Texte remanié de: Th. 3e cycle--Histoire--Paris IV, 1974. / Bibliogr. p. 319-333.

search for identity port

Mémoire d'étude diplôme de conservateur des bibliothèques : Bibliothéconomie : Villeurbanne, ENSSIB : 2004.

Rapport de stage diplôme de conservateur des bibliothèques : Bibliothéconomie : Villeurbanne, ENSSIB : 2004.

Thesis (M.Sc.) - Carleton University, 2008. / Includes bibliographical references (p. 93-99). Also available in electronic format on the Internet.

Thesis--Hamburg. / Lebenslauf. "Literaturverzeichnis": p. 132-137.

Ce travail consacré à la communauté ruthène des XVIe-XVIIe siècles s'intéresse à la vie religieuse des chrétiens orientaux de Pologne-Lituanie au moment de la division de la métropole de Kiev entre les obédiences romaine et constantinopolitaine. A partir de l'exemple de la Lituanie occidentale (voïvodes de Vilnius et de Trakai), qui correspondait à une zone frontière entre les structures ecclésiastiques des rites grec et latin, il propose de saisir les enjeux et les conséquences locales des conflits et des négociations, qui émanèrent du schisme survenu après l'Union de Brest de 1595/1596. Grâce à des sources variées (documentation judiciaire, registres fiscaux, visites pastorales, correspondances, archives romaines, traités de controverse etc), l'enquête vise à replacer les fidèles de rite oriental dans l'espace géographique et les structures sociales de ce territoire pluriconfessionnel. A une échelle plus petite, l'étude fait ressortir également la place de la Lituanie dans les bouleversements généraux de l'Eglise ruthène de cette période afin de comprendre les disparités avec les religions méridionales de la métropole, plus réticents à reconnaître l'obédience pontificale. La « régionalisation » de l'histoire de l'Union de Brest amène enfin à évaluer la réception des réformes religieuses par les laïcs et de dégager les processus en jeu dans la constitution des appartenances confessionnelles sur les frontières du christianisme latin de l'époque post-tridentine. / This study on the Ruthenian community of the 16th and 17th centuries analyses the religious life of Eastern Christians of the Polish-Lithuanian Commonwealth, at the moment of the division of the Kievan metropolinate between Roman and Constantinopolitan obediences. With the example of western Lithuania (Vilnius and Trakai voivodships), which corresponded to a border area between the ecclesiastical structures of Greek and Latin rites, it proposes to explain the issues and consequences of local conflicts and negotiations, associated to the schism occurred after the Union of Brest in 1595/1596. Through a variety of sources (court archives, tax records, pastoral visits, correspondences, Roman archives, controversial treatises etc), the survey aims to situate the faithful of the Eastern rite within geographic space and social structures of this multiconfessional territory. On a smaller scale, the work also highlights the rôle of Lithuania in the general upheavals of the Ruthenian Church of this period in order to understand the differences with the soutern parts of the metropolitan diocese which was more reluctant to recognize the authority of the Pope. This « regionalization » of the history of the Union of Brest finally tries to measure the impact of religious reforms on laity and ti identify different process involved in the formation of confessional identities on the borders of Latin Christianity of the post-Tridentine era.

Dans un contexte de profonde restructuration de la construction navale militaire française, la seconde moitié du XXe siècle a été marquée par un déclin continu de l’adhésion syndicale au sein d’un des bastions du militantisme ouvrier breton : l’arsenal de Brest. Face à une telle évolution, l’évocation régulière de quelques lointains « faits d’armes » a participé à la construction d’une image d’un établissement en perpétuelle ébullition. Sans faire abstraction d’un phénomène protestataire incontestable à certaines époques, cette recherche propose néanmoins de se démarquer de cette vision réductrice en reconsidérant une action syndicale longtemps guidée par la volonté de négocier avec une hiérarchie complaisante plus que par une opposition systématique. Des avancées sociales de l’entre-deux-guerres à la fin de la décennie 1960, elle s’attachera à analyser l’itinéraire d’un mouvement ouvrier tiraillé entre une condition « privilégiée » et un statut de « fer de lance » de la lutte prolétarienne, s’adaptant aux contextes politico-économiques successifs, de l’administration étatique traditionnelle à l’apparition d’une notion de productivité jusque lors étrangère à la construction navale militaire. Confrontée à une situation où histoire et mémoire sont parfois divergentes alors que l’arsenal du Ponant tend à devenir un fort enjeu patrimonial, cette recherche s’efforcera de faire la part entre les mythes et les réalités en replaçant les faits dans les contextes historiques successifs, en redonnant aux événements la juste place qu’ils ont occupée dans le quotidien des travailleurs et des syndicats et en rétablissant l’implication et les responsabilités de chaque acteur social dans le fonctionnement et la vie de l’établissement comme dans la constitution d’une aristocratie ouvrière à la pointe du Finistère. / In the context of fundamental changes to the french naval military structure, for many decades, the unions at the Brest arsenal are facing haemorrhaging membership at a side which was one of the bastions of Breton worker militancy throughout the 20th century. Confronted by a decline which seems irreversible, the repeated evocation of far off ‘feats of arms’ has helped the development of an image of an establishment in perpetual agitation. Without ignoring the protest culture, obvious at certain times, this research proposes the existence of a union policy guided by a wish for negotiations with a compliant hierarchy rather than systematic opposition. From the social advances between the wars to the end of the decade of the 60s, the research identifies the progress of a workers’ movement adapting to successive changes in the political-economic climate and of the traditional state administration to the notion of productivity hitherto foreign to naval military construction.Though history and memory sometimes diverge, while the arsenal tends to become a strong patrimonial stake, this study will try hard to announce between the myths and the realities by replacing the facts in the successive historic contexts, by restoring in the events the rightful place which they occupied in the life of the workers and the unions and by restoring the implication and the responsibilities of every social player in the functioning and the life of the establishment and also in the constitution of labor aristocracy in the Finistère. As well as cutting a new historical path, it seeks to understand and explain the image of confrontation at the finistère arsenal at the time it transformed into a cornerstone of the heritage of Brest.

Made available in DSpace on 2014-06-11T19:33:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-08-17Bitstream added on 2014-06-13T19:04:10Z : No. of bitstreams: 1 sanches_oc_dr_botfmvz.pdf: 1031367 bytes, checksum: 31652d18eb0eb85dfe96eb3f8e2db066 (MD5) / Universidade Estadual Paulista (UNESP) / O presente trabalho teve como objetivo quantificar e avaliar presença dos mastócitos nos diferentes tipos de neoplasias malignas da glândula mamária da cadela. Através de estudo retrospectivo, foi empregado à coloração histoquímica do azul de toluidina, para detecção de mastócitos, e a técnica imunoistoquímica, usando os anticorpos Ki-67 para proliferação celular e a caspase-3 para identificar as células em apoptose. As amostras (n= 102) foram descritas conforme a Classificação Histopatológica para Neoplasia Mamária do Cão e do Gato da Organização Mundial de Saúde. Os animais sem raça definida apresentaram o maior número de casos, e entre os animais com raça definida, a raça Poodle foi a que apresentou o maior número de casos. A idade média das cadelas foi de 8,6 anos. Os tipos morfológicos de neoplasias encontradas foram o carcinoma in situ com 0,98%, carcinoma complexo com 45,09%, carcinoma simples com 35,29%, carcinossarcoma com 10,78% e os tipos especiais de carcinomas que representaram 7,89% dos casos. Os mastócitos estavam presentes no foco neoplásico em 96,08% das amostras. 99% das amostras apresentaram marcação positiva para o anticorpo Ki-67 (MIB-1). Já a imunomarcação pela caspase-3 revelou marcação positiva em 95% dos casos. Foi observada correlação significativa positiva entre o número de mastócitos e o índice de proliferação (Ki-67) (p˂0,05) nos carcinomas do tipo complexo. Os mastócitos mostraram influência na proliferação das células dos carcinomas complexos, contudo, é necessário mais estudos para elucidar o papel destas células no índice de proliferação / The presented study aimed to quantify and evaluate the presence or absence of mast cells in different types of malignancies in the mammary gland of the female dogs. For this, it was used the blue toluidine in the histochemical colours with the purpose of detecting mast cells, and immunohistochemical techniques, using the antibodies Ki-67 to the proliferation of the cells and caspase-3 antibody to identify undergoing cells in apoptosis. All samples were put according to the pathological classification for dog’s and cat’s breast cancer in the World Health Organization. About the racial pattern, it was observed a higher number of cases in animals without breed, and in the animals with breed, the Poodle was the one with the largest number of cases. The average age of the female dogs was 8.6 years old. The morphological types of neoplasm founded were: carcinoma in situ with 0.98% (1/102), complex carcinoma with 45.09% (46/102), simple carcinoma in 35.29% (36/102) carcinosarcom in 10.78% (11/102) and special types of carcinomas that were represented with 7.89% (08/102) of the total number of cases. The mast cells were presented in the neoplasic focus with 96.08% (98/102), and it prevailed in areas where there are lots of human tissues, especially around the vessels. About the immune numbers of samples using the Ki-67 (MIB-1), it was conclude that 99% (101/102) showed positive results. However, using the caspase-3 it was showed positive results in 95% (97/102). About the influence of mast cells in the proliferation of neoplasic cells, it was observed a significant positive correlation between the number of mast cells and the proliferation (Ki-67) for the complex carcinoma (p 0.05). The correlation between death and cells proliferation showed a negative significant relation in spindle cells carcinomas, between the apoptotic number (Caspase-3) and the proliferation number (NORs). How bigger is the number

Yes / The synthesis and characterization of three aromatic oligoamides, constructed from the same pyridyl carboxamide core but incorporating distinct end groups of acetyl (Ac) 1, tert-butyloxycarbonyl (Boc) 2 and amine 3 is reported. Single crystal X-ray diffraction analysis of 1-3 and a dimethylsulfoxide (DMSO) solvate of 2 (2-DMSO), has identified the presence of a range of intra- and intermolecular interactions including N-H⋯N, N-H⋯O=C and N-H⋯O=S(CH3)2 hydrogen-bonding interactions, C-H⋯π interactions and off-set, face-to-face stacking π-π interactions that support the variety of slipped stack, herringbone and cofacial crystal packing arrangements observed in 1-3. Additionally, the cytotoxicity of this series of aromatic oligoamides was assessed against two human ovarian (A2780 and A2780cisR), two human breast (MCF-7 and MDA-MB-231) cancerous cell lines and one non-malignant human epithelial cell line (PNT-2), to investigate the influence of the terminal functionality of these aromatic oligoamides on their biological activity. The chemosensitivity results highlight that modification of the terminal group from Ac to Boc in 1 and 2 leads to a 3-fold increase in antiproliferative activity against the cisplatin-sensitive ovarian carcinoma cell line, A2780. The presence of the amine termini in 3 gave the only member of the series to display activity against the cisplatin-resistance ovarian carcinoma cell line, A2780cisR. Compound 2 is the lead candidate of this series, displaying high selectivity towards A2780 cancer cells when compared to non-malignant PNT-2 cells, with a selectivity index value >4.2. Importantly, this compound is more selective towards A2780 (cf. PNT-2) than the clinical platinum drugs oxaliplatin by > 2.6-fold and carboplatin by > 1.6-fold. / University of Bradford Development Fund; University of Birmingham - Birmingham Fellowship; UKRI Future Leaders Fellowship (MR/T041315/1); UKRI Future Leaders Fellowship (MR/S035486/2)