Schizophrenia is a complex and severe psychiatric disorder with positive symptoms, negative symptoms and cognitive deficits. Preclinical neurobiological studies showed that alterations of dopaminergic and glutamatergic neurotransmitter circuits involving the prefrontal cortex resulted in cognitive impairment such as working memory. Functional activation and functional connectivity findings of functional Magnetic Resonance Imaging (fMRI) data provided support for prefrontal dysfunction during fMRI working memory tasks in individuals with schizophrenia. However, these findings do not offer a neurobiological interpretation of the fMRI data. Biophysical modelling of functional large-scale networks has been designed for the analysis of fMRI data, which can be interpreted in a mechanistic way. This approach may enable the interpretation of fMRI data in terms of altered synaptic plasticity processes found in schizophrenia. One such process is gating mechanism, which has been shown to be altered for the thalamo-cortical and meso-cortical connection in schizophrenia. The primary aim of the thesis was to investigate altered synaptic plasticity and gating mechanisms with Dynamic Causal Modelling (DCM) within functional large-scale networks during two fMRI tasks in individuals with schizophrenia. Applying nonlinear DCM to the verbal fluency fMRI task of the Edinburgh High Risk Study, we showed that the connection strengths with nonlinear modulation for the thalamo-cortical connection was reduced in subjects at high familial risk of schizophrenia when compared to healthy controls. These results suggest that nonlinear DCM enables the investigation of altered synaptic plasticity and gating mechanism from fMRI data. For the Scottish Family Mental Health Study, we reported two different optimal linear models for individuals with established schizophrenia (EST) and healthy controls during working memory function. We suggested that this result may indicate that EST and healthy controls used different functional large-scale networks. The results of nonlinear DCM analyses may suggest that gating mechanism was intact in EST and healthy controls. In conclusion, the results presented in this thesis give evidence for the role of synaptic plasticity processes as assessed in functional large-scale networks during cognitive tasks in individuals with schizophrenia.

No description available.

No / The published literature on dementia care mapping (DCM) in improving quality of life and quality of care through practice development and research dates back to 1993. The purpose of this review of the research literature is to answer some key questions about the nature of the tool and its efficacy, to inform the ongoing revision of the tool, and to set an agenda for future research. Design and Methods: The DCM bibliographic database at the University of Bradford in the United Kingdom contains all publications known on DCM (http://www.bradford.ac.uk/acad/health/dcm). This formed the basis of the review. Texts that specifically examined the efficacy of DCM or in which DCM was used as a main measure in the evaluation or research were reviewed. Results: Thirty-four papers were categorized into five main types: (a) cross-sectional surveys, (b) evaluations of interventions, (c) practice development evaluations, (d) multimethod evaluations, and (e) papers investigating the psychometric properties of DCM.

Power Factor Correction rectifiers are widely adopted as the first stage in most grid-tied power conversion systems. Among all PFC converts for single phase system, Boost PFC is the most popular one due to simplicity of structure and high performance. Although the efficiency of Boost PFC keeps increasing with the evolution of semiconductor technology, the intrinsic feature of high output voltage may result cumbersome system structure with multiple power conversion stages and even diminished system efficiency. This disadvantage is aggravated especially in systems where resonant converters are selected as second stage. Especially for domestic induction cooker application, step-down PFC with wide range output regulation capability would be a reasonable solution, Conventional induction cooker is composed by input filter, diode-bridge rectifier, and full bridge or half bridge series resonant circuit (SRC). High frequency magnetic field is induced through the switching action to heat the pan. The power level is usually controlled through pulse frequency modulation (PFM). In such configuration, first, a bulky input differential filter is required to filter out the high frequency operating current in SRC. Second, as the output power decreases, the operating point of SRC is moved away from the optimum point, which would result large amount circulating energy. Third, when the pan is made of well conducting and non-ferromagnetic material such as aluminum, due to the heating resistance become much smaller and peak output voltage of the switching bridge equals to the peak voltage of the grid, operating the SRC at the series resonant frequency can result excessive current flowing through the switch and the heating coil. Thus for pan with smaller heating resistance, even at maximum power, the operating frequency is pushed further away from the series resonant point, which also results efficiency loss. To address these potential issues, a PFC circuit features continuous conducting input current, high power factor, step-down capability and wide range output regulation would be preferred. The Analysis and design work is present in this article for a non-isolated hard switching DCM SEPIC PFC. Due to DCM operation of SPEIC converter, wide adjustable step-down output voltage, continuous conduction of input current and elimination of reverse recovery loss can be achieved at same time. The thesis begins with circuit operation analysis for both DC-DC and PFC operation. Based on averaged switching model, small signal model and corresponding transfer functions are derived. Especially, the impact from small intermediate capacitor on steady state value are discussed. With the concept of ripple steering, theoretic analysis is applied to SEPIC converter with two coupled inductors. The results indicate if the coupling coefficient is well designed, the equivalent input inductance can be multiple times larger than the self-inductance. Because of this, while maintaining input current ripple same, the two inductors of SEPIC can be implemented with two smaller coupled inductors. Thus both the total volume of inductors and the total number of windings can be reduced, and the power density and efficiency can be improved. Based on magnetic reluctance model, a corresponding winding scheme to control the coupling coefficient between two coupled inductors is analyzed. Also the impact of coupled inductors on the small signal transfer function is discussed. For the voltage follower control scheme of DCM PFC, single loop controller and notch filter design are discussed. With properly designed notch filter or the PR controller in another word, the closed loop bandwidth can be increased; simple PI controller is sufficient to achieve high power factor; THD of the input current can be greatly reduced. Finally, to validate the analysis and design procedure, a 1 kW prototype is built. With 120 Vrms AC input, 60V to 100V output, experimental results demonstrate unity power factor, wide output voltage regulation can be achieved within a single stage, and the 1 kW efficiency is around 93%. / Master of Science

No description available.

<p>an Internal Navigational System and a Global Navigational Satellite System (GNSS). In navigational warfare the GNSS can be jammed, therefore are a third navigational system is needed. The system that has been tried in this thesis is camera based navigation. Through a video camera and a sensor reference the position is determined. This thesis will process the matching between the sensor reference and the video image.</p><p>Two methods have been implemented: normalized cross correlation and position determination through a homography. Normalized cross correlation creates a correlation matrix. The other method uses point correspondences between the images to determine a homography between the images. And through the homography obtain a position. The more point correspondences the better the position determination will be.</p><p>The results have been quite good. The methods have got the right position when the Euler angles of the UAV have been known. Normalized cross correlation has been the best method of the tested methods.</p>

<p>In this thesis a predefined design parameters are used to present theoretical guidelines for design of low voltage, and low power DC-DC converter with high power efficiency and low levels of EMI (Electro-Magnetic Interference). This converter is used to alter the DC voltage supplied by the power source. Several DC-DC converters of different types and topologies are described and analyzed. Switched converter of buck topology is found to satisfy the design criteria most adequately and therefore is chosen as the solution for the task of the thesis. Three control schemes are analysed PWM (Pulse-Width Modulation), PFM (Phase-Frequency Modulation), and Sliding control. PWM is found to be most appropriate for implementation with this type of converter. Further, basic operation of the buck converter which includes two modes of operation CCM (Continuous-Conduction Mode) and DCM (Discontinuous-Conduction Mode) is described. Power losses associated with it are analysed as well. Finally several techniques for power conversion improvement are presented.</p>

<p>The study introduces and puts forward Sector Policing as a model to expand community Policing and to broaden the scope of crime prevention. It also demonstrates how Sector Policing can be utilised to decentralise policing and deepen community participation.</p>

In this thesis a predefined design parameters are used to present theoretical guidelines for design of low voltage, and low power DC-DC converter with high power efficiency and low levels of EMI (Electro-Magnetic Interference). This converter is used to alter the DC voltage supplied by the power source. Several DC-DC converters of different types and topologies are described and analyzed. Switched converter of buck topology is found to satisfy the design criteria most adequately and therefore is chosen as the solution for the task of the thesis. Three control schemes are analysed PWM (Pulse-Width Modulation), PFM (Phase-Frequency Modulation), and Sliding control. PWM is found to be most appropriate for implementation with this type of converter. Further, basic operation of the buck converter which includes two modes of operation CCM (Continuous-Conduction Mode) and DCM (Discontinuous-Conduction Mode) is described. Power losses associated with it are analysed as well. Finally several techniques for power conversion improvement are presented.

We hypothesized that alterations in cardiac myofilaments are associated with hereditary canine DCM. DCM myofilaments demonstrated a reduction in EC50 and a modest decrease in maximum activity compared to non-failing dog samples. Treatment of myofilaments with the calcium sensitizer, bepridil, showed a reduction in EC50. Desmin and tropomyosin phosphorylation was increased in DCM. Desmin protein levels were increased in DCM. Total troponin I phosphorylation was unchanged, but S23/S24 phosphorylation was reduced in DCM. Myofilament-associated PKC-δ and -ζ were elevated in DCM, PKC- ε was modestly reduced, and PKC-α showed no change. These data are the first investigation of cardiac myofilaments in naturally occurring canine DCM, and support the hypothesis that alterations in cardiac myofilaments are associated with DCM. / OVC Pet Trust (operating funds)