The prevalence of Alcohol Use Disorders is rapidly increasing among college students. The use of real time monitoring in conjunction with contingency management procedures to reduce alcohol consumption has only recently been developed. Therefore, the purpose of this study was to learn more about natural patterns of alcohol consumption in college-aged adults. A second goal was to evaluate a novel, handheld technology for obtaining reliable samples over extended time periods. College students were given a SoberLinkTM SL2 breathalyzer for eight weeks to monitor their drinking behaviors and asked to self-report the number of drinks consumed each day. Participants received one to three text messages per day to provide breath samples and earned monetary rewards for submitting samples within the allotted time. The results of this study showed that college students tend to consume alcohol during the evening hours and mostly on the weekends. There was a weak to medium correlation between average breath alcohol concentration and conditional average drinks. Compliance with prompts ranged between 77 and 84 percent and monetary earnings ranged between $152 and $160. Naturalistic observations of college drinking may aid in the development of interventions to prevent excessive drinking and the SL2 breathalyzer may have great potential to be used in a number of therapeutic approaches.

Lau Yin Kei. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2005. / Includes bibliographical references (leaves 58-79). / Abstracts in English and Chinese. / Acknowledgement --- p.I / Abstract --- p.IV / Abstract in Chinese --- p.VI / Abbreviations --- p.VIII / Introduction --- p.1 / Chapter 1.1 --- Prevalence of COPD and asthma in Hong Kong --- p.1 / Chapter 1.2 --- Players in pathogenesis of COPD --- p.2 / Chapter 1.3 --- Players in pathogenesis of asthma --- p.4 / Chapter 1.4 --- The use of exhaled breath condensate in previous studies --- p.6 / Chapter 1. 5 --- Brief overview of chemokines --- p.8 / Chapter 1.6 --- Objective of this study --- p.12 / Materials and methods --- p.14 / Chapter 2.1 --- Study population --- p.14 / Chapter 2.1.1 --- Patients with COPD and control subjects --- p.14 / Chapter 2.1.2 --- Patients with asthma and control subjects --- p.15 / Chapter 2.2 --- Lung function --- p.15 / Chapter 2.3 --- Dyspnoea score measurement of patients with COPD --- p.16 / Chapter 2.4 --- Classification of patients and asthma severity --- p.16 / Chapter 2.5 --- Skin prick test and blood tests --- p.16 / Chapter 2.6 --- Collection of exhaled breath condensate --- p.17 / Chapter 2.7 --- Measurement of constituent in EBC --- p.17 / Chapter 2.7.1 --- "Measurement of 8-isoprostane, MCP-1 and GROα in patients with COPD and the corresponding control subjects" --- p.17 / Chapter 2.7.2 --- Measurement of eotaxin and MDC of patients with asthma and the corresponding control subjects --- p.18 / Chapter 2.8 --- Reproducibility of exhaled breath constituent --- p.18 / Chapter 2.8.1 --- "Assessment of reproducibility of the exhaled MCP-1, GROα and8- isoprostane measurements" --- p.19 / Chapter 2.8.2 --- Assessment of reproducibility of the exhaled eotaxin and MDC measurement --- p.19 / Chapter 2.9 --- Statistical analysis --- p.19 / Results --- p.21 / Chapter 3.1 --- Patients with COPD and corresponding control subjects --- p.21 / Chapter 3.2 --- Patients with asthma and corresponding control subjects --- p.28 / Discussion --- p.36 / Chapter 4.1 --- "Exhaled 8-isoprostane, GRO-α and MCP-1 of patients with COPD and corresponding control subjects" --- p.36 / Chapter 4.2 --- Exhaled eotaxin and MDC from patients with asthma and corresponding control subjects --- p.43 / Chapter 4.3 --- Technical aspects of EBC assessment --- p.49 / Future prospect --- p.54 / Conclusion --- p.56 / References --- p.58 / Tables and Figures / Table 1. Demographics of the COPD and control subjects --- p.22 / Figure 1. The level of 8-isoprostane in the exhaled breath condensate of COPD and control subjects --- p.23 / Figure 2. The level of GROa in the exhaled breath condensate of COPD and control subjects --- p.25 / "Figure 3 Bland and Altman's Plot of the repeatability of 8-isoprostane, GROa and MCP-1 in the exhaled breath condensate of normal controls" --- p.27 / Table2. Clinical and physiological details of the subjects --- p.29 / Figure 4. Level of eotaxin in exhaled breath condensate of asthma and control subjects --- p.30 / Figure 5 Level of MDC in exhaled breath condensate of asthma and control subjects --- p.31 / Table 3. Levels of eotaxin and MDC in exhaled breath condensate of asthma subjects on different dose of inhaled corticosteroids --- p.33 / Figure 6. Relationship between exhaled breath condensate level of MDC and total serum IgE level --- p.35

Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-07-20T20:50:03Z No. of bitstreams: 1 Vanderson Cunha do Nascimento.pdf: 1194346 bytes, checksum: ddb63f49374d9261ba822c5740a4bddf (MD5) / Made available in DSpace on 2018-07-20T20:50:04Z (GMT). No. of bitstreams: 1 Vanderson Cunha do Nascimento.pdf: 1194346 bytes, checksum: ddb63f49374d9261ba822c5740a4bddf (MD5) Previous issue date: 2018-03-08 / Objective: to verify in elderly women practitioners of resistance training (RT) the behavior of Maximum Inspiratory Pressure (Mip) and Expiratory (Mep), amplitude ring, Axillary (AAx), Xifoideana (AXi) and Abdominal (AAb), the peak of Expiratory flow (PEF) and the distance travelled in Incremental Shuttle Walk Test (ISWT). Methodology: Two studies were developed with elderly women aged between 60 and 79 years. In study I, the sample consisted of 53 elderly women divided into two groups. The group of trained (GT) was composed of 28 women participants of a RT program and the group of non-trained (GNT) was composed of 25 sedentary or irregularly active women. In study II, the sample consisted of 24 elderly women, sedentary or irregularly active, who underwent a 12-week RT program. The elderly women were evaluated for Mip and Mep with the use of manovacuometry, thoracoabdominal amplitudes by cirtometry, PEF using the PEF or Peak-Flow meter and walking performance through the ISWT. In the statistical analysis in the study I was applied the Unpaired Student's t-Test and in Study II Student's t-Test was applied for related samples. The Pearson Correlation Test was used to correlate the respiratory variables with the distance covered in the ISWT. The level of significance was p ≤ 0.05. RESULTS: In the study I of the walk and the respiratory variables studied, except for AAb, found significant and superior differences in GT in relation to GNT, as well as in study II in the post-RT study. Correlation between respiratory variables and ISWT performance was only observed between this and AXi in study I. Conclusion: In study I, elderly women participating in a RT extension program presented higher and significant differences in Mip, Mep, AAx , AXi, Peak-Flow and performance in the ISWT when compared to sedentary or irregularly active elderly women, as well as, showed a significant correlation between AXi and ISWT performance. In study II, the RT promoted significant changes in respiratory variables and walking performance, except in AAb, however, no correlation was found between the respiratory variables studied and the results in the ISWT. / Objetivo: Verificar em mulheres idosas praticantes de Treinamento Resistido (TR) o comportamento das Pressões Máximas Inspiratória (PImáx) e Expiratória (PEmáx), das Amplitudes toracoabdominal, Axilar (AAx), Xifoideana (AXi) e Abdominal (AAb), do Pico de Fluxo Expiratório (PFE) e da distância percorrida no Incremental Shuttle Walk Test (ISWT). Metodologia: Foram desenvolvidos dois estudos com mulheres idosas com idade entre 60 e 79 anos. No estudo I, a amostra foi constituída de 53 idosas divididas em dois grupos. O grupo de treinadas (GT) foi composto por 28 mulheres participantes de um programa de TR e o grupo de não treinadas (GNT) foi composto por 25 mulheres sedentárias ou irregularmente ativas. No estudo II, a amostra foi constituída de 24 idosas, sedentárias ou irregularmente ativas, submetidas a um programa de TR com duração de 12 semanas. As mulheres idosas foram avaliadas em relação a PImáx e PEmáx com uso da manovacuometria, as amplitudes toracoabdominal pela cirtometria, o PFE através do medidor de PFE ou Peak-Flow e do desempenho na caminhada através do ISWT. Na análise estatística no estudo I foi aplicado o Teste t de Student não pareado e no estudo II foi aplicado o Test t de Student para amostras relacionadas. O Teste de Correlação de Pearson foi utilizado para correlacionar as variáveis respiratórias com a distância percorrida no ISWT. O nível de significância foi de p ≤ 0,05. Resultados: No desempenho da caminhada e nas variáveis respiratórias estudadas, exceto na AAb, constataram-se no estudo I diferenças superiores e significativas no GT em relação ao GNT, bem como, no estudo II no pós-TR. Correlação entre as variáveis respiratórias e o desempenho no ISWT só foi observada entre este e a AXi no estudo I. Conclusão: No estudo I, mulheres idosas participantes de um programa de extensão de TR, apresentaram diferenças superiores e significativas na PImáx, PEmáx, AAx, AXi, Peak-Flow e desempenho no ISWT, quando comparadas com mulheres idosas sedentárias ou irregularmente ativas, bem como, apresentaram correlação significativa entre AXi e desempenho no ISWT. No estudo II o TR promoveu alterações significativas nas variáveis respiratórias e no desempenho da caminhada, exceto na AAb, no entanto, não foram verificadas correlações entre as variáveis respiratórias estudadas e os resultados no ISWT.

Introdução: A má digestão de lactose detectada por testes respiratórios é bastante comum em pacientes com síndrome do intestino irritável (SII), e alguns pacientes com SII referem exacerbar seus sintomas após a ingestão de leite e produtos lácteos. A fim de uma melhor percepção sobre este tema, este trabalho investigou os efeitos da dieta isenta de lactose em pacientes com SII e teste respiratório de hidrogênio para avaliação da digestão de lactose normal ou anormal. Objetivo: Avaliar os efeitos de uma dieta isenta de lactose em pacientes de SII com ou sem teste positivo para má digestão de lactose (teste respiratório). Métodos: 80 pacientes atendidos no Ambulatório de Doenças Funcionais Intestinais do Serviço de Gastroenterologia Clínica do HCFMUSP foram recrutados para o estudo prospectivo. Os pacientes preencheram os critérios de Roma III para SII. Durante o ensaio do teste respiratório de hidrogênio todos os sintomas desencadeados pela ingestão de lactose foram anotados. Ambos os grupos de pacientes com e sem má digestão de lactose, foram submetidos a uma dieta isenta de lactose durante 4 semanas. A história prévia de intolerância ao leite e derivados também foi documentada. No final de cada semana, os pacientes foram solicitados a informar a respeito dos seus sintomas, e os resultados, foram devidamente marcados de acordo com a sua intensidade (Escore Global). Além disso, foi também obtida a Avaliação Global do Paciente no final do tratamento (AFG). Resultados: 33/80 (41,25%) pacientes com SII tiveram um teste respiratório anormal para a má digestão de lactose, e 47/80 dos pacientes (58,75%) com SII tiveram um teste respiratório normal (ns). Não houve diferença significativa na freqüência de queixas de intolerância prévia ao leite e derivados em ambos os grupos. No entanto, mais pacientes no grupo com má digestão de lactose referiram sintomas durante o teste respiratório com 25 g de lactose do que o grupo com digestão normal a lactose (p <0,001). Ambos os grupos igualmente melhoraram após uma dieta isenta de lactose, quando avaliados pelo escore geral e pelo AFG. Conclusões: Ambos os grupos de pacientes com SII, com e sem má digestão de lactose, melhoraram após 4 semanas de dieta isenta de lactose. Os nossos resultados sugerem que outros mecanismos, além da intolerância à lactose, devem ser levados em conta para explicar a melhora com uma dieta isenta de lactose em pacientes com SII / Introduction: Lactose intolerance detected by respiratory tests is rather common in patients with irritable bowel syndrome(IBS); also, some IBS patients refer their symptoms exacerbate after ingestion of milk and dairy products. In order to gain some insight into this topic we investigated the effects of a lactose-free diet in IBS patients with and without lactose intolerance diagnosed by means of the hydrogen respiratory test. Objective: To evaluate the effects of a lactose-free diet in IBS patients with and without lactose intolerance. Methodos: 80 patients who attended the outpatient clinic at the University of São Paulo School of Medicine Hospital, Brazil, were recruited for this prospective study. Patient met the Rome III criteria for IBS. During the hydrogen respiratory test all the symptoms triggered by lactose ingestion were taken down. Both groups of patients, with and without lactose intolerance, were submitted to a lactose-free diet for 4 weeks. Previous history of milk/dairy products intolerance was documented. At the end of each week, patients were asked to inform about their symptoms and the results were duly scored according to their intensity (Global Score). Also, the Patient Final Global Evaluation of the Treatment (PFGET) was obtained as well. Results: 33/80 (41.25%) IBS patients had an abnormal respiratory test for lactose intolerance; 47/80 (58.75%) IBS patients had a normal respiratory test (n.s.). There was no significant difference in the frequency of previous complaints after milk/dairy products ingestion in both groups. However, more patients in the lactose intolerant group referred symptoms during the respiratory test with 25 g of lactose than the lactose tolerant group (p<0,001). Both groups similarly improved after a lactose-free diet when evaluated by both the Global Score and the PFGET. Conclusions: Both groups of IBS patients, with and without lactose intolerance, improved after a 4-week lactose-free diet. Our results suggest that other mechanisms, in addition to lactose intolerance, should be taken into account to explain why IBS patients improve with a lactose-free diet

Introdução: A má digestão de lactose detectada por testes respiratórios é bastante comum em pacientes com síndrome do intestino irritável (SII), e alguns pacientes com SII referem exacerbar seus sintomas após a ingestão de leite e produtos lácteos. A fim de uma melhor percepção sobre este tema, este trabalho investigou os efeitos da dieta isenta de lactose em pacientes com SII e teste respiratório de hidrogênio para avaliação da digestão de lactose normal ou anormal. Objetivo: Avaliar os efeitos de uma dieta isenta de lactose em pacientes de SII com ou sem teste positivo para má digestão de lactose (teste respiratório). Métodos: 80 pacientes atendidos no Ambulatório de Doenças Funcionais Intestinais do Serviço de Gastroenterologia Clínica do HCFMUSP foram recrutados para o estudo prospectivo. Os pacientes preencheram os critérios de Roma III para SII. Durante o ensaio do teste respiratório de hidrogênio todos os sintomas desencadeados pela ingestão de lactose foram anotados. Ambos os grupos de pacientes com e sem má digestão de lactose, foram submetidos a uma dieta isenta de lactose durante 4 semanas. A história prévia de intolerância ao leite e derivados também foi documentada. No final de cada semana, os pacientes foram solicitados a informar a respeito dos seus sintomas, e os resultados, foram devidamente marcados de acordo com a sua intensidade (Escore Global). Além disso, foi também obtida a Avaliação Global do Paciente no final do tratamento (AFG). Resultados: 33/80 (41,25%) pacientes com SII tiveram um teste respiratório anormal para a má digestão de lactose, e 47/80 dos pacientes (58,75%) com SII tiveram um teste respiratório normal (ns). Não houve diferença significativa na freqüência de queixas de intolerância prévia ao leite e derivados em ambos os grupos. No entanto, mais pacientes no grupo com má digestão de lactose referiram sintomas durante o teste respiratório com 25 g de lactose do que o grupo com digestão normal a lactose (p <0,001). Ambos os grupos igualmente melhoraram após uma dieta isenta de lactose, quando avaliados pelo escore geral e pelo AFG. Conclusões: Ambos os grupos de pacientes com SII, com e sem má digestão de lactose, melhoraram após 4 semanas de dieta isenta de lactose. Os nossos resultados sugerem que outros mecanismos, além da intolerância à lactose, devem ser levados em conta para explicar a melhora com uma dieta isenta de lactose em pacientes com SII / Introduction: Lactose intolerance detected by respiratory tests is rather common in patients with irritable bowel syndrome(IBS); also, some IBS patients refer their symptoms exacerbate after ingestion of milk and dairy products. In order to gain some insight into this topic we investigated the effects of a lactose-free diet in IBS patients with and without lactose intolerance diagnosed by means of the hydrogen respiratory test. Objective: To evaluate the effects of a lactose-free diet in IBS patients with and without lactose intolerance. Methodos: 80 patients who attended the outpatient clinic at the University of São Paulo School of Medicine Hospital, Brazil, were recruited for this prospective study. Patient met the Rome III criteria for IBS. During the hydrogen respiratory test all the symptoms triggered by lactose ingestion were taken down. Both groups of patients, with and without lactose intolerance, were submitted to a lactose-free diet for 4 weeks. Previous history of milk/dairy products intolerance was documented. At the end of each week, patients were asked to inform about their symptoms and the results were duly scored according to their intensity (Global Score). Also, the Patient Final Global Evaluation of the Treatment (PFGET) was obtained as well. Results: 33/80 (41.25%) IBS patients had an abnormal respiratory test for lactose intolerance; 47/80 (58.75%) IBS patients had a normal respiratory test (n.s.). There was no significant difference in the frequency of previous complaints after milk/dairy products ingestion in both groups. However, more patients in the lactose intolerant group referred symptoms during the respiratory test with 25 g of lactose than the lactose tolerant group (p<0,001). Both groups similarly improved after a lactose-free diet when evaluated by both the Global Score and the PFGET. Conclusions: Both groups of IBS patients, with and without lactose intolerance, improved after a 4-week lactose-free diet. Our results suggest that other mechanisms, in addition to lactose intolerance, should be taken into account to explain why IBS patients improve with a lactose-free diet

Orientador: Maria Luiza Moretti / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-18T15:05:39Z (GMT). No. of bitstreams: 1 Passos_AnaIsabelaMorsch_M.pdf: 2317515 bytes, checksum: 2a34cbc644c6ec0279e1f66cf58ccf4a (MD5) Previous issue date: 2011 / Resumo: A função pulmonar, em pacientes infectados pelo vírus da imunodeficiência humana (HIV), tem sido associada com a redução nos parâmetros de ventilação pulmonar. Métodos: Foi realizado estudo do tipo corte transversal para avaliar a função pulmonar de pacientes com aids atendidos em ambulatórios de doenças infecciosas. Foram avaliados dados de espirometria, pressão inspiratória máxima (PImáx) e pressão expiratória máxima (PEmáx). Também foram coletados, através de prontuários médicos, dados clínicos, demográficos e laboratoriais. Resultados: Os dados de PImáx e PEmáx foram avaliados em 73 pacientes, o exame de espirometria foi avaliado em 54 pacientes. O tempo médio de infecção pelo HIV (em anos) foi semelhante para os homens (8,5 ± 5,1) e mulheres (10,4 ± 4,2, p = 0,13) e o tempo médio de utilização da terapia antiretroviral foi de 8,5 ± 4,1 anos para as mulheres e 7,7 ± 4,1 anos para os homens (p = 0,46). Os valores de PImáx e PEmáx foram abaixo do previsto em 38 (52%) e 25 (34%) pacientes, respectivamente. O uso do tenofovir e a presença de tosse, no momento em que o teste foi realizado, foram independentemente associados com PEmáx abaixo do valor previsto. Valores elevados de creatinoquinase foram associados com o uso prolongado de terapia antiretroviral (9,6 ± 4,1 anos versus 7,4 ± 3,9 anos, p = 0,05). Os valores de capacidade vital forçada (CVF) se apresentaram reduzidos em 14 (26,4%) pacientes e foi independentemente associado com risco cardiovascular intermediário ou alto (p = 0,002) e com murmúrio vesicular reduzido à ausculta pulmonar (p = 0,047). Os valores de volume expiratório forçado no primeiro segundo (VEF1) foram significativamente menores nos pacientes com tempo prolongado de tabagismo (p = 0,019) e risco cardiovascular intermediário ou alto (p = 0,003). A redução da relação VEF1/CVF foi associada com o tabagismo (p = 0,041). Conclusão: Nas medidas de PImáx e PEmáx, 38 (52,1%) e 25 (34,2%) pacientes apresentaram resultados abaixo do previsto. O exame de Espirometria foi considerado normal em 45 pacientes. Houve diagnóstico de distúrbio obstrutivo e restritivo em um (1,9%) e 8 (14,8%) pacientes. O uso de Tenofovir e a presença de tosse foram independentemente associadas à PEmáx abaixo do previsto. Pacientes com menores valores de CVF foram os com maior risco cardiovascular e murmúrio vesicular diminuído à ausculta pulmonar. Pacientes com menores valores de VEF1 foram aqueles com maior tempo de tabagismo e maior risco cardiovascular. A variável independentemente associada a valores reduzidos de VEF1/CVF foi tabagismo / Abstract: Background: Pulmonary function, in HIV infected patients, has been associated with reduction in pulmonary ventilation parameters Methods: We conducted a sectional study to evaluate the pulmonary function of AIDS patients cared for in the infectious diseases ambulatories. Maximal inspiratory (MIP) and expiratory (MEP) pressures and spirometry were assessed. Clinical, demographic and laboratorial data were also evaluated. Results: MIP and MEP were assessed in 73 and spirometry in 54 patients. The mean time of HIV infection (in years) was similar for men (8.5+5.1) and women (10.4±4.2; p= .13) and the mean time of use of antiretroviral therapy (ART) was 8.5±4.1 years for women and 7.7±4.1 years for men (p= .46). MIP and MEP values were not normal in 38 (52%) and 25 (34%) patients, respectively. The use of tenofovir (TVF) and presence of cough, by the time the test was performed, were independently associated MEP below the predictive value. Elevated CK values were associated with prolonged time ARV usage (9.6±4.1 years vs 7.4±3.9 years; p= .05). FVC was reduced in 14 (26.4%) patients and was independently associated with high and/or intermediate cardiovascular risk (p= .002), and those with reduced vesicular murmur in auscultation (p= .047). FEV1 was significantly lower in patients with prolonged time of smoking (p= .019) and high and/or intermediate cardiovascular risk (p= .003). Reduced FEV1/FVC ratio was associated with smoking (p= .041). Conclusions: In measurements of MIP and MEP, 38 (52.1%) and 25 (34.2%) patients had results below forecast. The spirometry test was considered normal in 45 patients. There was a diagnosis of obstructive and restrictive ventilation disorder in one (1.9%) and 8 (14.8%) patients. The use of tenofovir and cough were independently associated with lower than expected MEP. Patients with lower values of FVC had the highest cardiovascular risk and reduced breath sounds on pulmonary auscultation. Patients with lower values of FEV1 were those with longer duration of smoking and increased cardiovascular risk. The variable independently associated with lower values of FEV1/FVC was smoking / Mestrado / Ciencias Basicas / Mestre em Clinica Medica

Avaliamos as mudanças no padrão respiratório, movimento toracoabdominal e ventilação em portadores de DPOC e indivíduos sadios. Estudou-se 45 indivíduos entre 45 e 75 anos conforme o VEF1. Utilizou-se sistemas de pletismografia respiratória por indutância, análise metabólica de gases em posição semi-sentada ao repouso e radiografia de tórax para a mobilidade diafragmática. Os grupos DPOC apresentaram redução do TI, TTOT, aumento do VC/TI, f, VE, das relações VEM/VC, VE/VO2, VE/VCO2 e diminuição da SpO2. Redução da mobilidade do diafragma e aumento da VEM/VC associaram-se à ineficiência da ventilação e a alterações no modelo ventilatório utilizado, sem alterações no movimento toracoabdominal. / We assessed changes in breathing patterns, thoracoabdominal movement and ventilation in COPD sufferers and healthy individuals. Forty-five individuals between 45 and 75 were grouped by FEV1. Inductive plethysmographic equipment, respiratory metabolism measuring (with subject at rest in semi-recumbent position), and radiographic measurement of diaphragm mobility were used. The COPD groups presented reduction in TI and TTOT and increased VT/TI, f, VE, and VD/VT, VE/VO2, VE/VCO2 and decreased SpO2. Reduction in diaphragm mobility and increase of VEM/VC were associated with ventilatory inefficiency and alterations in the ventilatory model used. No alterations in thoracoabdominal movement

Avaliamos as mudanças no padrão respiratório, movimento toracoabdominal e ventilação em portadores de DPOC e indivíduos sadios. Estudou-se 45 indivíduos entre 45 e 75 anos conforme o VEF1. Utilizou-se sistemas de pletismografia respiratória por indutância, análise metabólica de gases em posição semi-sentada ao repouso e radiografia de tórax para a mobilidade diafragmática. Os grupos DPOC apresentaram redução do TI, TTOT, aumento do VC/TI, f, VE, das relações VEM/VC, VE/VO2, VE/VCO2 e diminuição da SpO2. Redução da mobilidade do diafragma e aumento da VEM/VC associaram-se à ineficiência da ventilação e a alterações no modelo ventilatório utilizado, sem alterações no movimento toracoabdominal. / We assessed changes in breathing patterns, thoracoabdominal movement and ventilation in COPD sufferers and healthy individuals. Forty-five individuals between 45 and 75 were grouped by FEV1. Inductive plethysmographic equipment, respiratory metabolism measuring (with subject at rest in semi-recumbent position), and radiographic measurement of diaphragm mobility were used. The COPD groups presented reduction in TI and TTOT and increased VT/TI, f, VE, and VD/VT, VE/VO2, VE/VCO2 and decreased SpO2. Reduction in diaphragm mobility and increase of VEM/VC were associated with ventilatory inefficiency and alterations in the ventilatory model used. No alterations in thoracoabdominal movement