in the South have been subjected to significant economic discrimination, and, in turn, to give quantitative estimates of its magnitude if the hypothesis is accepted. The secondary purpose is to make a comparison of the relative importance of the independent variables for blacks and whites.

Typescript, etc. / Digitized by Kansas State University Libraries

This thesis attempts to reconstruct the manner and the effects of the forced removal of the Ravele community, from their historical homes in old Mauluma1 along the Luvuvhu River Valley. Luvuvhu is the name given to a river that dominates the area under discussion. The name Luvuvhu’ is retained until, it enters Kruger National Park, where the Vatsongas call it Phafuri - as the river flows through Chief Mphaphuli’s territory. After relocation, the whole area under discussion is now known as Levubu. Levubu is corruption of the word Luvuvhu by the local white farming community. Old Mauluma in the Luvuvhu valley was situated on the North Eastern part of Louis Trichardt. More or less 3000 Ravele community members were forcibly removed from their land, between 1920 and 1940 to new Mauluma or Beaconsfields.2 The removal constituted a severe crisis for the members of the community as they were taken from a rich ecological area and resettled 100 kilometres west of old Mauluma, a dry and rocky area. A study of the Ravele community’s removal from old Mauluma (Levubu area) is especially pertinent at this juncture because of the campaign by the previous owners to reclaim their land. Since the April 1994 election and the promise by the government that dispossessed people could reclaim their land, hundreds of the former Levubu residents (including Ravele community) have demanded compensation or return to their land. Not surprisingly, the campaign has the support of all those who were removed, but is viewed with suspicion by white farmers in Levubu and surrounding areas. Whether the Ravele community will succeed in their campaign or not is uncertain. However the campaign has highlighted the anger of people who were forcibly removed from their homes. Many of these people believe, naively perhaps, that the wrongs of the past will only be eradicated when they can escape the enforced racial segregation of the past and return to their old location where the Vhavenda and the Vatsonga lived together. / Prof. L.W.F Grundlingh

An understanding of the identity of reading and its social meanings should contribute to the quality of adult literacy work. This study is an inquiry into ways ot understanding reading, and specifically into its meaning and role in the lives of black workers in South Africa. The understanding of reading has been dominated by positivism, but 1ncreasing interest has been shown in the relationship cf literacy and society. However, even these approaches remain largely objective. Alternatives to objectivism are presented in some detail. This provides the background and rationale for a broad account of the social history and contexts of reading in black society in South Africa and for a study of what reading means to eighteen leading black employees at two East Rand factories. The reading world of black workers is characterised by various deprivations and disadvantages. The printed word is owned and controlled by white government and capital in a contradictory and contested hegemony, yet it is perceived positively as an aspect of our society in which black people participate fully, and from which they benefit unequivocally. Reading is understood in terms of aspirations to modernity and to be.ng at home in s national and cosmopolitan community. The experience of reading is felt to be vitally important, although it is not a major feature in the daily lives of most of the participants in this study. Newspapers occupy a dominant position in the reading world of black workers, but t ne level of critical awareness of the media would appeal to be low. The study as a whole works against reductionism; the tendency for literacy to be claimed in the name of instrumental purposes is contested. Implications of the study for adult education and research are briefly considered.

D.Arch., Faculty of Architecture, University of the Witwatersrand, 1953

Due to a number of reasons, black commuters In South Africa are often faced with long, timeous and complicated journeys to work. The purpose of this research report is to determine how these long commuting distances influence the punctuality and rate of absenteeism of black employers to the work-place. A survey was undertaken in Cape Town, Pretoria, Bloemfontein and Durban. The sample of 1238 respondents was divided into long and short-distance commuters and the answers of these two groups were compared. Respondents were questioned about factors causing them to be late or absent from work as well as . their attitudes towards punctuality. They were also questioned about their employers' attitude towards lateness. The results showed clearly that transport related problems constituted a major part of all late arrivals at the work place. Lateness due to transport problems was mainly influenced by the distance travelled to work, the total travel time, the number of transfers, the time the commuter had to leave his home, and the time he had to start work. Although absenteeism was also increased by the distance commuters had to travel and the difficulty of the journey, it was experienced much less than lateness. Lateness at the work-place due to transport problems is a big problem in South Africa, which is aggravated by the long distances faced by many commuters. It is important to try to minimize the problem and thereby cut the cost of lateness to industry.