Made available in DSpace on 2014-06-11T19:26:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-03-08Bitstream added on 2014-06-13T18:54:40Z : No. of bitstreams: 1 jose_nf_me_fran.pdf: 8739864 bytes, checksum: b3f24e69c48de437f36c3febdc92011f (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / A construção da imagem de Augusto é algo muito estudado pela historiografia atual. Obras como a Eneida de Virgílio e muitos escritos de Horácio, de escritores contemporâneos a Otávio Augusto, são usadas como referências desta propaganda política, militar, social e ideológica do Principado Romano. Notam-se, a partir de obras como estas, as construções em torno da imagem de Augusto e o uso desta, para legitimar o novo sistema político que surgia em Roma. Ainda, durante este processo de legitimação e propaganda, foi-nos possível perceber como se dá a utilização de imagens de grandes personagens públicos romanos, tais como Júlio César e Marco Antônio, e como é construída a representação de Augusto, como Princeps, em torno de semelhanças e diferenças destes personagens. Sendo assim, nosso objetivo nesta presente pesquisa é analisar como se criaram representações em torno da imagem de Augusto, a partir da oposição das figuras de Júlio César e Marco Antônio. Para tanto, selecionamos obras de períodos e gêneros narrativos distintos, a fim de, com isso, conseguirmos um entendimento mais amplo acerca do período analisado. Trata-se das obras de Veléio Patérculo, História Romana, duas biografias de Plutarco, César e Antônio, presentes na obra Vidas Paralelas, e duas biografias – O Divino Júlio César e O Divino Augusto – de Suetônio, presentes em sua obra A Vida dos Doze Césares / The formation of Augustus’ image is something much studied by the historiography nowadays. Works like the Aeneid by Virgil and many Horace’s writings, from contemporary writers in time of Octavius Augustus are used as references from these political, military, social and ideological of the Roman Principality. It is noticed, from works like these, formations around the image of Augustus and the usage of it to legitimate the new political as starting in Rome. Yet, during this process of legitimacy and spreading, it was possible to realize how the usage of images of great Roman political people works, such as Julius Caesar and MarK Antony, how the representation of Augustus is formed like Princeps, around the resemblance and difference of these characters. Thus, our aim in this present research is to analyze how representations around the image of Augustus were formed from the opposition of images of Juius Caesar and Mark Antony. Because of that, we selected works from periods and distinct narrative genres so we could understand better about the analyzed period. It is about Velleius Paterculus’ works. Roman History, two Plutarcus biographies, Caesar and Antony, present in the work Parallel Lives and two biographies – The Divine Julius Caesar and the Divine Augustus – by Suetonius, presented in his work The Twelve Caesars

Orientador: Flavio Ribeiro de Oliveira / Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem / Made available in DSpace on 2018-08-10T09:12:17Z (GMT). No. of bitstreams: 1 RochaJunior_RooseveltAraujoda_D.pdf: 2813810 bytes, checksum: cf6093712c864c346e60471a7a164df5 (MD5) Previous issue date: 2007 / Resumo: Esta Tese apresenta uma tradução para o português do livro Peri Mousikes, de Plutarco, acompanhada de notas. Além da tradução, apresenta-se também uma introdução e comentários ao texto. Na introdução, aborda-se o conteúdo do tratado (história da música grega e teoria musical); a questão da autoria; o problema da transmissão do texto; e, também, na introdução, apresenta-se uma breve iniciação à teoria musical grega e aos instrumentos musicais. Na parte dedicada aos comentários, trata-se de questões importantes presentes no tratado que pedem maiores esclarecimentos. Nessa parte, além disso, são relacionados temas que se encontram dispersos no texto de Plutarco, tentando assim oferecer uma costura mais coerente das idéias e assuntos discutidos / Abstract: This PhD dissertation presents a translation to the Portuguese of the book Peri Mousikes, by Plutarch, with notes. With the translation, it presents also an introduction and commentaries to the text. In the introduction, it deals with the treatise content (history of Greek music and musical theory); the authorship question; the text transmission problem; and, also, in the introduction, it presents a brief initiation to the Greek musical theory and to the study of the musical instruments. In the part dedicated to the commentaries, it deals with important questions present in the treatise which ask for more explanations. In this part, besides, some arguments, which are dispersed in Plutarch's text, are put in relation, trying in this way to offer a reading more coherent of the ideas and themes discussed. / Doutorado / Mestre em Linguística

Electronic biosensors utilizing micron-scale interdigitate electrodes (IDEs) in an SD card format have been developed with the objective of fast, sensitive detection of ovarian cancer biomarkers CA-125, CEA, and He4. The signal generated by the biosensors is a result of electrochemical impedance spectroscopy (EIS), a technique which probes changes that occur in the biosensor's electrical properties when the biosensor has detected one of the target biomarkers. A label-free biosensor has been developed to detect CA-125 in spiked buffer at concentrations between 10 and 80units/mL. A similar label-free biosensor was developed to detect CEA at concentrations between 10ug/mL and 10mg/mL. A biosensor employing a protein-enzyme conjugated label was developed to detect He4 at concentrations ranging from 1.56 to 100ng/mL in spiked buffer. All concentration ranges of CA-125, CEA, and He4 detected by the biosensors include the serum concentration currently used for clinical diagnosis of ovarian cancer. Efforts to improve the signals generated by the biosensors included altering the dimensions and composition of the IDEs used in the initial biosensors through software-created models. Modeled alterations included the size of the electrodes, the shape of the electrodes, and the incorporation of nanomaterials into the IDEs. An ideal geometry for the IDEs was developed through the models and IDEs with those dimensions were fabricated and tested against the IDEs used in the biosensors initially with the model-developed geometry improving the signal generated by the biosensor. Another attempt to improve the biosensor's signal was to generate a single strand of DNA (ssDNA) that would bind to CA-125, called an aptamer, that could be easily incorporated into the sensing layer on the IDEs. Through a multistep selection process nine different aptamers that exhibited binding to CA-125 were identified.

Structured abstract Study objectives: Ovarian carcinoma 1/ comparison of sensitivities among monitored markers CA 125, HE4, CA 19-9, CEA, TK, TPS, MonoTotal 2/ comparison of false positivity of markers CA 125 and HE4 3/ use of CA 125, HE4 and ROMA index in the diagnostics of ovarian carcinoma 4/ use of CA 125 and HE4 in the follow-up of ovarian cancer Endometrial carcinoma 1/ feasibility of use of biomarkers CA125 and HE4 in patients with endometrial cancer in pre- operative management Study design: Retrospective data analysis Settings: Department of Obstetrics and Gynecology, Medical Faculty and Teaching Hospital in Pilsen Patients and Methods: Ovarian cancer 1/ Sensitivity of markers CA 125, HE4, CA 19-9, CEA, TK, TPS, and MonoTotal was assessed in 266 patients - 19 with ovarian cancer and 247 with benign disorders. 2/ False positivity of markers CA125 and HE4 was evaluated in a total of 390 patients with benign diagnoses - 60 women with endometriosis, 70 pregnant patients, 67 patients with ascites, 60 with pleural effusion, 25 with cardiac failure , 80 with renal insufficiency and 28 with hepatic failure. 3/ As a part of this objective we evaluated 552 patients with abnormal pelvic abnormality - 30 women had a histologically confirmed malignant ovarian tumor. Other 522 women had a benign condition. The...

INTRODUÇÃO: O câncer de ovário é o mais letal de todos os cânceres ginecológicos e requer ser tratado por ginecologistas especializados em centros terciários para se obter melhor prognóstico. Este trabalho tem como objetivo analisar e comparar quatro estratégias diferentes para predizer a benignidade ou malignidade de tumores pélvicos supostamente de origem ovariana utilizando para este fim, marcadores tumorais CA 125 e HE4, índice de risco de malignidade (IRM) e algoritmo ROMA. MÉTODOS: Neste estudo prospectivo foram avaliadas 128 pacientes com diagnóstico de tumores pélvicos supostamente de origem ovariana atendidas na Divisão de Clínica Ginecológica do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo e Instituto do Câncer do Estado de São Paulo entre julho de 2008 e janeiro 2011. Foram calculadas a sensibilidade e a especificidade e construídas curvas ROC para comparar os quatro parâmetros (CA 125, HE4, ROMA e IRM) na eficácia de diferenciar tumores ovarianos. RESULTADOS: A sensibilidade obtida para CA 125, HE4, ROMA e IRM foi de, respectivamente, 70,4%, 79,7%, 74,1% e 63,0%. A especificidade para CA 125, HE4, ROMA e IRM foi de, respectivamente, 74,2%, 66,7%, 75,8% e 92,4%. Não houve diferença na comparação das áreas abaixo da curva ROC entre os quatro parâmetros. CONCLUSÕES: Nenhum dos quatro métodos estudados é o ideal na diferenciação de tumores ovarianos. Entre os quatro parâmetros analisados o HE4 foi o parâmetro com melhor sensibilidade na diferenciação de tumores ovarianos. A acurácia dos quatro métodos é equivalente e podem ser utilizados indistintamente para referenciar pacientes para serviços especializados no tratamento de câncer de ovário / BACKGROUND: Ovarian cancer is the most lethal of all gynecological cancers and requires to be treated by gynecologic oncologists in tertiary centers accustomed to treating this disease to achieve the best prognosis. This study aims to compare four different strategies to predict the benignity or malignancy of pelvic tumors presumably of ovarian origin using, for this purpose, tumor markers CA 125 and HE4, risk malignancy index (RMI) and algorithm ROMA. METHODS: This prospective study evaluated 128 patients supposedly with ovarian tumors treated at the Divisão de Clínica Ginecológica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo and at Instituto do Câncer do Estado de São Paulo between July 2008 and January 2011. We calculated sensitivity, specificity and ROC curves to compare the four parameters (CA 125, HE4, ROMA and RMI) ability to differentiate the ovarian tumors. RESULTS: The sensitivity obtained for CA 125, HE4, ROMA and RMI was, respectively, 70.4%, 79.7%, 74.1% and 63.0%. The specificity obtained for CA 125, HE4, ROMA and RMI was, respectively, 74.2%, 66.7%, 75.8% and 92.4%. There was no difference the areas under the ROC curve among the four parameters. CONCLUSIONS: None of the four studied methods is best in the differentiation of ovarian tumors. Among the four parameters analyzed, HE4 was the parameter with highest sensitivity in the differentiation of ovarian tumors. The accuracy of the four methods is equivalent and can be used interchangeably to refer patients for specialized services in the treatment of ovarian cancer

INTRODUÇÃO: O câncer de ovário é o mais letal de todos os cânceres ginecológicos e requer ser tratado por ginecologistas especializados em centros terciários para se obter melhor prognóstico. Este trabalho tem como objetivo analisar e comparar quatro estratégias diferentes para predizer a benignidade ou malignidade de tumores pélvicos supostamente de origem ovariana utilizando para este fim, marcadores tumorais CA 125 e HE4, índice de risco de malignidade (IRM) e algoritmo ROMA. MÉTODOS: Neste estudo prospectivo foram avaliadas 128 pacientes com diagnóstico de tumores pélvicos supostamente de origem ovariana atendidas na Divisão de Clínica Ginecológica do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo e Instituto do Câncer do Estado de São Paulo entre julho de 2008 e janeiro 2011. Foram calculadas a sensibilidade e a especificidade e construídas curvas ROC para comparar os quatro parâmetros (CA 125, HE4, ROMA e IRM) na eficácia de diferenciar tumores ovarianos. RESULTADOS: A sensibilidade obtida para CA 125, HE4, ROMA e IRM foi de, respectivamente, 70,4%, 79,7%, 74,1% e 63,0%. A especificidade para CA 125, HE4, ROMA e IRM foi de, respectivamente, 74,2%, 66,7%, 75,8% e 92,4%. Não houve diferença na comparação das áreas abaixo da curva ROC entre os quatro parâmetros. CONCLUSÕES: Nenhum dos quatro métodos estudados é o ideal na diferenciação de tumores ovarianos. Entre os quatro parâmetros analisados o HE4 foi o parâmetro com melhor sensibilidade na diferenciação de tumores ovarianos. A acurácia dos quatro métodos é equivalente e podem ser utilizados indistintamente para referenciar pacientes para serviços especializados no tratamento de câncer de ovário / BACKGROUND: Ovarian cancer is the most lethal of all gynecological cancers and requires to be treated by gynecologic oncologists in tertiary centers accustomed to treating this disease to achieve the best prognosis. This study aims to compare four different strategies to predict the benignity or malignancy of pelvic tumors presumably of ovarian origin using, for this purpose, tumor markers CA 125 and HE4, risk malignancy index (RMI) and algorithm ROMA. METHODS: This prospective study evaluated 128 patients supposedly with ovarian tumors treated at the Divisão de Clínica Ginecológica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo and at Instituto do Câncer do Estado de São Paulo between July 2008 and January 2011. We calculated sensitivity, specificity and ROC curves to compare the four parameters (CA 125, HE4, ROMA and RMI) ability to differentiate the ovarian tumors. RESULTS: The sensitivity obtained for CA 125, HE4, ROMA and RMI was, respectively, 70.4%, 79.7%, 74.1% and 63.0%. The specificity obtained for CA 125, HE4, ROMA and RMI was, respectively, 74.2%, 66.7%, 75.8% and 92.4%. There was no difference the areas under the ROC curve among the four parameters. CONCLUSIONS: None of the four studied methods is best in the differentiation of ovarian tumors. Among the four parameters analyzed, HE4 was the parameter with highest sensitivity in the differentiation of ovarian tumors. The accuracy of the four methods is equivalent and can be used interchangeably to refer patients for specialized services in the treatment of ovarian cancer

Peritoneal dialysis (PD) is a form of renal replacement therapy using the peritoneum as a dialysis membrane. PD solutions employed to remove nitrogen metabolites and excess plasma fluid, and to restore electrolyte and acid-base balance are being developed to minimize local and systemic inflammatory responses while maintaining peritoneal homeostasis and host defense. The effect of chronic action of PD solutions on the peritoneum results in its remodeling and, possibly, eventual loss of peritoneal ultrafiltration capacity. Factors most responsible for late complications and peritoneal remodeling include high glucose levels in PD solutions, and the presence and formation of glucose degradation products (GDP) and advanced glycation end - products (AGEs) in the peritoneal cavity. The aim of our study described in this dissertation was to test various PD solutions with different glucose content and GDP and, using AGEs receptor ligands, to define their systemic effects and identify PD solutions with highest biocompatibility. This part of the dissertation characterizes conventional glucose - based solutions, low - glucose and GDP load solutions as well as glucose polymer (icodextrin) - based PD solutions while determining the plasma and dialysate levels of soluble receptor for AGEs (s - RAGE) and its...

Peritoneal dialysis (PD) is a form of renal replacement therapy using the peritoneum as a dialysis membrane. PD solutions employed to remove nitrogen metabolites and excess plasma fluid, and to restore electrolyte and acid-base balance are being developed to minimize local and systemic inflammatory responses while maintaining peritoneal homeostasis and host defense. The effect of chronic action of PD solutions on the peritoneum results in its remodeling and, possibly, eventual loss of peritoneal ultrafiltration capacity. Factors most responsible for late complications and peritoneal remodeling include high glucose levels in PD solutions, and the presence and formation of glucose degradation products (GDP) and advanced glycation end - products (AGEs) in the peritoneal cavity. The aim of our study described in this dissertation was to test various PD solutions with different glucose content and GDP and, using AGEs receptor ligands, to define their systemic effects and identify PD solutions with highest biocompatibility. This part of the dissertation characterizes conventional glucose - based solutions, low - glucose and GDP load solutions as well as glucose polymer (icodextrin) - based PD solutions while determining the plasma and dialysate levels of soluble receptor for AGEs (s - RAGE) and its...

Made available in DSpace on 2014-06-11T19:26:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2003-09-26Bitstream added on 2014-06-13T20:28:15Z : No. of bitstreams: 1 santos_pv_me_assis.pdf: 683228 bytes, checksum: a1b11b554219e8c3ebbb9a4f2c9ad14e (MD5) / Osíris foi um dos deuses mais importantes dentro do panteão da civilização egípcia. Encontramos alusões ao seu mito desde o começo da era dinástica até o período greco-romano, onde temos a síntese realizada por Plutarco (45-120 d.C.) no seu tratado sobre Ísis e Osíris. Através da análise desse mito, tal como narrado por Plutarco, pode-se perceber que sua influência foi muito profunda e marcante na história do Egito abrangendo questões referentes aos aspectos principais dessa sociedade. Seu mito respondia questões e anseios pertinentes a todos os egípcios sendo dessa forma adorado em todo o país. Possuía características e funções como deus relacionado aos ciclos da natureza, como a Lua, o Nilo e o grão, como mantenedor da ordem e da sucessão real e fundamentalmente como aquele que transcendeu a morte e foi reinar no Ultra-Tumba, tornando-se rei e juiz desse mundo. Portanto, nosso objetivo será mostrar que o mito de Osíris estava relacionado com todos os aspectos da vida egípcia, da paz à guerra, da seca à enchente, da peste à abundância, da posição divina do faraó à dureza da servidão e fundamentalmente, da vida à morte. Conseguindo, assim, abarcar em sua personalidade divina todos os atributos necessários para solucionar e satisfazer as necessidades de todos os estratos sociais, do rei ao servo. / Osiris was one of the most important divinities inside the panteon of Egyptian civilization. We find hints of this myth since the beginning of the Dynastyc era until the Greco-Roman period, in which we have the syntesis made by Plutarch (45-120 A.D.) in his work about Isis and Osiris. Analyzing the myth of Osiris, as it is narrated by Plutarch, we can realize that its influence was very deep and very important in the history of Egypt, reaching questions concerning the main features of this society. The myth of Osiris answered questions and wishes which were pertinent to all egyptians, so that it was adored in entire country. It possessed characteristics and functions as god related to the cycles of nature, like the Moon, the Nile River and the seed; as keeper of order and of regal succession and, fundamentally, as the one which transcended the death and went to reign in Over-Grave, becoming king and judge of that world. Thus, our purpose will be to show that the myth of Osiris was related to all features of Egyptian life, from peace to war, from dryness to inundation, from plague to plenty, from the divine position of the king to the hardness of servitude, and fundamentally, from life to death. So, the myth of Osiris got to embrace, in its divine personality, all the necessary attributes to resolve and to satisfy the needs of all social classes, from the king to the serf.

Endometriosis is defined as the presence of endometrial cells outside the uterine cavity. The underlying symptom is pain, endometriosis is often associated with primary or secondary sterility, and it is assumed to be involved in the development of female dyspareunia and algopareunia. There are many theories regarding the cause of the disease, however, none of them affects the complex state of the disease which occurs in the population according to statistics in 10-15 % of women. In women with a diagnosis of sterility and infertility, the incidence of endometriosis is described in more than 40 %. Also, more than 50 % of women describe the most diverse forms of dyspareunia and algopareunia that affect not only women's own lives but also their relationships. The illness thus becomes important not only from a purely medical point of view but also from a psychosocial point of view. It should be noted that there is currently no known specific laboratory marker to diagnose endometriosis. Likewise, there is no unambiguous solution within the therapy, whether it is conservative, surgical, or combined. An important fact is that endometriosis is diagnosed with a considerable delay, according to statistics; it takes up to 11 years from the discovery of the first, often indefinite symptoms, to the unequivocal...