The knowledge of blood vessel biomechanics is used for understanding and developing treatments for cardiovascular disease. The objective of this project was to develop an experimental protocol, for education and research, that separates active diameter response from the passive, as a function of the intraluminal pressure in a pressure myograph. The design process was performed in three steps. First the protocol was designed for an artificial vessel and then expanded to include passive properties of blood vessels, finally further developments needed to analyze active blood vessels were suggested. The system was built as a pressure myograph containing a vessel chamber where the vessel was mounted on two cannulas, two pressure sensors for calculating the intraluminal pressure, and one microscope equipped with a camera for diameter observations. Reference data for the artificial vessel material was acquired from a uniaxial tensile test. The results was in the form of stress-stretch relations. Both the results from the artificial vessel and the passive blood vessel was in a acceptable reference range. The results indicate that the experimental protocol can be used for testing passive properties of both artificial vessels and small blood vessels. No results were obtained for active blood vessels, thus the experimental protocol can not be used for separating the active response to diameter change of blood vessels. However, further developments of the experimental protocol are discussed. / Kunskap om blodkärlens biomekanik används för att förstå och utveckla behandlingsmetoder mot hjärt- och kärlsjukdomar. Syftet med det här projektet var att utveckla ett experiment som mäter små blodkärls diameter och vätsketryck in vitro. Experimentet skulle sedan separera det aktiva muskelbidraget till diameterförändring från det passiva bidraget. Genom att göra detta kan kunskapen om biomekaniken hos blodkärl utvecklas inom såväl forskning som utbildning. Experimentet utvecklades i tre steg. Först utvecklades det för artificiella blodkärl och anpassades sedan för passiva blodkärl. Slutligen diskuteras vidareutvecklingar av experimentet gällande de aktiva egenskaperna för blodkärl. Experimentet utformades genom att ett kärl placerades i en kammare. Blodkärlet fästes i vardera ände på varsin kanyl som var kopplade till trycksensorer. För att registrera diametern placerades kammaren under ett kameramikroskop. Resultatet består av spänning-sträcknings diagram. Både resultatet för det artificiella blodkärlet och det passiva blodkärlet var inom ett godkänt referensintervall. Dessa resultat stödjer antagandet att experimentet kan användas för att studera passiva egenskaper av artificiella och verkliga blodkärl med storlek mellan 1.9-4.4 mm i ytterdiameter. Ingen mätdata från aktiva blodkärl kunde samlas in, utan utvecklingskrav på systemet för hantering av aktiva blodkärl har föreslagits.

In previous studies it was determined that the fiber diameter distribution in a peripheral nerve could be estimated by a simulation technique known as group delay. These results could be further improved using a combinatorial optimization algorithm called simulated annealing. This paper explores the structure and behavior of simulated annealing for the application of optimizing the group delay estimated fiber diameter distribution. Specifically, a set of parameters known as the cooling schedule is investigated to determine its effectiveness in the optimization process. Simulated annealing is a technique for finding the global minimum (or maximum) of a cost function which may have many local minima. The set of parameters which comprise the cooling schedule dictate the rate at which simulated annealing reaches its final solution. Converging too quickly can result in sub-optimal solutions while taking too long to determine a solution can result in an unnecessarily large computational effort that would be impractical in a real-world setting. The goal of this study is to minimize the computational effort of simulated annealing without sacrificing its effectiveness at minimizing the cost function. The cost function for this application is an error value computed as the difference in the maximum compound evoked potentials between an empirically-determined template distribution of fiber diameters and an optimized set of fiber diameters. The resulting information will be useful when developing the group delay estimation and subsequent simulated annealing optimization in an experimental laboratory setting.

Peripheral neuropathy refers to diseases of or injuries to the peripheral nerves in the human body. The damage can interfere with the vital connection between the central nervous system and other parts of the body, and can significantly reduce the quality of life of those affected. In the US, approximately between 15 and 20 million people over the age of 40 have some forms of peripheral neuropathy. The diagnosis of peripheral neuropathy often requires an invasive operation such as a biopsy because different forms of peripheral neuropathy can affect different types of nerve fibers. There are non-invasive methods available to diagnose peripheral neuropathy such as the nerve conduction velocity test (NCV). Although the NCV is useful to test the viability of an entire nerve trunk, it does not provide adequate information about the individual functioning nerve fibers in the nerve trunk to differentiate between the different forms of peripheral neuropathy. A novel technique was proposed to estimate the individual nerve fiber diameters using group delay and simulated annealing optimization. However, this technique assumed that the fiber depth is always constant at 1 mm and the fiber activation due to a stimulus is depth independent. This study aims to incorporate the effect of fiber depth into the fiber diameter estimation technique and to make the simulation more realistic, as well as to move a step closer to making this technique a viable diagnostic tool. From the simulation data, this study found that changing the assumption of the fiber depth significantly impacts the accuracy of the fiber diameter estimation. The results suggest that the accuracy of the fiber diameter estimation is dependent on whether the type of activation function is depth dependent or not, and whether the template fiber diameter distribution contains mostly large fibers or both small and large fibers, but not dependent on whether the fiber depth is constant or variable.

The conversion of red oak small diameter timber (SDT) into solid wood products was investigated. The objectives of this research were to 1) determine the yield of lumber, pallet and container parts, and residues from SDT and the market potential for these products; 2) determine the economic feasibility of a SDT sawmill and pallet part mill located in Southwest Virginia; 3) develop a business plan for a SDT sawmill and pallet part mill located in Southwest Virginia. The methods for this research consisted of resource, yield and economic analyses, and the development of a business model. The resource analysis indicated an ample supply of red oak SDT available in Southwest Virginia. The yield analysis used red oak SDT logs, which were manufactured into lumber, container parts and wood residues. The yield of 3" wide container parts from cants varied from 63% to 66%. The 1" nominal lumber produced was mainly 2A and 3A, 74%, and 24% was 1 common. The economic analysis utilized break even, net present value and internal rate of return analyses to determine the economic feasibility of utilizing red oak SDT. The results of the study indicated that the sawmill-only processing level scenario is not economically feasible given the specified conditions and assumptions. However, the results showed that the sawmill and pallet part mill, actual yield scenario at $35/ton delivered log cost is economically feasible. The hypothetical business model for Southwest Custom Hardwoods was economically feasible. The final net present value was calculated to be over $750,000 and the final internal rate of return was 11%. Future yield studies should weigh logs so that the yield of residues and solid wood products can be directly compared. Future research into the utilization of hardwood SDT should include yield studies of other species and other product mixes. / Master of Science

Finite element modeling of laminar shear box testing that consisted of loose sand treated with large diameter prefabricated vertical drains (PVDs), was performed. The objective of the modeling was to evaluate the reliability of the computer program FEQDrain for predicting excess pore pressure ratios (Ru) at sites treated with prefabricated drains. FEQDrain was found to be capable of successfully modeling measured excess pore pressure ratio time histories from the laminar shear box experiment, as long as an appropriate combination of €˜number of equivalent cycles and €˜shaking duration was chosen, and sensitive parameters were in the range of measured values. Hydraulic conductivity, soil compressibility, and cycles to liquefaction are sensitive parameters and govern the computed Ru values.Modeling shows that the loading rate in the laminar shear box (15 cycles at 2 Hz) likely induced higher Ru values than would be expected in a typical earthquake event with a longer duration. The longer duration allows the drains to dissipate pore pressures and prevent liquefaction. The number of equivalent cycles and duration of shaking combinations recommended for various moment magnitudes in the FEQDrain user manual predict lower, but similar Ru versus time curves. Thus, suggesting that PVDs would be equally effective for any size earthquake. However, drains are most effective at preventing liquefaction when earthquake ground motions are long and uniform, rather than short and intense.Results from models in this study compare favorably with those from computer modeling performed by Howell et al. (2014). The individual hydraulic conductivity and compressibility values were different they were somewhat compensating. Similar Ru values can be modeled with different combinations of these parameters.Based on computer analyses, wick drains and 2€ diameter PVDs were found to be relatively ineffective for preventing liquefaction. However, 3€ diameter PVDs are fairly effective but can be overwhelmed during intense shaking. In contrast, 4€ diameter and larger PVDs are significantly more effective.

Finite element modeling of laminar shear box testing that consisted of loose sand treated with large diameter prefabricated vertical drains (PVDs), was performed. The objective of the modeling was to evaluate the reliability of the computer program FEQDrain for predicting excess pore pressure ratios (Ru) at sites treated with prefabricated drains. FEQDrain was found to be capable of successfully modeling measured excess pore pressure ratio time histories from the laminar shear box experiment, as long as an appropriate combination of ˜number of equivalent cycles and ˜shaking duration was chosen, and sensitive parameters were in the range of measured values. Hydraulic conductivity, soil compressibility, and cycles to liquefaction are sensitive parameters and govern the computed Ru values.Modeling shows that the loading rate in the laminar shear box (15 cycles at 2 Hz) likely induced higher Ru values than would be expected in a typical earthquake event with a longer duration. The longer duration allows the drains to dissipate pore pressures and prevent liquefaction. The number of equivalent cycles and duration of shaking combinations recommended for various moment magnitudes in the FEQDrain user manual predict lower, but similar Ru versus time curves. Thus, suggesting that PVDs would be equally effective for any size earthquake. However, drains are most effective at preventing liquefaction when earthquake ground motions are long and uniform, rather than short and intense.Results from models in this study compare favorably with those from computer modeling performed by Howell et al. (2014). The individual hydraulic conductivity and compressibility values were different they were somewhat compensating. Similar Ru values can be modeled with different combinations of these parameters.Based on computer analyses, wick drains and 2 diameter PVDs were found to be relatively ineffective for preventing liquefaction. However, 3 diameter PVDs are fairly effective but can be overwhelmed during intense shaking. In contrast, 4 diameter and larger PVDs are significantly more effective.

<p> Measurements of soil temperature and soil moisture values beneath and in close proximity to circular mulches of hay and straw were made. The experiments were conducted to determine whether sub-surface effects vary with mulch diameter, and to acquire information concerning the seasonal changes in such effects produced by a mulch of most favourable diameter. The modification of soil climate increased with a greater mulch size. A circular mulch with a diameter of 60 cms or less was considered to be of no practical value for winter protection of roots. The mulch with a 240 cms. diameter, provided some winter protection, preventing freezing of the soil, and, in summer caused considerable modification of the sub-surface climate. In the summer, soil temperatures were lowered by values of up to 5°C and 2.5°C at 5 and 100 cms. depth respectively. After a two-month period of dry weather, moisture values at 0-10 cms. depth beneath the mulch were 20% by volume, whereas, outside the mulch they were 5%. These differences decreased with increasing depth but were over 10% at 100 ems. </p> / Thesis / Master of Science (MSc)

Pairwise comparison matrices (PCMs) play a key role in multi-criteria decision making, especially in the analytic hierarchy process. It could be necessary for an expert to compare alternatives based on various criteria. However, for a variety of reasons, such as lack of time or insufficient knowledge, it may happen that the expert cannot provide judgments on all pairs of alternatives. In this case, an incomplete pairwise comparison matrix is formed. In the first research part, an optimization algorithm is proposed for the optimal completion of an incomplete PCM. It is intended to numerically minimize a constrained eigenvalue problem, in which the objective function is difficult to write explicitly in terms of variables. Numerical simulations are carried out to examine the performance of the algorithm. The simulation results show that the proposed algorithm is capable of solving the minimization of the constrained eigenvalue problem. In the second part, a comparative analysis of eleven completion methods is studied. The similarity of the eleven completion methods is analyzed on the basis of numerical simulations and hierarchical clustering. Numerical simulations are performed for PCMs of different orders considering various numbers of missing comparisons. The results suggest the existence of a cluster of five extremely similar methods, and a method significantly dissimilar from all the others. In the third part, the filling in patterns (arrangements of known comparisons) of incomplete PCMs based on their graph representation are investigated under given conditions: regularity, diameter and number of vertices, but without prior information. Regular and quasi-regular graphs with minimal diameter are proposed. Finally, the simulation results indicate that the proposed graphs indeed provide better weight vectors than alternative graphs with the same number of comparisons. This research problem’s contributions include a list of (quasi-)regular graphs with diameters of 2 and 3, and vertices from 5 up to 24.

No description available.

Syftet med denna studie var att tillverka och mäta koncentration, diameter och storleksfördelning för mikrodroppar under olika temperaturer och omrörningstider. Datainsamlingen kom från flera observationer vilket bidrog till en grundlig förståelse för dess egenskaper under olika omständigheter. Ett av de viktigaste resultaten var att temperaturen hade en viktig roll för koncentrationen av mikrodroppar. En minskning av koncentrationsnivåerna observerades vid lägre temperaturer. Vidare noterades att omrörningstiden också spelade en roll, betydande minskningar av det totala antalet mikrodroppar observerades under längre omrörningstider. Mikrodropparnas medeldiameter hade storlekar som låg inom acceptabla intervaller i alla prov. De medeldiametrar som observerades låg inom ett intervall på 3,98 μm till 8,18 μm men större enskilda mikrodroppar med diameter över 10 μm kunde också hittas. Resultaten gav vägledande faktorer för ytterligare undersökningar för att fastställa dess medicinska tillämpningar. Framtida studier bör fortsätta att analysera dessa parametrar för att ytterligare optimera mikrodroppar för användning inom områden som ultraljudsavbildning eller läkemedelsleverans. / The aim of this study was to fabricate and measure the concentration, diameter, size distribution of microdroplets under different temperatures and stirring times. The data collection came from several observations which provided a thorough understanding of its properties under different circumstances. One of the key findings was that the temperature had an important role in the concentration of microdroplets. A decrease in concentration levels was observed at lower temperatures. Furthermore, it was noted that stirring time also played a role, leading to significant reductions in the total number of microdroplets when observed for longer stirring times. The mean diameters of the microdroplets had sizes that were within acceptable ranges in all samples. The mean diameters observed ranged from sizes between 3.98 μm and 8.18 μm but single microdroplets with diameters greater than 10 μm could also be found and observed. The results provided guiding factors for further investigations to determine its medical applications. Future studies should continue to analyze these parameters to further optimize microdroplets for use in areas such as ultrasound imaging or drug delivery.