[No copyright notice] Background: Moderate and chronic consumption of red wine protects against cardiovascular disease. Wine is a complex matrix containing multiple molecules whose concentrations can vary from one bottle to another. Therefore, the delineation of the putative cardioprotective components in wine such as alcohol, resveratrol and melatonin is very challenging when using commercially available red wine. Aim: We aimed to use synthetic wine, whose composition is well characterized, to explore whether the presence of alcohol, resveratrol and melatonin (as found in commercial wines) contributes to the cardioprotective effect of chronic and moderate consumption of red wine (equivalent to 2 glasses of wine/day) in an animal model. Additionally, we hypothesized that synthetic wine enriched with resveratrol and melatonin confers cardioprotection via improvement of overall antioxidant profile.

No description available.

No description available.

The research effort is an outgrowth of the authors exposure to the field of drug treatment in general, and therapeutic communities in particular. Both were acquainted with people who were graduates of therapeutic communities, and had been involved in m.any discussions concerning the relative merit of therapeutic communities as opposed to other methods of drug treatment.

There has been a continual emergence of shopping centres in the 21st century. In recent years the prevailing shopping centres have been designed as an indispensable part of city centres having all the urban elements and qualities of traditional streets in combination with convenience, commercial efficiency, and high functioning design. The evolving shopping malls are challenged to add diversity to the range of shopping facilities and add on to the new experience keeping up with the ever-changing trends in society. This study aims to investigate if shopping malls are over-managed consumer spaces embedded in privatisation and commercialisation, thus creating a hindrance for true public spaces to emerge, or do they have a possibility of becoming a real public realm with true public spaces. Two case studies of shopping centres provided valuable insights on how stakeholders pursued planned public spaces in shopping centres and how the public perceives them. The placemaking model, highlighting the fundamental rights in a public space by covering the tangible and intangible aspects, has been central to this research. The results indicate that the malls should integrate more into the cities. They should focus on incorporating adaptive flexibility with the diversity of usage inclusive of changing demographics and increased urbanisation, which means a greater need for public spaces for mingling and congregation. / Det har skett en ständig uppkomst av köpcentra under 2000-talet. Under de senaste åren har de rådande köpcentrumen utformats som en oumbärlig del av stadskärnan med alla urbana inslag och kvaliteter av traditionella gator i kombination med bekvämlighet, kommersiell effektivitet och hög fungerande design. De utvecklande köpcentrana utmanas att lägga till mångfald i utbudet av shoppingfaciliteter och lägga till den nya upplevelsen som följer de ständigt föränderliga trenderna i samhället. Denna studie syftar till att undersöka om köpcentra är överhanterade konsumentutrymmen inbäddade i privatisering och kommersialisering, och därmed skapa ett hinder för att verkliga offentliga utrymmen dyker upp eller har de en möjlighet att bli en riktig allmänhet med verkliga offentliga utrymmen. Två fallstudier av köpcentrum gav värdefull insikt om hur intressenter förföljde planerade allmänna utrymmen i köpcentra och hur allmänheten uppfattar dem. Platsframställningsmodellen, som belyser de grundläggande rättigheterna i ett offentligt rum genom att täcka de konkreta och immateriella aspekterna, har varit centralt i denna forskning. Resultaten indikerar att köpcentra bör integreras mer i städerna. De bör fokusera på att integrera anpassningsbar flexibilitet med mångfalden av användning inklusive förändrad demografi och ökad urbanisering, vilket innebär ett större behov av offentliga utrymmen för mingling och församling.

The Florida land boom was an orgy of real estate speculation and development that swept the state during the period 1924 through 1926. The few books and articles that deal with that event rarely mention Jacksonville, although it was Florida's largest city and its chief commercial and transportation center. This could lead one to the conclusion that the North Florida city did not become caught up in the boom. Yet scattered throughout the Jacksonville area are the remains of a number of real estate projects that date from that period. Therefore, this thesis examines the effects of the boom on greater Jacksonville during the 1920s. During the years immediately following World War I, Jacksonville's leaders concentrated on expansion of industry and commerce to promote their city's growth, rather than building tourism. Jacksonville had not been a major winter resort since the building of railroads southward in the late 1800s, and this made the North Florida city different than its downstate rivals. The increasing prosperity of the 1920s brought growing numbers of tourists, new residents, and land speculators to resort centers in South and Central Florida, but few to Jacksonville. As interest in Florida grew, the expanding numbers of land buyers created a frenzy of real estate sales and development downstate. The most immediate effect of the boom for Jacksonville was tremendous expansion of the city's industries, as they provisioned the state. However, many local residents became interested in syphoning off some of the tourists and land buyers for their own community. This resulted in civic promotion of Jacksonville as a resort, and the construction of a number of new real estate projects primarily for winter residents, including San Jose, Venetia, Florida Beach, and San Marco. Local expansion of business and real estate also resulted in the construction of several major buildings in downtown Jacksonville. Early in 1926, real estate prices broke downstate and many of the speculators and other newcomers went home. This created a statewide economic decline during the late 1920s that resulted in the failure of many real estate developments throughout Florida, including some in greater Jacksonville. With its extensive commercial and transportation complex, however, the North Florida city fared better than its tourist-dependent rivals downstate. Throughout the late 1920s, percentages of economic decline for Jacksonville were much smaller than in cities such as Miami and St. Petersburg.