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Until recently, academic and practitioner research on clinical trial supply chains focused on identifying innovative models and solutions in providing comparator and study drugs to global clinical sites. Due to the expansion of outsourcing efforts by pharmaceutical organizations, newly enacted global laws and regulations, and the continued push to increase the speed at which new drugs gain market approval, a new and extremely complex global “ancillary” supply chain has emerged. This manuscript focuses on the clinical trial ancillary supply chain: a supply chain that develops the end-to-end process resulting in the distribution and quality management of medical products and devices, consumable supplies, and patient giveaways to global clinical trial sites. Based on a series of quantitative analyses, this research assesses the influence of the customer, country, and product on the overall success of the supply chain. Three factors emerged from these analyses as having a direct influence on the clinical trial ancillary supply chain; product characteristics, magnitude (components of size), and stability (components of changes in scope). Part II of this research sought to understand the success of the supply chain by evaluating the moderating effects of knowledge management, organizational culture, therapeutic area, and type of shipment. Assessments of 444 customer and server surveys yielded components of a sense of shared culture, shared communication and transparency, and feeling educated and supported. Quantitative data analysis supported that these components had a moderating influence on success during the pre-trial phase of the supply chain. These research findings provide insight into the internal and external drivers of success within the complex and emergent clinical trial supply chain – a supply chain that helps pharmaceutical organizations bring innovative therapies to market and most important, those patients in need of such therapies to improve or even save their lives. / Business Administration/Interdisciplinary

The research aim was to gain a more detailed understanding of the operation of different key segments for fresh produce supply chains originating in the Highlands Provinces in Papua New Guinea (PNG). The research investigates a number of supply chain dimensions of effectiveness which include, value creation and integration of processes, logistics, quality, information, relationship/vertical integration and overall effectiveness. These were linked together in SC framework. Two potato chains were investigated, one formal, the other informal. The informal potato chain involves small holder farmers, input suppliers and local markets including kai bars and the urban market. The chain originates and ends within the Western Highlands Province. The formal potato chain has farmers, input suppliers, wholesaler/marker, transport companies (trucking and coastal shipping agents), supermarkets, hotels and kai bars. This chain originates in Mt Hagen, Western Highlands Province and ends in Port Moresby, National Capital District. The effectiveness of both the formal and informal chains was identified, and comparisons were made to see how each chain differed. The informal chain was found to have different problems to the formal chains. However, participants to both chains demonstrate a high entrepreneurial behavior. A key finding of the study was that the chains spread their risk by operating in multiple market segments and this can help to solve issues with variable quality. The marketers in each chain position themselves in these different market segments. It was clear from this work that focusing on functions and not the whole chain can lead to a distorted view of chain performance. For example, for the informal chain, a focus on logistics issues, particularly poor roads and problems with availability of seeds, can misrepresent the effectiveness of this chain. Therefore, it was concluded that it is important to look at the overall performance of each chain rather than looking specifically at particular chain functions in isolation.

Thesis (Ph. D.)--Oregon State University, 2007. / Printout. Includes bibliographical references (leaves 172-174). Also available on the World Wide Web.

This master thesis in geography investigates how remote sens- ing can be used in Transnational Corporations (TNC) global Corporate Social Responsibility (CSR) initiatives. The study aims to delineate an accurate method in remote sensing to be used to monitor deforestation in global value chains. Research questions asked are 1) What are the current monitoring practises used by TNCs to monitor global value chains? 2) Which is the most user-friendly and accurate remote sensing technique to map deforestation? 3) How can remote sensing successfully be implemented in TNCs CSR-initiatives? The study is approached from two perspectives, building on theories of value chains, and qualitative methods to answer the first research question. While the second question is a method study, investigating how well a spectral approach versus a contextual approach can map deforest- ation in Landsat scenes. The results are compared with Global Forest Watch (GFW), and the highest accuracy were acquired from the WICS (Window Indipendent Context Segmentation) technique. Conclusions includes that remote sensing can be used in CSR initiatives, to establish a baseline level or as a fifth dimen- sion in a score sheet approach. However, inconclusive mapping of value chains are a big hinder today.

BACKGROUND:Detection of B cell clonality is useful for assisting in the diagnosis of B cell lymphomas. Clonality assessment can be accomplished through evaluation of KAPPA and LAMBDA light chain expression. Currently, only slide based methods are available for the majority of patient biopsies and do not detect light chain protein or mRNA in many B-cell lymphomas. Herein we evaluated a new method, known as colorimetric in situ hybridization (CISH), with improved sensitivity and multiplexing capacity, for its usefulness in clonality detection in mature B cell malignancies.METHODS:The KAPPA and LAMBDA ISH was performed on a Ventana Benchmark XT utilizing two color chromogenetic detection. The probes comprised 2 haptenated riboprobes each approximately 500 base pairs long directed against the conserved regions of either KAPPA or LAMBDA mRNA. The dual colors consisted of silver deposition (black) for KAPPA light chain and a novel (pink) chromogen for LAMBDA light chain. Following optimization, CISH allowed visualization of mRNA in benign B cells in reactive tissues including germinal center, mantle zone, and post-germinal center cells. We then identified 79 cases of B cell lymphoma with formalin-fixed paraffin-embedded (FFPE) biopsies including: follicular (36 cases), mantle cell (6 cases), marginal zone (12 cases), lymphoplasmacytic (6 cases), small lymphocytic (4 cases), and diffuse large B cell (15 cases), which were selected on the basis of either prior flow cytometry or immunohistochemistry (IHC) results to serve as the predicate, "gold standard," comparator.RESULTS:39/79 (49.4%) cases were classified as KAPPA and 29/79 (36.7%) as LAMBDA light chain restricted / while 9/79 (11.3%) cases were classified as indeterminate. Of the 70 cases with KAPPA or LAMBDA light chain restricted CISH, 69/70 (98.6%) were concordant with the reference method, while 1/70 (1.4%) was discordant.CONCLUSIONS:Optimized CISH detected lower levels of mRNA than can be visualized with current slide based methods, making clonality assessment in FFPE biopsies possible for mature B cell neoplasms. In this preliminary study, CISH was highly accurate compared to flow cytometry or IHC. CISH offers the possibility of wider applicability of light chain ISH and is likely to become a useful diagnostic tool.Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1430491067123856

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This research aim to develop a framework to evaluate critically the effectiveness of health and safety strategies in supply chains in the UK was achieved through a range of objectives which included a review of literature on health and safety management in supply chains and small and medium-sized enterprises, an explanation of the effect of poor health and safety performance on organisations and analysis of factors that inspire health and safety management in organisations. Other objectives are the analysis of health and safety improvement strategies, an establishment of a basis for the development of a framework, the establishment of the perception and attitude to supply chain health and safety management, and the development of a conceptual framework based on ideal and best practices as well as theory that may be used to evaluate critically health and safety strategies in supply chains in the UK. The study adopted a triangulated research approach which used a questionnaire survey to ascertain the views of respondents on some health and safety issues. These views were combined with observations of a case study organisation to underpin the basis for the framework. It was established that the reliance on regulatory measures as means of improving health and safety standards in organisations is no longer advisable. An alternative and best strategy is the use of the influences inherent in supply chain relationships. There were noticeable improvements in the relationship of the case study organisation with its suppliers, and in the general awareness of supply chain health and safety management, when the framework that was developed was tried in their supply chain.

In this thesis we study how hash chains and other hash structures can be used in various cryptographic applications. In particular we focus on the applications of entity authentication, signatures and key establishment. We study recursive application of hash functions to create hash chains, hash trees and other hash structures. We collate all these to form a catalogue of structures that we apply to various cryptographic applications. We study existing work on authentication and create many entity authentication schemes based on structures from our catalogue. We present a novel algorithm to find efficient signature schemes from any given hash structure. We study some suggestions for suitable hash structures and define a particular scalable hash structure complete with a simple message to signature map that is the most efficient such scheme of which we know. We explore k-time signature schemes and identify two new properties, which we call perforated and porous. We look at the application of hash structures to key establishment schemes. We compare the existing schemes and make improvements on many. We present a new key establishment scheme, and show a link between certain k-time signatures and certain key establishment schemes. We look at the other applications of hash structures, and suggest areas in which our catalogue could be used for further development.

Thesis (PhD (Logistics))--University of Stellenbosch, 2010. / ENGLISH SUMMARY: In an effort to compete globally, South African supply chains must achieve and maintain a competitive advantage. One way of achieving this is by ensuring that South African supply chains are as efficient as possible. Consequently, steps must be taken to evaluate the efficiency levels of South African supply chains. This dissertation develops the composite supply chain efficiency model using variables specifically identified as problem areas experienced by South African supply chains. The composite supply chain efficiency model evaluates the overall efficiency of a supply chain based on three criteria, namely, reliability efficiency, cost efficiency and speed efficiency. It identifies bottlenecks along the supply chain and in so doing identifies key focus areas for firms if they want to improve their overall efficiency and become more competitive. 3 / AFRIKAANSE OPSOMMING: In ’n poging om wˆereldwyd te kompeteer, moet Suid-Afrikaanse voorsieningskettings ’n mededingende voordeel behaal en handhaaf. Een manier om dit te bereik is om te verseker dat Suid-Afrikaanse voorsieningskettings so doeltreffend as moontlik funksioneer. Gevolglik moet stappe gedoen word om die doeltreffendheidsvlakke van die Suid-Afrikaanse voorsieningskettings te evalueer. Hierdie proefskrif het die saamgestelde voorsieningsketting doeltreffendheidsmodel ontwikkel wat veranderlikes gebruik wat spesifiek ge¨ıdentifiseer is as probleemgebiede in Suid-Afrikaanse voorsieningskettings. Die saamgestelde voorsieningsketting doeltreffendheidsmodel evalueer die algehele doeltreffendheid van ’n voorsieningsketting gebaseer op drie kriteria, naamlik, betroubaarheidsdoeltreffendheid, koste-doeltreffendheid en spoed-doeltreffendheid. Dit identifiseer knelpunte in die voorsieningsketting en identifiseer belangrike fokusareas vir ondernemings wat aangespreek moet word as hul algehele doeltreffendheid wil verbeter en meer mededingend raak. / jfl2010