The first study researched turbulent forced convective heat (mass) transfer down- stream of blockages with round and elongated holes in a rectangular channel. The blockages and the channel had the same cross section, and a distance equal to twice the channel height separated consecutive blockages. Naphthalene sublimation experiments were conducted with four hole aspect ratios (hole-width-to-height ratios) and two hole-to-blockage area ratios (ratios of total hole cross-sectional area to blockage area). The effects of the hole aspect ratio, for each hole-to-blockage area ratio, on the local heat (mass) transfer distribution on the exposed primary channel wall between consecutive blockages were examined. Results showed that the blockages with holes enhanced the average heat (mass) transfer by up to 8.5 and 7.0 times that for fully developed turbulent flow through a smooth channel at the same mass flow rate, respectively, in the smaller and larger hole-to-blockage area ratio (or smaller and larger hole diameter) cases. The elongated holes caused a higher average heat (mass) transfer and a larger spanwise variation of the local heat (mass) transfer on the channel wall than did the round holes. The second study explored the heat transfer enhancement for pool boiling on nano-structured surfaces. Experiments were conducted with three horizontal silicon surfaces, two of which were coated with vertically aligned multi-walled carbon nanotubes (MWCNT) with heights of 9 and 25 ¹m, respectively, and diameters between 8 and 15 nm. The MWCNT arrays were synthesized on the two silicon wafers using chemical vapor deposition. Experimental results were obtained over the nucleate boiling and film boiling regimes under saturated and sub-cooled (5±C and 10±C) boiling conditions. PF-5060 was the test fluid. Results showed that the MWCNT array with a height of 25 ¹m enhanced the nucleate and film boiling heat fluxes on the silicon surface by up to 380% and 60%, respectively, under saturated boiling conditions, and by up to 300% and 80%, respectively, under 10±C sub-cooled boiling conditions, over corresponding heat fluxes on a smooth silicon surface. The MWCNT array with a height of 9 ¹m enhanced the nucleate boiling heat flux as much as the taller array, but did not significantly enhance the wall heat flux in the film boiling regime.

<p>In this thesis we apply linear feedback control to spatially evolving flows in order to minimize disturbance growth. The dynamics is assumed to be described by the linearized Navier--Stokes equations. Actuators and sensor are designed and a Kalman filtering technique is used to reconstruct the unknown flow state from noisy measurements. This reconstructed flow state is used to determine the control feedback which is applied to the Navier--Stokes equations through properly designed actuators. Since the control and estimation gains are obtained through an optimization process, and the Navier--Stokes equations typically forms a very high-dimensional system when discretized there is an interest in reducing the complexity of the equations. One possible approach is to perform Fourier decomposition along (almost) homogeneous spatial directions and another is by constructing a reduced order model by Galerkin projection on a suitable set of vectors. The first strategy is used to control the evolution of a range of instabilities in the classical family of Falkner--Skan--Cooke flows whereas the second is applied to a more complex cavity type of geometry.</p>

Cette thèse porte sur les effets combinés de l'excentricité et du débit axial sur les propriétés de stabilité linéaire de l'écoulement de Couette circulaire avec cylindre extérieur fixe. Cet écoulement intervient, entre autres, lors du forage de puits de pétrole. Une méthode pseudospectrale est mise en oeuvre pour calculer l'écoulement de base, stationnaire et invariant suivant la direction axiale, ainsi que les modes normaux d'instabilité. L'écoulement est régi par quatre paramètres adimensionnels : rapport de rayons _ et excentricité e pour la géométrie, nombres de Reynolds azimuthal et axial, Re et Rez, pour la dynamique. La première partie de l'étude est consacrée aux propriétés de stabilité temporelle. Il apparaît que l'excentricité repousse le seuil d'instabilité convective vers de plus fortes valeurs de Re. L'effet de l'advection axiale sur le seuil est principalement stabilisant également. L'excentricité a pour conséquence de déformer la structure des modes par rapport au cas concentrique. Le mode au plus fort taux de croissance temporelle est ainsi constitué de tourbillons de Taylor " pseudo-toroïdaux " lorsque le débit axial est nul, et de structures " pseudo-hélicoïdales " d'ordre azimuthal croissant lorsque Rez augmente. Les résultats sont qualitativement similaires lorsque l'on change le rapport de rayons. Les prédictions théoriques sont en bon accord avec les quelques résultats expérimentaux disponibles. Dans une seconde partie, l'instabilité absolue est étudiée par application d'un critère de point selle à la relation de dispersion. Le débit axial a pour effet d'inhiber fortement l'instabilité absolue, d'origine centrifuge, et la valeur de Re au seuil est typiquement supérieure à celle de Rez d'un ordre de grandeur. L'effet de l'excentricité est plus complexe : légère stabilisation aux faibles valeurs de e, puis déstabilisation marquée aux excentricités modérées lorsque Rez est suffisament grand, et enfin stabilisation lorsque e croît davantage. Contrairement au cas de l'instabilité convective, le mode dominant l'instabilité absolue correspond à l'écoulement tourbillonnaire " pseudo-toroïdal " pour toute la gamme de paramètres considérée.

Accurate values of thermophysical transport properties of particle beds are necessary to accurately model heat and mass transfer processes in particle beds that under-go preferred processes and changes. The objective of this study is to use a proven analytical/numerical methodology to estimate the unknown transport properties within test cells filled with silicagel particles and compare the results with the previously published data. An experimental test cell was designed and constructed to carry out transient heat transfer tests for both step change conduction and convection heat transfer within a packed bed of silicagel particles. For a known step change in the test cell temperature boundary condition, the temporal temperature distribution within the bed during heat conduction depends only on the effective heat conduction coefficient and the thermal capacity of the particle bed. The central problem is to, using only the boundary conditions and a few time-varying temperature sensors in the test cell of particles, determine the effective thermal conductivity of the test bed and specify the resulting measurement uncertainty. A similar problem occurs when the heat convection coefficient is sought after a step change in the airflow inlet temperature for the test cell. These types of problems are known as inverse heat transfer problems (IHTP). In this thesis, IHTP method was used to estimate the convective heat transfer coefficient. Good agreement was seen in experimental and numerical temperature profiles, which were modeled by using the estimated convective heat transfer coefficient. The same methodology was used to estimate the effective thermal conductivity of the particle bed. Comparison between the experimental temperature distribution and numerical temperature distribution, which was modeled by using the estimated effective conductivity, illustrated good agreement. On the other side, applying the effective thermal conductivity, obtained from a direct steady state measurement, in the numerical simulation could not present agreement between the numerical and experimental results. It was concluded that the IHTP methodology was a successful approach to find the thermophysical properties of the particle beds, which were hard to measure directly.

The molecular stress function model with convective constraint release (MSF with CCR) constitutive model [M.H. Wagner, P. Rubio, H. Bastian, The molecular stress function model for polydisperse polymer melts with dissipative convective constraint release, J. Rheol. 45 (2001) 1387] is capable of fitting all viscometric data for IUPAC LDPE, with only two adjustable parameters (with difference found only on reported ¿steady-state¿ elongational viscosities). The full MSF with CCR model is implemented in a backwards particle-tracking implementation, using an adaptive method for the computation of relative stretch that reduces simulation time many-fold, with insignificant loss of accuracy. The model is shown to give improved results over earlier versions of the MSF (without CCR) when compared to well-known experimental data from White and Kondo [J.L. White, A. Kondo, Flow patterns in polyethylene and polystyrene melts during extrusion through a die entry region: measurement and interpretation, J. Non-Newtonian Fluid Mech. 3 (1977) 41]; but still to under-predict contraction flow opening angles. The discrepancy is traced to the interaction between the rotational dissipative function and the large stretch levels caused by the contraction flow. A modified combination of dissipative functions in the constraint release mechanism is proposed, which aims to reduce this interaction to allow greater strain hardening in a mixed flow. The modified constraint release mechanism is shown to fit viscometric rheological data equally well, but to give opening angles in the complex contraction flow that are much closer to the experimental data from White and Kondo. It is shown (we believe for the first time) that a constitutive model demonstrates an accurate fit to all planar elongational, uniaxial elongational and shear viscometric data, with a simultaneous agreement with this well-known experimental opening angle data. The sensitivity of results to inaccuracies caused by representing the components of the deformation gradient tensor to finite precision is examined; results are found to be insensitive to even large reductions in the precision used for the representation of components. It is shown that two models that give identical response in elongational flow, and a very similar fit to available shear data, give significantly different results in flows containing a mix of deformation modes. The implication for constitutive models is that evaluation against mixed deformation mode flow data is desirable in addition to evaluation against viscometric measurements.

The rotating-disk boundary layer is not only a simpler model for the study of cross-flow instability than swept-wing boundary layers but also a useful simplification of many industrial-flow applications where rotating configurations are present. For the rotating disk, it has been suggested that a local absolute instability, leading to a global instability, is responsible for the small variation in the observed laminar-turbulent transition Reynolds number however the exact nature of the transition is still not fully understood. This thesis aims to clarify certain aspects of the transition process. Furthermore, the thesis considers the turbulent rotating-disk boundary layer, as an example of a class of three-dimensional turbulent boundary-layer flows. The rotating-disk boundary layer has been investigated in an experimental apparatus designed for low vibration levels and with a polished glass disk that gave a smooth surface. The apparatus provided a low-disturbance environment and velocity measurements of the azimuthal component were made with a single hot-wire probe. A new way to present data in the form of a probability density function (PDF) map of the azimuthal fluctuation velocity, which gives clear insights into the laminar-turbulent transition region, has been proposed. Measurements performed with various disk-edge conditions and edge Reynolds numbers showed that neither of these conditions a↵ect the transition process significantly, and the Reynolds number for the onset of transition was observed to be highly reproducible. Laminar-turbulent transition for a ‘clean’ disk was compared with that for a disk with roughness elements located upstream of the critical Reynolds number for absolute instability. This showed that, even with minute surface roughness elements, strong convectively unstable stationary disturbances were excited. In this case, breakdown of the flow occurred before reaching the absolutely unstable region, i.e. through a convectively unstable route. For the rough disk, the breakdown location was shown to depend on the amplitude of individual stationary vortices. In contrast, for the smooth (clean-disk) condition, the amplitude of the stationary vortices did not fix the breakdown location, which instead was fixed by a well-defined Reynolds number. Furthermore, for the clean-disk case, travelling disturbances have been observed at the onset of nonlinearity, and the associated disturbance profile is in good agreement with the eigenfunction of the critical absolute instability. Finally, the turbulent boundary layer on the rotating disk has been investigated. The azimuthal friction velocity was directly measured from the azimuthal velocity profile in the viscous sublayer and the velocity statistics, normalized by the inner scale, are presented. The characteristics of this three-dimensional turbulent boundary-layer flow have been compared with those for the two-dimensional flow over a flat plate and close to the wall they are found to be quite similar but with rather large differences in the outer region. / <p>QC 20150119</p>

A measurement-based reduced-order heat transfer modeling framework is developed to optimize cooling costs of dynamic and virtualized data centers. The reduced-order model is based on a proper orthogonal decomposition-based model order reduction technique. For data center heat transfer modeling, the framework simulates air temperatures and CPU temperatures as a parametric response surface with different cooling infrastructure design variables as the input parameters. The parametric framework enables an efficient design optimization tool and is used to solve several important problems related to energy-efficient thermal design of data centers. The first of these problems is about determining optimal response time during emergencies such as power outages in data centers. To solve this problem, transient air temperatures are modeled with time as a parameter. This parametric prediction framework is useful as a near-real-time thermal prognostic tool. The second problem pertains to reducing temperature monitoring cost in data centers. To solve this problem, transient air temperatures are modeled with spatial location as the parameter. This parametric model improves spatial resolution of measured temperature data and thereby reduces sensor requisition for transient temperature monitoring in data centers. The third problem is related to determining optimal cooling set points in response to dynamically-evolving heat loads in a data center. To solve this problem, transient air temperatures are modeled with heat load and time as the parameters. This modeling framework is particularly suitable for life-cycle design of data center cooling infrastructure. The last problem is related to determining optimal cooling set points in response to dynamically-evolving computing workload in a virtualized data center. To solve this problem, transient CPU temperatures under a given computing load profile are modeled with cooling resource set-points as the parameters.

In this thesis, natural convective heat transfer through an impermeable and fluid saturated porous medium is investigated numerically. A FORTRAN based code is developed and used in order to present the outputs of the applied model and the assumptions. The solutions of flow fields and temperature fields are presented within the medium. Moreover, Nusselt number variations for different values of Darcy, Prandtl, and Rayleigh numbers, and some other thermodynamic properties are investigated and presented. Comparisons with previous studies are also presented. Finally, the transition from convection to conduction in the heat transfer regime inside the porous medium is examined and an equation for estimating the heat transfer inside the porous medium is presented.

First part of the thesis introduces possibilities of depicting of the data provided by the MSG (Meteosat Second Generation) satellite. Different color combinations (RGB - red, green, blue) description made by the basic channels combination follows. The main part of this thesis is focused on T-re profiles (T - temperature, re - effective cloud particle radius). The analysis of profiles of temperature versus the effective radius of cloud particles shows the vertical distribution of the effective particle size in clouds. The profiles are computed and constructed from the satellite retrieved data and they show graphically the distribution of cloud particles and indirectly represent the severity of the developing storms. Forecasting and predicting dangerous phenomena such as hailstorms or tornados that occur in severe storms is the main objective of the technique. This nowcasting tool was tested in Central Europe and the end of this thesis presents the results of the testing.

Les gliomes de haut-grades sont des les tumeurs primitives les plus fréquentes du système nerveux central. Le traitement de cette pathologie associe chirurgie, radiothérapie et chimiothérapie. Les principales faiblesses de ces traitements sont le caractère infiltrant de la tumeur au sein d’un parenchyme hautement fonctionnel, l’existence de la barrière hémato-encéphalique limitant le passage trans-vasculaire de la chimiothérapie et la radiorésistance naturelle des cellules gliomateuses.Parmi les stratégies proposées pour outre-passer cette barrière hémato-encéphalique, une injection directe au sein du parenchyme a été évoquée. Afin d’optimiser cette délivrance le concept d’infusion convective a été développé, il s’agit d’une injection intra-parenchymateuse à un débit lent et contrôlé.Le bevacizumab est un anticorps dirigé contre le VEGF-A, un des principaux facteurs angiogéniques. Le but de ce traitement est de lutter contre l’ angiogénèse et de freiner la croissance tumorale.Dans un premier temps, la pharmacocinétique d’une injection intracérébrale de bevacizumab a été étudiée en comparaison avec une administration systémique plus classique. Les résultats permettent de mettre en évidence une concentration locale équivalente avec des concentrations systémiques beaucoup plus faibles avec une injection intra-tumorale. Un point important de cette étude est que la concentration dans l’hémisphère controlatéral à l’injection est aussi importante que lors d’une injection systémique.Puis l’efficacité d’une injection intratumorale de bevacizumab a été comparée à un traitement systémique sur un modèle de gliome chez la souris. L’efficacité du traitement est claire sur la survie de l’animal avec un avantage pour une injection intratumorale par rapport à une injection systémique. D’un point de vue microscopique cet avantage de survie peut être corrélé à une angiogénèse et une prolifération tumorale moins importante an cas d’injection directe au sein de la tumeur.Contrairement aux études pré-cliniques chez les rongeurs, les principaux essais cliniques n’ont pas permis de mettre en évidence un avantage d’une injection intra-tumorale directe. Principalement du à une mauvaise délivrance liée à des fuites et des reflux. Une des limites du modèle petit animal est l’absence de sillon cortical, vecteur de fuite. Le développement d’un modèle de gliome anatomiquement pertinent permettrait de simuler au mieux ces fuites et simultanément la mise au point de technologies de délivrance implantable à l’échelle humaine. Nous avons donc développé le premier modèle de gliome chez le porc. L’immunotolérance a été induite par un traitement par ciclosporine, des cellules de gliomes humains U87 et G6 ont été implantés, permettant se développer des tumeurs.Afin de dépister une mauvaise délivrance et anticiper les fuites ou les reflux, nous avons étudié les profils de pression le long de la ligne d’injection corrélés à l’existence de fuites ou de reflux. Nous avons pu identifier un profil pressionnel typique d’une injection de qualité. Les injections ne répondant pas à ces critères ont systématiquement conduits à des fuites ou reflux.L’étape suivante a été l’injection au sein d’une tumeur chez des porcs grâce à un système innovant implanté. Cette injection a été possible sans complication infectieuse avec une bonne tolérance locale et neurologique.La dernière étape de ce travail est l’étude anatomique de la diffusion d’un colorant injecté par une technique d’infusion convective. Cette étude s’intéressait notamment à la diffusion depuis la corona-radiata vers les différentes voies de substance blanche. La diffusion est anisotrope le long des fibres de substance blanche cependant la diffusion suit des voies différentes en fonction de la position du cathéter par rapport à elle. L’injection semble ouvrir des voies d’impédances rhéologiques faibles préférentielles nécessitant une adaptation anatomique aux voies qui seront la cible du traitement. / High grade gliomas are the most frequent primitive central nervous system tumor. The standard treatment is an association of surgery, radiotherapy and chemotherapy. The mains issues with these treatments are the infiltrative properties of the tumour in a highly functional parenchyma, the blood-brain barrier limiting the transvascular transport of chemotherapy and the inherent radioresistance of glioma cells.Upon different strategy to overpass the blood-brain barrier, a direct injection in the brain was advocated. In order to maximize this delivery, the concept of convection enhanced delivery was developed; it consists in a direct injection in the parenchyma with a low flow-rate.Bevacizumab is an anti-VEGF A antibody, VEGF is one of the most important angiogenic factors. The goal of this treatment is to inhibit the angiogenesis and slow down the tumor growth.We propose to study the use of this antibody in a direct intra-cerebral infusion.First, we focalize on the pharmacokinetic properties of an intratumoral injection by convection –enhanced delivery compared to a systemic administration. This shows an equivalent intratumoral concentration with systemic concentrations significantly lower with the intra-tumoral injection. An important result is the similar concentration in the controlateral hemisphere with the two routes of infusion. Convection-enhanced delivery is suitable to carry far from the infusion site high molecular weight proteins. An intra-tumoral bevacizumab may theoretically provide similar efficiency with less systemic side-effect.Then, the efficiency of an intra-tumoral infusion of bevacizumab is compared to a systemic injection on a mouse glioma model. In terms of survival the intra-tumoral treatment is significantly more efficient with an important decrease of angiogenesis and tumoral proliferation.If convection-enhanced delivery rodent study were promising, clinical trials failed to show any efficiency of intra-tumoral injection mainly due to inadequate delivery secondary to backflows and leakages. One of the limits of the rodent model is the absence of cortical sulci, main leakage provider. The development of a model anatomically relevant could simulate real conditions of injection and develop implantable device of injection in realistic conditions. We have developed the first induced model of glioma in a large animal. We choose the pig for the similarity of its brain anatomy and its size. The animals have been treated with ciclosporin to induce an immunosuppression, human glioma cells have been implanted, leading to the development of brain tumor.We have studied the pressure on the infusion line and correlate it to backflow and leakage. We have identified a pattern of pressure for successful infusion. Different pressure pattern have systematically led to backflow or leakage. These pressures criteria could permit to us an early detection of inadequate infusion to replace the catheter and avoid the failure of precedent clinical trials.Next step have been the intra-tumoral injection via an implanted device on pig glioma model. No infectious complication has been related with a good local and neurologic tolerance. The injections have led to a relevant diffusion through the tumor with a rapid flow to the periphery due to the interstitial pressure gradient between the tumor and the periphery.Last step of this work have been the anatomical study of a dye distribution by convection-enhanced delivery in a human encephalon. Indeed if pig brain is similar to human brain, human white matter structure is unique. This work is focalized on the diffusion from the corona-radiata to the main white matter tracts. The distribution is anisotropic following white matter but the diffusion is different depending on the position of the catheter. The infusion seems to open low rheological impedance paths the position of the catheter have to be adapted to the white matter tract to target.