Orientadores: Paulo Sollero / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica / Made available in DSpace on 2018-08-06T17:27:30Z (GMT). No. of bitstreams: 1 Innarelli_HumbertoCeleste_M.pdf: 5933187 bytes, checksum: 7266f9fcf1ad3fabbfa246f72516e192 (MD5) Previous issue date: 2006 / Resumo: Este trabalho tem como foco principal a preservação de documentos digitais no âmbito das mídias de CD-ROM e CD-R. Inicialmente, consiste na revisão da literatura de pesquisas e projetos desenvolvidos na área, na análise das mídias de CD-ROM e CD-R em relação a sua estrutura física e lógica, no estudo das variáveis que causam sua degradação, determinando uma relação causa versus efeito e no desenvolvimento de um software de verificação da confiabilidade das mídias, que conta com um modelo de confiabilidade desenvolvido com base na teoria da confiabilidade de sistemas e nos estudos existentes na área. Este software tem funcionalidades de identificação, armazenamento dos dados de mídia e módulos de análise de confiabilidade. Também é abordado neste trabalho uma análise experimental , a qual conta com metodologias de observação visual, observação por microscópio óptico e aplicação do software de verificação da confiabilidade, esta análise serve de base para a compreensão das variáveis relacionadas a confiabilidade e durabilidade das mídias, assim como, na fundamentação de propostas de preservação de documentos digitais No final do projeto é possível mostrar resultados e discuti-los, propor políticas para a preservação de documentos digitais em mídias de CD-ROM e CD-R e demonstrar conclusões e sugestões para próximos trabalhos / Abstract: The main object of this project is the digital documents preservation in the medias of COROM and CD-R. Initially, this project shows literature review of the studies and projects developed in this area, analyzing the medias of CO-ROM and CO-R in relation of physical and logic structure, showing the studies of the variables who degraded these medias. These studies are the bases of cause versus effect and the parameters to development of a software that can determinate a reliability of medias, that has reliability model developed based in system reliability theory and on the studies in this area. This software has functions of identify medias, data storage and module of reliability analysis. Besides, it does also object of this project an experimental analyses, which counts with visual observation methodology, optical observation and application of the software. This analysis is the base to understand the variables related to the reliability and durability of the medias, as well as, the fundament to propose digital documents preservation. At the end of the project is possible to show results, proposes digital documents preservation politics in medias of CD-ROM and CO-R and demonstrate conclusions and suggestions to the next projects / Mestrado / Mecanica dos Sólidos e Projeto Mecanico / Mestre em Engenharia Mecânica

Count Geoffrey V of Anjou (1129-51) features in Anglo-French historiography as a peripheral figure in the Anglo-Norman succession crisis which followed the death of his father-in-law, Henry I of England and Normandy (1100-35). The few studies which examine him directly do so primarily in this context, dealing briefly with his conquest and short reign as duke of Normandy (1144-50), with reference to a limited range of evidence, primarily Anglo-Norman chronicles. There has never been a comprehensive analysis of Geoffrey’s comital reign, nor a narrative of his entire career, despite an awareness of his importance as a powerful territorial prince and important political player. This thesis establishes a complete narrative framework for Geoffrey’s life and career, and examines the key aspects of his comital and ducal reigns. It compiles and employs a body of 180 acta relating to his Angevin and Norman administrations to do so, alongside narrative evidence from Greater Anjou, Normandy, England and elsewhere. It argues that rule of Greater Anjou prior to 1150 had more in common with neighbouring principalities such as Brittany, whose rulers had emerged in the tenth and eleventh centuries as primus inter pares, than with Normandy, where ducal powers over the native aristocracy were more wide-ranging, or royal government in England. It explores the count’s territories, the personnel of government, the dispensation of justice, revenue collection, the comital army, and Geoffrey’s ability to carry out ‘traditional’ princely duties such as religious patronage in the context of Angevin elite landed society’s virtual autonomy and tendency to rebel in the first half of the twelfth century. The character of Geoffrey’s power and authority was fundamentally shaped by the region’s tenurial and seigneurial history, and could only be conducted within that framework. This study also addresses Geoffrey’s activities as first conqueror then ruler of Normandy. The process by which the duchy was conquered is shown to be more intricate than the chroniclers’ accounts of Angevin siege warfare suggest, and the ducal reign more complex than merely a regency until Geoffrey’s son, the future Henry II (1150-89), came of age. Through use of a much wider body of evidence than previously considered in connection with Geoffrey’s career, and a charter-based methodology, this thesis provides a new and appropriate treatment of an important non-royal ruler. It situates Geoffrey in his proper context and provides an account of not only how he was presented by commentators who were sometimes geographically and temporally remote, but by his own administration and those over whom he ruled. It provides an in-depth analysis of the explicit and implicit characteristics of princely rulership, and how they were won, maintained and exploited in two different contexts.

Les ostéoclastes sont les cellules responsables de la résorption osseuse et par conséquent ils jouent un rôle primordial dans de nombreuses pathologies osseuses et articulaires, dont la polyarthrite rhumatoïde (PR). L'étude présentée dans ce mémoire a comme objectif de déterminer si l'ostéoclastogenèse, la capacité de résorption osseuse et la susceptibilité à l'apoptose des ostéoclastes matures peuvent être reliées à la présence et/ou à l'activité de la PR. Pour ce faire, des PBMCs, isolées par gradient de Ficoll du sang périphérique de patients atteints de PR ou de volontaires sains, sont différenciées en ostéoclastes matures in-vitro (ostéoclastogenèse) et leurs caractéristiques sont étudiées. Nous démontrons tout d'abord que l'ostéoclastogenèse est significativement plus élevée chez les patients atteints de PR en rémission comparativement aux patients en phase active et aux volontaires sains (contrôles). La caractérisation des ostéoclastes matures in-vitro a démontré que chez les patients atteints de PR, les ostéoclastes présentent une capacité de résorption accrue et une moins grande susceptibilité à l'apoptose comparativement à ceux des volontaires sains. Les résultats présentés dans ce mémoire suggèrent une modification phénotypique des ostéoclastes chez les patients atteints de PR. De plus, ces changements pourraient apparaître en amont de l'ostéoclaste, au niveau de cellules précurseures CD14[indice supérieur +] . Nos résultats soulignent l'importance des ostéoclastes dans la pathophysiologie de la PR et la pertinence d'approfondir nos recherches sur l'ostéoclastogenèse dans les pathologies osseuses afin de cerner de nouvelles cibles thérapeutiques.

Direct measurement of optical phase is used in a high-density optical disk reader. The increased density is achieved by introducing multiple pit depths to replace the single pit depths of a traditional compact disk. Having four independent pit depths can double the storage capacity of a disk. The multi-level pits are read by direct measurement of the phase difference between two laser spots focused onto the disk surface. Extraction of phase information utilizes the equations of phase shifting interferometry with four shifted fringe patterns created simultaneously by a compact optical head. The system speed is therefore limited by the readout electronics instead of by slow mechanical phase shifters. The resulting system can identify four independent levels as well as the direction of transition from one level to another. The system also has low sensitivity to vibrations and to changes in the fringe contrast and beam intensity.

In this research, a series of synthetically engineered copolymers were synthesized containing polysaccharides (e.g., β-cyclodextrin and chitosan) to address the removal of trihalomethanes (THMs) from water environments. There are two main parts in this research thesis: i) the preparation and characterization of polysaccharide-based copolymers; ii) sorption studies of the copolymers with chloroform and total THMs (TTHMs) in aqueous solution. In the first part of this thesis, grafted polyester, polyester and grafted polyamide copolymers were prepared by cross-linking β-cyclodextrin (β-CD) and chitosan (CS) with various cross-linkers, including poly (acrylic acid) (PAA), terephthaloyl (TCl), and sebacoyl chloride (SCl), respectively. The synthesized copolymer materials were characterized by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS), Scanning Electron Microscopy (SEM), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), elemental (C and H) analyses, and NMR spectroscopy. Nitrogen porosimetry was used to analyze the surface area and pore structure characteristics of the copolymers and starting materials in solid state. The sorption properties of the copolymers in aqueous solution were studied using different dye probes (e.g., p-nitrophenol and methylene blue) by UV–Vis spectrophotometry. The copolymers showed markedly varied interactions with dye probes in accordance with their composition, surface area, and pore structure characteristics. Diverse materials were afforded by variation of the synthetic conditions. The sorption isotherms were evaluated with various isotherm models (e.g., Langmuir, BET, Freundlich and Sips). The Sips isotherm showed the best overall agreement with the experimental results and the sorption parameters provided estimates of the sorbent surface area and the sorption capacity for various copolymers in aqueous solution. The copolymer sorbents display tunable physicochemical properties according to the synthetic conditions. In the second part of this thesis, the direct aqueous injection (DAI) method with gas chromatography (GC) with electron capture or electrolytic conductivity detectors (ECD) enabled quantitative detection of chloroform and TTHMs in water. A preliminary adsorption study and kinetic study of chloroform provided the information to establish the experimental protocol for the sorption study. The sorption parameters were evaluated using the Sips model. The sorption capacity (Qm) values of chloroform for these synthetically engineered copolymers at similar conditions ranged from 0.00335-1.70 mmol/g. The relative ordering of the Qm values was observed: β-CD/PAA 1:5 > SCl-5 > SCl-10 ~ CP-1 > β-CD/PAA 1:10 > CP-5 > AC > β-CD/PAA 1:5 at high mixing speed. An extension of the sorption study for copolymers toward the multi-component THMs in water was carried out. The copolymers showed distinct adsorption capacities to THMs: chloroform (0.0485-0.287 mmol/g); DBCM (0.0712-0.277 mmol/g); BDCM (0.0684-0.387mmol/g); and bromoform (0.0522-1.07 mmol/g). The copolymers exhibited relatively high selectivity toward individual components of THMs due to their variable molecular size and polarizability. The copolymers showed favorable adsorption (e.g., β-CD/PAA 1:5, CP-1) and each type of polysaccharide (e.g., β-CD and CS) copolymers displays great potential for the removal of halomethane-based contaminants.

We report the detection of morphology-dependent stellar age in massive quenched galaxies (QGs) at z similar to 1.2. The sense of the dependence is that compact QGs are 0.5-2 Gyr older than normal-sized ones. The evidence comes from three different age indicators-D(n)4000, H-delta, and fits to spectral synthesis models-applied to their stacked optical spectra. All age indicators consistently show that the stellar populations of compact QGs are older than those of their normal-sized counterparts. We detect weak [O II] emission in a fraction of QGs, and the strength of the line, when present, is similar between the two samples; however, compact galaxies exhibit a. significantly lower frequency of [O II] emission than normal ones. Fractions of both samples are individually detected in 7Ms Chandra X-ray images (luminosities similar to 10(40) - 10(41) erg s(-1)). The 7Ms stacks of nondetected galaxies show similarly low luminosities in the soft band only, consistent with a hot gas origin for the X-ray emission. While both [O II] emitters and nonemitters are also X-ray sources among normal galaxies, no compact galaxy with [O II] emission is an X-ray source, arguing against an active galactic nucleus (AGN) powering the line in compact galaxies. We interpret the [O II] properties as further evidence that compact galaxies are older and further along in. the process of quenching star formation and suppressing gas accretion. Finally, we argue that the older age of compact QGs is evidence of progenitor bias: compact QGs simply reflect the smaller sizes of galaxies at their earlier quenching epoch, with stellar density most likely having nothing directly to do with cessation of star formation.

International Telemetering Conference Proceedings / October 30-November 02, 1995 / Riviera Hotel, Las Vegas, Nevada / The Telemetry Data Distribution System (TDDS) solves the need to record, archive, and distribute sounding rocket and satellite data on a compact, user-friendly medium, such as CD-Recordable discs. The TDDS also archives telemetry data on floppy disks, nine-track tapes, and magneto-optical disc cartridges. The PC-based, semi-automated, TDDS digitizes, time stamps, formats, and archives frequency modulated (FM) or pulse code modulated (PCM) telemetry data. An analog tape or a real-time signal may provide the telemetry data source. The TDDS accepts IRIG A, B, G, H, and NASA 36 analog code sources for time stamp data. The output time tag includes time, frame, and subframe status information. Telemetry data may be time stamped based upon a user-specified number of frames, subframes, or words. Once recorded, the TDDS performs data quality testing, formatting, and validation and logs the results automatically. Telemetry data is quality checked to ensure a good analog source track was selected. Raw telemetry data is formatted by dividing the data into records and appending header information. The formatted telemetry data is validated by checking consecutive time tags and subframe identification counter values (if applicable) to identify data drop-outs. After validation, the TDDS archives the formatted data to any of the following media types: CD-Recordable (CD-R) Disc (650 megabytes capacity); nine track tape (180 megabytes capacity); and erasable optical disc (499 megabytes capacity). Additionally, previously archived science data may be re-formatted and archived to a different output media.

Under VT 2019 ägde projektet rum varav denna rapport är ett av resultaten. Projektets mål var att skapa en CI/CD pipeline vars syfte var tänkt att frekvent kunna leverera färdigtestad kod till olika molntjänster som Google Cloud Platform, Amazon Web Services och Azure. Projektspecifikationerna gavs av företaget Skira för att skapa en snabbare integrationsprocess för nya utvecklare. Detta så en ny utvecklare skulle kunna lägga mer tid på att koda istället för att gräva ner sig i leverans-/testningsprocessen. Slutprodukten ger företag möjligheten att koda direkt på sitt utvecklingskluster.

BACKGROUND: During the mid to late 20th century, parts of Europe and North America began experiencing increasing incidence of inflammatory bowel disease for unknown reasons. Epidemiological studies carried out at the time determined that incidence rates and disease severity were higher in the northern latitudes than in the southern latitudes. LITERATURE REVIEW: In the ensuing years, an inverse association was established between ultraviolet radiation and incidence of Crohn’s disease, a finding that has not proven to be as robust for ulcerative colitis. This association was explored further and vitamin D was implicated to be the factor of ultraviolet radiation which was associated with increased incidence. Currently, all evidence implicating vitamin D in the pathogenesis of Crohn’s disease comes from epidemiological, animal, and in vitro studies, providing strong evidence for an association, but none of which can prove causality. Causality must be proven in prospective clinical trials, which, at present, have come up short in providing statistically significant findings. METHODS: The proposed trial outlined below provides a method of studying the question at hand in a way that has not been previously studied. This is a randomized, double blind, controlled trial which assesses the effect of supplementation of vitamin D in patients with active Crohn’s disease. DISCUSSION: Acceptance of the alternative hypothesis would be a big step forward in the management of Crohn’s disease. It would have wide-ranging implications, resulting in decreased healthcare costs, decreased use of toxic medications, and increased quality of life.

This socio-palaeographic thesis maintains that behind the uniform appearance of Roman army writing was a particular, dedicated training. Focussing on the third century Dura-Europos, it uncovers evidence for the thorough schooling given to the clerks of the resident Cohors XX Palmyrenorum enabling them to fulfil their administrative duties. These include maintaining efficient documentation systems and preparing a range of accurate, legible texts, and the clerks were trained to produce a repertoire of standard military scripts. Additionally other soldiers and the more general public were taught to read and to understand, to varying degrees, but the clerks, distinct, were specialist writers who found dignity in the work that they did. This dissertation, a preliminary study, draws throughout from the camp’s rich epigraphic and papyrological evidence. It sets out the context in which clerical soldiers worked and the evidence for army literate education and then introduces Roman writing, its form and development generally, before analysing in detail the letter-forms used in one particular standard hand over the decades the cohort’s documents span. In this hand, the well-known development out of Old Roman Cursive is presented and discussed. A brief additional chapter presents the possibility that military clerks also produced camp signage.