INTRODUCTION: In the years that followed the 1994 Back to Sleep Campaign (BSC), a public health initiative designed to prevent Sudden Infant Death Syndrome (SIDS), the prevalence of SIDS decreased by nearly 50%. However, recent research questions the decline in SIDS with an appreciation of contemporaneous factors which may have contributed to it. There is a growing recognition that other, often indiscernible causes of Sudden Unexpected Infant Deaths (SUID) have increased prevalence rates. Several researchers have addressed the possibility of the effects of a diagnostic drift. OBJECTIVE: To evaluate the impact of certain contemporaneous factors on the decline in the prevalence of Sudden Infant Death Syndrome. METHODS: We examined a historically significant time period surrounding the implementation of the BSC, 1984-2009. It is a time-period that incorporates mortality statistics prior to the BSC, as well as immediately following. We utilized 1984-2009 mortality data obtained from the Center for Disease Control and Prevention and evaluated the following prevalence rates: SIDS, unknown and unspecified causes, Accidental Strangulation and Suffocation in Bed (ASSB), and Neglect. We then amalgamated unknown and unspecified causes, ASSB and Neglect into a single representation of non-SIDS SUID. We then proceeded to perform an analysis on these prevalence rates to determine linear trends. RESULTS: All-cause mortality rate decreased linearly by about .929 per 100,000 per year (p<.0001, β=-.929). SIDS mortality rates also experienced a significant decline of about .951 per 100,000 deaths per year (p<.0001, β=-.951). In contrast, the SUID cohort prevalence increased significantly with a rate of .930 per 100,000 per year (p<.0001, β=.930). DISCUSSION: Over our study period, SIDS declined significantly, but by 2001 it experienced a stagnant decline that was different than that from 1984-2000. From 2001 to 2009, our SUID cohort increased dramatically. It is our conclusion that the potential exists for a possible diagnostic drift from SIDS to these other SUID.

Para avaliar os aspectos necrológicos do envelhecimento, este estudo investigou as características relacionadas às mortes de moradores da cidade de São Paulo os quais foram submetidos à necropsia no Serviço de Verificação de Óbitos da Capital (SVOCSP) no período de Junho de 2004 a Novembro de 2005. A casuística foi constituída por 402 indivíduos com idade igual ou superior a 50 anos, divididos em dois grupos quanto à causa mortis: por causa encefálica (CE) e por outras causa (OC), que foram estudados quanto ao gênero, idade, cor, altura, peso, estado civil, presença de benefício social, presença de vícios (tabagismo e/ou alcoolismo), causa mortis e causas associadas ao óbito. Dentre os que apresentaram causas encefálicas (CE) de óbitos, foram mais prevalentes o enfarto cerebral isquêmico (50,7%) e as causas hemorrágicas centrais (32,3%) com predomínio dos óbitos no sexo feminino, enquanto que dentre os falecimentos por outras causas (OC) o enfarto agudo do miocárdio (27,9%), as demais cardiopatias (23,9%) e as neoplasias (11,9%) foram às causas mais freqüentes, com predomínio no sexo masculino cuja idade, ao morrer, foi inferior às mulheres. Em ambos os grupos, as evidências de aterosclerose disseminada foram muito prevalentes. O processo do envelhecimento em moradores da cidade de São Paulo é caracterizado pelo predomínio e prevalência das mortes por doenças cardiovasculares no sexo masculino e das cerebrovasculares no sexo feminino / For evaluating the obituary aspects of aging, this study investigated the characteristics related to deaths in residents of São Paulo who underwent autopsy in the Department of autopsies in the Capital (SVOC-SP) in the period from June 2004 to November 2005. The sample was consisted of 402 individuals aged over 50 years, divided into two groups as the cause of death: encephalic causes (EC) and other causes (OC), that were studied in relation to gender, age, color, height, weight, marital status, presence of social benefit, the presence of addictions (smoking and / or alcoholism), causa mortis and causes associated to death. Among those who died by encephalic causes (EC) were the most prevalent the ischemic cerebral infarction (50.7%) and central hemorrhagic causes (32.3%) with predominance of deaths in females, while among the deaths by other causes (OC) to acute myocardial infarction (27.9%), other heart diseases (23.9%) and neoplasm (11.9%) were the most frequent causes, with predominance in males, whose age was lower than women. In both groups, the evidence of widespread atherosclerosis was very prevalent. The aging process in residents of São Paulo is characterized by the dominance and prevalence of cardiovascular deaths in males and strokes in women

Para avaliar os aspectos necrológicos do envelhecimento, este estudo investigou as características relacionadas às mortes de moradores da cidade de São Paulo os quais foram submetidos à necropsia no Serviço de Verificação de Óbitos da Capital (SVOCSP) no período de Junho de 2004 a Novembro de 2005. A casuística foi constituída por 402 indivíduos com idade igual ou superior a 50 anos, divididos em dois grupos quanto à causa mortis: por causa encefálica (CE) e por outras causa (OC), que foram estudados quanto ao gênero, idade, cor, altura, peso, estado civil, presença de benefício social, presença de vícios (tabagismo e/ou alcoolismo), causa mortis e causas associadas ao óbito. Dentre os que apresentaram causas encefálicas (CE) de óbitos, foram mais prevalentes o enfarto cerebral isquêmico (50,7%) e as causas hemorrágicas centrais (32,3%) com predomínio dos óbitos no sexo feminino, enquanto que dentre os falecimentos por outras causas (OC) o enfarto agudo do miocárdio (27,9%), as demais cardiopatias (23,9%) e as neoplasias (11,9%) foram às causas mais freqüentes, com predomínio no sexo masculino cuja idade, ao morrer, foi inferior às mulheres. Em ambos os grupos, as evidências de aterosclerose disseminada foram muito prevalentes. O processo do envelhecimento em moradores da cidade de São Paulo é caracterizado pelo predomínio e prevalência das mortes por doenças cardiovasculares no sexo masculino e das cerebrovasculares no sexo feminino / For evaluating the obituary aspects of aging, this study investigated the characteristics related to deaths in residents of São Paulo who underwent autopsy in the Department of autopsies in the Capital (SVOC-SP) in the period from June 2004 to November 2005. The sample was consisted of 402 individuals aged over 50 years, divided into two groups as the cause of death: encephalic causes (EC) and other causes (OC), that were studied in relation to gender, age, color, height, weight, marital status, presence of social benefit, the presence of addictions (smoking and / or alcoholism), causa mortis and causes associated to death. Among those who died by encephalic causes (EC) were the most prevalent the ischemic cerebral infarction (50.7%) and central hemorrhagic causes (32.3%) with predominance of deaths in females, while among the deaths by other causes (OC) to acute myocardial infarction (27.9%), other heart diseases (23.9%) and neoplasm (11.9%) were the most frequent causes, with predominance in males, whose age was lower than women. In both groups, the evidence of widespread atherosclerosis was very prevalent. The aging process in residents of São Paulo is characterized by the dominance and prevalence of cardiovascular deaths in males and strokes in women

Introdução - O estudo de eventos de saúde deve levar em conta que as características dos indivíduos de uma determinada localidade não constituem simples somatórios das medidas de cada um dos sujeitos e há que se considerar um modelo explicativo baseado em níveis de organização e na estrutura de dependência entre o nível individual e o nível de contexto onde esses sujeitos estão inseridos. Assim, a análise dos nascimentos e da mortalidade neonatal e fetal pode incorporar diferentes variáveis associadas ao contexto onde se expressam considerando a complexidade e as particularidades dessas ocorrências numa população e num espaço tão diverso. Metodologia - Foi realizado estudo transversal dos nascimentos, óbitos neonatais (<28 dias de vida) e óbitos fetais de mães residentes e ocorridos no município de São Paulo. Os endereços de residência materna foram geocodificados e foi calculada a distância entre as residências e o hospital de ocorrência. Além disso, cada indivíduo foi caracterizado com informações socioeconômicas do Censo Demográfico de 2010, segundo área de Ponderação. Os setores censitários de residência foram classificados segundo Índice Paulista de Vulnerabilidade Social IPVS. Os hospitais foram classificados em SUS e não SUS e para os Nascidos Vivos (e óbitos neonatais) também foram classificados segundo referência para atendimento de risco gestacional. Foram obtidos aglomerados de Nascidos Vivos (NV) através da técnica de varredura espacial. Através de análise multinível foi verificado o efeito do contexto socioeconômico na mortalidade neonatal e fetal. Resultados - Verificou-se que os aglomerados tanto SUS como não SUS não são homogêneos entres si, com diferenças em relação à idade das mães, escolaridade, número de consultas pré-natal e prematuridade. A distância média teórica percorrida pelas mães até o hospital foi 51,8% menor nos aglomerados SUS que nos não SUS. A menor distância nos nascimentos SUS indica a regionalização da assistência ao parto no município de São Paulo. Os resultados mostraram que há um aumento da taxa de mortalidade neonatal com o aumento da vulnerabilidade social. Houve um efeito contextual da vulnerabilidade social e observa-se que apenas as variáveis individuais que representam as características da gestação, recém-nascido e assistência pré-natal mostraram-se associadas à mortalidade neonatal. O efeito contextual da vulnerabilidade social nas variáveis individuais que representam as características da gestação, feto e escolaridade materna mostrou-se associadas à mortalidade fetal. Na modelagem multinível não foi observada variabilidade importante da mortalidade fetal entre os níveis. Conclusões - A detecção de aglomerados e sua caracterização socioeconômica das áreas contribuem para o entendimento do padrão de nascimentos e nas intervenções de saúde pública, proporcionando melhoria no atendimento das necessidades de acesso ao pré-natal e parto de forma mais eficiente. Os resultados em relação à mortalidade neonatal e fetal revelam que as desigualdades sociais estão presentes na cadeia causal desses dois desfechos e o que contribui com a compreensão dos fatores de risco para a mortalidade neonatal e fetal, principalmente no que diz respeito à participação da vulnerabilidade social na mortalidade e explicita a distância entre a residência materna e o hospital como um indicador socioeconômico / Introduction - The study of health events should take into account that the characteristics of the individuals of a given locality are not simple sums of the measures of each one of the subjects and it is necessary to consider an explanatory model based on levels of organization and the structure of dependence between the Individual level and the context level where these subjects are inserted. Thus, the analysis of neonatal and fetal births and mortality can incorporate different variables associated to the context considering the complexity and the peculiarities of these occurrences in a population and in such a diverse space. Methodology - A cross-sectional study of births, neonatal deaths (<28 days of life) and fetal deaths of resident mothers occurred in the city of. The maternal residence addresses were geocoded to calculate the distance between the residences and the hospital. In addition, each individual was characterized with socioeconomic information from the Demographic Census of 2010, according to the weighting areas. The census tracts of residence were classified according to Index of Social Vulnerability - IPVS. Hospitals were classified in SUS and non-SUS and for live births (and neonatal deaths) were also classified according to reference for gestational risk care. The clusters of live births (LB) were obtained through the spatial sweep technique. The effect of the socioeconomic context on neonatal and fetal mortality was verified by multilevel analysis. Results - It was verified that the clusters both SUS and non-SUS are not homogeneous between them, with differences in relation to the mothers\' age, schooling, number of prenatal consultations and prematurity. The mean theoretical distance traveled by the mothers to the hospital was 51.8% lower in the SUS clusters than in the non-SUS. The shorter distance in SUS births indicates the regionalization of childbirth care in the city of São Paulo. The results showed that there is an increase in the neonatal mortality rate with increased social vulnerability. There was a contextual effect of social vulnerability and it was observed that only the individual variables that represent the characteristics of gestation, newborn and prenatal care were shown to be associated with neonatal mortality. The contextual effect of social vulnerability on the individual variables that represent the characteristics of gestation, fetus and maternal schooling has been shown to be associated with fetal mortality. In the multilevel modeling whose context was the level of vulnerability of the place of maternal residence, no significant variability of fetal mortality between the levels was observed. Conclusion - The detection of clusters and their socioeconomic characterization of the areas contribute to the understanding of the birth pattern and the public health interventions, providing an improvement in the attendance of prenatal access and delivery needs in a more efficient way. The results in relation to neonatal and fetal mortality reveal that social inequalities are present in the causal chain of these two outcomes and that contributes to the understanding of the risk factors for neonatal and fetal mortality, especially with regard to the participation of social vulnerability In mortality and explicit the distance between the maternal residence and the hospital as a socioeconomic indicator

Doctor of Public Health / For many years the major cause of infant mortality in NSW has been the result of Sudden Infant Death Syndrome (SIDS). Statistics show the area defined as 'Western Sydney' is no exception, and in 2002, a report prepared by the Epidemiology, Indicators, Evaluation and Research Unit (EIRE) in Western Sydney presented data indicating SIDS rates in the area were higher than the state average. In particular, two Local Government Areas (LGAs) had clusters of SIDS deaths. Previous Australian research identified a higher risk of SIDS and other causes of infant mortality in Aboriginal and Torres Strait Islander populations. The areas of Western Sydney where SIDS rates were higher than expected were home to Aboriginal, Torres Strait Islander and Pacific Island residents. The number of SIDS deaths in Aboriginal infants did not explain the higher than expected rate of SIDS in the areas under investigation. Studies undertaken in New Zealand and the Pacific Islands have identified higher than expected risk of SIDS in Maori and Pacific Island communities in those countries, although this has never been studied in Pacific Island residents living in Australia. The reasons for these communities exhibiting a higher than normal SIDS rate is not completely understood, but can be partially explained by behavioural practices which are known to impact adversely on the risk of SIDS. This study sought to investigate the level of knowledge concerning the prevention of sudden and unexpected death in infants (SUDI) in three key groups of infant caregivers: general practitioners, nurses and parents living or working in the area geographically defined by Sydney West Area Health Service (WSAHS). In addition, the study sought to identify any variation in knowledge of SIDS reduction strategies in the three groups under study, and to investigate factors influencing knowledge and practice in these participants. The study findings were then used as a basis on which to develop strategies and recommendations to enhance the delivery of safe sleeping messages through the health care system. Using a combination of qualitative and quantitative methods, this cross-sectional study highlights a number of issues around infant care practices and the major influences on new parents living in a multicultural community. Results of the study showed there is a large variation in knowledge around safe sleeping practices (including SIDS reduction strategies) in all the groups studied. Although educational campaigns are conducted regularly, many general practitioners and parents are confused about the key SIDS reduction messages and still place infants in sleeping positions considered unsafe. While nurses and midwives were aware of the SIDS reduction strategies, they still occasionally used infant sleeping positions considered unsafe. General practitioners born overseas in a country where English is not the first language were less likely to be familiar with safe sleeping messages, including SIDS reduction strategies. Families from a Culturally and Linguistically Diverse (CALD) background were less likely to have seen SIDS information in their own language than families who spoke English, and as a result were more likely to use traditional methods of infant care, including co-sleeping with siblings and parents and side or tummy sleeping. CALD parents were more likely to rely on herbal remedies and friends and family for assistance, than English speaking parents who accessed health professionals as the first point of call when infants were unwell. The study identified a relatively recent practice, which until reported in this study, has not been documented in the literature. The practice of draping infant prams with blankets originated from the Cancer Council of Australia guidelines which recommend covering a pram with a light muslin wrap to protect infants’ skin from the sun. It appears parents have misinterpreted this message and are covering infant prams with blankets to encourage sleep, even when sun exposure is not an issue. Research suggests that poor air quality around the head of an infant may affect an infant’s arousal response. While no research has been conducted on the air quality around an infants head when covered by a heavy blanket in a pram, it is possible based on research into air quality around infants, that that this practice may increase the risk of sudden and unexpected death in an infant. In conclusion, this study found that multiple changes to the SIDS reduction messages since the initial ‘Reduce the Risks’ Campaign have led to confusion about ways of preventing SIDS in GPs, nurses and parents in Western Sydney. The study makes seven recommendations aimed at improving knowledge of safe sleeping practices in these groups, and optimizing health outcomes for infants using a collaborative approach to service delivery and future initiatives.

Introdução - O estudo de eventos de saúde deve levar em conta que as características dos indivíduos de uma determinada localidade não constituem simples somatórios das medidas de cada um dos sujeitos e há que se considerar um modelo explicativo baseado em níveis de organização e na estrutura de dependência entre o nível individual e o nível de contexto onde esses sujeitos estão inseridos. Assim, a análise dos nascimentos e da mortalidade neonatal e fetal pode incorporar diferentes variáveis associadas ao contexto onde se expressam considerando a complexidade e as particularidades dessas ocorrências numa população e num espaço tão diverso. Metodologia - Foi realizado estudo transversal dos nascimentos, óbitos neonatais (<28 dias de vida) e óbitos fetais de mães residentes e ocorridos no município de São Paulo. Os endereços de residência materna foram geocodificados e foi calculada a distância entre as residências e o hospital de ocorrência. Além disso, cada indivíduo foi caracterizado com informações socioeconômicas do Censo Demográfico de 2010, segundo área de Ponderação. Os setores censitários de residência foram classificados segundo Índice Paulista de Vulnerabilidade Social IPVS. Os hospitais foram classificados em SUS e não SUS e para os Nascidos Vivos (e óbitos neonatais) também foram classificados segundo referência para atendimento de risco gestacional. Foram obtidos aglomerados de Nascidos Vivos (NV) através da técnica de varredura espacial. Através de análise multinível foi verificado o efeito do contexto socioeconômico na mortalidade neonatal e fetal. Resultados - Verificou-se que os aglomerados tanto SUS como não SUS não são homogêneos entres si, com diferenças em relação à idade das mães, escolaridade, número de consultas pré-natal e prematuridade. A distância média teórica percorrida pelas mães até o hospital foi 51,8% menor nos aglomerados SUS que nos não SUS. A menor distância nos nascimentos SUS indica a regionalização da assistência ao parto no município de São Paulo. Os resultados mostraram que há um aumento da taxa de mortalidade neonatal com o aumento da vulnerabilidade social. Houve um efeito contextual da vulnerabilidade social e observa-se que apenas as variáveis individuais que representam as características da gestação, recém-nascido e assistência pré-natal mostraram-se associadas à mortalidade neonatal. O efeito contextual da vulnerabilidade social nas variáveis individuais que representam as características da gestação, feto e escolaridade materna mostrou-se associadas à mortalidade fetal. Na modelagem multinível não foi observada variabilidade importante da mortalidade fetal entre os níveis. Conclusões - A detecção de aglomerados e sua caracterização socioeconômica das áreas contribuem para o entendimento do padrão de nascimentos e nas intervenções de saúde pública, proporcionando melhoria no atendimento das necessidades de acesso ao pré-natal e parto de forma mais eficiente. Os resultados em relação à mortalidade neonatal e fetal revelam que as desigualdades sociais estão presentes na cadeia causal desses dois desfechos e o que contribui com a compreensão dos fatores de risco para a mortalidade neonatal e fetal, principalmente no que diz respeito à participação da vulnerabilidade social na mortalidade e explicita a distância entre a residência materna e o hospital como um indicador socioeconômico / Introduction - The study of health events should take into account that the characteristics of the individuals of a given locality are not simple sums of the measures of each one of the subjects and it is necessary to consider an explanatory model based on levels of organization and the structure of dependence between the Individual level and the context level where these subjects are inserted. Thus, the analysis of neonatal and fetal births and mortality can incorporate different variables associated to the context considering the complexity and the peculiarities of these occurrences in a population and in such a diverse space. Methodology - A cross-sectional study of births, neonatal deaths (<28 days of life) and fetal deaths of resident mothers occurred in the city of. The maternal residence addresses were geocoded to calculate the distance between the residences and the hospital. In addition, each individual was characterized with socioeconomic information from the Demographic Census of 2010, according to the weighting areas. The census tracts of residence were classified according to Index of Social Vulnerability - IPVS. Hospitals were classified in SUS and non-SUS and for live births (and neonatal deaths) were also classified according to reference for gestational risk care. The clusters of live births (LB) were obtained through the spatial sweep technique. The effect of the socioeconomic context on neonatal and fetal mortality was verified by multilevel analysis. Results - It was verified that the clusters both SUS and non-SUS are not homogeneous between them, with differences in relation to the mothers\' age, schooling, number of prenatal consultations and prematurity. The mean theoretical distance traveled by the mothers to the hospital was 51.8% lower in the SUS clusters than in the non-SUS. The shorter distance in SUS births indicates the regionalization of childbirth care in the city of São Paulo. The results showed that there is an increase in the neonatal mortality rate with increased social vulnerability. There was a contextual effect of social vulnerability and it was observed that only the individual variables that represent the characteristics of gestation, newborn and prenatal care were shown to be associated with neonatal mortality. The contextual effect of social vulnerability on the individual variables that represent the characteristics of gestation, fetus and maternal schooling has been shown to be associated with fetal mortality. In the multilevel modeling whose context was the level of vulnerability of the place of maternal residence, no significant variability of fetal mortality between the levels was observed. Conclusion - The detection of clusters and their socioeconomic characterization of the areas contribute to the understanding of the birth pattern and the public health interventions, providing an improvement in the attendance of prenatal access and delivery needs in a more efficient way. The results in relation to neonatal and fetal mortality reveal that social inequalities are present in the causal chain of these two outcomes and that contributes to the understanding of the risk factors for neonatal and fetal mortality, especially with regard to the participation of social vulnerability In mortality and explicit the distance between the maternal residence and the hospital as a socioeconomic indicator

Sudden unexplained infant death (SUID) is a sudden death of an infant under 1 year of age that cannot be explained after an investigation or an autopsy. SUID is the leading cause of infant deaths in the United States; SUID is considered a sentinel event to the birth hospital. Birth hospitals are held accountable for education, training, and role modeling of infant safe sleep practices (SSP) to reduce infant sleep-related deaths up to 1 year of age. This educational project was designed to answer the project-focused question of whether the implementation of an evidence-based, safe sleep training program for nurses would improve their knowledge of SSP. Bandura's social cognitive theory and the root cause analysis theory were used to guide the project that provided education on SSP and methods for teaching SSP for 48 nurses who work in a postpartum unit in a large hospital in the northeastern United States. A search of the literature provided the content from the National Institute of Child Health and Human Development for the education program and served the basis for the 15-item multiple-choice test, which was used for the pretest, posttest design project. The test was administered to the nurse participants who ranged in education from associate degree, baccalaureate degree, to master's degrees. The project goal was to increase nurses' knowledge by training and role modeling infant safe sleep environments and to reduce SUIDs. Results of the pretest and posttest evaluation revealed significant improvement in test scores from a pretest M = 72.9 to a posttest M = 90.0 (p <.05). The implications of this project for social change are that each nurse's knowledge and abilities to teach parents and families about SUID prevention strategies improve, sudden infant deaths may decrease in this hospital setting.

Os óbitos de mulheres em idade reprodutiva correspondem a 16% do total de óbitos femininos em todo o Brasil, indicando a dificuldade dos serviços de saúde em implementar ações baseadas na atenção integral à saúde da mulher no Sistema Único de Saúde, sob o enfoque ampliado da assistência, incorporando a perspectiva de gênero. Objetivo: analisar óbitos de mulheres em idade reprodutiva, residentes em Ribeirão Preto-SP, no período de 2007 a 2009, com ênfase nas causas de morte. Método: foram analisadas 532 Declarações de Óbito (DO) de mulheres de 10 a 49 anos residentes no município de Ribeirão Preto/SP que foram a óbito no período de 2007 a 2009, obtidas por meio do Comitê Municipal de Prevenção da Mortalidade Materna para transcrição integral dos dados. As mortes foram classificadas em maternas declaradas, não maternas e presumíveis. Procedeu-se com a análise dos dados com o software STATA, codificação das causas de acordo com a CID 10 e seleção da causa básica de óbito. Resultados: Os principais grupos de causas de morte foram: neoplasias 137 (26%), doenças do aparelho circulatório 94 (18%), doenças infecciosas e parasitárias 67 (13%) e causas externas 65 (12%). As mortes por causas maternas representaram a antepenúltima causa de óbito. Foram identificadas, após análise dos campos preenchidos na DO, 467 (88%) mortes não maternas, 5 (1%) mortes maternas declaradas e 60 (11%) mortes maternas presumíveis. Conclusão: O padrão de mortalidade do município é semelhante ao do país, apontando a necessidade de incrementar ações nas três esferas de governo voltadas para a saúde da população feminina. Conhecer o perfil de mortalidade de mulheres em idade reprodutiva possibilita a compreensão de suas principais demandas e problemas de saúde oferecendo subsídios para o planejamento de ações focadas em reduzir mortes por causas evitáveis. / The deaths of women in reproductive age represent 16% of all female deaths in Brazil, indicating the difficulty of health services to implement actions based on comprehensive health care of women in the National Health System, under the approach extended care, incorporating a gender perspective. Objective: To analyze deaths of women in reproductive age residing in Ribeirao Preto-SP, in the period of 2007 to 2009, focusing on causes of death. Method: We analyzed 532 Death Certificates of women aged 10 to 49 years residing in Ribeirao Preto - SP who died in the period 2007 to 2009, obtained through the Municipal Committee for the Prevention of Maternal Mortality for transcription full of data. The deaths were classified as declared maternal, not maternal and presumed. Proceeded with the analysis of the data with STATA software, coding causes according to ICD 10 and selecting the underlying cause of death. Results: The main groups of causes of death were neoplasms 137 (26%), circulatory diseases 94 (18%), infectious and parasitic diseases 67 (13%) and external causes 65 (12%). Deaths from maternal causes represented the antepenultimate cause of death. Were identified after analysis of the fields filled in Death Certificates, 467 (88%) not maternal deaths, 5 (1%) declared maternal and 60 (11%) presumed maternal deaths. Conclusion: The pattern of mortality in the municipality is similar to the country, pointing to the need for increased action in the three spheres of government focused on the health of the female population. Knowing the profile of women mortality in reproductive age furthers our understanding of their main demands and health problems, offering support for the planning of actions focused on reducing deaths from preventable causes.

O humor vítreo (HV) é um gel aquoso, transparente e incolor, situado entre o cristalino e a retina. Ele pode ser uma ferramenta para determinação de drogas de abuso, sobretudo quando é impossível fazer a determinação em sangue devido à sua ausência ou sua deterioração, por exemplo em casos de exsanguinação, embalsamento e carbonização. As drogas e seus metabólitos passam para o HV por difusão passiva e, de modo geral, a concentração dos analitos no HV é similar às concentrações obtidas no sangue. A cocaína e a benzoilecgonina são facilmente detectadas na matriz. Por outro lado, a difusão da morfina é bem limitada. O maior interesse do estudo de opioides é a análise de 6-acetilmorfina, que pode diferenciar o uso de heroína e morfina. O delta-9-tetrahidrocanabinol é uma molécula muito polar e fortemente ligada a proteínas plasmáticas, o que limita a sua difusão para o HV. Entre as anfetaminas, a metilenodioximetanfetamina e a metanfetamina são as moléculas mais estudadas no HV. Foi desenvolvido e validado um método utilizando GC-MS para análise simultânea de cocaína, anfetaminas, opioides, canabinoides e respectivos metabólitos em HV. Os analitos de interesse foram extraídos do HV utilizando extração em fase sólida e analisadas por GC-MS, utilizando o modo de aquisição SIM. A faixa de linearidade foi de 10 a 1000 ng/mL para todos os analitos, com exceção do éster de metilanidroecgonina (10 a 750 ng/mL). A exatidão variou de 95,6 a 104,0%, a precisão inter-ensaio variou de 1,2 a 10,0% e a precisão intra-ensaio foi menor que 10,4% para todos os analitos. O limite de quantificação para todas as drogas foi de 10 ng/mL e a recuperação variou de 70,4 a 100,1% para compostos básicos e neutros, entretanto os compostos ácidos apresentaram baixa recuperação - menor que 40%. A dosagem de etanol foi realizada por GC-FID e extração por headspace. Os métodos validados foram aplicados em 250 amostras de HV coletadas de vítimas de morte violentas nos anos de 2011 e 2012 que foram necropsiadas no Departamento Médico Legal de Vitória - ES. A maioria das vítimas era do sexo masculino (85,4%) e a causa mais comum de morte foi homicídio (46,2%), destes, 89,5% foram mortos por disparo de arma de fogo. Os acidentes de trânsito corresponderam a 44,1%; suicídio, 2,4%; e outras mortes totalizaram 7,2% das amostras. Substâncias psicoativas (álcool e drogas) foram positivas em 60,4% dos casos. Em 23,2% das amostras foi quantificada cocaína e/ou seu metabólito, e em um terço destes foi identificado o uso de crack. O álcool estava presente em 19,2% dos casos e a associação entre cocaína e álcool em 12,8% dos casos. Outras drogas incluíram anfetaminas (13 casos) e codeína (1 caso). Quando comparadas as concentrações das drogas pesquisadas no sangue e HV, a anfetamina e metanfetamina mostraram boa correlação entre as duas matrizes. A 6-acetilmorfina encontrada no HV foi utilizada para demonstrar o uso de heroína, uma vez que as concentrações foram mais altas do que no sangue. Entretanto, o HV não pode ser utilizado como amostra alternativa para detecção de canabinoides. / Vitreous humor is the aqueous gel located between the lens and retina. Vitreous humor is a useful alternative postmortem matrix for the detection of drugs, particularly in death investigations where postmortem blood is not available or is of limited quality or quantity (e.g. after hemorrhagic shock, burns, embalming or decomposition processes). Drugs and their metabolites enter the vitreous humor by passive diffusion from blood across the blood-vitreous barrier. Vitreous humor concentrations are often similar to the drug concentrations in the circulation blood. Cocaine and benzoylecgonine are easily detected in this matrix. On the order hand, morphine diffusion is limited. The interest in opiates is due to 6-acetylmorphine, which is stable in vitreous humor and can confirm heroin abuse. Drugs that are highly protein-bound, such as THC, achieve lower vitreous humor concentrations as only the free fraction can cross the blood-vitreous barrier. Methamphetamine and methylenodioxymetamphetamine are also detected in vitreous humor. A GC-MS method for simultaneous analysis of cocaine, amphetamines, opiates, cannabinoids and its metabolites in vitreous humor was developed and fully validated. Vitreous humor samples were extracted using solid phase extraction and analyzed by GC-MS in SIM mode. For all analytes the linearity ranged from 10 to 1000 ng/mL, excepted for anydroecgonine methylester which ranged from 10 to 750 ng/mL. Inter-assay imprecision ranged from 1.2 to 10.0% and intra-assay imprecision was less than 10.4% for all analytes at all QC concentrations. Accuracy ranged from 95.6 to 104.0% and recoveries ranging from 70.4 - 100.1% for basic and neutral compounds, the acids compounds had poor recovery (less than 40%). The limits of detection were up to 1.0 ng/mL. Ethanol was quantified by headspace extraction and GC-FID. The validated methodology was applied to 250 vitreous humor samples collected from violent death victims between 2011 and 2012 in the Departamento Médico Legal de Vitória - ES. Most of the victims were male (85.4%) and the most common cause of death was homicide (46.2%), in which 89.5 occurred by firearm shot. Traffic accident represented 44.1%, suicide 2.4% and other deaths 7.2%. Psychoactive substances (alcohol and?or drugs of abuse) were positive in 60.4% of the cases. Cocaine was quantified in 23.2% of the samples and one third was positive for crack cocaine. Ethanol was present in 19.2% of the cases and the association between cocaine and alcohol in 12.8%. Other drugs included amphetamines (13 cases) and codeine (1 case). When comparing the drug concentrations in blood and vitreous humor, amphetamine and methamphetamine showed a good correlation. 6-acetylmorphine in vitreous humor can demonstrate heroine abuse and its concentration is higher in vitreous humor than in blood. However, vitreous humor is not a good matrix for the detection of cannabinoids.

ABSTRACT The purpose of this research study is to determine if the rate of unintentional injury death in selected medical districts differs significantly among citizen and non-citizen males ages 20-65 living in the United Arab Emirates (UAE). A profile of unintentional injury deaths was generated by specific cause for the six medical districts of Ajman, Dubai, Fujairah, Ra’s al-Khaimah, Sharjah and Umm al-Qaiwain managed for the UAE Ministry of Health for the years 2006-2008. During this time period the six medical districts reported a total of 14,101 deaths. Males were found to represent 73.9 per cent of the deaths reported by the six medical districts managed by the UAE Ministry of health for the years 2006-2008. Non –citizen males represented 74.8 per cent of the male fatalities reported by the six medical districts managed by the UAE Ministry of health for the years 2006-2008. Fatality rates for males ages 20-65 were generated and analyzed by citizen status and season of the year. This age group represented 6,141 deaths. In the two medical districts with the highest population (Dubai & Sharjah) unintentional injury deaths represented 77.1% of the total unintentional deaths reported by all the six medical districts managed by the UAE Ministry of Health for the years 2006-2008. A Chi-Square found the rate of fatalities among 20-65 years old male citizens and non-citizens in the six medical districts managed by the UAE Ministry of Health for the years 2006-2008 differed significantly by cause of unintentional injury death. The observed rate of death from accidental falls for non-citizen 20-65 males was found to be higher than expected for male citizens in the same age group. The observed unintentional injury death rate for males ages 20-65 caused by motor vehicle & traffic accidents and for accidental poisoning found the death rate for UAE citizens to be higher than the rate for non-citizens living in the UAE. The results of this study demonstrate the need for the reporting and analysis of unintentional deaths at the medical district level in the UAE by subgroups such as citizen status and age group.