Idiopathic clubfoot causes severe deformity of the foot and lower leg. Due to the complex anatomy and small size of the foot, the condition is difficult to define and describe. This study focused on 3D modeling of different foot positions associated with clubfoot relapse, and investigation of muscle parameters. The 3D modeling was performed in the AnyBody Modeling System to retrieve information about muscle length. Musculoskeletal modeling could provide further understanding of the condition and contribute to assessment and treatment evaluation. Five children that received clubfoot treatment as infants, and five typically developing children, serving as a control group, participated in the study. Despite treatment with the Ponseti method, Achilles tenotomy and use of an abduction orthosis, all participants of the clubfoot group showed signs of relapse. In total, seven affected legs were studied. Data from gait analyses of all participants were compiled and interpreted in the AnyBody Modeling System. The Plug-in-Gait Model for lower extremities and the Oxford Foot Model were used as marker protocol for the study. Studied lower leg muscles were Gastrocnemius Lateralis, Gastrocnemius Medialis, Soleus Lateralis and Soleus Medialis. Muscle length, defined as length of contractile element, for each leg and participant were evaluated using the AnyBody model template LowerExtremity. Compared to the control group, the models of the clubfoot group presented shorter mean muscle lengths of all investigated muscles. / Idiopatisk klumpfot orsakar allvarlig deformation av fot och underben. På grund av fotens anatomi och ringa storlek kan tillståndet vara svårt att beskriva och definiera. Denna studie innefattade 3Dmodellering av olika fotpositioner orakade av recidivklumpfot, för att undersöka muskelegenskaper. AnyBody Modeling System användes för att generera 3D-modeller och ta fram information om muskellängd. Muskuloskeletal modellering skulle kunna öka förståelsen för sjukdomen och bidra till förbättringar av initial bedömning och utvärdering av behandling. Fem barn som behandlades för klumpfot efter födseln deltog i studien. Även fem typiskt utvecklade barn medverkade och fungerade som en kontrollgrupp. Trots behandling med Ponseti-metoden, hälseneförlängning och användning av abduktionsortos, uppvisade samtliga barn i klumpfotsgruppen tecken på återfall. Totalt studerades sju ben med recidivklumpfot. Data från gånganalyser av deltagarna sammanställdes och analyserades i AnyBody Modeling System. Plug-in-Gait Model för nedre extremiteter och Oxford Foot Model användes som markörprotokoll. Under studien analyserades underbensmusklerna Gastrocnemius Lateralis, Gastrocnemius Medialis, Soleus Lateralis och Soleus Medialis. Muskellängd (längd av kontraktilelement) för varje patient och ben beräknades med hjälp av modellmallen LowerExtremity i AnyBody Modeling System. Jämfört med kontrollgruppen visade klumpfotsgruppen kortare medelmuskellängder för samtliga av de analyserade musklerna.

No description available.

Une morbidité et une mortalité néonatales élevées limitent l’efficacité du clonage somatique chez les bovins. Des malformations myoarthrosquelettiques, des anomalies ombilicales, des problèmes respiratoires et de la faiblesse ont été fréquemment observés chez les veaux clonés nouveaux-nés. Cette étude rétrospective porte sur 31 veaux clonés. Ses objectifs étaient de décrire les problèmes respiratoires rencontrés, leur évolution au cours du temps, les traitements instaurés pour soutenir la fonction respiratoire et la réponse aux traitements. Vingt-deux veaux ont souffert de problèmes respiratoires. La tachypnée, l’hypoxémie et l’hypercapnie sont les signes cliniques les plus fréquemment observés. L’analyse des gaz sanguins a été un outil essentiel dans le diagnostic et le suivi de la fonction respiratoire. La radiographie a permis une évaluation globale du poumon. L’oxygénothérapie intranasale et la ventilation mécanique ont permis de limiter la mortalité due à une insuffisance respiratoire à 18% (4/22). Cette étude a permis d’émettre des hypothèses quant à l’origine des problèmes respiratoires chez les veaux clonés. Plus d’une maladie semblent affecter les veaux clonés. La déficience en surfactant, l’hypertension pulmonaire persistante et le retard de résorption du fluide pulmonaire figurent parmi les entités pathologiques les plus probables. / High morbidity and mortality decrease the efficiency of somatic cell nuclear transfer. The main abnormalities observed in neonatal cloned calves are skeletal malformations, enlarged umbilical vessels, respiratory problems and weakness. This retrospective study involved 31 cloned calves. The objectives of this study were to describe the respiratory problems suffered by cloned calves during neonatal period, to assess their evolution, and to determine the possible causes. Secondary objectives were to describe the techniques used to assess and support respiratory function and the calves’ response. Respiratory problems affected 22 calves. Tachypnea, hypoxemia and hypercapnia were the most frequently observed signs. Arterial blood gas analyses and chest radiographs were precious to identify and assess respiratory problems. Intranasal oxygen and mechanical ventilation were efficient to limit mortality due to respiratory failure to 18% (4/22). It is plausible that more than one disease affect cloned calves. Delayed resorption of pulmonary fluid, persistent pulmonary hypertension and surfactant deficiency, or a combination of these factors, are among the most probable pathological entities.

Call number: LD2668 .T4 1986 N44 / Master of Science / Agricultural Economics

[pt] Os bezerros de Arão e Jeroboão: Uma verificação da relação intertextual entre Ex 32,1-6 e 1 Rs 12,26-33 tem por objetivo tanto verificar a existência das várias relações intertextuais entre as passagens de Ex 32,1-6 e 1 Rs 12,26-33 quanto apresentar e demonstrar como se manifesta essa intertextualidade. Esta tese faz uso do método sincrônico da análise narrativa. A necessidade de trabalhar com o método sincrônico da análise narrativa existe porque a verificação, a apresentação e a demonstração das relações intertextuais precisam considerar o texto na sua forma final. Este trabalho visar contribuir para o estudo das relações intertextuais aplicadas aos textos bíblicos tanto propondo uma clara conceituação de intertextualidade quanto apresentando os critérios de classificação de suas manifestações, bem como deseja verificar que existem relações intertextuais específicas entre Ex 32,1-6 e 1 Rs 12,26-33 e ampliar o horizonte dessas relações intertextuais a todos os versos dos textos de Ex 32,1-6 e 1 Rs 12,26-33. / [en] Aaron s and Jeroboam s Calves: An Intertextuality Verification Analyzing Exodus 32,1-6 and I Kings 12,26-33 has the purpose not only to verify the existence of a broad intertextuality relations between Exodus 32,1-6 and I Kings 12,26-33 but also to present and demonstrate how this intertextuality relation occurs. This thesis is based using the synchronic method of narrative analysis. The reason to use narrative analysis is because the verification in how the text is presented and demonstrated has to consider the text itself in its final form. This work is focused to shad light in the study of intertextuality relations to or deriving meaning applied to the biblical texts not only proposing a clear concept and thesis but also to present the criteria of classification and manifestation as well. Verifying that there are interrelationships in both texts between Exodus 32,1-6 and I Kings 12,26-33 and to broaden the perspective in these intertextuality to every single verses in Exodus 32,1-6 and I Kings 12,26-33. / [it] I vitelli di Aronne e Geroboamo: Una verifica del rapporto intertestuale tra Es 32, 1-6 e 1 Re 12,26-33 ha come oggetto tanto verificare l esistenza dei vari rapporti intertestuali tra i passaggi di Es 32,1-6 e 1 Re 12,26-33 quanto presentare e dimostrare come si manisfesta questa intertestualità. Questa tesi usa il metodo sincronico dell analise narrativa. La necessità di lavorare con il metodo sincronico dell analise esiste perché la verifica, la presentazione e la dimostrazione dei rapporti intertestuali hanno bisogno di considerare il testo nella sua forma finale. Questo lavoro si rivolge a contribuire con lo studio dei rapporti intertestuali applicati ai testi biblichi tanto al proporre un chiaro concetto di intertestualità quanto al presentare i criteri di classificazione delle sue manifestazioni cosí come desidera verificare che ci sono rapporti intertestuali specifichi tra Es 32, 1-6 e Re 12,26-33 e ampliare l orizzonte di questi rapporti intertestuali a tutti i versi dei testi di Es 32,1-6 e 1 Re 12,26-33.

O objetivo deste trabalho foi estimar as exigências e a eficiência energética de vacas de corte lactantes e não gestantes, bem como do par vaca/bezerro. Posteriormente foi correlacionada a eficiência do par vaca/bezerro durante a lactação com a eficiência das mesmas vacas durante a terminação. Na fase de lactação os pares vaca/bezerro foram avaliados desde após o nascimento (17±5, d DP) até a desmama (210 d). Após a desmama foi conduzido o ensaio de terminação (67 d) e abate somente das matrizes. Foram avaliadas 10 vacas adultas ½ Caracu x Nelore (CN) e 10 ½ Angus x Nelore (AN), acasaladas com touros Red Angus (RA) e Canchim (CC), respectivamente. Na lactação o oferecimento da dieta (2,30 Mcal EM/kg e 12,4% PB) variou individualmente ao longo do período com objetivo de manter constante o peso das matrizes ao longo da lactação. A mesma dieta foi oferecida a vontade para a progênie. Durante o ensaio de terminação em confinamento a dieta (2,37 Mcal EM/kg e 10,5% PB) foi fornecida à vontade. A ingestão de matéria seca das matrizes foi de 92,4 g MS/kg PM0,75 (CV=3,2%; P=0,458). Vacas AN apresentaram produção de leite corrigida para gordura 12% superior (P<0,05). A concentração energética do leite (Mcal/kg) das vacas CN foi 9,4% superior (P<0,05). A eficiência (Mcal leite/Mcal EM ingerida) não foi diferente. A exigência de energia metabolizável de lactação (EMl) foi maior (P<0,05) para vacas AN em relação as CN, 90,1 e 74,2 (EMl, kcal EMl/kg PM0,75), respectivamente. Bezerros ½CC¼AN¼NE apresentaram ingestão de energia metabolizável (IEM) proveniente do leite 11,3% (P<0,05) superior. Bezerros ½RA¼CR¼NE foram 10,7% mais eficientes (g GP210d/Mcal IEM leite+dieta sólida). Não houve diferença para eficiência dos pares vaca/bezerro, contudo houve considerável variação individual, onde a eficiência média foi 35,3 g GP210d/Mcal IEM par (CV=11,5%). A eficiência do par foi positivamente relacionada ao ganho do bezerro (r=0,79; P<0,01) e negativamente relacionada à IEM do par (r=-0,58; P<0,05). Vacas CN ao abate apresentaram EGS 29% menor, AOL 13% maior e maior proteína no corpo vazio (P<0,05). Vacas AN apresentaram 14,7% maior proporção de órgãos internos relativo ao peso vazio e maior peso dos intestinos (P<0,01). As correlações fenotípicas demonstraram associação entre as eficiência de secreção do leite das vacas nas fase de lactação e de ganho de peso na fase de terminação (r=0,43; P=0,09). A eficiência de secreção de leite das vacas na lactação apresentou correlação com a eficiência do par (r=0,68; P<0,01). O consumo alimentar residual (CAR) das vacas na terminação foi correlacionado com o CAR das vacas em lactação (r=0,53; P<0,05) e com o CAR dos pares (r=0.62; P<0.01). Isso indica que vacas de corte mais eficientes durante a terminação são também mais eficientes no período de cria. / This study estimated the requirements and feed efficiency of non-pregnant lactating beef cows, as well as cow calf pairs. It also correlated the efficiency of the cows and their progeny during lactation to efficiency determined for the same cows in a finishing trial after weaning. In the lactating phase cow calf pairs were evaluated from just after birth (17±5, d) to weaning at 210 d. The finishing trial for the mature cows started after weaning and lasted 67 d after wich cows were slaughtered. Twenty adult cows were evaluated, 10 ½ Caracu x Nelore (CN) and 10 Angus x Nelore, bred to Red Angus (RA) and Canchim (CC) bulls, respectively. During lactation the diet (2.30 Mcal ME/kg and 12.4% CP) was offered in variable amounts to maintain individual live weight and condition score constant. The same diet was offered ad libitum to the calves. During the finishing phase cows were fed ad libitum (2.37 Mcal ME/kg e 10.5% CP). The dry matter feed intake of cows was 92,4 and SD 2,9 g DM/kg BW0,75. AN cows had fat corrected milk 12% higher compared to CN cows (P<0.05). However, milk energy content (Mcal/kg) was 9.4% higher (P<0.05) for CN cows. Efficiency of milk production (Mcal milk/Mcal ME intake) was not different. Metabolizable energy for lactation (MEl) was higher (P<0.05) for AN cows in comparison to CN, respectively 90.1 and 74.2 (MEl, kcal MEl/kg BW0,75). ME milk intake was 11.3% (P<0.05) higher for ½CC¼AN¼NE calves. Rates of gain were not different between calves, but ½RA¼CR¼NE were 10.7% more efficient (g LWG210d/Mcal MEI milk+solid diet). There was no difference in cow calf pairs efficiency, but there was a great individual variability with a mean of 35,31 g and SD of 4,08 g LWG210d/Mcal EM for the pair. Cow/calf pair efficiency was positively related to calf weight gain (r=0.79; P<0.01) and negatively to the pair metabolizable energy intake (r=-0.58; P<0.05). At slaughter CN cows presented backfat thickness 29% lower, longissimus muscle area 13% higher and higher empty body weight protein (P<0,05). AN cows had 14.7% higher relative internal organ weight and higher total intestine weight (P<0.01). The phenotypical correlations between efficiency indexes indicate moderate association between cow efficiency measured during lactation and in a short finishing period after weaning (r=0.43; P=0.09). Exist correlations between cow efficiency lactation and efficiency of the pair (r=0.68; P<0.01). Residual Feed Intake (RFI) during the finishing phase was moderately correlated to the RFI calculated during the lactation period for the cow calf pairs RFI (r=0.62; P<0.01) and the cows (r=0.53; P<0.05) indicated that beef cows more efficient in feed conversion during the finishing phase are more efficient during the lactation period.

Une morbidité et une mortalité néonatales élevées limitent l’efficacité du clonage somatique chez les bovins. Des malformations myoarthrosquelettiques, des anomalies ombilicales, des problèmes respiratoires et de la faiblesse ont été fréquemment observés chez les veaux clonés nouveaux-nés. Cette étude rétrospective porte sur 31 veaux clonés. Ses objectifs étaient de décrire les problèmes respiratoires rencontrés, leur évolution au cours du temps, les traitements instaurés pour soutenir la fonction respiratoire et la réponse aux traitements. Vingt-deux veaux ont souffert de problèmes respiratoires. La tachypnée, l’hypoxémie et l’hypercapnie sont les signes cliniques les plus fréquemment observés. L’analyse des gaz sanguins a été un outil essentiel dans le diagnostic et le suivi de la fonction respiratoire. La radiographie a permis une évaluation globale du poumon. L’oxygénothérapie intranasale et la ventilation mécanique ont permis de limiter la mortalité due à une insuffisance respiratoire à 18% (4/22). Cette étude a permis d’émettre des hypothèses quant à l’origine des problèmes respiratoires chez les veaux clonés. Plus d’une maladie semblent affecter les veaux clonés. La déficience en surfactant, l’hypertension pulmonaire persistante et le retard de résorption du fluide pulmonaire figurent parmi les entités pathologiques les plus probables. / High morbidity and mortality decrease the efficiency of somatic cell nuclear transfer. The main abnormalities observed in neonatal cloned calves are skeletal malformations, enlarged umbilical vessels, respiratory problems and weakness. This retrospective study involved 31 cloned calves. The objectives of this study were to describe the respiratory problems suffered by cloned calves during neonatal period, to assess their evolution, and to determine the possible causes. Secondary objectives were to describe the techniques used to assess and support respiratory function and the calves’ response. Respiratory problems affected 22 calves. Tachypnea, hypoxemia and hypercapnia were the most frequently observed signs. Arterial blood gas analyses and chest radiographs were precious to identify and assess respiratory problems. Intranasal oxygen and mechanical ventilation were efficient to limit mortality due to respiratory failure to 18% (4/22). It is plausible that more than one disease affect cloned calves. Delayed resorption of pulmonary fluid, persistent pulmonary hypertension and surfactant deficiency, or a combination of these factors, are among the most probable pathological entities.

The dissertation is concerned to in vivo phosphorus MR spectroscopy (31 P MRS) and 1 H MR imaging (MRI) of muscle in combination with physical workload. The theoretical part of the thesis describes methodology of 31 P MRS measurement and its clinical use in research of metabolic changes in diabetes, heart failure and peripheral artery disease (PAD). The results of the thesis are divided into methodical and clinical parts. Methodical results deal with the construction of experimental equipment, software modification and development, and show of the reproducibility of the dynamic 31 P MRS. The MRI after exercise was used to the describe involvement of the individual calf muscles to muscle contraction during pedal movement in MR compatible ergometer. The first part of the clinical results of the thesis describes changes in muscle metabolism during diabetes and critical ischemia. In patients with critical ischemia the effect of treatment by angioplasty or transplantation of mesenchymal stem cells was evaluated. In the second part of the clinical results the metabolism of patients with heart failure complicated by sideropenia was studied. In these patients the effect of experimental treatment by iron carboxymaltose was described.

O objetivo deste trabalho foi estimar as exigências e a eficiência energética de vacas de corte lactantes e não gestantes, bem como do par vaca/bezerro. Posteriormente foi correlacionada a eficiência do par vaca/bezerro durante a lactação com a eficiência das mesmas vacas durante a terminação. Na fase de lactação os pares vaca/bezerro foram avaliados desde após o nascimento (17±5, d DP) até a desmama (210 d). Após a desmama foi conduzido o ensaio de terminação (67 d) e abate somente das matrizes. Foram avaliadas 10 vacas adultas ½ Caracu x Nelore (CN) e 10 ½ Angus x Nelore (AN), acasaladas com touros Red Angus (RA) e Canchim (CC), respectivamente. Na lactação o oferecimento da dieta (2,30 Mcal EM/kg e 12,4% PB) variou individualmente ao longo do período com objetivo de manter constante o peso das matrizes ao longo da lactação. A mesma dieta foi oferecida a vontade para a progênie. Durante o ensaio de terminação em confinamento a dieta (2,37 Mcal EM/kg e 10,5% PB) foi fornecida à vontade. A ingestão de matéria seca das matrizes foi de 92,4 g MS/kg PM0,75 (CV=3,2%; P=0,458). Vacas AN apresentaram produção de leite corrigida para gordura 12% superior (P<0,05). A concentração energética do leite (Mcal/kg) das vacas CN foi 9,4% superior (P<0,05). A eficiência (Mcal leite/Mcal EM ingerida) não foi diferente. A exigência de energia metabolizável de lactação (EMl) foi maior (P<0,05) para vacas AN em relação as CN, 90,1 e 74,2 (EMl, kcal EMl/kg PM0,75), respectivamente. Bezerros ½CC¼AN¼NE apresentaram ingestão de energia metabolizável (IEM) proveniente do leite 11,3% (P<0,05) superior. Bezerros ½RA¼CR¼NE foram 10,7% mais eficientes (g GP210d/Mcal IEM leite+dieta sólida). Não houve diferença para eficiência dos pares vaca/bezerro, contudo houve considerável variação individual, onde a eficiência média foi 35,3 g GP210d/Mcal IEM par (CV=11,5%). A eficiência do par foi positivamente relacionada ao ganho do bezerro (r=0,79; P<0,01) e negativamente relacionada à IEM do par (r=-0,58; P<0,05). Vacas CN ao abate apresentaram EGS 29% menor, AOL 13% maior e maior proteína no corpo vazio (P<0,05). Vacas AN apresentaram 14,7% maior proporção de órgãos internos relativo ao peso vazio e maior peso dos intestinos (P<0,01). As correlações fenotípicas demonstraram associação entre as eficiência de secreção do leite das vacas nas fase de lactação e de ganho de peso na fase de terminação (r=0,43; P=0,09). A eficiência de secreção de leite das vacas na lactação apresentou correlação com a eficiência do par (r=0,68; P<0,01). O consumo alimentar residual (CAR) das vacas na terminação foi correlacionado com o CAR das vacas em lactação (r=0,53; P<0,05) e com o CAR dos pares (r=0.62; P<0.01). Isso indica que vacas de corte mais eficientes durante a terminação são também mais eficientes no período de cria. / This study estimated the requirements and feed efficiency of non-pregnant lactating beef cows, as well as cow calf pairs. It also correlated the efficiency of the cows and their progeny during lactation to efficiency determined for the same cows in a finishing trial after weaning. In the lactating phase cow calf pairs were evaluated from just after birth (17±5, d) to weaning at 210 d. The finishing trial for the mature cows started after weaning and lasted 67 d after wich cows were slaughtered. Twenty adult cows were evaluated, 10 ½ Caracu x Nelore (CN) and 10 Angus x Nelore, bred to Red Angus (RA) and Canchim (CC) bulls, respectively. During lactation the diet (2.30 Mcal ME/kg and 12.4% CP) was offered in variable amounts to maintain individual live weight and condition score constant. The same diet was offered ad libitum to the calves. During the finishing phase cows were fed ad libitum (2.37 Mcal ME/kg e 10.5% CP). The dry matter feed intake of cows was 92,4 and SD 2,9 g DM/kg BW0,75. AN cows had fat corrected milk 12% higher compared to CN cows (P<0.05). However, milk energy content (Mcal/kg) was 9.4% higher (P<0.05) for CN cows. Efficiency of milk production (Mcal milk/Mcal ME intake) was not different. Metabolizable energy for lactation (MEl) was higher (P<0.05) for AN cows in comparison to CN, respectively 90.1 and 74.2 (MEl, kcal MEl/kg BW0,75). ME milk intake was 11.3% (P<0.05) higher for ½CC¼AN¼NE calves. Rates of gain were not different between calves, but ½RA¼CR¼NE were 10.7% more efficient (g LWG210d/Mcal MEI milk+solid diet). There was no difference in cow calf pairs efficiency, but there was a great individual variability with a mean of 35,31 g and SD of 4,08 g LWG210d/Mcal EM for the pair. Cow/calf pair efficiency was positively related to calf weight gain (r=0.79; P<0.01) and negatively to the pair metabolizable energy intake (r=-0.58; P<0.05). At slaughter CN cows presented backfat thickness 29% lower, longissimus muscle area 13% higher and higher empty body weight protein (P<0,05). AN cows had 14.7% higher relative internal organ weight and higher total intestine weight (P<0.01). The phenotypical correlations between efficiency indexes indicate moderate association between cow efficiency measured during lactation and in a short finishing period after weaning (r=0.43; P=0.09). Exist correlations between cow efficiency lactation and efficiency of the pair (r=0.68; P<0.01). Residual Feed Intake (RFI) during the finishing phase was moderately correlated to the RFI calculated during the lactation period for the cow calf pairs RFI (r=0.62; P<0.01) and the cows (r=0.53; P<0.05) indicated that beef cows more efficient in feed conversion during the finishing phase are more efficient during the lactation period.

The aim of this study is to highlight the significance of the prohibition of making any image of God as found in the second commandment of the Decalogue in Exodus 20:4-6 with its inner-biblical interpretations in Exodus 32:1-6 and in Isaiah 40:18-20. This study has discussed the close connection between the prohibition of making any image of God in the second commandment of the Decalogue, the idea of Yahweh’s incomparability in the introduction and the command to worship God only in the first commandment. God’s incomparability prevents Israel from worshipping any other god by making images of them or making any image of God. The ‘construct of the introduction and the first two commandments of the Decalogue’ serves as a linchpin concept in our understanding of the prohibition of making any image of God. The aniconism matriculated in the second commandment of the Decalogue in Exodus 20:4-6 in relation with the introduction and the first commandment in Exodus 20:2-3 forms the basis for the prohibition of making any image of God from the Sinai event onwards. This construct in Exodus 20:2-6 is shared with Exodus 32:1-6 and Isaiah 40:18-20. There an inner-biblical interpretation of the aniconism of the second commandment of the Decalogue in Exodus 20:4-6 in reaction with the introduction and the first commandment in Exodus 20:2-3 explicates and applies the meaning of the command in a new situation. Chapter 1 deals with the statement of the problem and the hypothesis of this study, its methodology, theological rationale, and the aim of this study. Chapter 2 discusses that the prohibition of making any image of God in the second commandment of the Decalogue in Exodus 20:4-6 is important, not only as a phenomenon in the Pentateuch, but also as the provenance of aniconism in the rest of Old Testament. Exodus 20:4-6 can be considered as the explicit traceable provenance of the prohibition of making any image of God in the Pentateuch and the rest of Old Testament. The ‘introduction and first two commandments of the Decaologue construct’ provides a framework within which the meaning of the prohibition of making any image of God in the second commandment can be understood in the context of the introduction of the Decalogue in Exodus and the first commandment of the Decalogue. The second commandment of the Decalogue is sometimes backed up by only the first commandment of the Decalogue and sometimes by both of them. The origin of the second commandment of the Decalogue in Exodus 20:4-6 as the prohibition of making any image of God whether it comes from the early or later stages of Israel’s history is discussed with the discussion on the arrangement of the Decalogue in the Sinai pericope (Ex 19:1-24:11) and the relation between the two Decalogues in Exodus 20:2-17 and Deuteronomy 5:6-21. The sharp differences of opinions on the provenance of the prohibition in the second commandment of the Decalogue in Exodus 20:4-6 is dealt with. This study supposes that the dating of the prohibition on making any image of God of the Decalogue should be attributed to Moses’ time as stated in the text of the Pentateuch. Chapter 3 deals with one key Pentateuchal text for the prohibition of making any image of God, Exodus 32:1-6, as an example that the second commandment represents the prohibition on making any image of God in relation with the introduction and the first commandment of the Decalogue proclaiming God’s incomparability, which is called ‘the introduction and the first two commandments of the Decalogue construct’ in this study. Exodus 32:1-6 is regarded to be an interpretation of the prohibition of making any image of God in the second commandment of the Decalogue in Exodus 20:4-6. Chapter 4 deals with Isaiah 40:18-20, which forbids idol-fabrication and the worship of an image of God in its relation with the proclamation of God’s incomparability, as well as with the worship of other gods and their images. This chapter deals with the similarity of the negative attitude toward worship of God through images found in the legal and prophetical parts of the Hebrew Bible. Theologically speaking, Isaiah’s message is in line with the Pentateuch, and flows from the office of the prophet as a plenipotentiary of God to condemn the transgression of the covenantal law. This similarity of the idea between them is seen in respect of its linguistic aspects. Considering the rules of the nature of analogies between texts, there can be seen a correlation between the introduction and first two commandments of the Decalogue in Exodus 20:2-6 and the passage dealing with the incomparability of God and the idol-fabrication in Isaiah 40:18-20. The final chapter summarizes the flow of the argument in this thesis dealing with three phenomena of aniconism in the Old Testament and suggests the conclusion of this thesis based on the result of the exegetical and thematic study on the three passages. / Thesis (PhD)--University of Pretoria, 2011. / Old Testament Studies / unrestricted