Orientadores: Francesco Langone, Licio Augusto Velloso / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia / Made available in DSpace on 2018-08-09T03:39:03Z (GMT). No. of bitstreams: 1 Vieira_AndreSchwambach_M.pdf: 3969141 bytes, checksum: 53eff5b5bbec953a73e9ddc63cd3ea39 (MD5) Previous issue date: 2007 / Resumo: O Fator Neurotrófico Ciliar (CNTF) é uma neurocitocina com múltiplas atividades biológicas, sendo notável sua habilidade de proteger motoneurônios. Entretanto, a administração de CNTF leva à redução de peso corporal. Por outro lado, a administração do CNTF fusionado a um Domínio de Transdução de Proteínas (PTD), denominado TAT-CNTF, é capaz de proteger motoneurônios da medula espinhal axotomizados sem causar este efeito. O presente trabalho investigou se a administração intracerebroventricular (i.c.v.) de TAT-CNTF produz os conhecidos efeitos catabólicos do CNTF. Para isso, ratos Wistar machos, com uma cânula crônicamente implantada no ventrículo lateral, foram distribuídos em quatro grupos: TAT-CNTF (2,5µg/8µl), CNTF (2,5µg/8µl), Leptina (LEP) (5µg/8µl) e PBS, que receberam uma infusão i.c.v. a cada 12h por 4 dias. O grupo tratado com TAT-CNTF apresentou menor perda de peso quando comparado aos grupos CNTF e LEP. As infusões i.c.v. de TAT-CNTF não reduziram o peso das gorduras retroperitonial (RP), epididimal (EP) e marrom interescapular (GM). O grupo CNTF apresentou redução do peso destas gorduras. Os grupos CNTF e LEP apresentaram aumento da fragmentação do DNA nas gorduras RP e EP. Por outro lado, o grupo TAT-CNTF não apresentou aumento da fragmentação do DNA nas amostras de RP, EP e GM. Um padrão de degradação internucleossomal do DNA e a presença de células TUNEL positivas foram detectados apenas nas gorduras dos animais dos grupos CNTF e LEP. Estes grupos também apresentaram aumento da expressão da UCP1 na GM, ao passo que o grupo TAT-CNTF não apresentou tal resultado. A análise da fosforilação da STAT3 no hipotálamo após uma única infusão i.c.v. de TAT-CNTF demonstrou, após 20 minutos, um efeito menor que o observado após infusão de CNTF. Em conclusão, nossos dados sugerem que o TAT-CNTF possui ação diferente do CNTF nas áreas hipotalâmicas envolvidas no controle da ingesta e do metabolismo / Abstract: The Ciliary Neurotrophic Factor (CNTF) is a neurocitokine with multiple biological activities, being notable its ability to protect lesioned motoneurons. However, administration of CNTF leads to reduction of body mass, while administration of CNTF fusioned with a Protein Transduction Domain (PTD), named TAT-CNTF, protects lesioned spinal motoneurons with no effects on body weight. In the present work, we investigated whether intracerebroventricular (i.c.v.) administration of TAT-CNTF would produce CNTF known catabolic effects. Male Wistar rats with a canula chronically implanted in the lateral ventricle were randomly assigned to four treatment groups: TAT-CNTF (2,5µg/8µl), CNTF (2,5µg/8µl), Leptin (LEP) (5µg/8µl) and PBS, that received an i.c.v. infusion every 12h for 4 days. TAT-CNTF treated group had a reduced weight loss when compared with CNTF and LEP groups. TAT-CNTF i.c.v. infusions did not reduce the weights of retroperitoneal (RP) and epididimal (EP) white adipose tissue, as well as interescapular brown adipose tissue (BAT) while CNTF i.c.v. administration reduced the weight of all these tissues. CNTF and LEP groups showed an increase of DNA fragmentation in RP and EP. On the other hand, TAT-CNTF group had no increase in DNA fragmentation in RP, EP and GM. A DNA ladder pattern and TUNEL positive cells could only be detected in adipose tissues from CNTF and LEP groups. CNTF and LEP treated groups had an increase in the expression of UCP1 in BAT, while TAT-CNTF treatment had no effects on UCP1 expression. An acute i.c.v. administration demonstrated that after 20 minutes TAT-CNTF induced less intense STAT3 phosphorilation in the hypothalamus when compared with CNTF acute infusions. In conclusion these data suggest that TAT-CNTF has a different action on hypothalamic areas involved in the control of food intake and energy metabolism / Mestrado / Fisiologia / Mestre em Biologia Funcional e Molecular

Introdução - A adolescência é um período em que ocorrem intensas transformações biopsicossociais, de modo que as experiências percebidas nessa etapa podem contribuir para a formação da imagem corporal. Objetivo - Analisar a associação entre percepção do peso corporal e variáveis relacionadas, em estudantes do ensino fundamental. Métodos - Estudo transversal, realizado em 2007, com estudantes de 8 a 17 anos, residentes em Vitória, Espírito Santo (ES). Dados antropométricos, demográficos, socioeconômicos e de maturação sexual foram coletados. A percepção do peso corporal foi verificada por meio de pergunta única sobre o que os estudantes achavam do próprio peso corporal em relação à sua estatura. Análises de regressão logística, estratificadas por sexo, foram realizadas para verificar a associação entre percepção do peso corporal e faixa etária, estado nutricional, perímetro da cintura, estágio de maturação sexual e nível socioeconômico. A categoria de referência para as análises foi percepção do peso adequado. Resultados - Participaram 397 estudantes, idade média (desvio-padrão) 12 (1,84) anos, sendo 52,4 por cento do sexo feminino. Em relação ao estado nutricional, meninos e meninas, respectivamente, apresentaram prevalências de 21,7 por cento e 20,1 por cento (excesso de peso), 76,9 por cento e 77,8 por cento (peso adequado para a estatura), e 1,4 por cento e 2,1 por cento (baixo peso). Houve associação estatisticamente significante entre percepção do peso corporal e estado nutricional (excesso de peso) em ambos os sexos (meninos: OR = 6,76; meninas: OR = 19,58) e faixa etária (10 a 14 anos) para os meninos (OR = 0,40). Conclusão - A percepção do peso corporal associou-se ao estado nutricional em ambos os sexos, e à faixa etária apenas em meninos. Isso reforça a necessidade do acompanhamento desses adolescentes por profissionais de saúde, visando melhor consciência do próprio corpo / Introduction - Adolescence is a time when several biological and psychosocial transformations take place. So, the experiences lived at this age can contribute to the formation of the individual, including the image that this individual builds of its body. Objective - Analyze the association between body weight perception and related variables in Elementary School students. Methods - Cross-sectional study performed in 2007, with students age 8 to 17, residents in Vitoria (ES). Anthropometric, demographic, socioeconomic and sexual maturation data were collected. The perception of body weight was verified by one single question about what the students thought of their own body weight in relation to their height. Logistic regression analysis, stratified by gender was used to verify the associations among body weight perception, age, body mass index, waist circumference, pubertal stage and maternal education. The reference category for analysis was appropriate weight perception. Results - 397 students participated, age mean (standard deviation) 12 (1.84) years of age, 52.4 per cent were females. Boys and girls showed, respectively, 21.7 per cent and 20.1 per cent overweight, 76.9 per cent and 77.8 per cent appropriate weight for height, 1.4 per cent and 2.1 per cent underweight. There was statistic association between body perception and nutritional status (overweight) in both genders (boys: OR = 6.76; girls: OR = 19.58) and age (10 to 14 years) for boys (OR = 0.40). The other variables did not show association. Conclusion - The body weight perception was associated to nutritional status in both genders, and with age group 10 to 14 years old only in boys. This reinforces the need for health professionals to monitor these adolescents in order for them to have a better understanding of their own bodies.

INTRODUÇÃO: Manter hábitos alimentares saudáveis durante a gravidez evita a retenção de peso pós-parto, desfecho que contribui para a elevação da prevalência de obesidade em mulheres. OBJETIVO: Estudar, em coorte de grávidas clientes de serviço público de pré-natal: o consumo alimentar e fatores sócio-econômicos associados; e a influência do consumo alimentar sobre a retenção de peso pós-parto. MÉTODOS: Em estudo de coorte realizado em 5 Unidades Básicas de Saúde do Município de São Paulo, foram acompanhadas 88 gestantes entrevistadas nas consultas de pré-natal e em visita domiciliar 15 dias pós-parto. Para avaliação do consumo alimentar utilizou-se o inquérito Recordatório de 24h, aplicado no 2º trimestre de gestação. Foram calculados o consumo energético e de frutas, verduras e legumes (FLVs), fibras, gordura saturada, açúcar adicionado, alimentos processados e a densidade energética da dieta por meio de tabelas de composição de alimentos. O consumo alimentar foi comparado com as metas de ingestão da OMS. Avaliou-se a retenção de peso pós-parto pela diferença entre a medida de peso 15 dias pós-parto e a realizada no início da gestação. A influência das variáveis sócio-econômicas (renda familiar per capita, escolaridade, estado marital e idade) sobre a adequação do consumo alimentar foi avaliada utilizando-se análise de regressão logística múltipla. Estudou-se a associação entre as variáveis de consumo alimentar (divididas em terços) e a retenção de peso pós-parto mediante análise de regressão linear múltipla. RESULTADOS: Mais de 30 por cento das mulheres apresentaram consumo excessivo de açúcar adicionado e gordura saturada, 64 por cento não atingiram a ingestão mínima de FLVs e nenhuma consumiu a quantidade de fibra alimentar recomendada. O aumento da renda reduziu o Odds Ratio de consumo insuficiente de FLVs (p=0,007). O Odds Ratio de consumo excessivo de açúcar adicionado elevou-se nas mulheres com companheiro (p=0,011) e com maior escolaridade (p=0,008). Maior consumo de gordura saturada elevou a retenção de peso pós-parto de forma estatisticamente significativa no modelo ajustado (p de tendência=0,033). Não foi encontrada relação significativa entre retenção de peso pós-parto e as demais variáveis de consumo alimentar. CONCLUSÃO: O padrão alimentar das gestantes não se mostrou adequado diante as recomendações da OMS, principalmente quanto à ingestão de alimentos saudáveis. O aumento da renda foi um fator de proteção para o consumo inadequado de FLVs na gestação. Houve aumento da retenção de peso pós-parto com a elevação do consumo de gordura saturada nas mulheres estudadas. / Introduction: Healthy food habits during pregnancy prevent postpartum weight retention, which contributes for increasing obesity prevalence among women. Objectives: To study in a cohort of pregnant women: dietary intake and related socioeconomic factors; and the influence of dietary intake on postpartum weight retention. Methods: In this cohort study, 88 pregnant women were interviewed during prenatal appointments in five Primary Units of Public Health and during a domiciliary visit 15 days after delivery, in the city of São Paulo, Brazil. For dietary intake evaluation, the 24-Hour Dietary Recall method was performed at the 2nd trimester of gestation. Energy, fruits and vegetables (FV), dietary fiber, added sugar, processed foods and saturated fat consumption and dietary energy density were calculated using food composition tables and adjusted by energy intake when necessary. Dietary intake variables were compared with WHO recommendations. Postpartum weight retention was calculated by the difference between the weight measured at the beginning of gestation and the same measure 15 days after delivery. The influence of socioeconomic variables (per capita familiar income, education, marital status and age) on dietary intake adequacy was analyzed by multiple logistic regression analysis. The association between dietary intake variables (divided in tertiles) and postpartum weight retention was assessed by multiple linear regression analysis. Results: More than 30 per cent of the women had inadequate added sugar and saturated fat consumption, 64 per cent didnt reach the minimum FV ingestion and none consumed the minimum recommendation for dietary fiber. Income increases reduced the odds ratio for insufficient FV consumption (p=0,007). The odds ratio for excessive added sugar consumption increased among women who lived with a partner (p=0,011) and who had higher educational levels (p=0,008). Postpartum weight retention was significantly higher with elevated ingestion of saturated fat in the adjusted model (p for trend=0,033). No significant relation was found between weight retention and the other dietary indicators. Conclusion: The dietary pattern of the pregnant women assessed in this study was not entirely adequate with regard to WHO recommendations, mainly because of the lack of healthy food ingestion. Income influenced positively the consumption of FV during gestation. Higher consumption of saturated fat increased postpartum weight retention among the studied women.

The objectives of the present research were to study the factors that influence postpartum reproductive characteristics of suckling beef cows in extensive production systems in Mozambique and to develop new management strategies to improve their reproductive efficiency. The effects and interactions between post-partum BW, BCS, age and parity number on plasma concentrations of estradiol, progesterone, creatinine, urea and cortisol around oestrus and the related conception rates of Bos indicus cows in extensive production system were analysed as well as the minimum BCS at the beginning of breeding to maximise the subsequent conception rates. Thirty-five days prior to the breeding season cows were synchronised using Crestar. During the second oestrus after synchronisation, 18 blood samples were collected per animal for hormonal analysis, from 24 hr before oestrus to 24 hr after oestrus. The hormonal pattern of estradiol and progesterone around oestrus were similar to that observed in Bos taurus cows under intensive conditions. Conception rates of cows in the experimental group were 90.5%. Better results on estradiol pattern and conception rates were related to a BCS of ≥ 2.5 and it was thus concluded that the post-partum management of extensive Bos inducus cows should aim to achieve at least a BCS of 2.5 at the beginning of the breeding season. Twelve-hour and 48-hr calf removal were conducted separately to evaluate their effects on conception rates of Bos indicus beef cows in extensive production systems and to quantify the related effects on calf-weaning weights. The 12-hr calf removal was performed from 45 days post-partum to the beginning of the breeding season, and the 48-hr calf removal was performed preceding the onset of the breeding season. It was concluded that 12-hr calf separation at night enhance the energy balance (3%), increases the conception rates (80%) and improves the calf-weaning weights, whereas 48-hr calf removal increases conception rates (76%) and does not affect calf weaning weights. Both calf removal management strategies concentrate conceptions in the early part of the breeding season and stress the importance of the effect of BCS and estradiol on conception rates in Bos indicus beef cows in extensive production systems. / Thesis (PhD)--University of Pretoria, 2012. / Animal and Wildlife Sciences / unrestricted

Objective: To explore the informational and behavioural factors, that affect women’s participation in physical activity (PA) and body weight changes during perimenopause. Methods: An environmental scan of online health websites to determine availability and quality of information for women about body weight changes during transition to menopause. An interpretive descriptive qualitative study of women age 40 – 60 to explore factors influencing their PA. Descriptive and inductive qualitative analysis were used. Results: Six of 52 websites (11.5%) contained information specific to perimenopausal women, with one site citing evidence. For 26 women interviewed, the most common enabling factors were daily structure, positive feelings, and accountability; while common barriers were disruptions in daily structure, competing demands, and self - sacrifice. Conclusions: There is a lack of information regarding body weight changes for perimenopausal women. Perimenopausal women attribute their PA participation to psychosocial factors, and not the physiology of menopause.

Shape- and weight-based self esteem was proposed to be a central cognitive component of the eating disorders. In this thesis, the psychometric properties of the Shape- and Weight-Based Selfesteem (SAWBS) Inventory, a newly-developed measure of the influence of shape and weight on feelings of self-worth, were determined. A preliminary examination of possible developmental precursors of shape- and weight-based self-esteem was also performed. SAWBS scores were stable over 1 week, and correlated with women's negative perceptions about their bodies in eating disorder and undergraduate control groups (EDG and UCG, respectively). In the UCG, SAWBS scores correlated with one of two measures of shape and weight cognitive schemata. The validity of shape- and weight-based self-esteem as a central feature of eating disorder symptomatology was supported in a number of ways. SAWBS scores correlated positively with eating disorder symptom scores in the UCG, and were significantly higher in women identified as "possible or probable" eating disorder cases than in women not suspected of having an eating disorder. SAWBS scores were also higher in the EDG than in the UCG or a psychiatric control group (PCG), even after controlling for age, socioeconomic status, Body Mass Index (BMT), selfesteem, and depression. Interestingly, a differing relationship between depression and SAWBS emerged as a function of group. Follow-up investigations revealed that SAWBS scores differed significantly between depressed, but not nondepressed women from the three groups. With regard to discriminant validity, SAWBS scores were uncorrelated with BMI and socioeconomic status in UCG and EDG women, and were uncorrelated with the tendency to respond in a socially sanctionned manner in UCG women. Although the tendency to respond in a socially sanctionned manner was related to SAWBS scores in EDG women, SAWBS scores remained higher in EDG than in UCG women after the effect of social desirability was controlled. The proposed developmental precursor variables of SAWBS included endorsement of stereotyped beliefs about thinness, perceived SAWBS in friends, siblings, and parents, and perceived importance placed by parents and romantic partner on the woman's own shape and weight. In both EDG and UCG women, endorsement of societal beliefs about shape and weight, and perceived importance placed on their own shape and weight by mother and father were significantly related to SAWBS scores. In sum, the SAWBS Inventory showed early promise as a reliable and valid measure of shape- and weight-based self-esteem, and may be a useful tool in the assessment of eating disorders. Theoretical and clinical implications with regard to the role of SAWBS in the development and treatment of eating disorders are discussed. / Arts, Faculty of / Psychology, Department of / Graduate

The purpose of the present study is to compare the calculated creatinine coefficients of young college women based on lean body mass weight with those based on actual body weight.

Orientador: Arlete Maria dos Santos Fernandes / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-14T10:32:39Z (GMT). No. of bitstreams: 1 Pantoja_MarciaHelenaBaptistaQueiroz_M.pdf: 2741473 bytes, checksum: bf1f55cb311a9f57eca090dbc49ffc47 (MD5) Previous issue date: 2009 / Resumo: Introdução: O ganho de peso tem sido referido como razão frequente para descontinuação do uso do contraceptivo injetável trimestral com acetato de medroxiprogesterona de depósito (AMPD). Objetivo: Determinar a variação do Índice de Massa Corporal (IMC) e do peso em mulheres usuárias do AMPD, com diferentes IMC no início de uso do método, e compará-los ao de mulheres usuárias de dispositivo intrauterino (DIU) TCu 380A, até seis anos de uso. Métodos: Estudo retrospectivo com revisão de prontuários realizado na Unidade de Reprodução Humana da FCM/UNICAMP, com obtenção de dois grupos de mulheres usuárias e tempos de seguimento entre três a seis anos. O primeiro grupo foi constituído por 379 mulheres usuárias de AMPD e 379 mulheres usuárias de DIU TCu 380A pareadas por idade e IMC com seguimento de três anos. O segundo grupo foi constituído por 226 mulheres usuárias de AMPD e 603 usuárias de DIU TCu 380A seguidas por seis anos. Em ambos os grupos, as mulheres foram distribuídas conforme o IMC inicial nas categorias de peso normal (IMC<25kg/m2), sobrepeso (IMC=25-29,9kg/m2) e obesas (IMC =30kg/m2) e comparadas anualmente com medidas de peso e IMC, em relação à população utilizada como controle. Aplicou-se o teste estatístico ANOVA para medir a variação de peso e IMC entre os grupos a cada ano. Resultados: No seguimento de três anos, a idade das usuárias de AMPD foi de 30,8 ± 6,8 anos e número de partos 2,6 ± 1,6 (média ± DP), enquanto o grupo de usuárias de DIU foi de 30,9 ± 6,8 anos e 3,0 ± 2,0 partos, não havendo diferenças no peso, altura e IMC iniciais entre os grupos. Nas categorias de peso normal e sobrepeso observou-se aumento do IMC das usuárias do AMPD em relação às usuárias de DIU TCu380A (p<0,01 e p<0,0001, respectivamente) e também em relação ao tempo de uso do método (p=0,0005 e p<0,0001, respectivamente). Na categoria obesas não houve variação na elevação do IIMC entre os grupos. Na segunda análise, com seguimento de seis anos, a média de idade da amostra de mulheres foi maior no grupo de estudo que nos controles em todos os grupos: 31,6 ± 7,1 anos X 27,4 ± 5,5 anos (p<0,0001) na categoria peso normal; 37,3 ± 6,8 anos X 29,2 ± 6,0 anos (p<0,0001) na categoria sobrepeso; e 35,3 ± 6,4 anos X 29,7 ± 5,8 anos (p<0,0001) na categoria obesas. Após análise de covariância com ajuste para idade, as usuárias de AMPD apresentaram aumento de peso em relação à população-controle na categoria sobrepeso (p=0,0082); e o aumento de peso com o tempo de uso do método também foi maior no grupo de usuárias de AMPD que nos controles na categoria peso normal (p<0,0001) e sobrepeso (p=0,0008). Na categoria obesas não houve variação no aumento de peso e do IMC entre os grupos, nem em relação ao tempo de uso do método. Conclusões: Não houve variação do IMC e do peso das mulheres obesas usuárias de AMPD durante os seguimentos de três e seis anos. Estudos prospectivos deverão ser realizados com testes metabólicos para determinar os fatores desencadeantes do ganho de peso nas mulheres usuárias de AMPD com peso normal e sobrepeso. / Abstract: Introduction: Weight gain is frequently reported by women as a reason for discontinuing the injectable contraceptive depot medroxyprogesterone acetate (DMPA). Objective: To determine the change in Body Mass Index (BMI) and weight in women using DMPA, with different BMI at the beginning of method use, and compare them to women using the TCu 380A intrauterine device (IUD), for up to six years of observation. Methods: A retrospective study with review of the medical records was conducted in the Human Reproduction Unit of the Unicamp Medical School, obtaining two groups of users with follow-up periods of three and six years. The first group was composed of 379 women using DMPA and 379 women using the TCu 380A IUD matched for age and BMI who were followed for three years. The second group was composed of 226 women using DMPA and 603 women using the T380A IUD who were followed for six years. In both groups, women were distributed into the following categories according to initial BMI: normal weight (BMI <25 Kg/m2), overweight (BMI= 25-29.9 Kg/m2) and obese (BMI =30 Kg/m2), comparing weight and BMI to those of a control population. The ANOVA statistical test was applied to measure change in weight and BMI between both groups each year. Results: In the three-year follow-up, the mean age of DMPA users was 30.8 ± 6.8 years and the number of deliveries was 2.6 ± 1.6 (mean ± SD), while the mean age of IUD users was 30.9 ± 6.8 years and the number of deliveries was 3.0 ± 2.0 (mean± SD). No differences in weight, height and BMI were observed between the groups at baseline. In the normal weight and overweight categories, an increase in BMI was observed in DMPA users compared to IUD users (p<0.01 and p<0.0001, respectively) and also in relation to length of method use (p=0.0005 and p<0.0001, respectively). In the obese category, there was no change in BMI and weight between the groups. In a second analysis of the six-year follow-up, the mean age of women was higher in the study group than in the controls in all groups: 31.6 ± 7.1 years X 27.4 ± 5.5 years (p<0.0001) in the normal weight category; 37.3 ± 6.8 years X 29.2 ± 6.0 years (p<0.0001) in the overweight category; and 35.3 ± 6.4 years X 29.7 ± 5.8 years (p<0.0001) in the obese category. After an analysis of covariance adjusted for age, DMPA users showed a weight increase compared to the control population in the overweight category (p=0.0082). Furthermore, weight gain according to length of method use was also higher in DMPA users, in comparison to controls in the normal weight (p<0.0001) and overweight categories (p=0.0008). In the obese category, no change in weight gain and BMI was observed between groups or in relation to length of method use. Conclusions: There was no change in BMI and weight in obese women using DMPA during follow-ups of three and six years. Prospective studies with metabolic tests are needed to determine the factors that trigger weight gain in DMPA users of normal weight and those who are overweight. / Mestrado / Tocoginecologia / Mestre em Tocoginecologia

Depot medroxyprogesterone acetate (DMPA) is a long acting progesterone only contraceptive agent. Side effects such as irregular bleeding patterns and weight gain are attributed to discontinuation. The purpose of this study was to describe depot medroxyprogesterone acetate discontinuation after weight gain in 17 to 19 year-old adolescent girls.

Este tesis fue publicado como artículo científico en la Revista Archivos de Medicina (DOI: http://doi.org/10.3823/1269) / Introducción. La nutrición en el Recién Nacido Pretérmino (RNPT) de Muy Bajo Peso al Nacer (MBPN) juega un rol importante en su recuperación y evolución general. Así, un soporte nutricional insuficiente puede resultar en un menor crecimiento y mayor incidencia de patologías, lo que perjudicaría la morbimortalidad de estos neonatos. Objetivo. Determinar la asociación entre el soporte nutricional y la mortalidad a los 28 días en RNPT de MBPN hospitalizados durante el año 2011 en la Unidad de Cuidados Intensivos Neonatales de un hospital público de referencia en Lima, Perú. Pacientes y método. Se realizó una cohorte retrospectiva con 60 historias clínicas de los RNPT de MBPN, nacidos y hospitalizados en la Unidad de Cuidados Intensivos Neonatales de un hospital de referencia durante el año 2011 en Lima, Perú. Se evaluó la evolución del soporte nutricional y del peso, y se asoció con la mortalidad. Resultados. 7 (11,7%) RNPT de MBPN fallecieron durante el estudio. Aquellos RNPT de MBPN que recibieron menos de 30 kcal/kg al tercer día, tuvieron 5 veces más riesgo de morir (IC 95% 1,1 – 23,5) con una diferencia estadísticamente significativa (p=0,036). Conclusiones. Recibir menores aportes nutricionales al tercer día está asociado con un mayor riesgo de mortalidad en estos neonatos. / Introduction. The nutrition in Very Low Birth Weight (VLBW) infants plays an important role in their recovery and overall development. Thus, an inadequate nutritional support can result in lower growth and higher incidence of diseases, which may affect the morbidity and mortality of these infants. Objective. Determine the association between the mortality at 28 days and the nutritional support given to VLBW infants hospitalized during 2011 in the Neonatal Intensive Care Unit of a public referral hospital in Lima, Peru. Patients and method. This retrospective cohort included 60 medical records from VLBW Infants, born and hospitalized during 2011 in the Neonatal Intensive Care Unit of a public referral hospital in Lima, Peru. The evolution of the nutritional support and weight was evaluated, and was associated with the mortality. Results. 7 (11.7%) VLBW infants died during the study. Those VLBW infants who received less than 30 kcal/kg on the third day, were 5 times more likely to die (CI 95% 1,1 – 23,5), with a statistically significant difference (p=0,036). Conclusions. Receive lower nutritional intake on the third day is associated with an increased risk of mortality in these infants. / Tesis