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The Maya sites of Marco Gonzalez and San Pedro are located on the southern end of Ambergris Caye, a limestone-based coral island off the coast of modern-day Belize. When combined, the archaeological settlements at these sites represent some of the longest occupations in coastal Belize. Evidence suggests the earliest occupation occurred at Marco Gonzalez in the Late Preclassic and extended into the Late Postclassic, while San Pedro's population thrived well into the Historic period. An analysis of the stone tools recovered from excavations at Marco Gonzalez and San Pedro and a study of the use-wear patterns on these artifacts has revealed that the Maya from both sites were primarily engaged in subsistence-based activities with a limited amount of small-scale craft production. Use-wear evidence suggests that the majority of these activities focused on the exploitation of local resources necessary in everyday Maya life. The activities included the acquisition of seafoods such as fish and molluscs, and the preservation and/or processing of fish and other marine by-products, such as shell, coral, and stingray spines for both local use and trade. As consumer sites, the Caye inhabitants offered many of these products in exchange for stone tools produced in mainland workshops, such as Colha, in the 'chert-bearing zone' of Northern Belize. In addition to the local and regional trade of marine resources and salt, the sites of Marco Gonzalez and San Pedro served as transshipment points for the long-distance exchange of valuable wealth or prestige goods along the coast. The large inland site of Lamanai likely served as ally and trade partner with these sites based on archaeological evidence for socioeconomic and sociopolitical ties between this mainland centre and the smaller Caye settlements. This relationship assisted the Maya from southern Ambergris Caye in surviving the breakdown in trade relations and depopulation that plagued other Maya centres in the Late to Terminal

Humanpatogena stammar av bakterien Yersinia enterocolitica kan orsaka akut gastroenterit. För identifiering av bakterien odlas fecesprover ut på CIN-agar. På senare år har en kromogen agarplatta framtagits som differentierar mellan patogena och apatogena stammar av Y. enterocolitica. Syftet med studien är att jämföra och utvärdera två CIN-agar, med agarbaser och supplement från två olika företag (Liofilchem och Oxoid), och CHROMagar Y. enterocolitica (CHROMagar). Odling av fecesprover samt seriespädning av sex Y. enterocolitica stammar och en Y. pseudotuberculosis utfördes. Vid utodlade fecesprover jämfördes växt och hämning av övriga bakterier. Vid seriespädning räknades antal kolonier på plattorna för respektive spädning, samt utseende av kolonier på plattor bedömdes. Resultatet tyder på att skillnad av hämningseffekt av Y. enterocolitica och utseende på kolonierna finns mellan de två CIN-agarplattorna. Oxoid’s CIN-agar erhöll större kolonier, lägre hämningseffekt av Y. enterocolitica och detektionsgräns än Liofilchem’s CIN-agar. På CHROMagar-plattan växte de patogena stammarna med bleklila kolonier och de apatogena stammarna med blåa kolonier. Hämningseffekt av Y. enterocolitica hos CHROMagar-plattan är densamma som Oxoid’s CIN-agar. Slutsatsen är således att Oxoid’s CIN-agar och CHROMagar har samma hämningseffekt av Y. enterocolitica men CHROMagar differentierar mellan patogena och apatogena stammar. Liofilchem’s CIN-agar har högre hämningseffekt än CHROMagar och Oxoid’s CIN-agar. / Pathogenic strains of Yersinia enterocolitica can cause acute gastroenteritis in humans. To identify the bacterium, cultivation of stool samples on CIN-agar are performed. A chromogenic medium has been developed that differentiate between pathogenic and nonpathogenic strains of Y. enterocolitica. The purpose is to compare and evaluate two CIN-agar, with agar bases and supplements from two companies (Liofilchem and Oxoid), and CHROMagar Y. enterocolitica (CHROMagar). Growth of stool samples and serial dilutions of six Y. enterocolitica strains and one strain of Y. pseudotuberculosis were performed. Comparisons of the growth and inhibition of other bacteria were done for the stool samples. Colonies for each dilution were counted and appearance of the colonies was evaluated. The result indicates that a difference in inhibitory effect on Y. enterocolitica and appearance of colonies exist between the two CIN-agar. All strains grew with larger colonies on Oxoid CIN-agar than on Liofilchem’s. Oxoid CIN-agar and CHROMagar have a lower inhibitory effect on Y. enterocolitica than Liofilchem’s. On CHROMagar, the pathogenic strains grew with mauve colonies, whilst the nonpathogenic strains grew with blue colonies. Thus, the conclusion is that CHROMagar and Oxoid CIN-agar have less inhibitory effect on Y. enterocolitica than Liofilchem’s. CHROMagar can differentiate between pathogenic and nonpathogenic strains.

O hidrÃide calcÃrio do gÃnero Mil/epora ocorre em regiÃes tropicais de todo o planeta como um componente regular dos recifes de coral. MilÃporas sÃo encontradas em profundidades menores que 1 atà 40 m. Os corais vivos criam uma sÃrie rica de habitats para um grande nÃmero de espÃcies fornecendo substrato para os organismos sedentÃrios e alimento ou abrigo para os organismos mÃveis. O objetivo deste estudo foi identificar e quantificar toda a macrofauna encontrada em colÃnias de Mil/epora a/cicornis na Ãrea de ProteÃÃo Estadual dos Recifes de Coral (RN). As 26 amostras foram coletadas manualmente atravÃs de mergulho autÃnomo, em profundidades de 1 a 3 m. No perÃodo de julho e novembro de 2004 e fevereiro de 2005, as colÃnias foram envolvidas por sacos plÃsticos e, em seguida, extraÃdas do substrato com o auxÃlio de martelo e talhadeira. Posteriormente, as amostras foram fixadas com formalina 4%. No laboratÃrio, as colÃnias foram analisadas para a retirada dos epibiontes e, em seguida, cuidadosamente fragmentadas para a remoÃÃo da fauna perfurante. Foram registrados 1.234 indivÃduos e 95 espÃcies de organismos nÃo coloniais dos grupos Crustacea, Echinodermata, Mollusca, Nemertea, Polychaeta e Sipuncula, e 86 colÃnias e 26 espÃcies de organismos coloniais dos tÃxons Cnidaria, Porifera e Tunicata. Os crustÃceos apresentaram o maior nÃmero de indivÃduos e espÃcies, seguidos por poliquetas e moluscos. Segundo coeficiente de correlaÃÃo de Spearman, o nÃmero de indivÃduos e espÃcies dos organismos nÃo coloniais associados aumenta com o crescimento da colÃnia. Em relaÃÃo à fauna colonial, os tunicados possuÃram maior nÃmero de colÃnias e os porÃferas, maior nÃmero de espÃcies. A epifauna dos grupos coloniais e nÃo coloniais foi mais numerosa que a endofauna. ComparaÃÃes entre milÃporas e corais escleractÃnios podem ser traÃadas devido a uma possÃvel convergÃncia funcional desses tÃxons. à possÃvel supor que as associaÃÃes com corais nÃo dependem exclusivamente da espÃcie hospedeira, pois espÃcies distintas habitam a mesma espÃcie de coral em regiÃes diferentes. Provavelmente o substrato exerÃe papel mais importante, cujas formas promovem a formaÃÃo de habitats distintos. / The limestone of the genus hidrÃide Mil / epora occurs in tropical regions around the planet as a regular component of coral reefs. MilÃporas are found at depths less than 1 to 40 m. The live coral create a rich variety of habitats for many species by providing substrate for sedentary organisms and food or shelter for the bodies moving. The aim of this study was to identify and quantify all the macrofauna found in colonies of Mil / epora a / cicornis Area of Protection of Coral Reefs of the State (RN). The 26 samples were collected manually through autonomous diving in depths from 1 to 3 m. In the period from July to November 2004 and February 2005, the colonies were surrounded by plastic bags and then extracted from the substrate with the aid of hammer and chisel. Subsequently, the samples were fixed with formalin 4%. In the laboratory, the colonies were tested for the withdrawal of epibiontes and then carefully to remove fragmented fauna Perforating. 1234 individuals were recorded and 95 species of non-colonial groups of Crustacea, Echinodermata, Mollusca, Nemertea, and Sipuncula Polychaeta, and 86 colonies and 26 species of organisms colonial taxa of Cnidaria, Porifera and Tunicata. The crustaceans had the highest number of individuals and species, followed by polychaetes and molluscs. According to Spearman correlation coefficient, the number of individuals and species of non-colonial increases associated with the growth of the colony. Regarding colonial fauna, tunicates owned the largest number of colonies and Porifera, greater number of species. The epifauna of non-colonial and colonial groups was larger that endofauna. Comparisons between milÃporas and coral escleractÃnios can be drawn due to a possible functional convergence of these taxa. You can assume that the associations with corals do not depend exclusively on the host species, as different species inhabit the same species of coral in different regions. Probably the most important role exercise substrate, which forms promote the formation of distinct habitats.

Holocene and Pleistocene grainstone deposits surrounding Ocean Cay located on the western margin of Great Bahama Bank provide key evidence for the comprehension of patterns, processes and petrophysical heterogeneity of carbonate grainstone shoals. New datasets consisting of high-resolution remote sensing data, acoustic Doppler current measurements, sub-bottom profiles, and sedimentological and petrophysical analyses offer an opportunity to elucidate the various factors in the deposition of a grainstone shoal complex and assess of how much of the sedimentary fabric and early diagenetic overprint influences the petrophysical characteristics of similar ancient deposits. The Holocene shoal complex investigated here includes the Cat Cay ooid shoal and the Ocean Cay tidal deltas, which collectively form a 1-3 km wide, 35 km long sand belt around Ocean Cay. These factors controlling the distribution, preservation and modification of these sediments are the antecedent Pleistocene topography, bathymetry, and hydrodynamics at this margin. High-resolution seismic data reveal that the laterally continuous and thick Cat Cay ooid shoal north of Ocean Cay is situated on top of a flat Pleistocene surface and located platformward of a Pleistocene rock ridge. This finding challenges the assumption of previous studies that an antecedent high is needed for ooid shoal initiation. In contrast, south of Ocean Cay, skeletal-rich tidal deltas occur east of rocky Pleistocene islands and formed over an irregular Pleistocene surface that is slightly shallower than the flat surface north of Ocean Cay. In addition to the antecedent topography, differences in shoal morphology and sediment attributes between the north and south areas around Ocean Cay are related to linkages among fluid flow patterns, shoal morphology and granulometry. The hydrodynamic data document the influence of tidal flows in modifying the shape of bars creating sinuous and parabolic forms during flood and ebb reversing flows. Spatial distribution of grain size and sorting is affected because high flow velocities (up to 100 cm sec-1) inside tidal channels and inlets can erode and remobilized sediments mixing skeletal grains, peloids and ooids. Dominance of flood tide across this Holocene shoal complex allowed tidal deltas to form bankward of inlets between rock islands. Tidal channels and inter-bar troughs can focus tidal flow during flood tide creating lobes platformward instead of previously assumptions on the effect of storm and formation of spillover lobes bankward. Cores from the subsurface at Ocean Cay show that the architecture of the Pleistocene grainstone facies is similar to the Holocene shoal configuration of bars, channels, and bioturbated stabilized areas. Cross-bedded oolitic/peloidal and bioturbated skeletal/peloidal facies exhibit facies-dependent petrophysical heterogeneity, and reveal depositional and early diagenetic controls on petrophysical properties. Porosity and permeability in the grainstones at Ocean Cay are high, up to 47% and up to 11500 mD, respectively. Early diagenesis modifies the pore geometry of the rock, thus reducing permeability. A comparison of petrographic and petrophysical properties of the Pleistocene shoal with those from the Pennsylvanian ooid shoals reveals that were strongly influenced by the original fabric and early near-surface diagenesis. The integration of data from both the modern and ancient carbonate systems provides a better understanding of the factors controlling shoal morphology, facies architecture, and rock properties. The results of this study can be used as a guide for interpreting heterogeneity and reservoir properties of analogous facies within ancient ooid shoals.

Submitted by Gsutavo Schardong (gustavoschardong@hotmail.com) on 2017-09-19T16:17:00Z No. of bitstreams: 1 Dissertação Final.pdf: 353912 bytes, checksum: c556502fa9d011ba8be8d6666ae3c3be (MD5) / Approved for entry into archive by Janete de Oliveira Feitosa (janete.feitosa@fgv.br) on 2017-09-19T19:04:04Z (GMT) No. of bitstreams: 1 Dissertação Final.pdf: 353912 bytes, checksum: c556502fa9d011ba8be8d6666ae3c3be (MD5) / Made available in DSpace on 2017-09-25T18:27:01Z (GMT). No. of bitstreams: 1 Dissertação Final.pdf: 353912 bytes, checksum: c556502fa9d011ba8be8d6666ae3c3be (MD5) Previous issue date: 2017-06-19 / Neste trabalho, buscamos testar a relação entre a razão consumo-riqueza e retornos financeiros, conforme proposto por Lettau e Ludvigson (2001). Como o capital humano é uma variável latente, os autores utilizam o cay como alternativa, e testam sua capacidade de previsão. Para avaliar o poder preditivo desta razão em sua forma original, utilizamos séries de capital humano construídas com base na metodologia proposta por Dias, Issler e Brotherhood (2016) para computar séries de riqueza agregada, e testamos o desempenho de previsões de modelos considerando a razão consumo-riqueza. Foram utilizados dados macroeconômicos e financeiros de países do G7, formando um painel não balanceado de frequência trimestral. De forma geral, os resultados foram favoráveis ao uso desta razão para prever excessos de retornos, e retornos reais de ativos.

Sedimentary characteristics of grainy non-skeletal tidal flats along windward platform margins have not been described in modern environments and may be misidentified or misclassified in the rock record. This study describes the sedimentology of such an environment to aid in accurate identification and characterization in the ancient. At Shroud Cay, a grain-dominated tidal flat is sheltered from the high energy of the shelf by a ring of cemented Pleistocene and partly indurated Holocene eolianite islands separated by several narrow tidal passes. Depositional texture, environment of deposition and geobody mapping, extensive sediment sampling, and vibracoring have shown that, though the cemented island provide a barrier from the high energy of the shelf, a high degree of tidal energy still occurs behind this barrier as indicated by the overwhelmingly grainy nature of all of the tidal flat sub-environments. Intertidal flats comprise the majority of the tidal flat surface. These flats are characterized by patchy Scytonema mats overlying bioturbated peloid-ooid grainstones to packstones with cemented lithoclasts. Three main tidal channels dissect the tidal flat and allow diurnal flow, one of those tidal channels does not exit the tidal flat but dead-ends behind a cemented Holocene beach dune ridge along the eastern side of Shroud Cay. Peloid-ooid-skeletal grainstone tidal bars and peloid-ooid packstones fill much of the channels. Most of the channels are bordered by low-relief grain-rich packstone levees often capped by red mangroves and algal mats. The interior-most supratidal parts of the flat, often in the lee of the windward Holocene ridge, are covered by a thick (5-~25cm) Scytonema microbial mat underlain by grain-rich ooid-peloid packstones. Ancient grain-dominated carbonate tidal flats and eolianite deposits like Shroud Cay?s are the reservoir rocks in some of today?s largest hydrocarbon fields. We develop a model for the evolution of the grain-dominated tidal flat, document and compare differences between the grain-rich tidal flat and surrounding environments of deposition, and develop a set of criteria for recognition. These criteria can be used to more accurately characterize reservoirs such as the Jurassic Smackover fields, to avoid mis-classification of similar settings, and more effectively produce those reservoirs.

Invasive fungal infections are prevalent and often deadly in immunocompromised patients. There continues to be a pressing need for the development of novel antifungal compounds since there are currently only 13 compounds licensed for the treatment of invasive fungal infections and antibiotic-resistant strains have been emerging. CAY-1 is an antifungal steroidal saponin which was isolated from the fruit of the cayenne pepper plant in 0.1% yield. In Vitro studies of CAY-1 have shown it to be an effective antifungal agent against sixteen pathogenic fungal strains and it showed no cytotoxicity toward mammalian cells up to 100 ìg/mL. The development of a practical synthesis of CAY-1 will potentially allow for further exploration of its medicinal utility and provide the opportunity to synthesize derivatives of CAY-1 which could be investigated in structure-activity relationship studies. To this end, methods for the preparation of they CAY-1 aglycone and pentasaccharide moieties have been investigated. Through this work, several partially protected stereoisomers of the CAY-1 aglycone have been prepared which can be used for the synthesis of saponin derivatives of CAY-1 for structure-activity relationship studies. Definitive characterization of one of these isomers, 3á-hydroxy-(22S, 25R)-5á-spirostan-2â-yl acetate, was achieved by X-ray crystallography. Furthermore, a quantitative inversion of the C-3 stereochemical configuration of this compound was achieved via an acetate group migration of the corresponding mesylate. The possibility of competition between the acetate migration and substitution mechanisms with various nucleophiles was explored. The results, however, indicate that this inversion only occurs via the acetate migration. Additionally, the CAY-1 pentasaccharide synthesis poses two significant challenges. First, these results demonstrate that the central 2, 3-branched portion can be synthesized efficiently from a partially protected glucopyranosyl acceptor since the C-2 and C-3 alcohols differ in their reactivity in glycosylation reactions. The second challenge is the ƒÀ-(1¨4) linkage to the galactosyl acceptor which significantly increases the complexity of the synthesis as compared to literature reported syntheses of other branched oligosaccharides. Nonetheless, this ƒÀ-(1¨4) linkage was achieved using a disarmed trichloroacetimidate glucosyl donor.