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1	Vliv kritického stavu pacientů na poškození DNA / The influence of critical condition of patients on DNA damage Verešpejová, Natália January 2021 (has links) The first cases of patients with pneumonia which grew into an acute respiratory distress syndrome and caused breathing problems began to appear in December 2019. Coronavirus disease 2019 (COVID-19) is the cause of a global pandemic and it is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A complex interplay of factors is responsible for the progression of the disease. Some studies suggest that it promotes oxidative stress and thus may lead to oxidative damage to cells and DNA. The purpose of this study was to observe the relationship between oxidative DNA damage and a critical condition caused by COVID-19 using a comet assay technique. The basic principle of the used method consists in fixation of lymphocytes in an agarose gel, removal of the membrane and cytoplasm of cells, incubation with specific enzymes and electrophoresis. In the process of electrophoresis, negatively charged DNA fragments migrates towards the anode and the cell thus acquires the typical shape of a comet. Comets are visualized using the DNA intercalation dye ethidium bromide. We quantified single - strand breaks and oxidized pyrimidines and purines by using specific enzymes (modification of the method for detecting specific lesions). Results are reported as % tail DNA, thus the percentage of DNA in the...
2	Le statut du patient hospitalisé en établissement de santé privé / Patient hospitalized in private sector Alquier, Isabelle 17 June 2011 (has links) Le système de santé français repose sur une dichotomie publique-privée. Cette dualité juridique se retrouve dans l’offre de soins proposée aux patients qui disposent du libre choix de se faire hospitaliser aussi bien en établissement de santé public qu’en établissement de santé privé, l’hospitalisation privée devenant prépondérante en France. Pour le patient peu importe la structure d’hospitalisation, puisque les droits des patients étant des droits fondamentaux, pour certains constitutionnellement garantis, ce dernier doit bénéficier des mêmes droits quel que soit le lieu de son hospitalisation. Or les conséquences engendrées par la spécificité « privée » de l’établissement de santé amène à s’interroger sur une éventuelle disparité dans l’application des droits du patient, qui pourraient être à l’origine d’un statut propre au patient hospitalisé en établissement de santé privé. / The French healthcare system relies on a public-private dichotomy. This difference in legal status is reflected in the actual provision of healthcare, as patients have the right to choose their preferred type of hospitalization with private sector hospitalizations now becoming predominant in France. However, patients must be granted the same rights regardless of which type of hospital they have chosen, due to the fact that patients' rights are fundamental rights, and for some of them they are constitutionally guaranteed. The implications of the specific nature of private hospitals raise questions about a potential disparity in the application of patients' rights, which would result in a different status for patients entering private hospitals. Accès aux soins Condition du patient Contrat d’exercice Contrat d’hospitalisation Contrat médical Droits des patients Entreprise Établissement de santé Libre choix Malade Patient Public Privé Responsabilité Statut du patient Access to care Beneficiaries Company Healthcare System Health facility Hospital agreement Liability Patient Patient care agreement Patient choice “Patient's condition Patients' Rights Private Public Service agreement

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Vliv kritického stavu pacientů na poškození DNA / The influence of critical condition of patients on DNA damage

Le statut du patient hospitalisé en établissement de santé privé / Patient hospitalized in private sector