Yes / Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H2O mixtures or in pure water at 65 °C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications. / University of Warwick, Swiss National Science Foundation and the EPSRC. The Royal Society - an Industry Fellowship to A.P.D. The Engineering and Physical Sciences Research Council (EP/G004897/1) - funding to support postdoctoral fellowships for A.P.B. as well as funding for J.S. and M.A.D. through the Warwick Centre for Analytical Science (EP/F034210/1). The Science City Research Alliance and the HEFCE Strategic Development Fund - funding support. Some items of equipment that were used in this research were funded by Birmingham Science City, with support from Advantage West Midlands and part-funded by the European Regional Development Fund.

Yes / We report the crystallization-driven self-assembly of diblock copolymers bearing a poly(L-lactide) block into cylindrical micelles. Three different hydrophilic corona-forming blocks have been employed: poly(4-acryloyl morpholine) (P4AM), poly(ethylene oxide) (PEO) and poly(N,N-dimethylacrylamide) (PDMA). Optimization of the experimental conditions to improve the dispersities of the resultant cylinders through variation of the solvent ratio, the polymer concentration, and the addition speed of the selective solvent is reported. The last parameter has been shown to play a crucial role in the homogeneity of the initial solution, which leads to a pure cylindrical phase with a narrow distribution of length. The hydrophilic characters of the polymers have been shown to direct the length of the resultant cylinders, with the most hydrophilic corona block leading to the shortest cylinders. / EPSRC and the University of Warwick, the Swiss National Science Foundation - Early Postdoc Mobility fellowship (Grant no PBNEP2-142949 to A.P.B.). The Warwick Research Development Fund. Some items of equipment funded by Birmingham Science City: Innovative Uses for Advanced Materials in the Modern World (West Midlands Centre for Advanced Materials Project 2), with support from Advantage West Midlands (AWM) and part funded by the European Regional Development Fund (ERDF).

Yes / Uniform onion micelles formed from up to ten nano-structured polymer layers were produced by the aqueous self-assembly of highly-branched copolymers. Highly-branched poly(alkyl methacrylate)s were chain extended with poly(acrylic acid) in a two-step reversible addition–fragmentation chain transfer-self-condensing vinyl polymerization (RAFT-SCVP) in solution. The resulting polymers were dispersed into water from oxolane (THF) using a self-organized precipitation-like method and the self-assembled particles were studied by phase-analysis light scattering, small-angle neutron scattering, and electron microscopy techniques. The relative hydrophobicity of the blocks was varied by changing the alkyl methacrylate (methyl, butyl, or lauryl) and this was found to affect the morphology of the particles. Only the poly(butyl methacrylate)-containing macromolecule formed an onion micelle structure. The formation of this morphology was observed to depend on: the evaporation of the good solvent (THF) during the self assembly process causing kinetic trapping of structures; the pH of the aqueous phase; and also on the ratio of hydrophobic to hydrophilic segments within the copolymer. The lamellar structure could be removed by annealing the dispersion above the glass transition temperature of the poly(butyl methacrylate). To exemplify how these onion micelles can be used to encapsulate and release an active compound, a dye, rhodamine B (Rh B), was encapsulated and released. The release behaviour was dependent on the morphology of the particles. Particles formed containing the poly(methyl methacrylate) or poly (lauryl methacrylate) core did not form onions and although these materials absorbed Rh B, it was continuously released at room temperature. On the other hand, the lamellar structure formed from branchpoly( butyl methacrylate)-[poly(butyl methacrylate)-block-poly(acrylic acid)] allowed for encapsulation of approximately 45% of the dye, without release, until heating disrupted the lamellar structure. / EPSRC and Domino UK Ltd for a Nanotechnology KTN CASE studentship to support SLC, Experiments at the ISIS Pulsed Neutron and Muon Source were supported by a beam time allocation from the Science and Technology Facilities Council (experiment numbers RB1220108 and RB1320167).

It’s becoming more and more difficult to make smaller, denser, and faster computer chips. There’s an increasing demand to design new materials to be applied in current lithographic process to get higher patterning performance. In this work, the aqueous developable single molecule resists were introduced, synthesized and patterned. A new group of epoxide other than glycidyl ether, cyclohexene oxide was introduced to functionalize a molecular core and 15 nm resolution was obtained. The directed self-assembly (DSA) of block copolymers as an alternative lithographic technique has received growing interest in the last several years for performing higher levels of pitch subdivision. A 3-step simplified process for DSA by using a photodefinable substrate was introduced by using a functionalized polyphenol with an energy switchable group and a crosslinkable group. Two high χ block copolymers PS-b-PAA and PS-b-PHEMA were successfully designed and synthesized via ATRP with controlled Mw and PDI. The size of the same PS-b-PAA polymer was tunable by varying the thermal annealing time. PS-b-PHEMA shows to be a suitable block polymer for the industry-friendly thermal annealing process. A self-complementary hydrogen-bonding urea group as a center group was used to facilitate the self-assembly of polymers. “Click” chemistry is promising for synthesis of PS-Urea-Urea-PMMA.

Thesis (PhD (Chemistry and Polymer Science)--University of Stellenbosch, 2005. / This study involves the synthesis and characterisation of PEG-based amphiphilic block copolymers for the hydrophilization of polysulphone ultrafiltration membranes. PEG based macro RAFT agents were synthesized and characterised. PEG-b-PS block copolymers were synthesized via the RAFT assisted controlled free radical polymerisation utilizing the synthesized PEG macro RAFT agents. The resulting polymerisation products were then analyzed by two-dimensional chromatography at the “critical conditions” for PS. In the second phase of this study PEG-b-PSU block copolymers were synthesized via the polycondensation of bis (4-chlorophenyl) sulphone, Bisphenol A, and PEG. The resulting products were characterised by NMR spectrometry. PEG-b-PS films and modified PSU membranes (modified by the addition of PEG-b-PSU block copolymer to the membrane casting solution) were prepared and analyzed. Surface analyses included static contact angle, AFM force-distance analysis, and FTIR-PAS analysis. Results showed the successful synthesis of both PEG-b-PS and PEG-b-PSU amphiphilic block copolymers. Surface analysis proved the successful hydrophilization of the surface of the modified PSU membranes.

Diallel cross experiments for comparing p test lines with a control in the set up of block designs and completely randomized designs are investigated. Complete diallel crosses including all p(p+1)/2 distinct crosses are considered. Families of A-optimal and efficient type S0 block designs for p=2,3, and for p>=4, k=2 are obtained, and the construction methods are given. For p>=k>=3, and p>=4, a sufficient condition for type S0 block designs with the control line appearing tb times, where t>=1 is an integer, to be A-optimal is obtained, and families of A-optimal type S0 block designs are provided. The A-optimality of type S designs under the model of completely randomized designs when 2<=p<=6 is also tudied, and some examples are given.

Introdução: Avaliar a relação do custo e da efetividade da radiofrequência (RF) em relação ao bloqueio seqüencial na Síndrome Dolorosa Complexa Regional-tipo I (SDCR-I). Métodos: 15 pacientes com dor somática e autonômica cervical foram submetidos a bloqueio torácico simpático, combinado com bloqueio facetário cervical bilateral por 4 semanas. Esta seqüência foi repetida quando a dor atingiu VAS 4 cm, e este período foi definido como tempo de analgesia. Posteriormente, os mesmos pacientes foram submetidos a um bloqueio teste seguido de modulação de RF do gânglio simpático torácico e ablação de ramos facetários medianos cervicais. Os pacientes atuaram como seu próprio controle relacionado à analgesia, atividades rotineiras e padrão de sono. Resultados: 13 pacientes completaram o estudo. O tempo de analgesia após a sequência de 4 bloqueios foi de 4 ± 1 mês e o custo anual R$ 15.000,00. O tempo de analgesia após RF foi de 13 ± 2 meses (p <0,001) e os custos foram reduzidos em 26% no primeiro ano e 34% -38% nos anos seguintes, com extrapolação. A qualidade de vida melhorou para ambos os tratamentos (p> 0,05). Não houve efeitos adversos. Discussão: A RF resultou em analgesia de 13 meses comparada a 4 meses após os bloqueios clássicos e melhora na capacidade física e no padrão de sono. Além disso, a RF foi rentável e reduziu as taxas em 23% durante a avaliação do primeiro ano, seguida de uma redução de custos de 32% a 36% nos anos seguintes, com extrapolação. / Objectives: To evaluate cost-effectiveness of radiofrequency (RF) compared to sequential block in Complex Regional Pain Syndrome-I (CRPS). Methods: 15 patients with cervical somathic and autonomic pain were submitted to a 4- weekly sympathetic thoracic block, combined to bilateral cervical facetary block. This sequence was repeated when pain reached VAS 4-cm, and this period was defined as time of analgesia. Thereafter, same patients were submitted to a test block followed by RF modulation of thoracic sympathetic ganglion and ablation of facetary cervical median branches. Patients acted as their own control related to analgesia, routine activities, sleep pattern and costs. Results: 13 patients completed the study. The analgesia time after the 4-block sequence was 4±1 months and the annual costs USA$5000. Analgesia time after RF was 13±2 months (p<0.001) and costs were reduced by 26% in the first year and 34%-38% in the following years extrapolation. Quality of life improved for both treatments (p> 0.05). There were no adverse effects. Discussion: RF resulted in 13-month compared to 4-month analgesia after the classical 4- weekly blocks, and improved physical capacity and sleep pattern. Besides that, RF was costeffective, and reduced rates by 23% during the first-year evaluation, followed by 32%-36% cost reduction in following years, by extrapolation.

Thesis advisor: David A. Karp / A qualitative study based on forty four in-depth interviews with undergraduates experiencing severe difficulties with academic writing, this dissertation examines how structural factors--social class and race in particular--contribute to academic "writer's block." Writing block is more than the "personal trouble" it is typically conceived of being, it is also a "public issue" with definitive structural contributors. All of my subjects perceived writing as a high stakes performance, and their writing blocks can be understood as instances of "choking" in the face of these high stakes. For many working class students, writing block is an expression of dominant cultural capital disadvantage; while for many upper middle class students, writing block represents the psychological costs of privilege. For students with unusual class-race identifications, writing block embodies their liminal social status. In the current economic climate of uncertainty, class status for students across the socioeconomic spectrum has become relatively unstable given individuals' increased risk of downward mobility. As such, academic writing blocks may be construed as angst experienced at the intersection of psychology and structure. This study contributes to and extends the literature on social reproduction in higher education as well as the literature on the price of privilege. / Thesis (PhD) — Boston College, 2013. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Sociology.

De nombreux phénomènes naturels sont trop complexes pour être pleinement reconnus par un seul instrument de mesure ou par une seule modalité. Par conséquent, le domaine de recherche de la multi-modalité a émergé pour mieux identifier les caractéristiques riches du phénomène naturel de la multi-propriété naturelle, en analysant conjointement les données collectées à partir d’uniques modalités, qui sont en quelque sorte complémentaires. Dans notre étude, le phénomène d’intérêt multi-propriétés est l’activité du cerveau humain et nous nous intéressons à mieux la localiser au moyen de ses propriétés électromagnétiques, mesurables de manière non invasive. En neurophysiologie, l’électroencéphalographie (EEG) et la magnétoencéphalographie (MEG) constituent un moyen courant de mesurer les propriétés électriques et magnétiques de l’activité cérébrale. Notre application dans le monde réel, à savoir le problème de reconstruction de source EEG / MEG, est un problème fondamental en neurosciences, allant des sciences cognitives à la neuropathologie en passant par la planification chirurgicale. Considérant que le problème de reconstruction de source EEG /MEG peut être reformulé en un système d’équations linéaires sous-déterminé, la solution (l’activité estimée de la source cérébrale) doit être suffisamment parcimonieuse pour pouvoir être récupérée de manière unique. La quantité de parcimonie est déterminée par les conditions dites de récupération. Cependant, dans les problèmes de grande dimension, les conditions de récupération conventionnelles sont extrêmement strictes. En regroupant les colonnes cohérentes d’un dictionnaire, on pourrait obtenir une structure plus incohérente. Cette stratégie a été proposée en tant que cadre d’identification de structure de bloc, ce qui aboutit à la segmentation automatique de l’espace source du cerveau, sans utiliser aucune information sur l’activité des sources du cerveau et les signaux EEG / MEG. En dépit du dictionnaire structuré en blocs moins cohérent qui en a résulté, la condition de récupération conventionnelle n’est plus en mesure de calculer la caractérisation de la cohérence. Afin de relever le défi mentionné, le cadre général des conditions de récupération exactes par bloc-parcimonie, comprenant trois conditions théoriques et une condition dépendante de l’algorithme, a été proposé. Enfin, nous avons étudié la multi-modalité EEG et MEG et montré qu’en combinant les deux modalités, des régions cérébrales plus raffinées sont apparues / Three main challenges have been addressed in this thesis, in three chapters.First challenge is about the ineffectiveness of some classic methods in high-dimensional problems. This challenge is partially addressed through the idea of clustering the coherent parts of a dictionary based on the proposed characterisation, in order to create more incoherent atomic entities in the dictionary, which is proposed as a block structure identification framework. The more incoherent atomic entities, the more improvement in the exact recovery conditions. In addition, we applied the mentioned clustering idea to real-world EEG/MEG leadfields to segment the brain source space, without using any information about the brain sources activity and EEG/MEG signals. Second challenge raises when classic recovery conditions cannot be established for the new concept of constraint, i.e., block-sparsity. Therefore, as the second research orientation, we developed a general framework for block-sparse exact recovery conditions, i.e., four theoretical and one algorithmic-dependent conditions, which ensure the uniqueness of the block-sparse solution of corresponding weighted mixed-norm optimisation problem in an underdetermined system of linear equations. The mentioned generality of the framework is in terms of the properties of the underdetermined system of linear equations, extracted dictionary characterisations, optimisation problems, and ultimately the recovery conditions. Finally, the combination of different information of a same phenomenon is the subject of the third challenge, which is addressed in the last part of dissertation with application to brain source space segmentation. More precisely, we showed that by combining the EEG and MEG leadfields and gaining the electromagnetic properties of the head, more refined brain regions appeared.

Thoracic paravertebral block (TPVB) consists of an injection of local anaesthetic alongside the thoracic vertebra close to where the spinal nerves emerge from the intervertebral foramen. Clinically TPVB can be accomplished either as a single-injection or as a multiple-injection. It can also be used as a continuous paravertebral infusion through an indwelling catheter for continuous pain relief. However compared to an epidural block, TPVB is less well understood and not commonly used for anaesthesia and or analgesia in anaesthetic practice. I hypothesized that TPVB is effective for producing unilateral segmental thoracic anaesthesia and managing pain of unilateral origin from the thorax. / The objective of this thesis was to develop the technique of TPVB so that it becomes a useful technique for anaesthesia and pain management. So to test my hypothesis a series of clinical studies were performed on 416 patients (396 adults and 20 young infants), presenting for anaesthesia and or acute pain management, to evaluate various aspects of TPVB, namely; clinical application, anatomy of the thoracic paravertebral space, technique and safety, and pharmacology of local anaesthetic after TPVB. Also included are 9 published case reports and letters-to-editor (Appendix 1-9) based on my research that have provided new insights into the mechanism and applications of TPVB. The following section summarizes my research... / Karmakar, Manoj Kumar. / Thesis (M.D.)--Chinese University of Hong Kong, 2012. / Includes bibliographical references (leaves 270-285). / Appendix includes Chinese. / ABSTRACT --- p.v / PREFACE --- p.xxvii / STATEMENT OF WORK --- p.xxviii / ACKNOWLEDGEMENTS --- p.xxix / PUBLICATIONS AND PRESENTATIONS --- p.xxxii / LIST OF ABBREVIATIONS --- p.xxxviii / LIST OF TABLES --- p.xli / LIST OF FIGURES --- p.xliii / Chapter Part 1. --- Introduction --- p.1 / Chapter Chapter 1. --- Objective and Plan of Research --- p.2 / Chapter Chapter 2. --- Thoracic Paravertebral Block A Review of the Literature. --- p.7 / Chapter 2.1. --- Introduction --- p.7 / Chapter 2.2. --- History --- p.7 / Chapter 2.3. --- Anatomy: --- p.9 / Chapter 2.4. --- Techniques --- p.17 / Chapter 2.4.1. --- Anatomical Landmark Based Techniques --- p.20 / Chapter 2.4.1.1. --- Loss-of-resistance Technique --- p.20 / Chapter 2.4.1.2. --- Advancing the Block Needle by a pre-determined Distance --- p.23 / Chapter 2.4.1.3. --- Other Landmark Based Techniques --- p.24 / Chapter 2.4.2. --- Fluoroscopic Guidance or Injection of Radiopaque Contrast medium --- p.24 / Chapter 2.4.3. --- Peripheral Nerve Stimulation --- p.25 / Chapter 2.4.4. --- Pressure Measurement Technique --- p.26 / Chapter 2.5. --- Thoracic Paravertebral Catheter Placement --- p.27 / Chapter 2.6. --- Ultrasound Guided Thoracic Paravertebral Block --- p.32 / Chapter 2.6.1. --- Two Dimensional (2D) Sonoanatomy of the Thoracic Paravertebral Region --- p.32 / Chapter 2.6.1.1. --- Basic Considerations --- p.32 / Chapter 2.6.1.2. --- Transverse Scan of the Thoracic Paravertebral Region --- p.33 / Chapter 2.6.1.3. --- Sagittal Scan of the Thoracic Paravertebral Region --- p.42 / Chapter 2.6.2. --- Three Dimensional (3D) Sonoanatomy of the Thoracic Paravertebral Region --- p.46 / Chapter 2.6.3. --- Ultrasound Guided Thoracic Paravertebral Block - Techniques --- p.49 / Chapter 2.6.3.1. --- Transverse scan with short axis needle insertion (Technique 1) --- p.54 / Chapter 2.6.3.2. --- Paramedian Sagittal scan with in-plane needle insertion (Technique 2) --- p.56 / Chapter 2.6.3.3. --- Transverse scan with in-plane needle insertion or the Intercostal approach to the TPVS (Technique 3) --- p.58 / Chapter 2.7. --- Mechanism and Spread of Anaesthesia --- p.58 / Chapter 2.8. --- Indications --- p.65 / Chapter 2.9. --- Contraindications --- p.65 / Chapter 2.10. --- Drugs Used and Dosage --- p.68 / Chapter 2.11. --- Pharmacokinetic Considerations --- p.70 / Chapter 2.12. --- Failure Rate and Complications --- p.72 / Chapter 2.13. --- Clinical Applications of Thoracic Paravertebral Block --- p.76 / Chapter 2.13.1. --- Pain Relief after Thoracic Surgery --- p.76 / Chapter 2.13.2. --- Pain Relief after Multiple Fractured Ribs --- p.78 / Chapter 2.13.3. --- Anaesthesia and Analgesia for Breast Surgery --- p.80 / Chapter 2.13.4. --- Thoracic Paravertebral Block and Chronic Pain after Breast Cancer Surgery --- p.84 / Chapter 2.13.5. --- Thoracic Paravertebral Block and Cancer Recurrence after Breast Cancer Surgery --- p.85 / Chapter 2.13.6. --- Anaesthesia and Analgesia for Inguinal Herniorrhaphy --- p.87 / Chapter 2.13.7. --- Pain Relief after Cholecystectomy and Renal Surgery --- p.90 / Chapter 2.13.8. --- Anaesthesia and Analgesia for Liver and Biliary Tract Surgery --- p.91 / Chapter 2.13.9. --- Analgesia after Cardiac Surgery --- p.92 / Chapter 2.13.10. --- Thoracic Paravertebral Block and Chronic Pain Management --- p.94 / Chapter 2.13.11. --- Bilateral Thoracic Paravertebral Block --- p.94 / Chapter 2.13.12. --- Miscellaneous Applications --- p.95 / Chapter Part 2. --- Studies Evaluating the Efficacy of Thoracic Paravertebral Block in Adults. --- p.96 / Chapter Chapter 3. --- Prospective Randomized Evaluation of the Effects of Combining a Single-injection Thoracic Paravertebral Block with General Anesthesia in Patients Undergoing Modified Radical Mastectomy. --- p.97 / Chapter Chapter 4. --- Continuous Thoracic Paravertebral Infusion of Bupivacaine for Postthoracotomy Analgesia A Prospective, Randomized, Double Blind, Controlled Trial. --- p.120 / Chapter Chapter 5. --- Continuous Thoracic Paravertebral Infusion of Bupivacaine for Pain Management in Patients with Multiple Fractured Ribs. --- p.137 / Chapter Chapter 6. --- Thoracic Paravertebral Block and Its Effects on Chronic Pain and Health-related Quality of Life after Modified Radical Mastectomy. --- p.154 / Chapter Chapter 7. --- Right Thoracic Paravertebral Anaesthesia for Percutaneous Radiofrequency Ablation of Liver Tumours. --- p.186 / Chapter Part 3. --- Studies Evaluating The Efficacy Of Thoracic Paravertebral Block In Children. --- p.198 / Chapter Chapter 8. --- Continuous Extrapleural Paravertebral Infusion of Bupivacaine for Postthoracotomy Analgesia in Young Infants. --- p.199 / Chapter Part 4. --- Studies Evaluating The Anatomy Relevant For Thoracic Paravertebral Block. --- p.213 / Chapter Chapter 9. --- Thoracic Paravertebral Sonography - A Quantitative Evaluation of the Paramedian Sagittal Window for Visualizing the Anatomy Relevant for Thoracic Paravertebral Block. --- p.214 / Chapter Chapter 10. --- Volumetric 3D Ultrasound Imaging of the Anatomy Relevant for Thoracic Paravertebral Block. --- p.228 / Chapter Part 5. --- Pharmacokinetics of Ropivacaine after Thoracic Paravertebral Block. --- p.242 / Chapter Chapter 11. --- Arterial and Venous Pharmacokinetics of Ropivacaine With and Without Epinephrine after Thoracic Paravertebral Block. --- p.243 / Chapter Part 6. --- Summary and Conclusions --- p.266 / Chapter Chapter 12. --- Summary and Conclusions --- p.266 / Chapter Part 7. --- Bibliography --- p.270 / Chapter Part 8. --- Appendix --- p.296 / Chapter A. --- Published Case Reports and Letters-to-editor. --- p.297 / Chapter Appendix: 1.0. --- Variability of a Thoracic Paravertebral Block. Are we ignoring the endothoracic fascia? (Published Commentary) --- p.297 / Chapter Appendix: 2.0. --- Ipsilateral Thoraco-lumbar Anaesthesia and Paravertebral Spread after Low Thoracic Paravertebral Injection. (Published Case Report) --- p.301 / Chapter Appendix: 3.0. --- The Use of a Nerve Stimulator for Thoracic Paravertebral Block Reply. (Published Letter-to-editor) --- p.310 / Chapter Appendix: 4.0. --- Bilateral Continuous Paravertebral Block Used for Postoperative analgesia in an Infant having Bilateral Thoracotomy. (Published Case Report) --- p.312 / Chapter Appendix: 5.0. --- Thoracic Paravertebral Block: Radiological evidence of Contralateral Spread Anterior to the Vertebral Bodies. (Published Case Report) --- p.317 / Chapter Appendix: 6.0. --- Lymphatic Drainage of the Thoracic Paravertebral Space A Reply. (Published Letter-to-editor) --- p.325 / Chapter Appendix: 7.0. --- Thoracic Paravertebral Block for Management of Pain Associated with Multiple Fractured Ribs in Patients with Concomitant lumbar Spinal Trauma. (Published Case Report) --- p.328 / Chapter Appendix: 8.0. --- Right Thoracic Paravertebral Analgesia for Hepatectomy. (Published Case Report) --- p.340 / Chapter Appendix: 9.0. --- Resolution of ST-segment Depression after High Thoracic Paravertebral Block during General Anesthesia. (Published Case Report) --- p.348 / Chapter B. --- Medical Outcomes Study 36-Item Short-Form Questionnaire (SF-36) - Appendix 10. --- p.353 / Chapter C. --- Hospital Anxiety and Depression Scale - Appendix 11. --- p.362 / Chapter D. --- Postoperative Telephone Follow Up Questionnaire: Appendix 12. --- p.364