The thesis describes the financial background that prevails in the company Johnson & Johnson. It contains the most essential processes which are applied in the financial department. Each event is specified in theoretical way and also described in practical examples. Special attention is given to pricing policy, accountancy system and periodic financial closing.

The aim of this thesis is to describe the process of financial statements in the joint stock company in terms of Czech legislation. The thesis is divided into two parts, a theoretical part discusses the operations preceding the closing of accounting books, the closing ledger accounts and financial statements with focus on respecting the true and fair view of the company and subsequent accounting duties related to financial statements. The practical part follows analysing the steps of the financial statements of particular joint stock company. The whole text is based on real data and demonstrates some situations characterised in the theoretical part.

By using neural network, the relationship between the low price and the closing price in IMKB is developed by a fuzzy membership function.

Thesis advisor: Amir H. Hoveyda / Chapter 1. In Situ Methylene Capping: A Key Strategy in Catalytic Stereoretentive Olefin MetathesisA general approach for in situ methylene capping that significantly expands the scope of catalyst-controlled stereoselective olefin metathesis is presented. By incorporation of stereodefined 2-butene as the capping reagent, the catechothiolate Ru complex is enabled to catalyze olefin metathesis reactions of terminal alkenes. Substrates bearing a carboxylic acid, an aldehyde, an aryl substituent, an α substituent were thus converted to the desired products in 47–88% yield and 90:10–98:2 Z:E selectivity. The capping strategy was also applied in ring-closing metathesis reactions leading to 14- to 21-membered macrocyclic alkenes (96:4–98:2 Z:E). The utility of this method was highlighted through synthesis of a platelet aggregate inhibitor and two members of the prostaglandin family compounds by cross-metathesis reaction, as well as a strained 14-membered ring stapled peptide by macrocyclic ring-closing metathesis. Examples of the corresponding E-selective cross-processes are provided as well. Chapter 2. Synthesis of Z- or E-Trisubstituted Allylic Alcohols and Ethers by Kinetically Controlled Catalytic Cross-MetathesisKinetically controlled Ru-catalyzed cross-metathesis reactions that generate Z- or E-trisubstituted alkenes are discussed. Reactions were catalyzed by catechothiolate Ru complex to generate trisubstituted allylic alcohols and ethers in up to 81% yield and >98% stereoisomeric purity. The approach is applicable to synthesis of products containing an alcohol, an aldehyde, a carboxylic acid or an alkenyl substituent. Mechanistic models that account for the observed trends in efficiency and stereoselectivity will be provided. Chapter 3. A New Ru-Based Catechothiolate Complex Bearing an Unsaturated NHC Ligand for Synthesis of Z-α,β-Unsaturated Carbonyl Compounds by Cross Metathesis Design and development of a new Ru catechothiolate complex that may be used to promote Z-selective cross-metathesis transformations that afford Z-α,β-unsaturated esters, acids, and amides (including Weinweb amides) are discussed. Comparison between Ru catechothiolate complexes with an unsaturated NHC and a saturated NHC ligand will be provided. Utility of the approach is demonstrated by an eight-step synthesis (15% overall yield) of an intermediate for synthesis of stagonolide E, and a five-step synthesis of a precursor to dihydrocompactin / Thesis (PhD) — Boston College, 2020. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Chemistry.

This thesis is focused on design of equipment for injection molding. The work discusses current state of technology for injection molding. In the work is conducted structural design of horizontal injection press for plastics processing with horizontal closing movement. Injection molding machine is designed to form the parting plane of maximum dimension 350 x 350 mm.

Industrial ecology is a field of study that encourages the use of closed-loop material cycles to achieve sustainability. Loop closing requires the movement of materials over space, and has long been practiced in the iron and steel industry. Iron and steel (ferrous) scrap generated in the U.S. is increasingly exported to countries in Asia, lengthening the transportation distance associated with closing the loop on the iron and steel life cycle. In order to understand the environmental cost of transporting this commodity, an activity-based maritime transportation model and a theoretical in-land transportation model are used to estimate emissions generated. Results indicate that 10.4 mmt of total emissions were generated, and emissions increased by 136 percent from 2004 to 2009. Increases in the amount of emissions generated are due to increases in the amount of scrap exported and distance it is transported.

Cerebral hemodynamics monitoring is vital in the neuroscience intensive care unit to assess brain health. Diffuse optical methods using near-infrared light, e.g., near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS), allow for non-invasive prolonged monitoring of cerebral hemoglobin oxygenation and blood flow. For patients suffering from cerebral fluid or tissue volume buildup, intracranial pressure (ICP) is monitored invasively as its elevation compromises cerebral perfusion. The critical closing pressure (CrCP) is a transcranial doppler (TCD) derived non-invasive parameter that correlates with ICP; however, its use is limited due to discomfort during extended TCD measurement. I expanded on Sutin’s preliminary study using DCS to estimate CrCP and found high correlations between DCS obtained CrCP against TCD (R2: 0.77-0.83) in stroke patients. The use of DCS to monitor CrCP is advantageous because its sensors are comfortable to wear and easy to use continuously without the need of a specialized operator. However, the low DCS signal-to-noise ratio (SNR) limits the depth sensitivity and temporal resolution of CrCP measures. Following these encouraging results, I built a low-cost wireless cerebral oximeter based on multi-distance continuous wave NIRS called FlexNIRS, which exhibits high SNR (NEP < 70 fw/Hz0.5) and high sampling rate (266 Hz). This device not only quantifies cerebral oxygenation but resolves the pulsatile blood volume signal at large source-detector separations (33 mm). Using the relationship between blood flow and volume, I augmented pulsatile DCS blood flow measurements with FlexNIRS pulsatile signals. I experimentally demonstrated the high fidelity (R2: 0.98) and > 50-fold SNR improvement of the method, resulting in a one order of magnitude increase in the temporal resolution of CrCP estimates. / 2024-06-12T00:00:00Z

No description available.

No description available.

The use of check valves in the nuclear industry is of great importance from a safety precaution point ofview (McElhaney, 1995). Choosing check valves for these high-pressurized systems comes with agreat challenge. The valves causes what is called check valve slams when closing, leading to a hugepressure wave traveling through the system. To prevent this from happening calculations have to bedone to see what kind of forces are generated during a check valve slam. When the forces are known itis easier designing systems that will endure these slams. A commonly used software in the nuclearindustry is RELAP5 (Reactor Excursion and Leak Analysis Program), its main purpose is to calculatetransients in piping systems. This program can also be used when calculating a check valve slam. Buthow precise is the code compared to the real event? By doing an experiment measuring pressures created by swing check valves during slams, the codewas compared to real data and analyzed to decide what was of importance when modeling for thesetypes of simulations. The RELAP5 code was not initially designed to calculate transients during a check valve slam. This isclearly shown when the code overestimates the pressure waves in the system when using themanufacturer data for the check valve model. Matching the data from the simulations in RELAP5 withthe data recorded from the experiment is not easy. The parameters used for this have no connection tothe specifications for the check valve, which means that transients are hard to estimate withoutexperimental data.