Context: Chat applications have been around since the beginning of the modern internet. Today, there are many different chat systems with various communication solutions, but only a few utilize the fully decentralized Peer-to-Peer concept. Objectives: In this report, we want to investigate to see if a fully decentralized P2P concept is a suitable choice for chat applications. In order to investigate, a P2P architecture was selected and a simulation was implemented in Java. The simulation was used to make a performance evaluation in order see if the P2P concept could meet the requirements of a chat application, and to identify problems and difficulties. Methods: Two main methods were used in this thesis. First, a qualitative design method was used to identify and discuss different possibilities of designing a distributed chat application. Second, a performance evaluation was conducted to verify the selected and implemented mechanisms are able to obtain their general performance capabilities and to tune them towards anticipated performance. Results: The simulation proved that a decentralized P2P system can scale and find resources in a network quite efficiently without the need of any centralized service. It also proved to be simpler for the user to use the P2P concept, as no special configurations are needed. However, the selected protocol (Chord) had problems with high rates of churn, which could cause problems in big chat environments. The P2P concept was also shown to be highly complex to implement. Conclusion: P2P technology is a more complex technology, but it gives the host a lower cost in terms of hardware and maintenance. It also makes the system more robust and fault-tolerant. As we have seen in this report, P2P can scale and find other resources efficiently without the need of a centralized service. However, it will consume more power for each user, which makes mobile devices bad peers.

This research focuses on the redesign of trust and reputation algorithms in the context of hierarchically structured Peer-to-Peer (P2P) networks with Chord, a scalable P2P lookup service for Internet applications. Chord, which is an open source project, is an overlay network based on a distributed hash table(DHT), and all peers in Chord are arranged around a circle. In this work, we propose four adapted trust and reputation algorithms for hierarchically structured P2P networks: EigenTrust, PowerTrust, Absolute Trust and NodeRanking. EigenTrust is one of the most well-known trust and reputation algorithms, as well as the most simple. To calculate the reputation, EigenTrust needs to normalize trust and rely on pre-trusted peers. Like EigenTrust, PowerTrust relies on feedback and the use of a distributed ranking mechanism. It chooses a limited number of power nodes with a high reputation. By combining a random walk strategy and the power nodes, it improves accuracy of global reputation. AbsoluteTrust does not require normalization of trust, pretrusted peers or any centralized authority. Weighted average combined with feedback from peers is employed to determine trust. NodeRanking relies on both individual reputation and social relationship to compute the trust value. NodeRanking evaluates reputation using local information. A node's reputation value can be readily determined by the number of references from other nodes in the network. These adapted algorithms are capable of handling a huge number of nodes disseminated in different rings, which improves complexity and reduces the number of malicious nodes in a hierarchical context. Furthermore, we describe the components of the hierarchical model architecture and present and discuss the results from the experiments. These experiments are employed to verify and compare reduction of downloads from malicious peers, load distribution and residual curl in at structured networks and in hierarchically structured networks.

Machine-to-machine (M2M) communications is a field of research expected to grow in the following years. New business opportunities arise in this area, for instance the 50 Billion Project and the Future Internet Project at Ericsson. Thus new protocols and architectures need to be defined for the different scenarios where this technology is applicable. At the same time well known structured P2P networks, for instance by means of a Distributed Hash Table (DHT), present great synergy possibilities with M2M, in particular in the Wireless Sensor Networks (WSN) Area. M2M scenarios in which sensors become more autonomous and self-reliant, independent from a centralized decision-making entity can benefit from the use of DHTs. This thesis aims at adapting current DHT (Distributed Hash Table) procedures to a M2M (Machine-to-Machine) environment. Moreover it will consist on implementing a layer for M2M communication on top of an existing DHT. We analyze the state of the art in both sensor and P2P technologies. Based on that, we explain the motivations to create such a layer and the its benefits. Following the design we implement a fully working prototype and prepare some use case scenarios. Finally, we draw conclusions from the experience and trace future paths of research for our project.

Wireless sensor networks (WSNs) have been an increasingly interest for both researchers and entrepreneurs. As WSN technologies gradually matured and more and more use is reported, we find that most of current WSNs are still designed only for specific purposes. For example, one WSN may be used to gather information from a field and the collected data is not shared with other parties. We propose a distributed hash table (DHT) based machine-to-machine (M2M) system for connecting different WSNs together in order to fully utilize information collected from currently available WSNs. This thesis specifically looks at how to design and implement a proxy for such a system. We discuss why such a proxy can be useful for DHT-based M2M systems, what the proxy should consist of, and what kind of architecture is suitable. We also look into different communication protocols that can be used in these systems and discuss which ones best suit our purposes. The design of the proxy focuses on network management and service discovery of WSNs, and security considerations as well as caching mechanisms in order to improve performance. A prototype is implemented based on our design and evaluated. We find it feasible to implement such a DHT-based M2M system and a proxy in the system can be necessary and useful. Finally, we draw conclusions and discuss what future work remains to be done.

Grooming behavior in rats has so far been known to be induced mainly by dopamine agonists type D1. In order to explore the involvement of serotonine (5-HT) and its receptors in such a behavior, rats were exposed to two phases of treatment: to the serotonin neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), injected intraventricularly three days after birth, and to the serotonin partial agonist m-chlorophenylpiperazine (mCPP), administered in two dose levels, two months later. Grooming behavior was monitored immediately before and after the higher dose of mCPP, while brain levels of 5-HT and its major metabolite 5-HIAA were assayed one week after mCPP administration. It is documented that while a low dose of mCPP in the non-lesioned rats increased the grooming-time by 5.7-fold, the higher mCPP dose in the non-lesioned non-primed rats increased grooming behavior by 3.6-fold. The 5,7-DHT lesions caused a 6.7-fold increase in the non-primed rats, and a 4.2-fold increase in the primed ones. These increases were noticeable only in male rats. When a higher dose of mCPP followed its lower dose in the 5,7-DHT-lesioned rats, a 3.6-fold decrease was recorded only in the female rats. A 88% and 94% drop in 5-HT and 5-HIAA levels in the brain neostriatum of the 5,7-DHT-lesioned rats was noticed in both sexes, one week after mCPP administration. These findings are the first to demonstrate that the 5-HT2 partial agonist mCPP is capable of modifying grooming behavior, and that 5,7,-DHT brain lesions increase basal grooming time, suggesting that 5-HT neurons and receptors are involved in grooming behavior in rats.

The aim of this study was to determine histamine content in the brain and the effect of histamine receptor antagonists on behavior of adult rats lesioned as neonates with the serotonin (5-HT) neurotoxin 5,7-dihydroxytryptamine (5,7-DHT). At 3 days after birth Wistar rats were pretreated with desipramine (20 mg/kg ip) before bilateral icv administration of 5,7-DHT (37.5 μg base on each side) or saline-ascorbic (0.1%) vehicle (control). At 10 week levels of 5-HT and its metabolite 5-hydroxyindole acetic acid (5-HIAA) were determined in frontal cortex, striatum, and hippocampus by an HPLC/ED technique. In the hypothalamus, frontal cortex, hippocampus and medulla oblongata, the level of histamine was analyzed by an immunoenzymatic method. Behavioral observations (locomotion, exploratory-, oral-, and stereotyped activity) were performed, and effects of DA receptor agonists (SKF 38393, apomorphine) and histamine receptor antagonists S(+)chlorpheniramine (H1), cimetidine (H2), and thioperamide (H3) were determined. We confirmed that 5,7-DHT profoundly reduced contents of 5-HT and 5-HIAA in the brain in adulthood. Histamine content was also reduced in all examined brain regions. Moreover, in 5,7-DHT-lesioned rats the locomotor and oral activity responses to thioperamide were altered, and apomorphineinduced stereotype was intensified. From the above, we conclude that an intact central serotoninergic system modulates histamine H3 receptor antagonist effects on the dopaminergic neurons in rats.

As a first attempt at exploring an association between histaminergic and serotoninergic neuronal phenotypes in glucose regulation, the influence of the histamine H 3 receptor antagonist thioperamide on glucose uptake by brain was determined in rats in which the serotoninergic innervations of brain was largely destroyed perinatally. Male Wistar rats were initially treated on the 3rd day after birth with the serotoninergic neurotoxin 5,7- dihydroxytryptamine (5,7-DHT) (75 μg icv) or saline vehicle (10 μl icv). At 8 weeks lesioned and control rats were terminated in order to validate the effectiveness of 5,7-DHT: reduction in 5-HT and 5-HIAA by 83-91% and 69-83% in striatum, frontal cortex, and hippocampus (HPLC/ED method). Other groups of rats were pretreated with thioperamide (5.0 mg/kg ip) or saline vehicle 60 min prior to 6-[ 3 H]-D-glucose (500 μCi/kg ip). Fifteen-min later rats were decapitated and brains were excised and dissected to remove frontal cortex, striatum, hippocampus, thalamus/hypothalamus, pons, and cerebellum. Liquid scintillation spectroscopy was used to determine that [ 3 H]glucose uptake, which was enhanced in 5,7-DHT lesioned rats in cortex (by 88%), hippocampus, thalamus/hypothalamus, pons and cerebellum (each by 47-56%), and in striatum (by 35%). In contrast, thioperamide prevented the enhancement in [ 3 H]glucose uptake in all brain regions of 5,7-DHT neonatally lesioned rats; and [ 3 H]glucose levels were significantly different in all brain regions (except thalamus/hypothalamus) in thioperamide-versus saline-treated rats. These findings indicate a functional association between histaminergic and serotoninergic systems in brain in relation to glucose regulation.

To assess the possible modulatory effects of noradrenergic and serotoninergic neurons on dopaminergic neuronal activity, the noradrenergic and serotoninergic neurotoxins DSP-4 N-(2-chlorethyl)-N-ethyl-2-bromobenzylamine (50.0 mg/kg, sc) and 5,7- dihydroxytryptamine (5,7-DHT) (37.5 μg icv, half in each lateral ventricle), respectively, were administered to Wistar rats on the first and third days of postnatal ontogeny, and dopamine (DA) agonist-induced behaviors were assessed in adulthood. At eight weeks, using an HPLC/ED technique, DSP-4 treatment was associated with a reduction in NE content of the corpus striatum (> 60%), hippocampus (95%), and frontal cortex (> 85%), while 5,7-DHT was associated with an 80-90% serotonin reduction in the same brain regions. DA content was unaltered in the striatum and the cortex. In the group lesioned with both DSP-4 and 5,7-DHT, quinpirole-induced (DA D2-agonist-agonist) yawning, 7-hydroxy-DPAT-induced (DA D3 agonist) yawning, and apomorphine-induced (non-selective DA agonist) stereotypies were enhanced. However, SKF 38393-induced (DA D1 agonist) oral activity was reduced in the DSP-4 + 5,7-DHT group. These findings demonstrate that DA D2- and D3-agonist-induced behaviors are enhanced while DA D1-agonist-induced behaviors are suppressed in adult rats in which brain noradrenergic and serotoninergic innervation of the brain has largely been destroyed. This study indicates that noradrenergic and serotoninergic neurons have a great impact on the development of DA receptor reactivity (sensitivity).

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