I en projektering är det många aktörer som behöver samarbeta och tillsammans med att ta fram handlingar för att producera en byggnad. Det är en komplicerad process med många infallsvinklar och åsikter som behövs ta med i beaktning innan ett välfungerande resultat kan nås. Under de senaste åren har det uppmärksammats i tidigare studier hur kommunikationen under denna process inte alltid är så välfungerande som det hade önskats. I denna studie har en undersökning genomförts för att undersöka vid vilka tillfällen kommunikationen brister under projekteringen samt alternativa lösningar angående hur en förbättrad kommunikation kan ske mellan de berörda aktörerna. Syftet med denna studie var att undersöka hur väl kommunikationen fungerar i dagsläget. Detta uppnås genom att studera under vilka tillfällen kommunikationen anses vara bättre i jämförelse när det anses finnas rum för förbättringar. Studiens mål var att lämna över ett antal förslag som en entreprenad ska kunna implementera i projekteringen för att få en mer sammanhållen projekteringsgrupp med färre missförstånd och irritationer.   Av kvalitativ karaktär har denna studie genomförts med en nulägesanalys, insamlad teori samt datainsamling i form av intervjuer. I nulägesanalysen studerades hur projekteringen fungerade i dagsläget och vad för kommunikationsverktyg som används för stunden. Den inkluderande teorin i denna studie har tagits med i avseende av att antingen bidra till datainsamlingen eller diskussionen i avlutningen för att stötta de förslag som rekommenderas i slutsatsen. Datainsamlingen har skett via genomförandet av intervjuer i samarbete med entreprenadföretaget In3prenör samt projektörer som har varit underentreprenörer till In3prenör i minst ett projekt. Personerna som deltog i intervjustudien har alla varit eller är aktiva inom projekteringen i någon roll. Resultaten delas upp i tre olika stycken dagens situation, kommunikation och förbättringsförslag. Dagens situation fokuserar på att hitta aktiviteter eller tillfällen då respondenterna anser att kommunikationen fungerar väl och när det finns förbättringsmöjligheter. Här var det tydligt att just kommunikationen inom projekteringsteamet samt med beställaren var en utmaning för många och där finns det behov för förbättring. Fortsättningsvis i avsnittet kommunikation jämförs de olika kommunikationsverktygen som används i dagsläget för att höra tankar och åsikter om deras olika för- och nackdelar. Fysiska möten ansågs då som det bästa alternativet medan mejl har en tendens att försvinna och telefonsamtal saknar spårbarhet. I förbättringsförslagen valdes fyra olika kommunikationsmetoder ut Big Room, I.C.E, Scrum och Kanban. Respondenterna föredrog Big Room och I.C.E över Scrum och Kanban med anledning att man utnyttjar alla inom projekteringsteamets kunskaper och skapar mer samarbete inom gruppen. Arbetet resulterade i 3 förslag en entreprenad möjligtvis skulle kunna implementera: Spelregler i ett tidigt stadie: Sätta sig ner med hela projekteringsteamet för att från ett tidigt skede sätta spelgregler angåend kommunikation och andra relevanta ärenden tillsammans. Projektstudio: Införskaffa en projektstudio för de större disciplinerna som exempelvis arkitekten och konstruktören. Skaffa en förståelse för den gemensamma portalen: Spendera en tid att skaffa förståelse och strukturera upp portalen för enklare kommunikation. / In a construction design process, many participators need to collaborate and together produce documents to construct a building. It is a complicated process with many angles and opinions that need to be considered before a well-functioning result can be reached. In recent years, attention has been drawn in previous studies to how communication during this process is not always as well-functioning as would have been desired. This study has been carried out to investigate at what times the communication is lacking during the design process as well as alternative solutions regarding how improved communication can take place between the actors involved. The purpose of this study was to investigate how well communication is dealt with in the present. This is achieved by studying the occasions when communication is considered to be better in comparison when there is room for improvement. The study aimed to submit several proposals that a contractor should be able to implement in the design to have a more cohesive design group with fewer misunderstandings and irritations. Of a qualitative nature, this study has been conducted with a current situation analysis, reveiwed theory and data collection in the form of interviews. The current situation analysis studied how the design process worked in the current situation and what communication tools that are currently used. The theory in this study has been included in terms of either contributing to the data collection or the discussion in the conclusion to support the recomenden proposals. The data collection has taken place through the conduct of interviews in collaboration with the construction company In3prenör and designers who have been subcontractors to In3prenör in at least one project. The people who participated in the interview study have all been or are active in the design process in some role. The results are divided into three different sections, the current situation, communication and improvement proposals. Today's situation focuses on finding activities when respondents believe that communication works well and when there are opportunities for improvement. Here it was clear that communication within the design team and with the client was a challenge for many and there is a need for improvement. The section on communication continues to compare the different communication tools that are currently used to hear thoughts and opinions about their various advantages and disadvantages. Physical meetings were then considered the best option, while emails tend to disappear and telephone calls lack traceability. In the improvement proposals, four different communication methods were presented Big Room, I.C.E, Scrum and Kanban. The respondents preferred Big Room and I.C.E over Scrum and Kanban since they utilize the knowledge from everyone within the design team and create more collaboration within the group.   The work resulted in 3 proposals a contractor could implement: Set rules within the design team at an early stage: In an early stage decide on communication rules and other relevant preferences for the design team.  Project studio: Acquire a project studio for the major disciplines sucha as the architect and the constructor.  Gain an understanding of the common portal: Spend time understanding and structuring the portal for easier communication.

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Concurrent Design studies have become of great importance in the space industry reducing the time and costs associated to the feasibility assessments for future space missions. This has also helped companies and space agencies to be at the forefront of this fast-developing sector. These collaborative sessions are carried out by an interdisciplinary group of engineers, experts and customers who are capable of achieving an optimal design solution within a short period of time, typically a few weeks. They make use of dedicated tools, like COMET® which is developed by RHEA Group, to store and share the data within the team, as well as with other partners or stakeholders. As new software tools are developed for Model-Based Systems Engineering (MBSE) applications, parallel improvements are needed for Concurrent Engineering teams, since this can be one of the first steps for a model-based approach. One of the main constraints during Concurrent Design studies is the limited number of analysed options, since evaluating the entire design space would require longer sessions and increased time availability from the experts, and would consequently result in more expensive projects. One solution for this problem can be the application of generative engineering technologies to Concurrent Design studies. This method would allow to explore the entire design space by first defining the study model together with the system constraints, and then using a software to automatically generate all the possible architecture variants for that specific model. An example of state-of-the-art technologies for generative design is Simcenter™ Studio, a recently released tool from Siemens Digital Industries Software. The complexity of space missions requires a very detailed definition and evaluation of the system architecture, even at the early stages of the design process. Therefore, research is needed on the use and implementation of new methodologies that will tackle the challenges related to Concurrent Design. The context of the research presented in this thesis is the new project proposed by RHEA Group, Siemens and OHB, called Generative Concurrent Design (GCD). It aims to combine their software tools COMET® and Simcenter Studio, bringing generative engineering to Concurrent Design. One of the main advantages is achieving more optimised solutions in shorter times, reducing the number of necessary iterations on the system architecture during the entire project lifecycle. An enhanced feature of this tool is the possibility for the users to explore the solutions trade space with the support of an Artificial Intelligence (AI) based system. This thesis presents and demonstrates the application of the GCD methodology to a use case at system level, focused on the evaluation of configuration and assembly options in the design of a spacecraft. Using the mission EnVision, selected in 2021 by ESA’s Science Programme Committee, as the design baseline, the GCD methodology has been implemented in this use case study making use of both software tools and showing potential future features and applications. / Les études de conception concourante ont pris une grande importance dans l'industrie spatiale, en réduisant le temps et les coûts associés aux évaluations de faisabilité des futures missions spatiales. Cela a également permis aux entreprises et aux agences spatiales d'être à l'avant-garde de ce secteur en plein essor. Ces sessions de collaboration sont menées par un groupe interdisciplinaire d'ingénieurs, d'experts et de clients qui sont capables d'obtenir une solution de conception optimale dans un délai court, généralement quelques semaines. Ils utilisent des outils dédiés, comme COMET® qui est développé par RHEA Group, pour stocker et partager les données au sein de l'équipe, ainsi qu'avec d'autres partenaires ou parties prenantes. Au fur et à mesure que de nouveaux outils logiciels sont développés pour les applications d'ingénierie des systèmes basés sur les modèles (MBSE), des améliorations parallèles sont nécessaires pour les équipes d'ingénierie concourante, car cela peut constituer l'une des premières étapes d'une approche basée sur les modèles. L'une des principales contraintes lors des études de conception concourante est le nombre limité d'options analysées, car l'évaluation de l'ensemble de l'espace de conception nécessiterait des sessions plus longues et une plus grande disponibilité des experts, ce qui se traduirait par des projets plus coûteux.  Une solution à ce problème pourrait être l'application des technologies d'ingénierie générative aux études de conception concourante. Cette méthode permettrait d'explorer l'ensemble de l'espace de conception en définissant d'abord le modèle d'étude ainsi que les contraintes du système, puis en utilisant un logiciel pour générer automatiquement toutes les variantes possibles du système pour ce modèle spécifique. Un exemple de technologies de pointe pour la conception générative est Simcenter™ Studio, un outil récemment publié par Siemens Digital Industries Software.  La complexité des missions spatiales exige une définition et une évaluation très détaillées de l'architecture du système, même aux premiers stades du processus de conception. Par conséquent, des recherches sont nécessaires sur l'utilisation et la mise en œuvre de nouvelles méthodologies qui permettront de relever les défis liés à la conception concourante. Le contexte de la recherche présentée dans cette thèse est le nouveau projet proposé par RHEA Group, Siemens et OHB, appelé Conception Concurrente Générative (Generative Concurrent Design ou GCD en anglais). Il vise à combiner leurs outils logiciels COMET® et Simcenter Studio, en apportant l'ingénierie générative à la conception concourante. L'un des principaux avantages est de parvenir à des solutions plus optimisées dans des délais plus courts, en réduisant le nombre d'itérations nécessaires sur l'architecture du système pendant tout le cycle de vie du projet. Une caractéristique améliorée de cet outil est la possibilité, pour les utilisateurs, d'explorer l'espace commercial des solutions avec le soutien d'un système basé sur l'intelligence artificielle (IA). Cette thèse présente et démontre l'application de la méthodologie GCD à un cas d'utilisation au niveau système, centré sur l'évaluation des options de configuration et d'assemblage dans la conception d'un vaisseau spatial. En utilisant la mission EnVision, sélectionnée en 2021 par le Comité du Programme Scientifique de l'ESA, comme base de conception, la méthodologie GCD a été mise en œuvre dans cette étude de cas d'utilisation, en employant les deux outils logiciels et en montrant les fonctionnalités et applications potentielles futures.

Global navigation satellite systems (GNSS) have radically changed business, industry, and society, shaping the way we transport, navigate, and generally live every day. After all these years, however, GNSS location information remains only valuable outdoors, leaving indoor environments where people dwell most of the time without proper localization support. Many technologies and systems have approached this problem including optical, inertial, ultrasonic, and radio-frequency (RF), to name a few; yet the problem remains. In this thesis, inspired by the indisputable success of GNSS and the re-emergence of ultra-wideband (UWB) radios to the forefront of technology, we aim to change the state of affairs in RF localization by proposing novel clean-slate UWB ranging and localization schemes based on concurrent transmissions. These are generally considered harmful for communication but become a rich source of localization information when combined with knowledge of the channel impulse response (CIR). Our first novel contribution lies in the concept of concurrent ranging, which allows mobile nodes to simultaneously measure the distance to multiple devices—hereafter, called responders—removing the need for the wasteful long packet exchanges traditionally used for ranging and localization. Different from conventional schemes, which spread responder transmissions over time, we force responders to transmit concurrently and let their signals “fuse” in the wireless channel; the resulting impulse response, as measured by commercial UWB radios, contains all the necessary timing information to extract the desired distance to all responders. This first contribution, however, also serves us to realize the many challenges ahead to unlock the real power of concurrent transmissions for localization. We address these challenges along the way, starting with Chorus, our second contribution. Chorus exploits an anchor infrastructure that transmits packets concurrently. Mobile nodes listen for these transmissions and measure from the CIR the time difference of arrival (TDoA) of the concurrent signals, privately computing their own position at a high rate using hyperbolic localization. This reverse TDoA scheme, although simple in concept, is extremely powerful in that it enables passive self-localization of infinitely many targets at once, a feature largely missing in the RF literature. In Chorus, we address the difficult challenges to reliably detect and identify the signal from the different responders. Yet, the limited transmission precision of commercial UWB transceivers constrains the many benefits of Chorus. In this context, we i) contribute a model to ascertain the impact of the transmission uncertainty on concurrent transmissions, and ii) address the issue with a compensation mechanism that fine-tunes the local oscillator frequency of responders while they prepare to transmit, allowing us to simultaneously tackle the impact of clock drift on distance estimation. We demonstrate in our evaluation that with this compensation mechanism we can schedule transmissions with < 1 ns error, removing the need to share timestamps to precisely measure distance. We rebuild concurrent ranging around this mechanism, obtaining decimeter-level ranging and localization at a fraction of the cost of conventional schemes. These results turn concurrent ranging into an immediately applicable technique that new systems can now exploit, benefiting from a different set of trade-offs hitherto unavailable. Further, the TX compensation mechanism can be directly applied to Chorus, similarly making fast and accurate passive self-localization a tangible reality. We continue our endeavor with a systematic characterization of the conditions under which UWB concurrent transmissions succeed to provide reliable ranging and communication across different complex channels. The results we put forth empower developers to fully exploit concurrent transmissions in their designs, potentially inspiring a new wave of ranging, and also communication, primitives that can bring to UWB the same striking benefits found in low-power narrowband radios. The thesis is completed by looking at other challenges preventing the wide adoption of UWB localization systems, namely, large-scale operation, energy efficiency, and the complexity to install anchor deployments. We tackle these aspects in the last part of the thesis with three additional contributions. First, we propose Talla, a TDoA system that provides seamless large-scale localization for many tags across cells of time-synchronized anchors. Secondly, we fuse UWB ranging with odometry information and build an uncertainty model that only triggers new UWB estimates if and when needed, reducing consumption and channel utilization while satisfying the application-specific demands in terms of accuracy. And thirdly, we build state-of-the-art mechanisms to automatically compute the positions of all anchors deployed across large areas based on ranging information, facilitating anchor network deployment for the many UWB-based real-time location systems (RTLS) to come. Overall, this thesis changes the landscape of UWB localization with a new set of potentially disruptive schemes and systems that exploit the peculiar benefits of concurrent transmissions and that consequently redefine the trade-offs of the technology.

An approach was developed which allows for design studies of commercial aircraft using physics-based noise analysis methods while retaining the ability to perform the rapid tradeoff and risk analysis studies needed at the conceptual design stage. A prototype integrated analysis process was created for computing the total aircraft EPNL at the Federal Aviation Regulations Part 36 certification measurement locations using physics-based methods for fan rotor-stator interaction tones and jet mixing noise. The analysis process was then used in combination with design of experiments to create response surface equations (RSEs) for the engine and aircraft performance metrics, geometric constraints and takeoff and landing noise levels. In addition, Monte Carlo analysis was used to assess the expected variability of the metrics under the influence of uncertainty, and to determine how the variability is affected by the choice of engine cycle. Finally, the RSEs were used to conduct a series of proof-of-concept conceptual-level design studies demonstrating the utility of the approach. The study found that a key advantage to using physics-based analysis during conceptual design lies in the ability to assess the benefits of new technologies as a function of the design to which they are applied. The greatest difficulty in implementing the physics-based analysis proved to be the generation of design geometry at a sufficient level of detail for high-fidelity analysis.

Engineering design may be viewed as a decision making process that supports design tradeoffs. The designer makes decisions based on information available and engineering judgment. The designer determines the direction in which the design must proceed, the procedures that need to be adopted, and develops a strategy to perform successive decisions. The design is only as good as the decisions made, which is in turn dependent on the information available. Information is time and process dependent. This thesis work focuses on developing a coherent bottom-up framework and methodology to improve information transfer and decision making while designing complex systems. The rotorcraft drive system is used as a test system for this methodology. The traditional serial design approach required the information from one discipline and/or process in order to proceed with the subsequent design phase. The Systems Engineering (SE) implementation of Concurrent Engineering (CE) and Integrated Product and Process Development (IPPD) processes tries to alleviate this problem by allowing design processes to be performed in parallel and collaboratively. The biggest challenge in implementing Concurrent Engineering is the availability of information when dealing with complex systems such as aerospace systems. The information is often incomplete, with large amounts of uncertainties around the requirements, constraints and system objectives. As complexity increases, the design process starts trending back towards a serial design approach. The gap in information can be overcome by either “softening” the requirements to be adaptable to variation in information or to delay the decision. Delayed decisions lead to expensive modifications and longer product design lifecycle. Digitization of IPPD tools for complex system enables the system to be more adaptable to changing requirements. Design can proceed with “soft” information and decisions adapted as information becomes available even at early stages. The advent of modern day computing has made digitization and automation possible and feasible in engineering. Automation has demonstrated superior capability in design cycle efficiency [1]. When a digitized framework is enhanced through automation, design can be made adaptable without the requirement for human interaction. This can increase productivity, and reduce design time and associated cost. An important aspect in making digitization feasible is having the availability of parameterized Computer Aided Design (CAD) geometry [2]. The CAD geometry gives the design a physical form that can interact with other disciplines and geometries. Central common CAD database allows other disciplines to access information and extract requirements; this feature is of immense importance while performing systems syntheses. Through database management using a Product Lifecycle Management (PLM) system, Integrated Product Teams (IPTs) can exchange information between disciplines and develop new designs more efficiently by collaborating more and from far [3]. This thesis focuses on the challenges associated with automation and digitization of design. Making more information available earlier goes jointly with making the design adaptable to new information. Using digitized sizing, synthesis, cost analysis and integration, the drive system design is brought in to early design. With modularity as the objective, information transfer is made streamlined through the use of a software integration suite. Using parametric CAD tools, a novel ‘Fully-Relational Design’ framework is developed where geometry and design are adaptable to related geometry and requirement changes. During conceptual and preliminary design stages, the airframe goes through many stages of modifications and refinement; these changes affect the sub-system requirements and its design optimum. A fully-relational design framework takes this into account to create interfaces between disciplines. A novel aspect of the fully-relational design methodology is to include geometry, spacing and volume requirements in the system design process. Enabling fully-relational design has certain challenges, requiring suitable optimization and analysis automation. Also it is important to ensure that the process does not get overly complicated. So the method is required to possess the capability to intelligently propagate change. There is a need for suitable optimization techniques to approach gear train type design problems, where the design variables are discrete in nature and the values a variables can assume is a result of cascading effects of other variables. A heuristic optimization method is developed to analyze this multimodal problem. Experiments are setup to study constraint dependencies, constraint-handling penalty methods, algorithm tuning factors and innovative techniques to improve the performance of the algorithm. Inclusion of higher fidelity analysis in early design is an important element of this research. Higher fidelity analyses such as nonlinear contact Finite Element Analysis (FEA) are useful in defining true implied stresses and developing rating modification factors. The use of Topology Optimization (TO) using Finite Element Methods (FEM) is proposed here to study excess material removal in the gear web region.

Modern build systems that build large software projects often utilize a distributed compiler, allowing the compilation of object files to be parallelized over multiple machines. These build systems are often not able to fully utilize all the resources available on all machines. As linking is not part of this distributed process, the unused resources could be used to perform linking instead, reducing the total build time. However, linking is often performed at the end of the build process, thus not being able to access the previously unused resources. In this thesis project, a linker that runs concurrently with the compilation process of the build system is designed, implemented, and evaluated . As the compilation process produces an object file, the linker performs a partial link using this file. The link is finalized at the end of the build, not unlike a traditional linker. The results show that the total build time is reduced when using the new linker in a build system utilizing a distributed compiler. In some cases, the time spent linking at the end of the build system is reduced over 50 percent when compared to the reference linker.

Les nouveaux acteurs, les nouveaux services et les nouveaux contenus multimédias qui transitent sur le réseau internet génèrent un trafic et des débits de plus en plus élevés. Ceci peut occasionner une congestion, source de latence et de dépréciation de la qualité de service ressentie par les utilisateurs. Un fournisseur d'accès à internet dont l'objectif est de garantir un réseau d'excellence doit donc prendre des mesures pour améliorer sans cesse la fluidité de son réseau. Cela passe notamment par la mise en place d'un réseau de distribution de contenus (déploiement de dispositifs sur le réseau existant). Dans un premier temps cette thèse s'articule à présenter des approches de programmation dynamique de localisation de serveurs optimales dans des arborescences. Nous présentons également un approche pour résoudre le problème de déploiement de CDN et de k serveurs/caches à l'aide de l'algorithme exact et polynomial d'intersection de matroïdes. Nous explicitons ensuite ce qu'est un cache et quelles sont ses caractéristiques. Nous définissons ensuite les hypothèses effectuées et la modélisation associée pour le déploiement de caches transparents dans une arborescence, et le liens avec les algorithmes existants présentés précédemment. Nous présentons alors un modèle complet pour un programme linéaire en nombres entiers (PLNE) et un nouveau paradigme de programmation dynamique pour résoudre ce même problème. Nous montrons alors en quoi cette approche se généralise à des problèmes connexes de localisation dans les arborescences, ainsi que les performances pratiques d'une telle approche. D'un regard plus théorique, nous mesurons la capacité d'un réseau donné par le routage optimal de ses demandes, et, de ce fait, ses liens critiques. Nous manipulons alors le problème de flot concurrent maximal (FCM), un problème classique de la littérature de recherche opérationnelle. Nous exhibons alors de nouvelles formulations exactes pour résoudre ce problème, ainsi que les problèmes de multi-flots de manière plus générale. Une heuristique de construction de formulation pour le FCM est également proposée, pour tirer parti de la distribution spécifique des capacités d'une instance. Nous montrons alors la supériorité des performances de ces nouvelles formulations par le biais de comparaisons. Enfin, nous décrivons le premier algorithme exact et fortement polynomial pour résoudre le problème de flot concurrent maximal dans le cas d'une seule source; et nous montrons l'efficacité pratique d'une telle approche, comparée aux meilleures formulations explicitées précédemment / Streaming requirements on internet network are even more driven by new actors, new services and new digital contents. This leads to high probability of congestion, latency and therefore, a critical decrease of quality of service and/or experience for customers. An internet service provider (ISP) whose goal is to guarantee a first-class performance, needs to take measures to constantly enhance the fluidity of the traffic streaming on its network. One way to face the problem, is to build a Content Delivery Network (CDN). A CDN mainly consists in the deployment of different devices on an existing network. First of all, this thesis presents dynamic programming approaches to tackle server location problems in tree networks. Then, we address a variation of the matroïd intersection algorithm to solve the k-server/cache location problem. We start by giving the definition and characteristics of transparent-caching, as well as the hypothesis that we will use it to build models for transparent cache location in tree network. We tract it to a Mixed Integer Program, and formulate a new paradigm of dynamic programming. We show the relevance of such approach for our problem, and to what extent it can be tractable in other related problems. From a more theoretical point of view, we manage to measure the capacity of a network which is given by the optimal routing strategy, and hence, to identify its critical links. We deal with the Maximum Concurrent Flow (MCF), a classical combinatorial optimization problem. We propose new models and formulations to solve this problem exactly, and more general multi-flows problems as well. A heuristic is also given, to adapt the model to the specific instance values. We experiment these formulations to show the improvements they can provide. Finally, we describe the first strongly polynomial algorithm to solve the maximum concurrent flow to optimality, in the single source case. We show the efficiency of such an approach, even compared to the best models previously presented

In recent years, customers demand for new products has increased in line with a rapid technological change. This has put pressure on industrial companies regarding New Product Development (NPD) in order to continuously develop and produce products at or above the customers’ expectations. Furthermore, products need to be profitable throughout the whole product lifecycle.In order to consider the whole product lifecycle in NPD, inputs with information, as well as, involvement from/of downstream functions are considered as two critical factors to ensure that profitable products are developed. Information from other functions with a wide range of perspectives, knowledge and experiences from previous products are vital.This thesis uses the above mentioned notion while examining a large multinational company, Company X. Product Development in the Company X Group follows the Gateway process which was released group-wide in 2009. This process consists of gateways which cannot be passed if not all requirements are satisfied in each step. This ensures that all areas are covered and that products are developed in an effective matter.Interviews, observations and archive analysis are methods utilized to define the current state at CXDY. The current workways and processes are compared to the outspoken ones by the company. Also, the workways and processes are compared to the theory of project management, product development, Design for X methodology and management of knowledge. In the analysis, gaps are identified and the authors present their solutions to improve the NPD process at the Company XThe major findings in the proposed solution were a new approach of the Gateway process that; takes the Internal Customer into consideration, has clear definitions of roles and responsibilities and has a cross-functional team that represent the Internal Customer in order to encourage concurrent engineering.Due to confidentiality reasons some parts of this report are hidden.Keywords: New product development, Project management, Product Lifecycle, Concurrent engineering, Design for X, Management of knowledge. / Under senare år har kundernas efterfrågan på nya produkter ökat i takt med en snabb teknologisk utveckling. Detta har ställt krav på tillverkande företag att fokusera på produktutvecklingprojekt för att kontinuerligt leverera produkter som uppnår eller överträffar kunders förväntningar. Vidare måste produkterna vara lönsamma genom hela produktlivscykeln.För att kunna beakta hela produktlivscykeln i produktutvecklingsprojekt anses input med information och involvering från/av nedströmsfunktioner vara två kritiska faktorer för att säkerställa att lönsamma produkter utvecklas. I detta är informationen från andra funktioner med olika perspektiv, kunskaper och erfarenheter från tidigare produkter avgörande.Denna avhandling behandlar ovanstående tankar när ett stort multinationellt företag, Företag X. Produktutveckling i Företag X-koncernen följer Gateway-processen som släpptes på grupp-nivå under 2009. Denna process består av Gateways som inte kan godkännas om inte alla krav är uppfyllda i varje steg. Detta säkerställer att alla områden har behandlats och att produkter utvecklas effektivt.Intervjuer, observationer och arkivanalys är metoder som applicerats för att definiera det aktuella läget vid CXDY. De nuvarande arbetssätten och processerna jämförs med företagets uttalade. Arbetssätten och processerna jämförs vidare med teorin om projektledning, produktutveckling, Design för X-metodik och kunskapsförvaltning. I analysen identifieras luckor och författarna presenterar sina lösningar för att förbättra produktutvecklingsprojekten på CXDY.De viktigaste resultaten i den föreslagna lösningen var ett nytt tillvägagångssätt av Gateway-processen som; tar hänsyn till interna kunder, har tydliga definitioner av roller och ansvar och har ett tvärfunktionellt team som representerar den interna kunden för att främja Concurrent engineering.På grund av sekretesskäl har vissa delar av denna rapport gömts.Nyckelord: Produktutveckling, Projektledning, Produktlivscykel, Concurrent engineering, Design för X, Kunskapsförvaltning.

Skeletal muscle adapts differently to specific modes of exercise, where resistance training results in muscle growth and endurance training induces mitochondrial biogenesis. These are results of molecular events that occur after each exercise session, increasing the expression of specific genes and the rate of both synthesis and breakdown of protein. The rate of protein synthesis is controlled by the mTORC1 signaling pathway, which is potently stimulated by resistance exercise and amino acid, and their combined effect is needed for muscle growth. The essential amino acids (EAA) are responsible for the stimulation of protein synthesis and here leucine has been attributed specific attention, but its particular role among the EAA, and the involvement of the other branched-chain amino acids (BCAA) is unclear. Endurance exercise activates the protein AMPK which, in animal models, has been shown to inhibit mTORC1 signaling and protein synthesis.  Suggesting that concurrent endurance and resistance exercise could restrain muscle growth, but it is unknown if this mechanism is relevant in exercising human muscle. Little is known about the regulation of protein breakdown and although much attention has been given the proteins MuRF-1 and MAFbx which target proteins for degradation, their role requires further investigation. The aim of thesis was to address the mentioned uncertainties by examining how different modes of exercise and amino acids affect mTORC1 signaling, protein synthesis and markers of protein breakdown in human muscle. In study I, the influence of high intensity endurance exercise on subsequent resistance exercised induced mTORC1 signaling was examined. Despite robust activation of AMPK by the endurance exercise there was no inhibition of mTORC1 signaling or protein synthesis during recovery from resistance exercise. Study II utilized a similar set up, but with the difference that resistance exercise was performed with the triceps. The cycling exercise reduced the resistance exercise stimulated mTORC1 signaling immediately after the exercise, but during the recovery period mTORC1 signaling and protein synthesis was similar between trials. Concurrent exercise induced the mRNA expression of MuRF-1 and that of PGC-1α, the master regulator of mitochondrial biogenesis, in both studies, despite that the exercise modes in study II were separated between legs and arms. In study III, the effect of an EAA supplement with or without leucine, in the stimulation of mTORC1 signaling in connection with resistance exercise was examined. Intake of EAA robustly stimulated mTORC1 signaling after exercise, but this was only minor when leucine was excluded from the supplement. In study IV, subjects were supplied with leucine, BCAA, EAA or placebo in a randomized fashion during four sessions of resistance exercise. Leucine alone stimulated mTORC1 signaling after the exercise, but both the amplitude and extent of stimulation was substantially greater with EAA, an effect that was largely mediated by the BCAA as a group. In conclusion, endurance exercise prior to resistance exercise using the leg or arm muscles does not affect mTORC1 signaling or protein synthesis during the three hour recovery period from exercise, supporting compatibility between resistance- and endurance exercise induced signaling. Concurrent exercise increases the expression of the proteolytic marker MuRF-1 compared to resistance exercise only, which could indicate both and increased demand of cellular adaptive remodeling or a more direct detrimental proteolytic effect. Leucine is crucial among the EAA in the stimulation of mTORC1 signaling after exercise, its effect is however potentiated by intake of the remaining EAA. As a supplement a mixture of EAA must be regarded preferable, although the effect is largely mediated by the BCAA as a group.