Blindness is one of the most debilitating health disorders and avoidable blindness is a major international health problem. The World Health Organization has estimated that globally, there are 45 million persons who are blind - a figure that is expected to increase to approximately 76 million by the year 2020. Approximately 80% of blindness is avoidable and can be prevented or cured with appropriate service delivery efforts. Research suggests that the combined annual global GDP loss from blindness in 2000 was more than $40 billion. Yet blindness has received relatively little attention in worldwide efforts to promote health and it is not at present a high health priority in many countries. Consequently, unless there are alternative and more efficient and extended endeavours to address this situation and model an approach that will provide a long-term solution, avoidable blindness will continue. In recent years, eye care service delivery organisations have assumed a greater level of responsibility for addressing the problem of avoidable blindness. A number of successful approaches have been designed and implemented to expand the delivery of eye care services. The approaches have focused on the development of organisational capacity and on sustainability, and they have effectuated a reduction in avoidable blindness in particular target populations. However, despite their importance, contemporary eye care service delivery models have largely been neglected in the literature and few formal organisational approaches to eye care have been developed and documented. There are few definitive independent studies available that outline the bases of these approaches and no explicit and standardised methodologies that can assist service delivery organisations to replicate the approaches. Objective and comprehensive research is accordingly required to promote current and new approaches to eye care and to develop ways of facilitating their adoption. The thesis attempts to address this problem by developing a theory–based, case study–supported practical methodology to identify, support the progression of, and measure the strategic and operational objectives of eye care service delivery organisations. The research seeks to identify the issues relevant to the management of eye care service delivery organisations and subsequently evaluate whether they can be incorporated into a distinct and explicit management framework. It seeks to present the value of the process and the possibility that it can be accomplished elsewhere and in dissimilar organisations. By developing a widely applicable management framework, the research's primary contribution is that it extends eye care organisational management theory to assist in the facilitation of blindness reduction. A conceptual management framework is developed in the thesis which unifies contemporary eye care organisational approaches with the Balanced Scorecard management framework. The framework was devised for and evaluated by undertaking two case studies – one in India and one in South Africa. The significance of developing such a framework is demonstrated at various points throughout the thesis. The research process reveals the potential applicability of the framework – the Strategic Management Framework (SMF). The research concludes that the SMF is able to support and enhance organisational development, performance management, and scenario analyses in eye care service delivery organisations operating in developing countries. Although the framework developed in the thesis is specific to eye care organisations it is flexible enough to be transferable to other healthcare organisations in developed countries. The final conclusion of the thesis is that, while the SMF is not in itself a solution to the problem of avoidable blindness, it is an appropriate and practical management tool which will improve existing, and assist in the establishment of new, eye care service delivery organisations. In this context, the research makes a number of significant and original contributions to prevention of blindness literature and theory. / Thesis (Ph.D.)--School of History and Politics, 2004.

Mobile communication has become an essential part of our daily life. We love the flexibility of wireless cell phones and even accept their lower quality of service when compared to wired links. Similarly, we are looking forward to the day that we can continue watching our favorite TV programs while travelling anywhere and everywhere. Mobility, flexibility, and portability are the themes of the next generation communication. Motivated and fascinated by such technology breakthroughs, this effort is geared towards enhancing the quality of wireless services and bringing mobile satellite reception one step closer to the market. Meanwhile, phased array antennas are vital components for RADAR applications where the antenna is required to have certain scan capabilities. One of the main concerns in that perspective is how to avoid the potential of scan blindness in the required scan range. Targeting to achieve wide-band wide-scan angle phased arrays free from any scan blindness our efforts is also geared. Conventionally, the key to lower the profile of the antenna is to use planar structures. In that perspective microstrip patch antennas have drawn the attention of antenna engineers since the 1970s due to their attractive features of being low profile, compact size, light weight, and amenable to low-cost PCB fabrication processes. However, patch elements are basically resonating at a single frequency, typically have <2% bandwidth, which is a major deficit that impedes their usage in relatively wide-band applications. There are various approaches to enhance the patch antennas bandwidth including suspended substrates, multi-stack patches, and metalized cavities backing these patches. Metalized cavity-backed patch structures have been demonstrated to give the best performance, however, they are very expensive to manufacture. In this dissertation, we develop an alternative low-cost bandwidth enhancement topology. The proposed topology is based on substrate-integrated waveguides. The great potential of the proposed structure lies in being amenable to the conventional PCB fabrication. Moreover, substrate-integrated cavity-backed structures facilitate the design of sophisticated arrays that are very expensive to develop using the conventional metalized cavity-backed topology, which includes the common broadside arrays used in fixed-beam applications and the scanned phased arrays used in RADAR applications.

The ability to differentiate between colours varies from individual to individual. This variation is attributed to factors such as the presence of colour blindness. Colour is used to encode information in information visualizations. An example of such an encoding is categorization using colour (e.g., green for land, blue for water).<p> As a result of the variation in colour differentiation ability among individuals, many people experience difficulties when using colour-encoded information visualizations. These difficulties result from the inability to adequately differentiate between two colours, resulting in confusion, errors, frustration, and dissatisfaction.<p> If a user-specific model of colour differentiation was available, these difficulties could be predicted and corrected. Prediction and correction of these difficulties would reduce the amount of confusion, errors, frustration, and dissatisfaction experienced by users. This thesis presents a model of colour differentiation that is tuned to the abilities of a particular user. To construct this model, a series of judgement tasks are performed by the user. The data from these judgement tasks is used to calibrate a general colour differentiation model to the user. This calibrated model is used to construct a predictor. This predictor can then be used to make predictions about the user's ability to differentiate between two colours.<p> Two participant-based studies were used to evaluate this solution. The first study evaluated the basic approach used to model colour differentiation. The second study evaluated the accuracy of the predictor by comparing its performance to the performance of human participants. It was found that the predictor was as accurate as the human participants 86.3% of the time. Using such a predictor, the colour differentiation abilities of particular users can be accurately modeled.

The ability to differentiate between colours varies from individual to individual. This variation is attributed to factors such as the presence of colour blindness. Colour is used to encode information in information visualizations. An example of such an encoding is categorization using colour (e.g., green for land, blue for water).<p> As a result of the variation in colour differentiation ability among individuals, many people experience difficulties when using colour-encoded information visualizations. These difficulties result from the inability to adequately differentiate between two colours, resulting in confusion, errors, frustration, and dissatisfaction.<p> If a user-specific model of colour differentiation was available, these difficulties could be predicted and corrected. Prediction and correction of these difficulties would reduce the amount of confusion, errors, frustration, and dissatisfaction experienced by users. This thesis presents a model of colour differentiation that is tuned to the abilities of a particular user. To construct this model, a series of judgement tasks are performed by the user. The data from these judgement tasks is used to calibrate a general colour differentiation model to the user. This calibrated model is used to construct a predictor. This predictor can then be used to make predictions about the user's ability to differentiate between two colours.<p> Two participant-based studies were used to evaluate this solution. The first study evaluated the basic approach used to model colour differentiation. The second study evaluated the accuracy of the predictor by comparing its performance to the performance of human participants. It was found that the predictor was as accurate as the human participants 86.3% of the time. Using such a predictor, the colour differentiation abilities of particular users can be accurately modeled.

本研究欲了解「大家來找碴」（Spot the Differences）此類偵測作業的遊戲在設計時應注意的元素為何？兩個實驗皆為參與者內設計，在實驗一中操弄產品置入在遊戲畫面中的聚焦區（area of interest, AOI）與否，以及產品是否為遊戲目標，測量偵測的正確率、反應時間和再認表現，以檢視產品置入在遊戲中是否能吸引注意力？結果發現當產品置入在聚焦區時的反應時間快於在非聚焦區。當產品是遊戲目標時的再認表現，優於不是遊戲目標時；而當產品位在非聚焦區時的再認表現，會優於廣告在聚焦區時。然而，實驗一中的產品並未包含商標，為進一步探討探討廣告效益，在實驗二中加入有商標的廣告商品，並使用眼動儀，測量參與者對商品的眼動處理模式，如凝視時間（fixation duration）與凝視次數（number of fixation），並請參與者評估對商品的喜好程度和購買意圖。結果發現商品置入在聚焦區的反應時間顯著快於非聚焦區，但商品置入在非聚焦區時的再認表現、喜好程度和購買意圖皆優於置入在聚焦區時。眼動的結果發現，商品是遊戲目標時和在聚焦區時有更長的凝視時間和更多的凝視次數。依據實驗一與實驗二的結果顯示，參與者有可能是在無意識受到商品曝光的影響而產生廣告效果，建議未來研究可加入內隱指標探討當商品位在非聚焦區時的廣告效果，以提供更直接的證據驗證。 / The purpose of this study is to investigate what elements that we should notice when we design kind of Spot-the-Differences games. Two within-subject-designed experiments were conducted. In experiment 1, we manipulated the location of products（area-of-interest or non-area-of-interest）and the type of products（target or non-target）to examine how products attract our attention in in-game advertising.. The results of experiment 1 showed that when products were in the AOI, the reaction times were shorter than those in non-AOI. However, participants could recognize the products better when they were in non-AOI. Furthermore, participants could recognize the products better when products were the targets than non-targets in the game. In order to investigate the effect of in-game advertising, in experiment 2, we added trade mark and used an eye tracker to examine the role of visual attention in-game advertising. Besides, we used liking and purchase intention as an index of advertising effects. The results of experiment 2 showed that products that were in the AOI attracted participants' attention more quickly. However, products in non-AOI showed better recognition performance, liking and purchase intention than those in AOI. The results of eye movements showed that longer fixation duration and more fixation number was observed for targets than for non-targets. According to the results, the effects of advertisement may be resulted from participants being exposed for products in an unconscious manner. Future studies could add the index of unconscious processing to clarify the implicit effects of in-game advertising.

La navigation repose en majeure partie sur la vision puisque ce sens nous permet de rassembler des informations spatiales de façon simultanée et de mettre à jour notre position par rapport à notre environnement. Pour plusieurs aveugles qui se fient à l’audition, le toucher, la proprioception, l’odorat et l’écholocation pour naviguer, sortir à l’extérieur de chez soi peut représenter un défi considérable. Les recherches sur le circuit neuronal de la navigation chez cette population en particulier s’avèrent donc primordiales pour mieux adapter les ressources aux handicapés visuels et réussir à les sortir de leur isolement. Les aveugles de naissance constituent aussi une population d’intérêt pour l’étude de la neuroplasticité. Comme leur cerveau s’est construit en absence d’intrant visuel, la plupart des structures reliées au sens de la vue sont réduites en volume par rapport à ceux de sujets voyants. De plus, leur cortex occipital, une région normalement dédiée à la vision, possède une activité supramétabolique au repos, ce qui peut représenter un territoire vierge pouvant être recruté par les autres modalités pour exécuter diverses tâches sensorielles. Plusieurs chercheurs ont déjà démontré l’implication de cette région dans des tâches sensorielles comme la discrimination tactile et la localisation auditive. D’autres changements plastiques de nature intramodale ont aussi été observés dans le circuit neuronal de la navigation chez ces aveugles. Par exemple, la partie postérieure de l’hippocampe, impliquée dans l’utilisation de cartes mentales, est réduite en volume alors que la section antérieure est élargie chez ces sujets. Bien que ces changements plastiques anatomiques aient bel et bien été observés chez les aveugles de naissance, il reste toutefois à les relier avec leur aspect fonctionnel. Le but de la présente étude était d’investiguer les corrélats neuronaux de la navigation chez l’aveugle de naissance tout en les reliant avec leurs habiletés spatio-cognitives. La première étude comportementale a permis d’identifier chez les aveugles congénitaux une difficulté d’apprentissage de routes tactiles construites dans des labyrinthes de petite échelle. La seconde étude, employant la technique d’imagerie par résonance magnétique fonctionnelle, a relié ces faiblesses au recrutement de régions cérébrales impliquées dans le traitement d’une perspective égocentrique, comme le lobule pariétal supérieur droit. Alors que des sujets voyants aux yeux bandés excellaient dans la tâche des labyrinthes, ces derniers recrutaient des structures impliquées dans un traitement allocentrique, comme l’hippocampe et le parahippocampe. Par ailleurs, la deuxième étude a confirmé le recrutement du cortex occipital dans une tâche de navigation chez les aveugles seulement. Ceci confirme l’implication de la plasticité intermodale dans des tâches cognitives de plus haut niveau, comme la navigation. / Navigation is predominately based on vision as it gathers spatial information simultaneously and allows a continuous update of our position relative to space. For many blind people who rely mainly on auditive, haptic, proprioceptive, olfactive and echolocating cues to navigate, leaving outside their home can be a challenge. Research on the navigational neural network in this particular population is therefore crucial to better adapt resources for visually impaired people and free them from isolation. Congenitally blind subjects are also an interesting population for the study of neuroplasticity. As their brain was built without any visual input, most structures related to vision are reduced in volume compared to those of seeing subjects. Moreover, their occipital cortex, a region normally dedicated to vision, has a suprametabolic activity at rest, which could represent a virgin territory that can be recruited by other modalities to accomplish various sensory tasks. Recently some researchers have demonstrated the involvement of this region in sensory tasks such as tactile discrimination and auditive localisation. Other intramodal plastic changes have also been observed in the blind’s navigational neural network. The posterior part of hippocampus, involved in cognitive mapping, is reduced in volume while the anterior section is enlarged in blind subjects. Although some anatomical plastic changes have been observed in congenitally blind’s brain navigational system, their functional aspect remains to be elucidated. The purpose of this study was to investigate the neural correlates of navigation in congenital blindness and to link them with the blinds’ spatio-cognitive skills. The first behavioral study identified route learning difficulties in congenitally blind participants when they were ask to navigate inside small-scaled tactile mazes. Using functional magnetic resonance imagery in the second study, these problems were associated with the recruitment of brain regions involved in an egocentric perspective processing, such as right superior parietal lobule. While blindfolded seeing subjects excelled in the maze task, they recruited structures involved in allocentric processing, such as hippocampus and parahippocampus. Moreover, the second study confirmed the recruitment of occipital cortex in a navigation task for blind subjects only. This strengthens the involvement of crossmodal plasticity in higher level cognitive tasks, such as navigation.

La littérature décrit certains phénomènes de réorganisation physiologique et fonctionnelle dans le cerveau des aveugles de naissance, notamment en ce qui a trait au traitement de l’information tactile et auditive. Cependant, le système olfactif des aveugles n’a reçu que très peu d’attention de la part des chercheurs. Le but de cette étude est donc de comprendre comment les aveugles traitent l’information olfactive au niveau comportemental et d’investiguer les substrats neuronaux impliqués dans ce processus. Puisque, en règle générale, les aveugles utilisent leurs sens résiduels de façon compensatoire et que le système olfactif est extrêmement plastique, des changements au niveau de l’organisation anatomo-fonctionnelle pourraient en résulter. Par le biais de méthodes psychophysiques et d’imagerie cérébrale (Imagerie par Résonance Magnétique fonctionnelle-IRMf), nous avons investigué les substrats anatomo-fonctionnels sollicités par des stimuli olfactifs. Nous avons trouvé que les aveugles ont un seuil de détection plus bas que les voyants, mais que leur capacité à discriminer et identifier des odeurs est similaire au groupe contrôle. Ils ont aussi plus conscience de l’environnement olfactif. Les résultats d’imagerie révèlent un signal BOLD plus intense dans le cortex orbitofrontal droit, le thalamus, l’hippocampe droit et le cortex occipital lors de l’exécution d’une tâche de détection d’odeur. Nous concluons que les individus aveugles se fient d’avantage à leur sens de l’odorat que les voyants afin d’évoluer dans leur environnement physique et social. Cette étude démontre pour la première fois que le cortex visuel des aveugles peut être recruté par des stimuli olfactifs, ce qui prouve que cette région assume des fonctions multimodales. / It is generally acknowledged that people blind from birth develop supra-normal sensory abilities in order to compensate for their visual deficit. While extensive research has been done on the somatosensory and auditory modalities of the blind, information about their sense of smell remains scant. The goal of this study was therefore to understand olfactory processing in the blind at the behavioral and the neuroanatomical levels. Since blind individuals use their remaining senses in a compensatory way to assess their environment and since the olfactory system is highly plastic, it is likely to be susceptible to changes similar to those observed for tactile and auditory modalities. We used psychophysical testing and functional magnetic resonance imaging (fMRI) to investigate the neuronal substrates responsible for odor processing. Our data showed that blind subjects had a lower odor detection threshold compared to the sighted. However, no group differences were found for odor discrimination and odor identification. Interestingly, the OAS revealed that blind participants scored higher for odor awareness. Our fMRI data revealed stronger BOLD responses in the right lateral orbitofrontal cortex, bilateral medio-dorsal thalamus, right hippocampus and left occipital cortex in the blind participants during an odor detection task. We conclude that blind subjects rely more on their sense of smell than the sighted in order to assess their environment and to recognize places and people. This is the first demonstration that the visual cortex of the blind can also be recruited by odorants, thus adding new evidence to its multimodal function.

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Thesis (Ph.D.)--Yale University, 2004. / Presented to the Faculty of the Graduate School of Yale University in candidacy for the degree of Doctor of Philosophy. Includes bibliography. Preview available online at: http://proquest.umi.com/pqdlink?did=765029031&Fmt=7&clientId%20=43258&RQT=309&VName=PQD.

Orientador: Silvana Artioli Schellini / Resumo: Introdução: No Brasil o Sistema Único de Saúde (SUS) é responsável por prover assistência universal a saúde para toda a população. Contudo, o acesso ao atendimento oftalmológico é sabidamente deficitário. As Unidades Móveis Oftalmológicas (UMO) podem facilitar o acesso ao atendimento oftalmológico à população, sendo importante a interface com o serviço terciário, para onde devem ser referenciados os casos mais complexos e os que exigem tratamento cirúrgico. Objetivo: Verificar a efetividade do atendimento oftalmológico realizado em um centro de referência após triagem oftalmológica realizada pela UMO. Materiais e Métodos: Estudo prospectivo realizado com pacientes atendidos em 10 municípios do centro-oeste paulista em 2015. Os pacientes passaram por consulta oftalmológica completa na UMO e os com necessidade de procedimentos ou avaliações complementares foram encaminhados ao centro de referência da região, o Hospital das Clínicas de Botucatu (HCFMB). As informações dos pacientes encaminhados foram pesquisadas no prontuário eletrônico da instituição para verificar o comparecimento, tempo até a consulta, tratamento realizado e complicações. Além disso, foram utilizados dados demográficos do Instituto Brasileiro de Geografia e Estatística. Análise estatística realizada no SPSS 22.0, considerado significativo p<0,05. Resultados: Foram atendidos 1928 indivíduos pela UMO, sendo encaminhados 714 (37,0%) ao serviço especializado. A média de idade dos encaminhados foi 57,12±19,53 anos... (Resumo completo, clicar acesso eletrônico abaixo) / Mestre